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Samala, Srinivas,Ryu, Do Hyun,Song, Choong Eui,Yoo, Eun Jeong The Royal Society of Chemistry 2019 Organic & Biomolecular Chemistry Vol.17 No.7
<P>An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using <I>N</I>-aromatic zwitterions, aldehydes, and amino acids. The developed reactions proceed through azomethine ylides generated <I>in situ</I> from the decarboxylated reactions of aldehydes and amino acids followed by the [3 + 2] cycloaddition of <I>N</I>-aromatic zwitterions under mild reaction conditions.</P>
Samala, Mallesham,Lu, Thien Nhan,Mandava, Suresh,Hwang, Jungjoong,Bogonda, Ganganna,Kim, Donghoon,Park, Haeil,Kim, Deukjoon,Lee, Jongkook American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.20
<P>A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (<B>1</B>), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF-THF-THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-controlled fashion. The inter-ring stereochemistry (<I>threo,threo,threo</I>) of the oxatricyclic core was established in a stereoselective fashion by a chelation-controlled Keck allylation, whereas the intraring <I>cis</I> or <I>trans</I> relative stereochemistry was controlled by a stereoselective internal alkylation.</P> [FIG OMISSION]</BR>
Rajesh Kumar Samala,K. Mercy Rosalina 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.1
In this concept, an enhanced idea is proposed for solving the optimal load fl ow issues with uncertainties. The proposed hybrid algorithm is the combination of the fuzzy logic controller (FLC) technique and Ant-Lion Optimization Algorithm’s (ALOA). The ALO imitates the hunting mechanism of ant lions in nature. The FLC is trained based on training dataset and testing time. Based on the variation of radial distribution network parameters, the proposed hybrid technique provides the optimal allocation parameters. In this research, photo-voltaic units and wind turbine generations (PV and WT) are considering as distributed generators (DGs). Initially, the multi objective function was defi ned. That includes voltage deviation, minimization of power loss, and minimization of total operating cost (TOC) and improvement of voltage stability index (VSI). The eff ectiveness of this proposed hybrid technique was demonstrated on IEEE-33 standard radial distribution systems. With the new hybrid technique, allocation of multi-DGs at diff erent sites, and the optimal load fl ow in various cases were analyzed.
Micropropagation and somaclonal variation of Doritis pulcherrima (Lindl.)
Thipwong Jaturon,Kongton Kittima,Samala Sainiya 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.4
In this research, in vitro micropropagation of the economically important orchid Doritis pulcherrima was conducted because its numbers in nature are greatly decreasing in Thailand. Different types of medium (Vacin and Went (VW), Murashige and Skoog (MS), and New Dogashima Media (NDM)) with plant growth regulators (1-naphthalene acetic acid (NAA) and 6-benzyladenine (BA) at 0, 0.1, 0.5, 1.0, and 1.5 mg·L–1) were evaluated for protocorm-like body (PLB) formation and plantlet regeneration. The results indicated that after three months of culture, NDM medium produced a significantly higher survival rate (46.70 ± 0.51%), number (11.00 ± 2.94 PLBs per protocorm), and size (6.35 ± 4.31 mm) of PLBs. Addition- ally, all media could stimulate plantlet regeneration. However, NDM supplemented with NAA and BA at a concentration of 0.1 mg L−1 provided the best stimulation of most observed parameters, including the shoot number and leaf and root number and length. Unexpectedly, after maintaining and subculturing D. pulcherrima plantlets for two years, somaclonal variation occurred, with the clones showing a morphology and physiology that were distinct from those of the wild type. Last, a suitable medium for wild-type and cloned plantlet development was investigated, and VW and ½MS supplemented with or without 2,4-dichlorophenoxyacetic acid (2,4-D) (1.0 mg·L–1) were used. The results showed that VW supplemented with 2,4-D at a concentration of 1.0 mg L−1 led to the best plantlet development. This report presented an efficient system for the micropropagation of D. pulcherrima and showed that prolonged subculture leads to somaclonal variation.
