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SangHui Chu,WolMi Park,KyungEun Lee,YoungSook Pae 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.2
<P> Intracellular accumulation of bile acids in the hepatocytes during cholestasis is thought to be pathogenic in cholestatic liver diseases. The objective of this study was to determine the role of lipid peroxidation and glutathione on the bile acid-induced hepatic cell death mechanism in primary cultured rat hepatocytes. To induce hepatic cell death, we incubated primary cultured rat hepatocytes with glycochenodeoxycholic acid (GCDC; 0∼400μM) for 3 hours. In electron microscopic examination and agarose gel electrophoresis, low concentration of GCDC treatment mainly induced apoptotic feature. Whereas 400μM GCDC treated cells demonstrated both apoptosis and necrosis. Lipid peroxidation was increased dose- dependently in GCDC treated hepatocyte. And this was also accompanied by decreased glutathione. Therefore, oxygen free radical damage may play a partial role in GCDC-induced hepatic cell death.
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만성요통환자에서의 통증신념과 우울, 통증생활방해와의 관계에서 대처전략의 매개효과
김경아(Kyoung-A Kim),추상희(Sanghui Chu) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.10
본 연구는 만성 요통 환자의 통증 신념과 우울, 통증 신념과 통증생활방해 사이의 통증대처(능동적 대처와 수동적 대처)의 매개 효과를 확인하고자 하였다. 수집된 자료는 SPSS-WIN 21.0 프로그램으로, 다중매개 효과는 Indirect SPSS macro (Bootsrapping)를 사용하여 분석하였다. 분석결과 통증신념은 3.42 ± 9.67점이었고, 수동적 대처 29.68 ± 8.04점, 능동적 대처 25.49 ± 4.22점, 우울은 25.49 ± 11.56점, 통증생활방해는 46.94 ± 12.65점 이었으며, 이 5 가지 변수 간에 유의한 상관관계가 있었다. 만성요통 환자의 통증신념과 우울 사이에서 수동적 대처와 능동적 대처의 다중매개효과는 (b=.453, 95% CI=.228, .703)로 유의하였다. 통증신념과 통증생활방해에서 수동적 대처와 능동적 대처의 다중매개효과는 (b=.285, 95% CI=.131, .519)로 유의하였다. 능동적인 대처 전략은 통증 신념과 우울, 통증생활방해 사이의 관계에 긍정적인 중재 효과로 작용할 수 있음을 발견하였으며, 수동적 대처 전략은 부정적인 효과를 보임을 알 수 있었다. 따라서 만성 요통 환자를 대상으로 능동적 대처를 늘리는 대처 전략 프로그램이 필요하다. The Purpose of this study was to investigate of coping strategies(active and passive) between pain beliefs and depression, pain disability among chronic back pain patients. Data were analyzed by the SPSS-WIN 21.0 program. Indirect SPSS macro(Bootsrapping)was used to analyze the multiple-mediation model of this study. The result showed that the mean score for pain belief was 3.42±9.67, and he passive coping strategies was 29.68±8.04, active coping was 25.49±4.22. The mean score of depression was 25.49±11.56. The pain disability index was 46.94±12.65. It found that there were significant correlations among the 5 variables. The multiple mediated effects of passive coping and active coping on pain beliefs and depression were (b=.453, 95% CI=.228, .703) and on pain beliefs and pain disability were (b = .285, 95% CI = .131, .519) in chronic low back pain patients. This study discovered that the active coping strategies had a positive mediating effect in the relationship between pain beliefs and depression, pain beliefs and pain disability. And passive coping strategies had a negative mediating effect. Based on findings of this study, improving the active coping strategy programs or management is highly recommended in chronic back pain patients.
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간이식 환자의 퇴원 준비도와 자가간호와의 관계: 종단적 연구
박선복(SunBok Park),최지연(JiYeon Choi),주동진(DongJin Joo),추상희(SangHui Chu) 한국기초간호학회 2022 Journal of korean biological nursing science Vol.24 No.4
Purpose: The purpose of this longitudinal study was to identify the relationship between the readiness for hospital discharge and self-care changes in an early stage of liver transplantation after discharge. Methods: Data of 75 liver transplant recipients within one year of surgery from a transplantation center from May 2019 to May 2020 were collected for this study. Their readiness for discharge was measured before discharge. Self-care after liver transplantation was evaluated at one week, one month, and three months of discharge at outpatient visits. Linear mixed model was used to evaluate the statistical relationship. Results: The readiness for hospital discharge was significantly higher when the caregiver was a spouse (p=.027), with fewer post-transplantation days (p=.027), absence of acute rejection (p=.004), or high self-efficacy (p<.001). As a result of the linear mixed model analysis, the higher the discharge readiness score, the higher the self-care score (β=0.29, p<.001). However, after three months, their self-care had decreased regardless of their level of readiness for hospital discharge compared to one week after discharge. Conclusion: Improving the readiness before discharge is essential to enhance self-care. Also, active intervention at 3 months of discharge should be performed to check and promote their long-term self-care.
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Factors Associated with Insomnia among the Elderly in a Korean Rural Community
WooJung Kim,Wontak Joo,Jiwon Baek,SungYun Sohn,Namkoong Kee,Yoosik Youm,HyeonChang Kim,YeongRan Park,SangHui Chu,EunLee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.4
Objective-Sleep disturbance is common in the elderly, which is result from multi-factorial causes encompassing socio-demographic, behavioral, and clinical factors. We aimed to identify factors associated with insomnia among the elderly in a rural community in South Korea, a country with a rapidly growing aged population. Methods-This cross-sectional study used the data from the second wave of the Korean Social life, Health and Ageing Project, which is a cohort study of individuals living in a typical rural community in South Korea. Socio-demographic, behavioral, and clinical characteristics were obtained through face-to-face interviews. Various factors suspected to be associated with insomnia were compared between elderly participants with and without insomnia, and multiple logistic regression analyses were conducted to identify independent risk factors for insomnia. Results-We found that 32.4% of 509 participants (72.8±7.7 years old) had insomnia. Female sex [odds ratio (OR)=2.19], low education level (OR=2.44), current smoking (OR=2.26), number of chronic diseases (OR=2.21 for 2-3 chronic diseases; OR=2.06 for 4 or more chronic diseases), and depression (OR=2.53) were independently associated with insomnia. Conclusion-We found that sex, education, chronic disease, and depression independently increase the risk of insomnia of the elderly in a Korean rural community. To overcome the elderly’s insomnia, interventions should target modifiable factors such as depression. To promote active aging, longitudinal studies of factors associated with insomnia among the elderly should be performed in different regions and communities.
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