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박정훈 ( Junghun Park ),조원일 ( Won-il Jo ),변대흥 ( Dae-heung Byeon ),강소영 ( So Young Kang ),남충현 ( Choong-hyun Nam ),서경우 ( Kyoung-woo Seo ),박준규 ( Jun-kyu Park ) 한국공업화학회 2022 공업화학 Vol.33 No.5
급격한 고령화 사회로의 진입과 서구화된 식습관에 의해 협심증, 심근경색증, 고혈압 등에 의한 심장질환자의 수가 5년간 10만명 이상 증가했다. 심장질환은 지난 8년간 꾸준히 국내 사망원인 2위를 기록 중이며, 이로 인해 연간 소모되는 의료비는 6조원에 달한다. 증가한 환자와 함께 다양한 치료법이 제시되고 있는 가운데, 현재 보편화 된 관상동맥 중재시술 중 스텐트 삽입술의 단점인 재협착이나 장기간 이중항혈소판제 복용으로 인한 출혈의 위험 증가 등의 문제점을 보완하기 위해 약물코팅풍선카테터가 개발되어 점차 상용화되고 있는데, 국내에선 2010년 ‘SeQuent Please<sup>Ⓡ</sup> (비브라운코리아)’라는 제품이 처음 출시되면서 약물코팅풍선카테터를 사용한 시술이 시작되었고, 이후 2012년 보험급여가 적용되면서 그 사용량이 본격적으로 늘어났다. 약물코팅풍선치료는 국내뿐만 아니라 전 세계적으로 사용이 증가하고 있는데, 특히 일본을 포함한 아시아태평양 지역에서 그 사용량이 급격히 증가하고 있다. 현재까지 국산 제품의 수요가 증가하고 있는 상황이며 향후, 동물시험 및 임상시험에서의 성능이 입증된다면 위험성이 높은 스텐트 삽입술에 비해 효과적인 시술이 될 것이라 예상한다. As a result of the rapid entry into an aging society and westernized eating habits, the number of heart disease patients caused by angina pectoris, myocardial infarction, and high blood pressure has increased by more than 100,000 over five years. Heart disease has consistently ranked second in the cause of death in Korea over the past eight years, and medical expenses consumed annually reach 6 trillion won. While various treatments are being proposed for more patients, drug-coated balloon catheters have been developed and gradually commercialized to solve the disadvantages of stent implantation such as restenosis and increased risk of bleeding due to long-term double antiplatelet medication. In Korea, it began to use a drug-coated balloon catheter with the first release of it called “SeQuent Please<sup>Ⓡ</sup> (Bibrown Korea)” in 2010. Its demand increased gradually as insurance benefits were applied in 2012. Drug-coated balloon angioplasty is increasing in use not only in Korea but also around the world, especially in the Asia-Pacific region, including Japan. Until now, the demand for domestic products is increasing, and if the efficiency in vivo and clinical trials is proven in the future, it is expected to be an effective procedure compared to high-risk stent implantation.
Jin-Won Seo,Won Jin Kang,Min-Jun Kim,Jun-Won Park,Seung-Hwan Yun,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
In Korea, six mealybug species have been reported on pears. This study investigated the occurrence of mealybugs in 19 pear orchards from 2013 to 2014. Two species, Crisicoccus matsumotoi (Siraiwa) (Hemiptera: Pseudococcidae) and Pseudococcus comstocki (Kuwana) were mainly found. The dominant species was C. matsumotoi identified on 73% of infested fruit. Toxicities of 14 registered insecticides (7 single formulations and 7 mixed formulations) commonly used to control P. comstocki were evaluated to C. matsumotoi nymphs and adults at the recommended concentration. As a results, all insecticides exhibited strong insecticidal activity with 100% mortality of both nymphs and adults. These results indicate that the 14 insecticides can be used in control for C. matsumotoi in field.
Structure of Direct RF Sampling Receivers for GNSS Signals
Won, Yu-Jun,Ahn, Woo-Hyun,Lee, MinJoon,Park, Chansik,Seo, Bo-Seok The Institute of Positioning 2014 Journal of Positioning, Navigation, and Timing Vol.3 No.3
A direct RF sampling method refers to a technique that directly converts a passband signal to an intermediate band or a baseband without using a mixer. This method is less complicated than an existing RF receiver because a mixer is not used. It uses digital processing after sampling, and thus can flexibly process signals in a number of bands using software. In this process, it is important to select an appropriate sampling frequency so that a number of signals can be converted to an intermediate band that is easy to process. In this study, going beyond previously studied direct RF sampling frequency selection methods, conditions that need to be additionally considered during receiver design were examined, and the structure of a direct RF sampling receiver that satisfies these conditions was suggested.
Seo, Kyung Won,Park, Mi Jung,Park, Chang Won,Kim, Jun Gyou,Lee, Yoon Sook,Kim,Tae Wan,Song, Yeon Jung,Kim, Sang Geon,Lee, Sun Hee,Kim, Ju Il,Kil, Kwang Sup 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
Tobacco smoke condensate (TSC) has been reported to be carcinogenic to several animal species and include a nom'her of tumor initiators and tumor Promot☞rs.3-Hydroxypyridine (3-PfOH ), asignificant constituent of tobacco smoke, has been shown to induce the cytochrome P4S02El. In thisstudy we have investigated the influence of 3-PyOH on the activities of hepatic cytechromes P4SOuonooxygenases 1p450s) and UDP-glucuronyltransferase (UDP-GT), sulfotransferase (57) and gluts-thioue-5-transferase (GST) in male Sprague-Dawley rats. and compared with effect of TSC on metabo-lizing enBymes in rats hep,atocytes. We also examined if 3-PyOH and TSC would change the toxificationof acetaminophen (AA) through modulation of metaboliaing eazymes.3-PyOH (2mmo1/kg, p.o., 5 days)significantly increased the hepatic P4501Al and eST activity to 1.5 fold and 1.3 fold of control,respectivety. Treatment of TSC (250#g/m f, 2 days) dramatically enhanced the activity of PfSOIAl to7.5 fotd of control in rats hepatocytes. Smaller, but significant increase was observed with the activityof P4501A2(1.6 fold of control) in TSC-treated hepatocytes. After pretreatment of 3-PyOH (2mmo1/kg,p.o.5 days) iB ICR mice, potentiation of hepatotoricity by AA (400mg/kg, i.p., 24 hr) tras observed bymeasuring serum ALT activities. In rats hepatocytes, cytoteficity of AA was caused by pretreatmentwith TSC (250#g/mf,2 days) at non-cytotoxic concentration (ImMf. These results indicate that both of3-PyOH.and .?SC are potent inducers of PfSOIAl, but have lift)e effect on the phase rl metabolizing en-zymes. Moreover, potentiation of AA toxicity by pretreatments of 3-PyOH or TSC may be related to in-ductioa of Pfsos.
Inhibition of Corneal Neovascularization in Rats by Systemic Administration of Sorafenib
Seo, Jeong Won,Chung, So-Hyang,Choi, Jun-Sub,Joo, Choun-Ki Masson Pub. USA 2012 Cornea Vol.31 No.8
PURPOSE:: To evaluate the effect of orally administered sorafenib on corneal neovascularization in rat models. METHODS:: In male Sprague-Dawley rats, a silver nitrate applicator was placed on the central cornea in both eyes to elicit angiogenesis. Rats were divided into 3 groups, the control group and the 2 sorafenib-treated groups (low dose, 30 mg·kg·day; high dose, 60 mg·kg·day). The area of corneal neovascularization was measured by image analysis. Vascular endothelial growth factor receptor 2 (VEGFR2) messenger RNA expression was measured in rat corneas by reverse transcription–polymerase chain reaction, and the expression of phosphorylated extracellular signal-regulated kinase (ERK) was measured by Western blot analysis 1 week after cauterization. RESULTS:: The area of corneal neovascularization was significantly reduced by 44% in the 30 mg·kg·day group and by 66% in the 60 mg·kg·day group, compared with the control group (P = 0.014 and P < 0.0001). Corneal VEGFR2 messenger RNA expression was higher in the control group than in the sorafenib-treated groups. The expression of phosphorylated ERK in rat corneas was suppressed in the sorafenib-treated groups but not in the control group. CONCLUSIONS:: Oral administration of a multikinase inhibitor (sorafenib) significantly reduced the development of experimental corneal neovascularization in a dose-dependent manner. This inhibitory effect is probably related to the suppression of ERK phosphorylation by sorafenib.
Extraneural Metastasis of Glioblastoma Multiforme Presenting as an Unusual Neck Mass
Seo, Young-Jun,Cho, Won-Ho,Kang, Dong-Wan,Cha, Seung-Heon The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.3
Glioblastoma multiforme(GBM) is the most aggressive intracranial tumor and it commonly spreads by direct extension and infiltration into the adjacent brain tissue and along the white matter tract. The metastatic spread of GBM outside of the central nervous system (CNS) is rare. The possible mechanisms of extraneural metastasis of the GBM have been suggested. They include the lymphatic spread, the venous invasion and the direct invasion through dura and bone. We experienced a 46-year-old man who had extraneural metastasis of the G8M on his left neck. The patient was treated with surgery for 5 times, radiotherapy and chemotherapy. He had survived 6 years since first diagnosed. Although the exact mechanism of the extraneural metastasis is not well understood, this present case shows the possibility of extraneural metastasis of the G8M, especially in patients with long survival.