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( Min Keun Kim ),( Sangah Baek ),( Ga Young Kim ),( Hyeon Chul Lee ),( Hyesun Lee ),( Eun Jeong Kim ),( Chang Hyeong Lee ),( Byung Seok Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Recently, treatment of hepatitis C virus (HCV) has evolved and improved remarkably. Use of all-oral combination regimens of direct- acting antivirals (DAAs) in chronic hepatitis C (CHC) patients shows a sustained virologic response (SVR) rate of ≥90%. Daclatasvir (DCV) plus asunaprevir (ASV) combination therapy has produced high rates of SVR among HCV genotype 1b patients without baseline NS5A resistance-associated variants (RAVs) in clinical trials. We evaluated the efficacy and safety of DCV and ASV combination therapy for chronic HCV genotype 1b infection in real world. Methods: We retrospectively reviewed the medical records of patients with chronic HCV genotype 1b infection. A total of 86 patients (57 treatment-naive patients), who were treated with DCV and ASV combination at their recommended doses, were enrolled in this study. We evaluated the virologic response rates at week 4, 12, 24 of treatment, and week 12 after completion of treatment (SVR12). Results: The mean age was 58.52±9.78 years, and 41 patients (47.7%) were men. Thirty patients (34.9%) had cirrhosis. Baseline NS5A sequences were available from 80 patients. Pretreatment NS5A RAVs were present in 4 patients (5.0%). DCV plus ASV provided virologic response in 73 patients (100%) at week 4; 55 patients (96.5%) at week 12; 18 patients (94.7%) at week 24 of treatment; one patient (100%) at week 12 after completion of treatment. Adverse events occurred in 6 patients. Adverse events included headache, nausea, diarrhea, and skin rash. No serious adverse events occurred. Conclusions: DCV and ASV combination therapy provided high rates of virologic response at week 4, 12, 24 of treatment, and week 12 after completion of treatment in chronic HCV genotype 1b infection patients in real world. DCV plus ASV was well tolerated without serious adverse events. We also expect high SVR rate after DCV plus ASV treatment in a large number of cases.
Do Young Kim,Soojin Kim,Sangah Kim,Jun Mo Lee,Ji Hyun Kim 대한안과학회 2024 Korean Journal of Ophthalmology Vol.38 No.1
Purpose: This study aimed to assess the difference in the vascular parameters of perfusion in the optic nerve head in normal tension glaucoma (NTG) across disease stages using optical coherence tomography angiography and its correlation with peripapillary retinal nerve fiber layer (RNFL) thickness. Methods: In this retrospective study, 83 eyes with varying stages of NTG (25 mild, 31 moderate, and 27 severe) and 90 healthy eyes were enrolled. The perfusion density (PD) and flux index (FI) of the optic nerve head divided into four sectors were determined. We compared the vascular, structural, and functional parameters between normal and glaucomatous eyes and performed a subgroup analysis among the NTG stages. Pearson correlation coefficient was used to assess the topographic correlation between vascular parameters and RNFL thickness. Results: PD and FI were significantly decreased in the NTG group. Subgroup analysis revealed a significant decrease in vascular parameters in most regions in the NTG group, except for the nasal PD and temporal FI. Post hoc analysis showed a significant decrease in PD in the inferior region across all severity levels (mild vs. moderate, p = 0.012; moderate vs. severe, p = 0.012; mild vs. severe, p < 0.001). PD and FI were strongly correlated with RNFL thickness in all quadrants (all p < 0.001), with the strongest correlation observed in the inferior region. Conclusions: Vascular parameters were significantly decreased in glaucomatous eyes, and the degree of decrease in vascular parameters was proportional to glaucoma severity. Peripapillary perfusion analysis using optical coherence tomography angiography may complement other measurements used for glaucoma diagnosis.
( Min Keun Kim ),( Sangah Baek ),( Ga Young Kim ),( Hyeon Chul Lee ),( Hyesun Lee ),( Eun Jeong Kim ),( Chang Hyeong Lee ),( Byung Seok Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Tenofovir disoproxil fumarate (TDF) has highly potent antiviral activity with a high genetic barrier to resistance in chronic hepatitis B (CHB) patients. The optimal management of CHB patients exhibiting a partial virologic response (PVR) to TDF is currently not established. The aim of this study was to evaluate the long-term efficacy of prolonged TDF monotherapy in treatment-naive CHB patients exhibiting a PVR to TDF therapy. Methods: This retrospective study included 139 treatment-naive CHB patients treated with TDF for ≥48 weeks and who received continuous TDF monotherapy for ≥24 weeks at Daegu Catholic University Hospital. PVR was defined as a decrease in serum HBV DNA of more than 2 log10 IU/mL from baseline but detectable HBV DNA by real- time PCR assay at week 48. All patients were monitored at baseline and every 3 months during treatment. Results: Thirty of 139 patients (21.6%) showed PVR. The mean follow- up duration in PVR group was 90.0±17.7 weeks. The mean age was 48.4±13.9 years, and 20 patients (66.7%) were men. Twenty-two patients (73.3%) were HBeAg-positive, and 13 patients (43.3%) had cirrhosis. Fifteen of 30 patients (50.0%) achieved a virologic response (VR, HBV DNA <20 IU/ml) during prolonged TDF monotherapy for ≥24 weeks. VR rate in HBeAg-positive patients was 50.0% (11/22). Among 15 patients who did not achieve a VR during continuous TDF therapy, 10 patients had poor drug compliance. The overall cumulative rates of VR at week 60, 72, 84, and 96 from treatment initiation in patients with PVR were 25.0%, 41.4%, 47.1%, and 53.3%, respectively. The PVR was associated with HBV DNA levels at baseline, week 4, 12, and 24, and also with virologic breakthrough. Conclusions: Long-term continuous TDF monotherapy with good medication compliance may be effective for achieving VR in treatment- naive CHB patients exhibiting a PVR to TDF therapy.