P. Sarat Chandra,Raghu Samala,Ramesh Doddamani,Satish Verma,Pankaj Singh,Mahendra Singh Chauhan 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
Objective: Chronic ‘displaced’ displaced type II fractures, though uncommon, are difficult to manage. They usually require a transoral procedure followed by a posterior instrumented fusion. We describe here, a new method to reduce the fractured displaced odontoid using a posterior cervical approach only. Methods: Prospective and observational, n = 14 had a ‘displaced and irreducible’ old fracture dens causing cord compression (type I, 1; type II, 13). They underwent a novel technique to reduce the fracture. The C1 arch was first drilled and removed. The C1 lateral masses on both sides were then drilled completely and a spacer was placed between the occiput and C2 facet. Following this, an intraoperative reducing maneuver was performed, utilizing the spacer as a fulcrum, and then achieving complete reduction and realignment. Results: All patients improved clinically (mean Nurick preoperative score: 4.07 ± 0.8; the postoperative score was 1.3 ± 0.4). The mean correction in effective canal diameter was 74.3% ± 9.5% and the mean correction in actual canal diameter was 77% ± 8.7%. Solid bone fusion was demonstrated in 12 patients with at least 1-year follow-up (follow-up range, 12–35 months; mean, 21.8 ± 9.8 months). Conclusion: The new described modification of distraction, compression extension, and reduction seems to be effective for ‘displaced’ chronic fracture dens with cord compression. It avoids additional transoral surgery in these patients.
Scalable synthesis of the C14–C23 fragment of Eribulin and Halichondrin B
Kim U Bin,Samala Srinivas,Kim Namhyeon,Bogonda Ganganna,Lago‐Santomé Hugo,Jeong Youngdo,Kim Jin,Jung Jaehun,Jeon Sung‐Hyun,Lee Seung Jong,신현석 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.12
A novel, scalable approach to the C14–C23 fragment of eribulin mesylate is disclosed. Key 2,3-Wittig rearrangement is strategically effected via [Rh] mediated decomposition of 1,2,3-triazole intermediate to derive the 2,5-trans-tetrahydrofuran motif, enabling multi-kilogram access to the desired C14–C23 fragment.
Synthesis and Structure Revision of Dimeric Tadalafil Analogue Adulterants in Dietary Supplements
Mandava, S.,Ganganna, B.,Hwang, Ju.,Jang, Y.,Hwang, Ji.,Samala, M.,Kim, K.-B.,Park, H.,Lee, J. H.,Baek, S. Y. Pharmaceutical Society of Japan 2017 Chemical & pharmaceutical bulletin Vol. No.
<P>A number of phosphodiesterase 5 (PDE5) inhibitors approved by authorities have been used successfully in the treatment of erectile dysfunction. These medicines must be prescribed carefully due to their adverse effects, but they and their analogues are being illegally added to dietary supplements. These illegal dietary supplements pose a significant risk to public health. Several dimeric tadalafil analogues have been synthesized for use as reference standards in the inspection of functional foods that are mainly advertised as sexual enhancement products. During the course of this synthesis, 1-Ibis(dimethylamino)methylenek1H-1,2,3triazolo14,5-blpyridinium 3-oxid hexafluorophosphate (HATU) was proven to be the reagent of choice for amide coupling to produce these dimeric tadalafil analogues. Moreover, the trans-isomer structures tentatively assigned for the isolated dimeric tadalafil analogues (bisprehomotadalafil and bisprecyclopentyltadalafil) found in dietary supplements are now revised to cis-isomer structures.</P>
Lee, J.H.,Ko, H.J.,Woo, E.R.,Lee, S.K.,Moon, B.S.,Lee, C.W.,Mandava, S.,Samala, M.,Lee, J.,Kim, H.P. North-Holland ; Elsevier Science Ltd 2016 european journal of pharmacology Vol.783 No.-
<P>The therapeutic effectiveness of moracins as 2-arylbenzofuran derivatives against airway inflammation was examined. Moracin M, O, and R were isolated from the root barks of Morus alba, and they inhibited interleukin (IL)-6 production from IL-1 beta-treated lung epithelial cells (A549) at 101-00 mu M. Among them, moracin M showed the strongest inhibitory effect (IC50=8.1 mu M). Downregulation of IL-6 expression by moracin M was mediated by interrupting the c-Jun N-terminal kinase (JNK)/c-Jun pathway. Moracin derivatives inhibited inducible nitric oxide synthase (iNOS)-catalyzed NO production from lipopolysaccharide (LPS)-treated alveolar macrophages (MH-S) at 50-100 mu M. In particular, moracin M inhibited NO production by downregulating iNOS. When orally administered, moracin M (20-60mg/kg) showed comparable inhibitory action with dexamethasone (30mg/kg) against LPS-induced lung inflammation, acute lung injury, in mice with that of dexamethasone (30mg/kg). The action mechanism included interfering with the activation of nuclear transcription factor-kB in inflamed lungs. Therefore, it is concluded that moracin M inhibited airway inflammation in vitro and in vivo, and it has therapeutic potential for treating lung inflammatory disorders. (C) 2016 Elsevier B.V. All rights reserved.</P>