Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast

Daoud, Sahar Aly,Ismail, Wesam Maghawri,Abdelhamid, Mohamed Salah,Nabil, Tamer Mohamed,Daoud, Sahar Aly Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with vastly different clinical implications, the role of HER2/neu expression in atypical ductal hyperplasia is not well defined either. The aim of this study was to evaluate over expression of HER2/neu in DCIS and cases of ADH in comparison with invasive breast carcinoma. Archival primary breast carcinoma paraffin blocks (n=15), DCIS only (n=10) and ductal epithelial hyperplasia and other breast benign lesions (n=25) were analyzed for HER2/neu immunoexpression. Follow up was available for 40% of the patients. HER2/neu was positive in 80%of both DCIS and invasive carcinoma, and 67% of atypical ductal hyperplasia (ADH) cases. Thus at least a subset of patients with preinvasive breast lesions were positive, which strongly suggests a role for Her2/neu in identifying high-risk patients for malignant transformation. Although these are preliminary data, which need further studies of gene amplification within these patients as well as a larger patient cohort with longer periods of follow up, they support the implementation of routine Her2/neu testing in patients diagnosed as pure DCIS and in florid ADH.

Study on the Tensile Strength and Micromechanical Analysis of Alfa Fibers Reinforced High Density Polyethylene Composites

Sahar Salem,Helena Oliver-Ortega,Francesc X. Espinach,Karim Ben Hamed,Nizar Nasri,Manel Alcalà,Pere Mutjé 한국섬유공학회 2019 Fibers and polymers Vol.20 No.3

In the recent years, there has been a growing interest in eco-friendly composites, based on natural fiberreinforcements. In this work, Alfa fibers were obtained from Alfa grass (Stipa tenacissima) through an intensive cooking with sodium hydroxide and anthraquinone. These fibers, with contents ranging from 20 to 50 wt%, were used to reinforce a high density polyethylene. The composites were prepared in a kinetic mixer and later on tensile tested under standard conditions. The results showed that the tensile strength of the composites increased with the amount of fiber in the composite. Aditionally, a morphology and chemical composition analysis of the fibers surface were carried on, in order to further discuss the micromechanics analysis results. The average orientation factor and intrinsic tensile strength of the fibers were also determined during the micromechanics analysis.

A study of the Characterization and Synthesis of MWCNTs under a Magnetic Field via an Arc Discharge Technique

Sahar Tabrizi,Nafiseh Moghimi,Amir Hassanjani-Roshan,Alireza Hojabri 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.4

Multi-walled carbon nanotubes (MWCNTs) were synthesized by arc discharge in a magnetic field and a low pressure helium gas using mixtures of FeS/Co, FeS/Ni and FeS/Co/Ni catalysts. The synthesized carbon materials indicated a high-purity of MWCNTs related to decreasing the metal catalysts results from applying the magnetic field which was investigated by X-ray diffraction (XRD) analysis and a high-yield of MWCNTs with less amorphous carbon in the presence of the magnetic field for all mixtures as shown by scanning electron microscopy (SEM). Raman spectroscopy was used to characterize the MWCNTs. The ratio of intensity of the graphitic mode to the defect mode (IG/ID) showed that the quality and crystallity of MWCNTs, which were synthesized using FeS/Ni and FeS/Co/Ni decreased in the presence of magnetic field while the quality of MWCNTs, synthesized using FeS/Co increased. Thermo gravimetric analysis (TG/DTA) was performed for quantitative MWCNTs purity assessment. Results showed that the purity of MWCNTs was increased for all cases in the presence of a magnetic field. This was attributed to the concentration of carbon monomers in the arc plasma with the magnetic field.

Promoting the American Senior Tourism to Egypt

Sahar Ibrahim Elkadi,Soha Mohamed Abd el Wahab 세계문화관광학회 2008 Conference Proceedings Vol.9 No.0

Mindful of the global rapid growth in senior tourism, this research aims at studying and evaluating the industry operators' role towards increasing Egypt's market share of the American senior traffic. Within this context, three questionnaire forms were directed to the concerned public and private organizations, and to a random sample of the American seniors in Egypt to stand over the strategies of matching the Egyptian tourism product to the current seniors' wants and expectations. It was concluded that the Egyptian actors must be more senior oriented through advocating innovative approaches to satisfy the American seniors better than the competition.

Durability assessment of self-compacting concrete with fly ash

Sahar Deilami,Farhad Aslani,Mohamed Elchalakani 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.5

Self-Compacting Concrete (SCC) is a new technology capable to flow without segregation or any addition of energy which leads to efficient construction and cost savings. In this study, the effect of replacing the Ordinary Portland Cement (OPC) with Fly Ash (FA) on the strength, durability of the concrete was investigated experimentally, and carbon footprint and cost were also assessed. Four different replacement FA ratios (0%, 20%, 40% and 60%) were used to create four SCC mixes. Standard test methods were used to determine the workability, strength, and durability of the SCC mixes including resist chloride ion penetration, water permeability, water absorption, and initial surface absorption. The axial cube compressive strength tests were performed on the SCC mixes at 1, 7, 14, 28 and 35 days. Replacing the OPC with FA had a significant positive impact on chloride iron penetration resistance and water absorption but had a considerable negative impact on the compressive strength. The SCC mix with 60% FA had 36.7% and 15.8% enhancement in the resistance to chloride ion penetration and water absorption, respectively. Evaluation of the carbon footprint and the cost of each SCC mixes showed the CO2 emissions mixes 1, 2, 3 and 4 were significantly reduced by increasing the FA content from 0% to 60%. Compared with the control mix, the cost of all mixes increased when the FA content increased, but no significant differences were seen between the estimated costs of all four mixes.

