http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sang-Keun Song(Sang-Keun Song),Yoo-Keun Kim(Yoo-Keun Kim),Yun-Seob Moon(Yun-Seob Moon) 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.E1
Meteorological mechanisms in association with long-range transport of Asian dust in April 2001 have been investigated using weather maps, satellite images, TOMS and surface PM_10 data, backward trajectories, plus modeling output results (geopotential heights, horizontal wind vectors, potential temperatures, and streamlines). The results indicated that long-range transport of Asian dust to the west coast of North America was associated with strong westerlies between the Aleutian low and the Pacific high acting as a conveyor belt. Accelerating westerly flows due to cyclogenesis at the source regions over East Asia transported pollution from the continent to the central Pacific. When the system reached the Aleutian Islands, the intensity of troughs and the westerlies were amplified in the North Pacific. Thereafter the winds between the Aleutian Islands and the Pacific Ocean were more intensified from the air flow transport of the conveyor belt. Consequently, the strong wind in the conveyor belt enhanced the dust transport from the Pacific Ocean to the west coast of North America. This was evidenced by PM_10 concentration (maximum of about 100㎍m³) observed in California. Further evidence of the dust transport was found through the observation of satellite images, the distribution of TOMS aerosol index, and the analyses of streamlines and backward trajectories.
Song, In Ho,Jeong, Mun Sik,Hong, Hyo Jeong,Shin, Jong Il,Park, Yong Serk,Woo, Sang-Keun,Moon, Byung Seok,Kim, Kwang Il,Lee, Yong Jin,Kang, Joo Hyun,Lee, Tae Sup American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.20
<P><B>Purpose:</B></P><P>Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been known as a novel prognostic marker and therapeutic target for cholangiocarcinoma. This study aimed to evaluate the feasibility of immuno-PET imaging–based radioimmunotherapy using radiolabeled anti-L1CAM antibody in cholangiocarcinoma xenograft model.</P><P><B>Experimental Design:</B></P><P>We prepared a theranostic convergence bioradiopharmaceutical using chimeric anti-L1CAM antibody (cA10-A3) conjugated with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator and labeled with <SUP>64</SUP>Cu or <SUP>177</SUP>Lu and evaluated the immuno-PET or SPECT/CT imaging and biodistribution with <SUP>64</SUP>Cu-/<SUP>177</SUP>Lu-cA10-A3 in various cholangiocarcinoma xenograft models. Therapeutic efficacy and response monitoring were performed by <SUP>177</SUP>Lu-cA10-A3 and <SUP>18</SUP>F-FDG-PET, respectively, and immunohistochemistry was done by TUNEL and Ki-67.</P><P><B>Results:</B></P><P>Radiolabeled cA10-A3 antibodies specifically recognized L1CAM <I>in vitro</I>, clearly visualized cholangiocarcinoma tumors in immuno-PET and SPECT/CT imaging, and differentiated the L1CAM expression level in cholangiocarcinoma xenograft models. <SUP>177</SUP>Lu-cA10-A3 (12.95 MBq/100 μg) showed statistically significant reduction in tumor volumes (<I>P</I> < 0.05) and decreased glucose metabolism (<I>P</I> < 0.01). IHC analysis revealed <SUP>177</SUP>Lu-cA10-A3 treatment increased TUNEL-positive and decreased Ki-67-positive cells, compared with saline, cA10-A3, or <SUP>177</SUP>Lu-isotype.</P><P><B>Conclusions:</B></P><P>Anti-L1CAM immuno-PET imaging using <SUP>64</SUP>Cu-cA10-A3 could be translated into the clinic for characterizing the pharmacokinetics and selecting appropriate patients for radioimmunotherapy. Radioimmunotherapy using <SUP>177</SUP>Lu-cA10-A3 may provide survival benefit in L1CAM-expressing cholangiocarcinoma tumor. Theranostic convergence bioradiopharmaceutical strategy would be applied as imaging biomarker-based personalized medicine in L1CAM-expressing patients with cholangiocarcinoma.</P>
( Sang-hyon Oh ),( Chul Young Lee ),( Dong-heon Song ),( Hyun-wook Kim ),( Sang Keun Jin ),( Young-min Song ) 한국축산학회 2022 한국축산학회지 Vol.64 No.2
