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Simple Synthesis of Multi-Halogen Pyrazino[1,2-a]indole-1,8(2H,5aH)-diones
Rui-Xia Yang,Yu-Cheng Zhao,Ling-Bin Kong,Sheng-jiao Yan,Jun Lin 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
A concise and efficient one-pot synthesis of multi-halogen pyrazino[1,2-a]indole-1,8(2H,5aH)-dione (MHPID) derivatives by the reaction of an enamino ester with multi-halogen benzoquinone derivatives is described. MHPIDs 3a–3d were obtained with good yields (78–83%) by refluxing enamino esters 1a and 1b and tetrahalogen-1,4-benzoquinones 2a and 2b for 24 h without the use of catalysts. Compounds 3e–3p were also obtained with excellent yields (69–92%) via the reaction of the phenyl-substituted enamino esters 1c–1h with tetrahalogen-1,4-benzoquinones 2a and 2b in CH3CN catalyzed by Cs2CO3. These two protocols are efficient and effective for the synthesis of MHPIDs.
TSHR Variant Screening and Phenotype Analysis in 367 Chinese Patients With Congenital Hypothyroidism
Zhang Hai-Yang,Wu Feng-Yao,Li Xue-Song,Tu Ping-Hui,Zhang Cao-Xu,Yang Rui-Meng,Cui Ren-Jie,Wu Chen-Yang,Fang Ya,Yang Liu,Song Huai-Dong,Zhao Shuang-Xia 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.4
Background: Genetic defects in the human thyroid-stimulating hormone (TSH) receptor (TSHR) gene can cause congenital hypothyroidism (CH). However, the biological functions and comprehensive genotype–phenotype relationships for most TSHR variants associated with CH remain unexplored. We aimed to identify TSHR variants in Chinese patients with CH, analyze the functions of the variants, and explore the relationships between TSHR genotypes and clinical phenotypes. Methods: In total, 367 patients with CH were recruited for TSHR variant screening using whole-exome sequencing. The effects of the variants were evaluated by in-silico programs such as SIFT and polyphen2. Furthermore, these variants were transfected into 293T cells to detect their Gs/cyclic AMP and Gq/11 signaling activity. Results: Among the 367 patients with CH, 17 TSHR variants, including three novel variants, were identified in 45 patients, and 18 patients carried biallelic TSHR variants. In vitro experiments showed that 10 variants were associated with Gs/cyclic AMP and Gq/11 signaling pathway impairment to varying degrees. Patients with TSHR biallelic variants had lower serum TSH levels and higher free triiodothyronine and thyroxine levels at diagnosis than those with DUOX2 biallelic variants. Conclusions: We found a high frequency of TSHR variants in Chinese patients with CH (12.3%), and 4.9% of cases were caused by TSHR biallelic variants. Ten variants were identified as loss-of-function variants. The data suggest that the clinical phenotype of CH patients caused by TSHR biallelic variants is relatively mild. Our study expands the TSHR variant spectrum and provides further evidence for the elucidation of the genetic etiology of CH.
OPTIMAL IMPULSE AND REGULAR CONTROL STRATEGIES FOR PROPORTIONAL REINSURANCE PROBLEM
RUI-CHENG, YANG,KUN-HUI, LIU,BING, XIA 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1
We formulate a stochastic control problem on proportional reinsurance that includes impulse and regular control strategies. For the first time we combine impulse control with regular control, and derive the expected total discount pay-out (return function) from present to bankruptcy. By relying on both stochastic calculus and the classical theory of impulse and regular controls, we state a set of sufficient conditions for its solution in terms of optimal return function. Moreover, we also derive its explicit form and corresponding impulse and regular control strategies.
Optimal impulse and regular control strategies for proportionalreinsurance problem
Yang Rui-cheng,Liu Kun-hui,Xia Bing 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1-2
We formulate a stochastic control problem on proportional reinsurance that includes impulse and regular control strategies. For the first time we combine impulse control with regular control, and derive the expected total discount pay-out (return function) from present to bankruptcy. By relying on both stochastic calculus and the classical theory of impulse and regular controls, we state a set of sufficient conditions for its solution in terms of optimal return function. Moreover, we also derive its explicit form and corresponding impulse and regular control strategies.
EXISTENCE OF SOLUTION FOR A FRACTIONAL DIFFERENTIAL INCLUSION VIA NONSMOOTH CRITICAL POINT THEORY
YANG, BIAN-XIA,SUN, HONG-RUI The Kangwon-Kyungki Mathematical Society 2015 한국수학논문집 Vol.23 No.4
This paper is concerned with the existence of solutions to the following fractional differential inclusion $$\{-{\frac{d}{dx}}\(p_0D^{-{\beta}}_x(u^{\prime}(x)))+q_xD^{-{\beta}}_1(u^{\prime}(x))\){\in}{\partial}F_u(x,u),\;x{\in}(0,1),\\u(0)=u(1)=0,$$ where $_0D^{-{\beta}}_x$ and $_xD^{-{\beta}}_1$ are left and right Riemann-Liouville fractional integrals of order ${\beta}{\in}(0,1)$ respectively, 0 < p = 1 - q < 1 and $F:[0,1]{\times}{\mathbb{R}}{\rightarrow}{\mathbb{R}}$ is locally Lipschitz with respect to the second variable. Due to the general assumption on the constants p and q, the problem does not have a variational structure. Despite that, here we study it combining with an iterative technique and nonsmooth critical point theory, we obtain an existence result for the above problem under suitable assumptions. The result extends some corresponding results in the literatures.