A two-stage structural damage detection method using dynamic responses based on Kalman filter and particle swarm optimization

Sahar Beygzadeh,Peyman Torkzadeh,Eysa Salajegheh 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.83 No.5

To solve the problem of detecting structural damage, a two-stage method using the Kalman filter and Particle Swarm Optimization (PSO) is proposed. In this method, the first PSO population is enhanced using the Kalman filter method based on dynamic responses. Due to noise in the sensor responses and errors in the damage detection process, the accuracy of the damage detection process is reduced. This method proposes a novel approach for solve this problem by integrating the Kalman filter and sensitivity analysis. In the Kalman filter, an approximate damage equation is considered as the equation of state and the damage detection equation based on sensitivity analysis is considered as the observation equation. The first population of PSO are the random damage scenarios. These damage scenarios are estimated using a step of the Kalman filter. The results of this stage are then used to detect the exact location of the damage and its severity with the PSO algorithm. The efficiency of the proposed method is investigated using three numerical examples: a 31-element planer truss, a 52-element space dome, and a 56-element space truss. In these examples, damage is detected for several scenarios in two states: using the no noise responses and using the noisy responses. The results show that the precision and efficiency of the proposed method are appropriate in structural damage detection.

Study the Influence of Dressing Tool Tip in Determining the Geometry of Surface Textures during 3D Simulation

Sahar M. Sana Ullah(사하르사나울리),K. M. Park(박기문),T. J. Ko(고태조) 한국정밀공학회 2016 한국정밀공학회 학술발표대회 논문집 Vol.2016 No.5월

Effect of Machining Parameters on Texturing Pattern during Simulation of Patterned Grinding on Non-Planar Surface

Sahar M. Sana Ullah(사하르 사나울라),T. J. Ko(고태조),K. M. Park(박기문) 한국정밀공학회 2015 한국정밀공학회 학술발표대회 논문집 Vol.2015 No.12월

Experimental study of hydrogen fluoride adsorption on sodium fluoride

Sahar Afzal,Mohammad Reza Ehsani,Hossein Tavakoli,Amir Rahimi 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.1

In uranium conversion industry, the fluorine is used as chemical raw material gas to produce UF4 and UF6 while its purity is very important. In this study, the adsorption process of hydrogen fluoride, as an impurity in the process of fluorine production, on sodium fluoride pellets is experimentally studied in a lab-scale fixed bed adsorbent. Also, the effects of some operating parameters including inlet concentration and inlet temperature of hydrogen fluoride are precisely investigated on the adsorption process. The data of adsorption are analyzed and correlated by Langmuir, Freundlich and Temkin isotherms. The adsorption capacity is found to be 1.908 and 0.750 g HF/g NaF by the Langmuir isotherm at 22 and 54 8C, respectively. The favorability nature of adsorption which is expressed in terms of a dimensionless separation factor (RL) is found to be more than 1 which indicates an unfavorable adsorption. In addition, the data analysis shows that the Langmuir and Temkin isotherms correlate the equilibrium isotherms better than that of Freundlich.

Statistical Profiles of Users’ Interactions with Videos in Large Repositories: Mining of Khan Academy Repository

( Sahar Yassine ),( Seifedine Kadry ),( Miguel Angel Sicilia ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.5

The rapid growth of instructional videos repositories and their widespread use as a tool to support education have raised the need of studies to assess the quality of those educational resources and their impact on the quality of learning process that depends on them. Khan Academy (KA) repository is one of the prominent educational videos’ repositories. It is famous and widely used by different types of learners, students and teachers. To better understand its characteristics and the impact of such repositories on education, we gathered a huge amount of KA data using its API and different web scraping techniques, then we analyzed them. This paper reports the first quantitative and descriptive analysis of Khan Academy repository (KA repository) of open video lessons. First, we described the structure of repository. Then, we demonstrated some analyses highlighting content-based growth and evolution. Those descriptive analyses spotted the main important findings in KA repository. Finally, we focused on users’ interactions with video lessons. Those interactions consisted of questions and answers posted on videos. We developed interaction profiles for those videos based on the number of users’ interactions. We conducted regression analysis and statistical tests to mine the relation between those profiles and some quality related proposed metrics. The results of analysis showed that all interaction profiles are highly affected by video length and reuse rate in different subjects. We believe that our study demonstrated in this paper provides valuable information in understanding the logic and the learning mechanism inside learning repositories, which can have major impacts on the education field in general, and particularly on the informal learning process and the instructional design process. This study can be considered as one of the first quantitative studies to shed the light on Khan Academy as an open educational resources (OER) repository. The results presented in this paper are crucial in understanding KA videos repository, its characteristics and its impact on education.