The present study aimed to assess the feasibility of increasing the slaughter weight (SW) of non-lean finishing pigs to improve their meat quality. A total of 36 (Landrace × Yorkshire) × Duroc gilts and barrows were slaughtered at 115 (Av), 125 (Hi), or 135 (XHi) kg, followed by physicochemical analyses and sensory evaluation on their longissimus dorsi (LD) and Semimembranosus (SM) muscles. Backfat thickness was greater (p < 0.05) for the XHi (31.2 mm) and Hi (29.3 mm) groups than for Av (25.0 mm). Dressing percentage and yield of the belly per whole carcass were also slightly greater for XHi and Hi vs. Av. The intramuscular fat (IMF) content of SM was greater for XHi (2.64%) than for Av (1.83%) and Hi (2.04%) and also was correlated with SW (r = 0.55). The pH value, lightness, redness, drip loss, shear force, and moisture and protein contents of LD and SM, as well as IMF content of LD, were unaffected by SW. Percentages of 14:0, 16:0, and total saturated fatty acids (FA) were less for Hi and XHi vs. Av in SM, those of total unsaturated FA, 18:2, 20:4, and n-6 being opposite; FA composition of LM was not influenced by SW except for a reduced 18:0 percentage for XHi vs. Av. The sensory score was less for XHi vs. Av for odor in fresh LD and SM, and less for Hi and XHi vs. Av for aroma in fresh LM; scores for color, drip loss, marbling, and acceptability were unaffected by SW. As for cooked muscles, none of the scores for color, aroma, flavor, juiciness, tenderness, and acceptability was affected by SW, except for a greater LD color score for Hi and XHi vs. Av. Collectively, the results suggested that the increased yield of the carcass and belly due to increased SW is outbalanced negatively by excessive backfat deposition in production efficiency, whereas the SW increase exerts little influence on overall sensory quality of fresh or cooked meat. Production of non-lean market pigs overweighing 115 kg therefore will be uneconomical unless consumers pay a substantial premium for the over-fattened pork.
( Keun Na ),( Seul Ki Jeong ),( Min Jung Lee ),( Sang Yun Cho ),( Sun A Kim ),( Min Ji Lee ),( Si Young Song ),( Ho Guen Kim ),( Kyung Sik Kim ),( Sung Won Cho ),( Young Ki Paik ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Hepatocellular carcinoma (HCC) is a common cancer worldwide and accounts for nearly 40% of all cancers and ~90% of primary liver cancers in Southeast Asia.1,2 In our laboratory, we have previously used various clinical proteomic approaches3-8, to identify differences in protein expression in plasma and liver tissue of clinical samples. Although alpha-fetoprotein (AFP) is only available serologic biomarker for the hepatocellular carcinoma, it has very low sensitivity which cannot efficiently distinguish HCC from other forms of liver disease (e.g. chronic hepatitis [CH], liver chirrosis [LC].9. The aims of this study were to investigate how human carboxylesterase (hCE1)10 performs in discriminating HCC from CH and LC compared to AFP in the patients` plasma using ELISA. The relative diagnostic ability of both AFP and hCE1 for HCC was assessed using established ELISA system against total 260 patients` plasma specimens. The hCE1 and AFP were compared in a total 260 cohorts including patients with HCC (n=57), LC (n=27), CH (n=37), cholangiocarcinoma (n=22), gastric cancer (n=31), and pancreatic cancer (n=34), along with 52 healthy donors without any liver diseases. When the evaluation of these markers for liver disease and HCC was performed with respect to sensitivity, specificity, Youden`s index (Y-index) and the area under the curve through receiver operating characteristic analysis, hCE1 was shown to have much higher values than those of AFP (p<0.01). Furthermore, hCE1 shows good early detection capability of HCC over AFP. Our ELISA assay system containing a monoclonal antibody (10E8) raised against hCE1 demonstrates that hCE1 outperforms AFP in discriminating HCC from other forms of liver disease at the earlier stage. It would now be feasible to validate hCE1 as novel plasma-based HCC biomarker using the large cohort specimens.