http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim,Jung-Keun 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4
This study was conducted to investigate the preventingeffects of OPB (Rehmannia glutinosa Libosch and Eleuth-erococcus senticosus Max extracts) and combined OPB/Calcium therapy on bone loss in ovariectomized rats. SixtySprague Dawley rats of 12-week-old were divided into eightgroups: OVX (ovariectomized), OPBL (OPB 50mg/kg),OPBM (OPB100mg/kg), OPBH (OPB 200mg/kg), OPBL/CAL(OPBL+CAL), OPBM/CAL (OPBM+CAL), OPBH/CAL (OPBH+CAL) and CAL (Calcium citrate 88.33mg/kg+1α, 25-dihydroxy-vitamin D3 33.33IU/kg). Bone mineraldensity (BMD), bone mineral content (BMC), bone strengthindices and cortical thickness were analyzed by peripheralquantitative computerized tomography (pQCT). pQCTscanning showed that OVX induced a significant decreasein trabecular bone mineral density and bone mineralcontent in the proximal tibia (-36.4±2.4%, -21.8±12.7%).These decreases were significantly prevented by theadministration of OPBM and OPBM/CAL. Cortical BMDand BMC of tibia were slightly enhanced by OPB and OPB/CAL. However there was no significant difference betweenOVX and OPB, OPB/CAL treated group. Bone strengthindices and cortical thickness were not significantly different.Our results suggest that OPB and combined OPB/Calciumtherapy are effective in preventing the development of boneloss induced by ovariectomy in rats.
Kim, Gwan-Shik,Cheong, Dong-Kyun,Kim, Se-Won,Ko, Seong-Hee,Kim, Myung-Soo,Kim, Kyung-Nyun,Kim, Joong-Soo,Lee, Jong-Heun The Official Publication of Korean Academy of Oral 1994 International Journal of Oral Biology Vol.18 No.2
To study the effect of changes in intracellular Ca^2+ on osteoclast generation from their precursor cells, the bone marrow cells were prepared from 7-9 weeks old male ICR mice. The femur and tibia were dissected aseptically and the marrow cavity was slowly flushed with 1 ml of α-minimum essential medium. Collected marrow cells were seeded at a density of 1.5-2.0×10^6 cells/well on 24-well plate and cultured for 8 days. In experimental group, PTH(10, 100 ng/ml), calcium ionophore A23187(0.3, 0.6μM), PGE₂(10^-5 M) or verapamil ((10^-7 M) were added alone or in combination from the beginning of culture. At the end of culture, cells were stained for tartrate-resistant acid phosphatase(TRACP), a marker enzyme of osteoclast, according to the modified method of Burstone. The number of TRACP-positive multinucleated cells, which have 3 or more nuclei, were counted. TRACP-positive mononuclear cells were present in control group, but TRACP-positive multinuclear osteoclast-like cells (OC-like cells) were not. When added alone, PTH, but not calcium ionophore A23187, stimulated the formation of OC-like cells. However, calcium ionophore increased the PTH-induced formation of OC-like cells. Verapamil, a calcium channel blocker, comlpletely inhibited the OC-like cell generation induced by combined treatment with PTH and calcium ionophore A23187. A23187 potentiated the OC-like cell formation induced by PGE₂also. These results indicate that increase in intracellular Ca^2+ contributes to the generation of OC-like cells, and suggest that its primary mode of action seems to be a modulating one rather a direct inductant in itself.
Kim, Taeil,Yoon, Joonsun,Cho, Hwansung,Lee, Wook-bin,Kim, Joon,Song, Young-Hwa,Kim, Se Nyun,Yoon, Jeong Ho,Kim-Ha, Jeongsil,Kim, Young-Joon Nature America Inc 2005 Nature immunology Vol.6 No.2
IκB kinase (IKK) and Jun N-terminal kinase (Jnk) signaling modules are important in the synthesis of immune effector molecules during innate immune responses against lipopolysaccharide and peptidoglycan. However, the regulatory mechanisms required for specificity and termination of these immune responses are unclear. We show here that crosstalk occurred between the drosophila Jnk and IKK pathways, which led to downregulation of each other's activity. The inhibitory action of Jnk was mediated by binding of drosophila activator protein 1 (AP1) to promoters activated by the transcription factor NF-κB. This binding led to recruitment of the histone deacetylase dHDAC1 to the promoter of the gene encoding the antibacterial protein Attacin-A and to local modification of histone acetylation content. Thus, AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-κB target genes.
Prognostic impact of chromogranin A in patients with acute heart failure
( Hong Nyun Kim ),( Dong Heon Yang ),( Bo Eun Park ),( Yoon Jung Park ),( Hyeon Jeong Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ) 영남대학교 의과대학 2021 Yeungnam University Journal of Medicine Vol.38 No.4
Background: Chromogranin A (CgA) levels have been reported to predict mortality in patients with heart failure. However, information on the prognostic value and clinical availability of CgA is limited. We compared the prognostic value of CgA to that of previously proven natriuretic peptide biomarkers in patients with acute heart failure. Methods: We retrospectively evaluated 272 patients (mean age, 68.5±15.6 years; 62.9% male) who underwent CgA test in the acute stage of heart failure hospitalization between June 2017 and June 2018. The median follow-up period was 348 days. Prognosis was assessed using the composite events of 1-year death and heart failure hospitalization. Results: In-hospital mortality rate during index admission was 7.0% (n=19). During the 1-year follow-up, a composite event rate was observed in 12.1% (n=33) of the patients. The areas under the receiver-operating characteristic curves for predicting 1-year adverse events were 0.737 and 0.697 for N-terminal pro-B-type natriuretic peptide (NT-proBNP) and CgA, respectively. During follow-up, patients with high CgA levels (>158 pmol/L) had worse outcomes than those with low CgA levels (≤158 pmol/L) (85.2% vs. 58.6%, p<0.001). When stratifying the patients into four subgroups based on CgA and NT-proBNP levels, patients with high NT-proBNP and high CgA had the worst outcome. CgA had an incremental prognostic value when added to the combination of NT-proBNP and clinically relevant risk factors. Conclusion: The prognostic power of CgA was comparable to that of NT-proBNP in patients with acute heart failure. The combination of CgA and NT-proBNP can improve prognosis prediction in these patients.