Coronal Plane Gap Increases Postoperative Pseudoarthrosis after Lateral Interbody Fusion for Adult Spinal Deformity

Okada Eijiro,Yagi Mitsuru,Yamamoto Yusuke,Suzuki Satoshi,Nori Satoshi,Tsuji Osahiko,Nagoshi Narihito,Fujita Nobuyuki,Nakamura Masaya,Matsumoto Morio,Watanabe Kota 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.3

Study Design: This is a retrospective study.Purpose: This study aims to evaluate the risk factor associated with pseudoarthrosis after placement of lateral interbody fusion (LIF) cages for adult spinal deformity (ASD) treatment. Overview of Literature: LIF technique is widely used for ASD correction. Furthermore, pseudoarthrosis is a major complication of fusion surgery required for revision surgery.Methods: This study included 42 patients with ASD (two men and 40 women; 112 segments; mean, 68.5±8.4 years; and mean follow-up, 31.6±17.0 months) who underwent LIF and posterior correction surgery. The concave slot of the LIF cage was filled with an autologous iliac crest bone graft (IBG), and the convex slot with a porous hydroxyapatite/collagen (HAp/Col) composite was soaked with bone marrow aspirate. Endplate injury, the gap between vertebral endplate and cage in the coronal or sagittal plane, and fusion status were evaluated using computed tomography multiplanar reconstruction at 12 months after surgery. Moreover, the associated risk factors for pseudoarthrosis were analyzed.Results: Fusion at LIF segments were observed in 71.4% segments at 12 months after surgery. Fusion on the concave slot (autologous IBG side), convex slot (porous HAp/Col composite side), and both concave and convex slots were observed in 66.1%, 37.5%, and 36.6% of patients, respectively. Moreover, pseudoarthrosis was observed in 28.6% at 12 months after surgery. Consequently, logistic regression analysis of the fusion at the LIF segment revealed that the gap between the LIF cage and endplate in the coronal plane (p=0.030; odds ratio, 0.183; 95% confidence interval, 0.030–0.183) was significantly associated with pseudoarthrosis at the LIF segments.Conclusions: ASD surgery fusion rate using LIF cages was 71.4% at 12 months after surgery. The fusion rate was higher on the concave slot filled with autologous IBG than on the convex slot filled with a porous HAp/Col composite. The gap in the coronal plane was a risk factor for pseudoarthrosis at the LIF segment.

Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis

Eijiro Okada,Shinichi Ishihara,Koichiro Azuma,Takehiro Michikawa,Satoshi Suzuki,Osahiko Tsuji,Satoshi Nori,Narihito Nagoshi,Mitsuru Yagi,Michiyo Takayama,Takashi Tsuji,Nobuyuki Fujita,Masaya Nakamura 대한척추신경외과학회 2021 Neurospine Vol.18 No.1

Objective: Diffuse idiopathic skeletal hyperostosis (DISH) causes spinal ankylosis, which can result in patients suffering specific spinal fractures that lead to a reduction in the activities of daily life in older patients. Currently, DISH is associated with diabetes mellitus and cardiovascular disease; however, the association between DISH and metabolic syndrome has not been established. The purpose of this study was to investigate a potential association between DISH and metabolic syndrome. Methods: We retrospectively reviewed clinical data from consecutive subjects undergoing the musculoskeletal health medical checkups, and enrolled 327 subjects (174 men and 153 women; mean, 63.4±13.7-years). Subjects who had spinal ankylosis at least 4 contiguous vertebral bodies were classified as the DISH group (n=39) while the others were part of the non-DISH group (n=288). The definition of the metabolic syndrome comes from diagnostic criteria used by the Japanese Society for Internal Medicine. Age, sex, body max index (BMI), hematological evaluation, blood pressure, presence of metabolic syndrome, the visceral fat area on abdominal computed tomography, and spinal epidural lipomatosis (SEL) on magnetic resonance imaging were evaluated. Results: Compared to the non-DISH group, in the DISH group, mean age (DISH group, 74.3 years; non-DISH group, 1.9 years; p<0.001), male prevalence were higher (DISH group, 82.1%; non-DISH group, 49.3%; p<0.001), and BMI was greater (DISH group, 24.8; non-DISH group, 23.0; p=0.006). the metabolic syndrome was more frequently observed in DISH group (28.9%) than in the non-DISH group (16.0%) (p=0.045). The visceral fat area was significantly larger in the DISH group than in the non-DISH group (DISH group, 130.7±58.2 cm2; Non-DISH group, 89.0±48.1 cm2; p<0.001). The prevalence of SEL was similar between the 2 groups (10.3% in the DISH group vs. 8.7% in the non-DISH group; p=0.464). Poisson regression analysis revealed that the metabolic syndrome was significantly associated with DISH with odds ratio of 2.0 (95% confidence interval, 1.0–3.7; p=0.004). Conclusion: Metabolic syndrome was significantly associated with DISH. Our data showed metabolic syndrome is potentially related to DISH.

