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Fredholm operators, evolution semigroups, and periodic solutions of nonlinear periodic systems
Miyazaki, R.,Kim, D.,Naito, T.,Shin, J.S. Academic Press 2014 Journal of differential equations Vol.257 No.11
Let X be a Banach space and L the generator of the evolution semigroup associated with the τ-periodic evolutionary process {U(t,s)}<SUB>t≥s</SUB> on the space P<SUB>τ</SUB>(X) of all τ-periodic continuous X-valued functions. We give criteria for the existence of periodic solutions to nonlinear systems of the form Lp=-εF(p,ε) under the condition that 1 is a normal eigenvalue of the monodromy operator U(τ,0). The proof is based on a new decomposition of the space P<SUB>τ</SUB>(X) by constructing a right inverse of L.
Generalized eigenspaces of generators of evolution semigroups
Miyazaki, R.,Kim, D.,Naito, T.,Shin, J.S. Academic Press 2016 Journal of mathematical analysis and applications Vol.433 No.2
<P>A periodic evolutionary process {U(t, s)}(t >= s), with period T on a Banach space X gives an evolution semigroup with the generator L on the space of T-periodic continuous X-valued functions. We prove that the generalized eigenspaces ATL = N((alpha I - L)(n)) and Nu = N((e(alpha tau) I - U (tau,0))(n)) are isomorphic. The algebraic representation of a function u is an element of N-L, is given by the initial value u(0) = w is an element of Nu. (C) 2015 Elsevier Inc. All rights reserved.</P>
Electronic behavior of visible light sensitive ZrO2/Cr2O3/carbon clusters composite materials
H. Miyazaki,H. Matsui,Y. Kita,S. Karuppuchamy,S. Ito,M. Yoshihara 한국물리학회 2009 Current Applied Physics Vol.9 No.1
Nano-sized ZrO2/Cr2O3/carbon clusters composite materials were successfully obtained by the microwave-irradiated calcinations of a Zr(acac)4/Cr(acac)3/epoxy resin complex. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD, SEM and TEM. The UV–Vis spectra of the composites were also obtained. ESR spectral examinations of the composites indicate that an electron transfer takes place in the process Cr2O3 → carbon clusters → ZrO2. The composite materials have been found to show visible light-responsive catalytic activities. Nano-sized ZrO2/Cr2O3/carbon clusters composite materials were successfully obtained by the microwave-irradiated calcinations of a Zr(acac)4/Cr(acac)3/epoxy resin complex. The compositions of the resulting composite materials were determined using ICP, elemental analysis and surface characterization by XRD, SEM and TEM. The UV–Vis spectra of the composites were also obtained. ESR spectral examinations of the composites indicate that an electron transfer takes place in the process Cr2O3 → carbon clusters → ZrO2. The composite materials have been found to show visible light-responsive catalytic activities.
Kyle S. Miyazaki,Yu Kuang,Sandi A. Kwee 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.2
Radium-223 dichloride is an alpha-emitting radiopharmaceutical shown to prolong survival in patients with castrate-resistant prostate cancer (CRPC) and symptomatic skeletal metastases. This report describes in two patients the acute changes in bone metastatic activity detected by F-18 choline PET/CT imaging midway during treatment with radium-223 dichloride. In addition to visual and standardized uptake value analysis, changes in the whole-body tumor burden were quantified by measuring the difference in net metabolically active tumor volume (MATV) and total lesion activity (TLA) between pre- and mid-treatment PET scans. After the third dose of radium-223 dichloride, near-total disappearance of abnormal skeletal activity was observed in one case (net MATV change from 260.7 to 0.8 cc; net TLA change from 510.7 to 2.1), while a heterogeneous tumor response was observed in the other (net MATV change from 272.2 to 241.3 cc; net TLA change from 987.1 to 779.4). Corresponding normalization and persistent elevation in serum alkaline phosphatase levels were observed in these cases, respectively. Further research is needed to determine the predictive value of serial F-18 choline PET/CT imaging in patients receiving radium-223 dichloride for CRPC.
Choe, H.j.,Kim, J.h.,Lee, S.h.,Noh, J.p.,Kim, Y.w.,Miyazaki, S.,Nam, T.h. Elsevier Sequoia 2013 JOURNAL OF ALLOYS AND COMPOUNDS Vol.577 No.suppl1
Amorphous Ti-36Ni-7Sn (at%) alloy ribbons prepared by melt spinning were annealed at various temperatures for crystallization and then microstructures and transformation behavior were investigated by means of electron microscopy, X-ray diffraction and differential scanning calorimetry. Crystallized Ti-36Ni-7Sn alloy ribbons consisted of Ti<SUB>3</SUB>Sn, Ti<SUB>2</SUB>Ni and TiNi phases. Size of Ti<SUB>3</SUB>Sn phase was in the range of 50-850nm depending on annealing temperature. Average size of TiNi phase increased from 25nm to 100nm with raising annealing temperature from 873K to 1073K. Volume fraction of Ti<SUB>2</SUB>Ni phase decreased by raising annealing temperature through decomposition reaction of 3Ti<SUB>2</SUB>Ni+Sn (solved in TiNi phase)→3TiNi+Ti<SUB>3</SUB>Sn and then Ti<SUB>2</SUB>Ni almost disappeared by annealing at 1173K. The TiNi phase in crystallized Ti-36Ni-7Sn alloy ribbons showed the B2-R-B19' transformation behavior. DSC peak temperature associated with the B2-R transformation (T<SUB>R</SUB>*) decreased from 303K to 292K with raising annealing temperature from 973K to 1173K, while DSC peak temperature associated with the R-B19' transformation (M<SUB>s</SUB>*) increased from 187K to 237K with raising annealing temperature from 1073K to 1173K and thus the temperature gap between T<SUB>R</SUB>* and M<SUB>s</SUB>* decreases from 112K to 55K.
Nishiyama, N.,Nakagishi, Y.,Morimoto, Y.,Lai, P.S.,Miyazaki, K.,Urano, K.,Horie, S.,Kumagai, M.,Fukushima, S.,Cheng, Y.,Jang, W.D.,Kikuchi, M.,Kataoka, K. Elsevier Science Publishers 2009 Journal of controlled release Vol.133 No.3
Photodynamic therapy (PDT) is a promising method for the localized treatment of solid tumors. In order to enhance the efficacy of PDT, we have recently developed a novel class of photosensitizer formulation, i.e., the dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m). The DPc/m induced efficient and unprecedentedly rapid cell death accompanied by characteristic morphological changes such as blebbing of cell membranes, when the cells were photoirradiated using a low power halogen lamp or a high power diode laser. The fluorescent microscopic observation using organelle-specific dyes demonstrated that DPc/m might accumulate in the endo-/lysosomes; however, upon photoirradiation, DPc/m might be promptly released into the cytoplasm and photodamage the mitochondria, which may account for the enhanced photocytotoxicity of DPc/m. This study also demonstrated that DPc/m showed significantly higher in vivo PDT efficacy than clinically used Photofrin<SUP>(</SUP>R) (polyhematoporphyrin esters, PHE) in mice bearing human lung adenocarcinoma A549 cells. Furthermore, the DPc/m-treated mice did not show skin phototoxiciy, which was apparently observed for the PHE-treated mice, under the tested conditions. These results strongly suggest the usefulness of DPc/m in clinical PDT.