식품으로 인한 유해물질 노출조사를 위한 식생활 설문지의 타당도 평가
김혜미(Kim,Hyemi),최슬기(Choi,Seul Ki),신상아(Shin,Sangah),이경윤(Lee,Kyung Youn),신상희 (Shin,Sanghee ),이정원 (Lee,Jung Won ),유수현 (Yu,Soo Hyun ),남혜선 (Nam,Hye-Soen ),김미경 (Kim,Mi-Gyeong ),정효지 (Joung,Hyojee ) 韓國營養學會 2011 Journal of Nutrition and Health Vol.44 No.2
Assessing human exposure to food-borne hazards requires standardized assessment tools. The objective of this study was to validate a newly developed dietary assessment questionnaire to assess human exposure to food-borne hazards, which include dietary behavior and food consumption patterns such as eating frequency, types of food containers and cooking methods. A total of 216 adults were recruited for two questionnaire surveys (questionnaire 1 and 2) about 1 week apart with a 3 day diet record. Reproducibility was evaluated by comparing responses from questionnaires 1 and 2, and validity was checked by comparing responses from questionnaire 2 and the 3 day diet record. Comparisons were based on the percent agreement and Spearman’s rank correlation coefficient. The mean exact agreement of food containers at purchase between questionnaires 1 and 2 was 73.5%, for storing containers it was 71.9%, and for cooking methods it was 83.0%. The mean correlation coefficient for food intake frequency between questionnaires 1 and 2 was 0.71 (range, 0.50-0.83). The mean correlation coefficient of the food intake frequency between questionnaire 2 and the 3 day diet record was 0.21 (range, 0.04-0.48). The exact and adjacent agreement of food intake frequency quartile assessed by questionnaire 2 and the 3 day diet record was 65.4% (range, 51.0-82.1%). Although the correlation coefficient for food intake frequency between questionnaire 2 and the 3 day diet record was low, the exact and adjacent food intake frequency agreement was higher than 50% and reproducibility of the dietary behaviors exceeded 70%. Therefore, the questionnaire developed in this study could be applied to assess diets for the human exposure to food-borne hazards as a qualitative assessment in a large population. (Korean J Nutr 2011 44(2): 171 ~ 180)
김상아(Kim, Sangah),윤주영(Yoon, Jooyoung),김재홍(Kim, Jaehong) 한국신재생에너지학회 2010 한국신재생에너지학회 학술대회논문집 Vol.2010 No.06
The dye-sensitized solar cell (DSSC) is a device for the conversion of visible light into electricity, based on the sensitization of wide bandgap semiconductors. The performance of the cell mainly depends on a dye used as sensitizer. The absorption spectrum of the dye and the anchorage of the dye to the surface of TiO₂ are important parameters determining the efficiency of the cell. Generally, transition metal coordination compounds(ruthenium polypyridyl complexes) are used as the effective sensitizers, due to their intense charge-transfer absorption in the whole visible range and highly efficient metal-to ligand charge transfer. However, ruthenium polypyridyl complexes contain a heavy metal, which is undesirable from point of view of the environmental aspects. Moreover, the process to synthesize the complexes is complicated and costly. Alternatively, organic dyes can be used for the same purpose with an acceptable efficiency. The advantages of organic dyes include their availability and low cost. We designed and synthesized a series of organic sensitizers containing long wavelength absorption-chromophores for the dye sensitized solar cell. The DSSC composed of Blue-chromophores for the sensitization absorbed long wavelength region which is different also applied into the dye-cocktail (mixing) system. The photovoltaic property of DSSCs organic long wavelength absorption-chromophores were measured and evaluated by comparison with that of individual chromophores.
Synthesis and Photovoltaic Performance of NIR Absorption Dyes for the Dye Sensitized Solar Cell
김상아(Kim, Sangah),정미란(Jung, Miran),이민경(Lee, Minkyung),김재홍(Kim, Jaehong) 한국신재생에너지학회 2011 한국신재생에너지학회 학술대회논문집 Vol.2011 No.05
The dye-sensitized solar cell (DSSC) is a device for the conversion of visible light into electricity, based on the sensitization of wide bandgap semiconductors. The performance of the cell mainly depends on a dye used as sensitizer. The absorption spectrum of the dye and the anchorage of the dye to the surface of TiO2 are important parameters determining the efficiency of the cell. Generally, transition metal coordination compounds(ruthenium polypyridyl complexes) are used as the effective sensitizers, due to their intense charge-transfer absorption in the whole visible range and highly efficient metal-to ligand charge transfer. However, ruthenium polypyridyl complexes contain a heavy metal, which is undesirable from point of view of the environmental aspects. Moreover, the process to synthesize the complexes is complicated and costly. Alternatively, organic dyes can be used for the same purpose with an acceptable efficiency. The advantages of organic dyes include their availability and low cost. We designed and synthesized a series of organic sensitizers containing long wavelength absorption-chromophores for the dye sensitized solar cell. The DSSC composed of Blue-chromophores for the sensitization absorbed long wavelength region which is different also applied into the dye-cocktail (mixing) system. The photovoltaic property of DSSCs organic long wavelength absorption-chromophores were measured and evaluated by comparison with that of individual chromophores.