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Antiplatelet, anticoagulant, and profibrinolytic activities of cudratricusxanthone A
Yoo, Hayoung,Ku, Sae-Kwang,Lee, Wonhwa,Kwak, Soyoung,Baek, Young-Doo,Min, Byung-Woon,Jeong, Gil-Saeng,Bae, Jong-Sup 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudrania tricuspidata Bureau, is known to possess hepatoprotective, antiproliferative and anti-inflammatory activities. However, antiplatelet, anticoagulant, and profibrinolytic properties have not been studied. The anticoagulant activities of CTXA were measured by monitoring activated partial thromboplastin-time (aPTT), prothrombin time (PT), and the activities of cell-based thrombin and activated factor X (FXa). The effects of CTXA on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were also tested in tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ activated human umbilical vein endothelial cells. Our data showed that CTXA inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation, prolonged aPTT and PT significantly and inhibited the activities and production of thrombin and FXa. CTXA prolonged in vivo bleeding time and inhibited $TNF-{\alpha}$ induced PAI-1 production. Furthermore, PAI-1/t-PA ratio was significantly decreased by CTXA. Collectively, these results indicate that CTXA possesses antithrombotic activities and suggest that the current study could provide bases for the development of new anticoagulant agents.
正常 大腸粘膜과 大腸癌의 癌性胎兒性抗原, 分泌成分 및 分泌型 IgA의 出現에 관한 免疫組織化學的 硏究
柳建一,崔宗相,金世民 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
The predominant immunoglobulin in external secretions of humans and various other mainmals is a special form of IgA known as secretory IgA, a molecule composed of a dimer of serum-type IgA plus a J chain :and a distinctive polypeptide chain known as secretory component (SC). Histological localization of SC and a chain of IgA in normal mucosa has been studied by immunchistological methods and identified in the cytoplasm of epithelial cells in mucous membranes, spaces between these cells, and secretion. On the other hand. carcinoembryonic antigen is a fetal glycoprotein which may reappear during malignant transformation of entodermal epithelial cell. The purpose of this study is ito compare distribution of SC in normal and malignant epithelial cell to understand local immunological defense mechanism, especially along the luminal surface replaced by tumor mass. Each 5 cases of formalin fixed and paraffin embedded well, moderately and poorly differentiated adenocarcinoma of colon were selected and immunoperoxidase staining of Avidin-Biotin-Complex method mere performed using anti-CEA, SC, and IgA antiserum and compared distribution of each antigen between normal mucosa and carcinoma. The result obtained are as follows : 1. Carcmoma of the colon revealed strong CEA positive reaction along the luminal surface of the gland structure or in the cytoplasm while normal Lieberkuhn epithelial cell showed negative reaction. 2. Normal Lieberkuhn epithelial cells showed SC positive reaction in the cytoplasm while carcinoma cells of the colon disclosed no SC in the cytoplasm, regardless of degree of differentiation of the tumor cell. 3. IgA positive plasma cells were noted mainly along the lamina propria and epithelial cells lining Lieberkuhn's crypt also revealed positive reaction while neither tumor cell not interstitium revealed any evidence IgA. Above findings suggests that mucosa of colon which is replaced by carcinoma is devoid of local immunological defense mechanism as far as SC and IgA are concerned. And disappearance of SC in colonic carcinoma cell seems to be a useful indicator in the field of histologic differential diagnosis of metastatic carcinoma.
The Clinical Usefulness of $^{18}F$-FDG PET/CT in Patients with Systemic Autoimmune Disease
Oh, Jong-Ryool,Song, Ho-Chun,Kang, Sae-Ryung,Yoo, Su-Woong,Kim, Ja-Hae,Chong, A-Ri,Min, Jung-Joon,Bom, Hee-Seung,Lee, Shin-Seok,Park, Yong-Wook The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.3
Purpose Individuals with systemic autoimmune disease have an increased susceptibility to both inflammation and malignancy. The aim of this study was to evaluate the clinical usefulness of $^{18}F$-FDG PET/CT in patients with systemic autoimmune disease. Methods Forty patients diagnosed with systemic autoimmune disease were enrolled. Diagnostic accuracy of FDG PET/CT for detecting malignancy was assessed. FDG PET/CT findings, including maximum standardized uptake (SUVmax) of lymphadenopathy (LAP), liver, bone marrow, spleen, joint and muscles, were considered for the characterization of LAPs. Results FDG PET/CT could detect metabolically activated lesions in 36 out of 40 patients (90%) including inflammatory lesions in 28 out of 32 patients (88%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG PET/CT for the detection of malignancy were 100, 67, 70, 25, and 100%, respectively. Multiple LAPs were found in 25 of 40 patients (63%), and comprised three malignancies, four cases of tuberculosis, and 18 reactive changes. A SUVmax ratio of bone marrow to liver below 0.78 could distinguish malignancy from tuberculosis + reactive change (AUC=1.000, sensitivity: 100%, specificity: 100%). The SUVmax ratio of spleen to liver in the reactive group was also significantly higher than that in the malignancy group (P=0.014). SUVmax of LAP in the TB group was significantly higher than that in the reactive group (P=0.040). Conclusions PET/CT is useful in detecting and differentiating inflammation and malignancy in patients with systemic autoimmune disease. Frequent false-positive interpretations can be minimized by consideration of FDG uptake in bone marrow and spleen.