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

Okada, Chimari,Yamashita, Eiki,Lee, Soo Jae,Shibata, Satoshi,Katahira, Jun,Nakagawa, Atsushi,Yoneda, Yoshihiro,Tsukihara, Tomitake American Association for the Advancement of Scienc 2009 Science Vol.326 No.5957

<P>Nuclear export of microRNAs (miRNAs) by exportin-5 (Exp-5) is an essential step in miRNA biogenesis. Here, we present the 2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and a guanine triphosphate (GTP)-bound form of the small nuclear guanine triphosphatase (GTPase) Ran (RanGTP). The x-ray structure shows that Exp-5:RanGTP recognizes the 2-nucleotide 3′ overhang structure and the double-stranded stem of the pre-miRNA. Exp-5:RanGTP shields the pre-miRNA stem from degradation in a baseball mitt-like structure where it is held by broadly distributed weak interactions, whereas a tunnel-like structure of Exp-5 interacts strongly with the 2-nucleotide 3′ overhang through hydrogen bonds and ionic interactions. RNA recognition by Exp-5:RanGTP does not depend on RNA sequence, implying that Exp-5:RanGTP can recognize a variety of pre-miRNAs.</P>

Structural Design of Nakanoshima Festival Tower

Okada, Ken,Yoshida, Satoshi Council on Tall Building and Urban Habitat Korea 2014 International journal of high-rise buildings Vol.3 No.3

Nakanoshima Festival Tower is a 200 m high-rise complex building which contains a renewed 2700-seat capacity concert hall known as "Festival Hall" and offices including headquarter of a news company. In order to build up an office tower on the hall which requires large open space, a giant truss system is employed. The giant trusses being composed of mega-trusses and belt-trusses support all the building weight above them and transfer the load to the outside of the hall. The building also requires high seismic resistance performance for a news company. Application of mid-story seismic isolation enables the building to satisfy high-level seismic resistance criteria.

Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

Satoshi Ugi,Hiroshi Maegawa,Katsutaro Morino,Yoshihiko Nishio,Toshiyuki Sato,Seiki Okada,Yasuo Kikkawa,Toshihiro Watanabe,Hiromu Nakajima,Atsunori Kashiwagi 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.4

Background: Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration. Methods: Twenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels. Results: AUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours. Conclusion: Our system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.

Crystallization of a-Si Films with Smooth Surfaces by Using Blue Multi-Laser Diode Annealing

Tatsuya Okada,Kouya Sugihara,Satoshi Chinen,Takashi Noguchi 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.8

Crystallization of ∼50-nm-thick amorphous Si (a-Si) with a smooth surface was achieved by using Blue Multi-Laser Diode Annealing (BLDA). The a-Si films were deposited by using RF sputtering with Ne gas or by using plasma enhanced chemical vapor deposition (PE-CVD) and were annealed by using BLDA with CW scanning. After the films had been annealed a relatively low laser power below 4 W, the root-mean-square (RMS) roughness deduced from the atomic force microscopy (AFM) results for the surfaces of the Si films was slightly increased, but smoothness was within 3 nm despite the conditions under which the films had been crystallized. BLDA has a potential to realize next-generation poly-Si thin film transistors (TFTs).