Ten Year Literature on Psychological and Behavioral Interventions Against Cancer: a Terms Analysis
Feng, Rui,Chai, Jing,Wang, De-Bin,Xia, Yi,Cheng, Peng-Lai,Dai, Zhao-Yang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
We here performed a systematic review of PBIC literature using terms analysis in a hope of both identifying potential trends and patterns and exploring methods leveraging traditional literature reviews in this specific area. Articles meeting inclusion criteria were retrieved from PUBMED and translated into dichotomized article records representing presence or non-presence of MeSH terms and a metric consisting of numbers of times of co-occurrence between all pairs of terms identified using a self-designed program. The occurrence of and relations among the terms were calculated and visualized using Excel2007 and UCINET respectively. A total of 1,742 terms were identified from 997 articles retrieved. Put in a descending order, the lines representing the times of term occurrence formed a typical hyperbolic curve; when plotted along the x-axis of whole MESH terms, the lines clustered within four specific regions. Comparison of term occurrence between 2002 and 2011 revealed priority changes in population and subjects (from general groups to priority groups), intervention approaches (from medicine to exercise and psychotherapy), methodology and techniques (from cohort studies to randomized controlled trials) and outcomes (from health and mental health to quality of life, depression etc.). Networks of the terms featured a number of closely linked groups of topics including method and questionnaires, therapy and outcomes, survival management, psychological assessment and intervention, behavioral intervention (individual and community oriented). Terms analysis revealed interesting trends and patterns about PBIC publications and both the analysis methods and findings have implications for future research and literature reviews.
A Highly Integrated Automatic Fiber Optical Gyroscope Sensing Coil Winding System
Shuang-Chao Ge,Rui-Feng Yang,Chen-Xia Guo 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.2
Fiber optic gyroscope (FOG) is a new type of optical sensor used to measure the rotating angular velocity. As the core component, fiber optic coil (FOC) plays a decisive role in the FOG output precision. The manufacturing level and efficiency of FOC have been main factors restricting the application and development of high precision FOG. Precision mechanical positioning method based on the photoelectric devices was researched, and high-performance fully automatic micro mechanical error compensation technique was developed. On these basis, automatic fiber distribution and winding control technology were realized. Eventually a multifunctional system was developed with fiber splitting module, fiber winding module, and calibration module. This system could accomplish automatic preparation of FOC with quadrupolar symmetric pattern according to the parameters set by user. The principle and working flow of each functional module are discussed in details. Experiments show that the system can achieve automatic speed changing, automatic reversing, constant small tension control and precise fiber arrangement. The new designed system greatly improve FOC production efficiency and is conductive to promotinghigh level FOG development.
Lu Wu,Li Xia Tan,Fen Fang Gong,Yu Xia,Rui Ge Chu,Hua Sheng Yang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.5
This study was designed to evaluate theabsorption promoting capacity of Maillard Reaction Products(MRPs) produced during the stir-frying process ofHordei Fructus Germinatus on catechin, ferulic acid,quercetin and kaempferol by the ex vivo rat everted gut sacmodel, in situ single-pass intestinal perfusion model andthe whole animal model. Moreover, verapamil, EDTA andmannitol were used for determining the transport mechanismof catechin, ferulic acid, quercetin and kaempferol. The tight junction (TJ) proteins including zonula occudens-1(ZO-1) and claudin-1 were chosen to investigate thepromoting mechanism of MRPs by quantitative real-timePCR (qRT-PCR) and western blot analyses. The resultsshowed that the MRPs produced during the stir-fryingprocess of Hordei Fructus Germinatus could improve theintestinal absorption of catechin, ferulic acid, quercetin andkaempferol. And the absorption-promoting effect of MRPswas related to chelating effect and the reduced expressionof claudin-1 and ZO-1. Our results suggested that MRPscould be promising oral absorption promoters, which mightbe another processing mechanism of Hordei FructusGerminatus.
Li-Jun Zuo,Shu-Yang Yu,Fang Wang,Yanghui Xia,Ying-Shan Piao,Yang Du,Teng-Hong Lian,Rui-Dan Wang,Qiu-Jin Yu,Ya-Jie Wang,Xiao-Min Wang,Piu Chan,Sheng-Di Chen,Yongjun Wang,Wei Zhang 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2
Background and Purpose The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson’s disease (PD) patients who experience fatigue. Methods PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins—α-synuclein oligomer, β-amyloid (Aβ)1-42, and tau—were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients. Results The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders. Conclusions PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF