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Gwang-Il Noh,Ki-Young Kim,Seo-Ho Shin,Seo-Ho Shin,Hyun-Su Park,Bo-Kyeong Kim,Mun-Sik Shin,Jae-Kwon Ko 한국육종학회 2008 한국육종학회지 Vol.40 No.3
This study was carried out to get the genetic information on the germination rate and fat acidity after 12 weeks’storage at 35 . Germination rate decreased with longer storage period, ℃ while fat acidity increased. Germination rate was higher in the order of Koshihikari, Hanmaeum and Unkwangbyeo after 12 weeks’storage at 35℃. Fat acidity of Koshihikari and Hanmaeum was gradually increased, but that of Unkwangbyeo was dramatically increased after 4 weeks’storage at 35℃. The genetic mode on germination rate and fat acidity using the joint scaling test was shown to be additive-dominance gene effects. Additive([d]) effect was higher than dominance effect([h]) in all crosses. The average degree of dominance, [h]/[d], was less than 1, indicating that germination rate and fat acidity was partially dominant. Germination rate and fat acidity based on frequency distribution of 2 crosses were quantitative characters expressed by polygenes.
Gwang-Sik Kim,Gwangwe Yoo,Yujin Seo,Seung-Hwan Kim,Karam Cho,Byung Jin Cho,Changhwan Shin,Jin-Hong Park,Hyun-Yong Yu IEEE 2016 IEEE electron device letters Vol.37 No.6
<P>The effect of post-deposition H<SUB>2</SUB> annealing (PDHA) on the reduction of a contact resistance by the metal-interlayer-semiconductor (M-I-S) source/drain (S/D) structure of the germanium (Ge) n-channel field-effect transistor (FET) is demonstrated in this letter. The M-I-S structure reduces the contact resistance of the metal/n-type Ge (n-Ge) contact by alleviating the Fermi-level pinning (FLP). In addition, the PDHA induces interlayer doping and interface controlling effects that result in a reduction of the tunneling resistance and the series resistance regarding the interlayer and an alleviation of the FLP, respectively. A specific contact resistivity (p<SUB>c</SUB>) of 3.4×10<SUP>-4</SUP>Ω·cm<SUP>2</SUP> was achieved on a moderately doped n-Ge substrate (1×10<SUP>17</SUP> cm<SUP>-3</SUP>), whereby 5900× reduction was exhibited from the Ti/n-Ge structure, and a 10× reduction was achieved from the Ti/Ar plasma-treated TiO<SUB>2-x</SUB>/n-Ge structure. The PDHA technique is, therefore, presented as a promising S/D contact technique for the development of the Ge n-channel FET, as it can further lower the contact resistance of the M-I-S structure.</P>
Kim, Gwang-Sik,Kim, Sun-Woo,Kim, Seung-Hwan,Park, June,Seo, Yujin,Cho, Byung Jin,Shin, Changhwan,Shim, Joon Hyung,Yu, Hyun-Yong American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.51
<P>A perfect ohmic contact formation technique for low-resistance source/drain (S/D) contact of germanium (Ge) n-channel metal-oxide-semiconductor field-effect transistors (MOSFETs) is developed. A metal interlayer semiconductor (M-I-S) structure with an ultrathin TiO2/GeO2 interlayer stack is introduced into the contact scheme to alleviate Fermi-level pinning (FLP), and reduce the electron Schottky barrier height (SBH). The TiO2 interlayer can alleviate FLP by preventing formation of metal-induced gap states (MIGS) with its very low tunneling resistance and series resistance and can provide very small electron energy barrier at the metal/TiO2 interface. The GeO2 layer can induce further alleviation of FLP by reducing interface state density (D-it) on Ge which is one of main causes of FLP. Moreover, the proposed TiO2/GeO2 stack can minimize interface dipole formation which induces the SBH increase. The M-I-S structure incorporating the TiO2/GeO2 interlayer stack achieves a perfect ohmic characteristic, which has proved unattainable with a single interlayer. FLP can be perfectly alleviated, and the SBH of the metal/n-Ge can be tremendously reduced. The proposed structure (Ti/TiO2/GeO2/n-Ge) exhibits 0.193 eV of effective electron SBH which achieves 0.36 eV of SBH reduction from that of the Ti/n-Ge structure. The proposed M-I-S structure can be suggested as a promising S/D contact technique for nanoscale Ge n-channel transistors to overcome the large electron SBH problem caused by severe FLP.</P>
임상검체로부터 분리된 methicillin 내성 Staphylococcus aureus의 독소 및 항생제 내성
Keun Sik Baik(백근식),Gwang Seo Ki(기광서),Han Na Choe(최한나),Seong Chan Park(박성찬),Eun Cho Koh(고은초),Hyung Rak Kim(김형락),Chi Nam Seong(성치남) 한국생명과학회 2011 생명과학회지 Vol.21 No.2
2009년 7월부터 12월까지 순천 소재 한 병원에 내원한 환자의 검체로부터 methicillin 내성 Staphylococcus aureus(MRSA) 75균주와 methicillin 감수성 S. aureus (MSSA) 24균주를 분리하였다. 분리균의 항생제 감수성 조사는 디스크 확산법을 사용하여 측정하였다. 분리균의 독소 유전자 보유는 multiplex PCR을 이용하여 장독소(enterotoxin; SE), 독성 쇼크 증상 독소 1(toxic shock syndrome toxin-1; TSST-1), 피부박탈성 독소(exfoliative toxin; ET) 및 백혈구 용해 독소(Panton-Valentine leukocidin; PVL) 유전자를 검출하였다. 분리된 MRSA 60개 균주는 1개 혹은 2개의 독소 유전자를 가지고 있으며, 22.7%의 균주가 seb, sec, seg, sei와 tst 유전자를 동시에 보유하고 있었으며 18.7%는 sec, seg, sei와 tst 유전자를 동시에 보유하고 있었다. 백혈구 용해독소를 암호하는 pvl 유전자는 검출되지 않았다. MRSA는 sec, seg, sei와 tst 유전자 보유에 높은 상관성을 보였다. MRSA 균주들은 erythromycin(분리균의 89%), gentamicin (70.7%), ciprofloxacin (69.3%), clindamycin (61.3%)과 tetracycline (58.7%)에 내성이 높은 반면, MSSA 균주들은 erythromycin를 제외한 다른 항생제에는 민감하였다. 독소 유전자 seb, sec와 tst는 tetracycline 내성과 높은 상관관계가 있었다. Seventy five methicillin- resistant Staphylococcus aureus (MRSA) strains and 24 methicillin- susceptible S. aureus (MSSA) were isolated from clinical specimens obtained from a hospital in Suncheon, Jeonnam province, Korea, from July to December, 2009. Antibiotic resistance was determined using the disc diffusion method. Genes encoding enterotoxin (SE), toxic shock syndrome toxin-1 (TSST-1), exfoliative toxin (ET) and Panton-Valentine leukocidin (PVL) were detected by multiplex PCR-mediated amplification using specific primers. Sixty (80%) MRSA isolates possessed either one or more toxin genes and the most common pattern that coexisted in MRSA was seb, sec, seg, sei and tst (22.7%) followed by coexistence of sec, seg, sei and tst genes (18.7%). Gene pvl encoding leukocidin was not found. Significant correlation between the production of sec, seg, sei and tst genes was found. MRSAs were resistant to erythromycin (89% of the isolates), gentamicin (70.7%), ciprofloxacin (69.3%), clindamycin (61.3%) and tetracycline (58.7%), while MSSAs were susceptible to the antibiotics with the exception of erythromycin. Toxin genes seb, sec and tst were related to the tetracycline resistance of MRSA.
( Myeongsook Seo ),( Eun Mi Song ),( Gwang Un Kim ),( Sung Wook Hwang ),( Sang Hyoung Park ),( Dong-hoon Yang ),( Kyung-jo Kim ),( Byong Duk Ye ),( Seung-jae Myung ),( Suk-kyun Yang ),( Jeong-sik Byeo 대한장연구학회 2017 Intestinal Research Vol.15 No.4
Background/Aims: Precutting before endoscopic piecemeal mucosal resection (EPMR) may increase colorectal polyp resection effectiveness. We aimed to identify risk factors for recurrence after conventional EPMR (CEPMR) and precut EPMR (PEPMR) and investigated endoscopic treatment outcomes for recurrent cases. Methods: The medical records of patients with colorectal polyps treated by EPMR were analyzed. Patients without follow-up surveillance colonoscopies were excluded. Results: Among 359 lesions, the local recurrence rate on the first surveillance colonoscopy was 5.8% (18/312) and 6.4% (3/47) after CEPMR and PEPMR, respectively. Among lesions without recurrence at the first surveillance colonoscopy, the rates of late recurrence on subsequent surveillance colonoscopy were 3.9% (6/152) and 0% after CEPMR and PEPMR, respectively. Larger tumor size was the only independent risk factor for recurrence (odds ratio, 7.93; 95% confidence interval, 1.95-32.30; P<0.001). Endoscopic treatment was performed for all 27 recurrences. A combination of ≥2 endoscopic treatment modalities was used in 19 of 27 recurrences (70.4%). Surveillance colonoscopies were performed in 20 of 27 recurrences after endoscopic treatment. One (5.0%) had a re-recurrence and was treated by surgical resection because recurrence occurred at the appendiceal orifice. Nineteen of 20 lesions (95.0%) could be cured endoscopically, although 3 of the 19 showed second or third recurrences and were treated by repeat endoscopic resection. Conclusions: The local recurrence rates after CEPMR and PEPMR were similar. Larger tumor size was an independent risk factor for local recurrence after EPMR. Endoscopic treatment of recurrences resulted in high cure rates, although combination methods were necessary in many cases. (Intest Res 2017;15:502-510)
Jang, Dae-Sik,Min, Hye-Young,Kim, Moon-Sun,Han, Ah-Reum,Windono, Tri,Jeohn, Gwang-Ho,Kang, Sam-Sik,Lee, Sang-Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16
A new humulene sesqulterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxlde (2) were isolated from the rhizomes of Ziagiber zerumbet (Zinglberraceae), and found to Inhibit lipopolysaccharlde-Induced nitric oxide production in murlne macrophage RAW 264.7 cells with IC_(50) values of 14.1 and 23.5㎛, respectlvely, by bloassay-guided fractlonation (positive control: N^(ω) monomethyl-L-arginine, IC_(50)=21.3㎛). The structure of 1 was determined by spectroscopic methods Including 1D and 2D-NMR.
Microsatellite Analysis of the Genetic Diversity and Population Structure in Dairy Goats in Thailand
Seilsuth, Somkiat,Seo, Joo Hee,Kong, Hong Sik,Jeon, Gwang Joo Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3
The genetic relationships between different populations and breeds of exotic dairy goats in Thailand were studied using 12 microsatellite markers. Blood samples were obtained from 211 goats from Department of Livestock Development breeding and research farms: 29 Anglonubian (AN), 21 Alpine (AP), 23 Jamunapari (JAM), 50 Saanen (SN), and 88 Toggenburg (TG). Five of the 12 microsatellite markers were found to be polymorphic. A mean of 7.40 alleles per locus was found, with a range from 5 (SPS115 and ETH225) to 11 (TGLA122). We found 24, 27, 19, 32, and 24 alleles in the AN, AP, JAM, SN, and TG breeds, respectively; 37 alleles were present in all breeds. The mean number of alleles in each population ranged from 3.2 (ETH225 locus) to 7.6 (TGLA122 locus). Genetic variability within the breeds was moderate as evidenced by the mean expected heterozygosity of 0.539. The average observed heterozygosity across the 5 markers in all breeds was 0.529 with the maximum observed at the BM1818 locus (0.772) and the minimum at the ETH225 locus (0.248). The observed and expected heterozygosity for all breeds for the 5 microsatellite markers ranged from 0.419 to 0.772 and 0.227 to 0.792, respectively. On the basis of their means, the TGLA122 and BM1818 loci were the most suitable markers for distinguishing genetic diversity among the goats. The estimated average $F_{is}$ value for the breeds ranged from -0.044 (ETH225) to 0.180 (SPS115), while the estimated average $F_{st}$ value ranged from 0.021 (SPS115) to 0.104 (ETH10). These results indicated that TGLA122 and BM1818 markers are suitable to be used for aiding conservation and breeding improvement strategies of dairy.