Screw Tightening Methods with Ultrasonic Vibration Resonance

Manabu OKADA,Tomonari TSUCHIDA,Satoshi NAKATSUKA,Yukihiro OTANI,Kouhei KUWABARA 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5

STATE OF ART OF SELFBEARING MOTOR

Yohji Okada,Satoshi Ueno,Tetsuo Ohishi 한국소음진동공학회 1997 한국소음진동공학회 학술대회논문집 Vol.1997 No.11

Surgical and Functional Outcomes of Expansive Open-Door Laminoplasty for Patients With Mild Kyphotic Cervical Alignment

Narihito Nagoshi,Satoshi Nori,Osahiko Tsuji,Satoshi Suzuki,Eijiro Okada,Mitsuru Yagi,Masaya Nakamura,Morio Matsumoto,Kota Watanabe 대한척추신경외과학회 2021 Neurospine Vol.18 No.4

Objective: To evaluate the cervical dynamics, neurological function, pain, and quality of life in patients with mild cervical kyphotic alignment who underwent expansive unilateral open-door laminoplasty (ELAP). Methods: In this retrospective single-center study, we reviewed the surgical outcomes of 80 patients with cervical spondylotic myelopathy who were followed for at least 2 years. The patients were categorized into the preoperative kyphotic group (C2–7 angle <0°) and nonkyphotic group (angle ≥0°). We compared clinical information, radiographic parameters, Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) scores, and cervical Japanese Orthopaedic Association (JOA) scores between the groups. Results: The kyphotic and nonkyphotic groups comprised 17 and 63 patients, respectively. The preoperative C2–7 angles were -3.7° in the kyphotic group and 15.4° in the nonkyphotic group (p<0.01). In the kyphotic group, kyphotic alignment improved to lordosis at the final follow-up (2.6°, p=0.01). The preoperative (16.4° vs. 24.1°, p<0.01) and final-follow-up (17.8° vs. 24.5°, p<0.01) C7 slopes were significantly smaller in the kyphotic group. ELAP reduced pain in the arms or hands (p=0.02) and improved the JOA scores (p<0.01) in the kyphotic group. Patient-reported outcomes assessed using the JOACMEQ showed comparable effective rates in both groups. Conclusion: Patients with mild cervical kyphosis showed smaller C7 slopes as a compensatory mechanism. Kyphotic angles significantly improved to lordosis after ELAP, resulting in favorable clinical outcomes. ELAP is a useful surgical option for patients even if they present mild kyphotic cervical angles.

Thermal Hazard Evaluation on Self-polymerization of MDI

Sato, Yoshihiko,Okada, Ken,Akiyoshi, Miyako,Murayama, Satoshi,Matsunaga, Takehiro The Korean Society of Safety 2010 International Journal of Safety Vol.9 No.1

Thermal analysis, heating test on gram scale and simulation of exothermic behavior based on kinetic analysis has been conducted in order to evaluate thermal hazards of self-polymerization of MDI. The exothermic reactions of MDI are expected to be the polymerization which forms carbodiimide and carbon dioxide, dimerization and trimerization. When MDI is kept in adiabatic condition during 1 week (10080 hours), the simulated result shows runaway reaction can occur in the case that initial temperature was more than $130^{\circ}C$. The relationship between the initial temperature (T, $^{\circ}C$) and TMR is given in a following equation. TMR=$4.493{\times}10^{-7}$ exp ($9.532{\times}10^3$/(T+273.15)) We propose that the relationship gives important criteria of handling temperature of MDl to prevent a runaway reaction.