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Heo Seo-Yeong,An Byungheon,Kim Dohyeon,Park Minji,Lee Haenghwa,Lee Youngjin 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.3
AS a medical imaging technology, dual-energy computed tomography (DECT) has attracted attention owing to its higher accuracy in terms of material separation compared with conventional single-energy CT imaging. A multi-material decomposition (MMD) technique that can separate two or more materials from DECT images has recently been developed. Although a highly accurate material separation can be obtained when MMD technology is applied to CT images, the inevitable addition of noise to the image is a disadvantage. Thus, block-matching and 3D fltering (BM3D) denoising algorithm was modeled to evaluate its applicability to CT images of materials separated using MMD technology. The simulation results confrmed that when the BM3D denoising algorithm was applied to CT images separated from the material using MMD technology, the root mean square (RMS), structural similarity index, and coefcient of variation (COV) were improved by 92.44%, 16.44%, and 92.82%, respectively, compared to when only MMD was applied. In addition, the experimental results showed the same tendencies as the simulations, and volume fraction accuracy (VFA) along with the RMS and COV evaluation parameters showed the best results when BM3D was applied to CT images. Improved results were obtained using the BM3D denoising algorithm when applying the MMD technique to DECT images.
자궁경부 편평상피암에서 DDRT-PCR 기법을 이용한 유전자 발현 및 Gene Ontology 분석
서민제 ( Seo Min Je ),배수미 ( Bae Su Mi ),박경미 ( Park Gyeong Mi ),김병훈 ( Kim Byeong Hun ),김용완 ( Kim Yong Wan ),서경윤 ( Seo Gyeong Yun ),서경아 ( Seo Gyeong A ),김용욱 ( Kim Yong Ug ),허수영 ( Heo Su Yeong ),노덕영 ( No De 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
목적: 인유두종 바이러스 감염에 의한 자궁경부암 발생에 대한 자연사 (natural history)는 비교적 잘 알려져 있으나 분자생물학적인 면에서의 병태생리는 아직 명확하게 규명되어 있지 않다. 자궁경부 편평상피암 조직에서 유전자 발현 양상을 조사하여 암화과정에 관여하는 유전자들의 다양한 기능과 상호작용에 대해서 알아보고자 하였다. 연구 방법: 양성질환으로 자궁 적출술을 시행한 17명의 자궁경부에서 추출한 RNA를 동일한 농도로 섞어 대조군으로 이용하 Objective: The molecular pathology of cervical cancer associated with human papillomavirus infection is presently unclear. In an effort to clarify the multiple interactions of a number of genes involved in cervical carcinogenesis, the gene expression prof
Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles
Heo, Nam Su,Lee, Sun Uk,Rethinasabapathy, Muruganantham,Lee, Eun Zoo,Cho, Hye-Jin,Oh, Seo Yeong,Choe, Sang Rak,Kim, Yeonho,Hong, Won G,Krishnan, Giribabu,Hong, Won Hi,Jeon, Tae-Joon,Jun, Young-Si,Kim, Elsevier 2018 Materials Science and Engineering C Vol.90 No.-
<P><B>Abstract</B></P> <P>Organic graphitic carbon nitride nanoparticles (NP-g-CN), less than 30 nm in size, were synthesized and evaluated for photodynamic therapy (PDT) and cell imaging applications. NP-g-CN particles were prepared through an intercalation process using a rod-like melamine-cyanuric acid adduct (MCA) as the molecular precursor and a eutectic mixture of LiCl-KCl (45:55 wt%) as the reaction medium for polycondensation. The nano-dimensional NP-g-CN penetrated the malignant tumor cells with minimal hindrance and effectively generated reactive oxygen species (ROS) under visible light irradiation, which could ablate cancer cells. When excited by visible light irradiation (<I>λ</I> > 420 nm), NP-g-CN introduced to HeLa and cos-7 cells generated a significant amount of ROS and killed the cancerous cells selectively. The cytotoxicity of NP-g-CN was manipulated by altering the light irradiation and the BP-g-CN caused more damage to the cancer cells than normal cells at low concentrations. As a potential non-toxic organic nanomaterial, the synthesized NP-g-CN are biocompatible with less cytotoxicity than toxic inorganic materials. The combined effects of the high efficacy of ROS generation under visible light irradiation, low toxicity, and bio-compatibility highlight the potential of NP-g-CN for PDT and imaging without further modification.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NP-g-CN are metal free non-toxic organic matter. </LI> <LI> Bulk-g-CN are breakdown into uniform NP-g-CN through intercalation of LiCl. </LI> <LI> NP-g-CN has high efficacy to generate ROS under visible light irradiation </LI> <LI> NP-g-CN is biocompatible, selectively kills cancer cells and less toxic to normal cells. </LI> <LI> Being organic, NP-g-CN avoids the potential toxicity from heavy metal in humans. </LI> <LI> NP-g-CN can be used for both photodynamic therapy (PDT) and imaging applications. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Heo, Nam Su,Shukla, Shruti,Oh, Seo Yeong,Bajpai, Vivek K.,Lee, Sun Uk,Cho, Hye-Jin,Kim, Suji,Kim, Yeonho,Kim, Hae Jin,Lee, Sang Yup,Jun, Young-Si,Oh, Mi-Hwa,Han, Young-Kyu,Yoo, Seung Min,Huh, Yun Suk Elsevier 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>Bacterial pathogens of water origin have potential public threats thus suggesting the need of developing efficient and sustainable water disinfection strategies from waterborne pathogens. We set out to synthesize different controlled morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer, evaluate their comparative effects on the generation of reactive oxygen species (ROS), and investigate potential applications in water purification systems. Characterization of the synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB>, such as melamine-cyanuric acid (MCA)-based rosette-type, rod-type, 2D hexagonal, and 3D cubic mesoporous silica was accomplished using Fourier transform infrared (FT-IR), energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), X-ray diffractometry (XRD), and transmission electron microscopy (TEM). The microbial inhibitory potential of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> photocatalyst against waterborne <I>Escherichia coli</I>, <I>Staphylococcus aureus</I>, and <I>Salmonella typhimurium</I> was evaluated based on the effective activity of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> upon visible light excitations. The microbicidal efficiency of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> was evident within 30 min of visible light exposure via direct interaction, while other microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> demonstrated only slight antimicrobial effects after 120 min, with insufficient ROS generation. The antimicrobial and ROS-generating effects of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> depended on the type and surface area of the synthesized 2D g-C<SUB>3</SUB>N<SUB>4</SUB> material. Considering its availability and excellent disinfection activity, 2D g-C<SUB>3</SUB>N<SUB>4</SUB> obtained from simple and convenient facile synthesis is a promising solar-driven photocatalyst for clearing microbial contamination from water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Waterborne pathogenic bacteria pose significant health risks to the public. </LI> <LI> We synthesized different morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer. </LI> <LI> Synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> had potential effect on ROS generation. </LI> <LI> 2D hexagonal g-C<SUB>3</SUB>N<SUB>4</SUB> exhibited significant antimicrobial potential. </LI> <LI> 2D g-C<SUB>3</SUB>N<SUB>4</SUB> had photocatalytic inactivation efficiency in a water purifying system. </LI> </UL> </P>