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RISS 인기검색어
- 검색키워드
- 저자 : Robin A McGregor (검색결과 5 건)
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Voluntary stand-up physical activity enhances endurance exercise capacity in rats
서대윤,이성률,곽효범,서교원,Robin A McGregor,여지영,고태희,Saranhuu Bolorerdene,김나리,고경수,이병두,한진 대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
Involuntary physical activity induced by the avoidance of electrical shock leads to improved endurance exercise capacity in animals. However, it remains unknown whether voluntary stand-up physical activity (SPA) without forced simulating factors improves endurance exercise capacity in animals. We examined the eff ects of SPA on body weight, cardiac function, and endurance exercise capacity for 12 weeks. Twelve male Sprague-Dawley rats (aged 8 weeks, n=6 per group) were randomly assigned to a control group (CON) or a voluntary SPA group. The rats were induced to perform voluntary SPA (lifting a load equal to their body weight), while the food height (18.0 cm) in cages was increased progressively by 3.5 every 4 weeks until it reached 28.5 cm for 12 weeks. The SPA group showed a lower body weight compared to the CON group, but voluntary SPA did not affect the skeletal muscle and heart weights, food intake, and echocardiography results. Although the SPA group showed higher grip strength, running time, and distance compared to the CON group, the level of irisin, corticosterone, genetic expression of mitochondrial biogenesis, and nuclei numbers were not affected. These findings show that voluntary SPA without any forced stimuli in rats can eff ectively reduce body weight and enhance endurance exercise capacity, suggesting that it may be an important alternative strategy to enhance endurance exercise capacity.
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Cardiac proteome underpins differential adaptation to morning or evening exercise training
( Dae Yun Seo ),( Hyo-bum Kwak ),( Robin A Mcgregor ),( Hyoung Kyu Kim ),( Jin Han ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1
Purpose: Circadian related changes in the cardiac proteome may underlie differential cardiac adaptation to morning or evening exercise training. Global proteome changes underpin adaptations to exercise training, which is a potent stimulus to improve cardiovascular health, but the impact of time-of-day on exercise-induced cardiac adaptation is unknown. The aim of the present study was to determine the effect of morning or evening exercise training on the cardiac proteome and cardiovascular adaptations. Method: Eight weeks old Sprague Dawley rats underwent either morning (ME) or evening exercise (EE) with treadmill running, 60 min/day, 5 days/week for twelve weeks compared to non-exercise trained controls (MC and EC). Differences in body weight, organ weight and cardiac function were assessed. Nano-LC-ESI-MS/MS was used for quantification of differences in the global cardiac proteome. Result: Exercise training decreased body weight, but cardiac mass was not significantly different between groups trained in the morning or evening. Ejection fraction and fractional shortening were significantly higher in the morning compared to evening exercise trained rats (p<0.05). Global proteomics identified 1647 proteins in the heart. Of these 194 proteins showed circadian regulation. We identified 826 proteins that were commonly or divergently modulated by exercise training regardless of time of day. However, 278 and 188 proteins were modulated only by morning exercise training or only by evening exercise training respectively. Ingenuity Pathway Analysis revealed differentially modulated proteins were involved a range of molecular pathways including mitochondrial dysfunction, oxidative phosphorylation, and calcium signaling. Conclusion: Cardiac adaptations appear to be greater in response to morning rather than evening exercise training.
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Voluntary stand-up physical activity enhances endurance exercise capacity in rats
Seo, Dae Yun,Lee, Sung Ryul,Kwak, Hyo-Bum,Seo, Kyo Won,McGregor, Robin A,Yeo, Ji Young,Ko, Tae Hee,Bolorerdene, Saranhuu,Kim, Nari,Ko, Kyung Soo,Rhee, Byoung Doo,Han, Jin The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
Involuntary physical activity induced by the avoidance of electrical shock leads to improved endurance exercise capacity in animals. However, it remains unknown whether voluntary stand-up physical activity (SPA) without forced simulating factors improves endurance exercise capacity in animals. We examined the effects of SPA on body weight, cardiac function, and endurance exercise capacity for 12 weeks. Twelve male Sprague-Dawley rats (aged 8 weeks, n=6 per group) were randomly assigned to a control group (CON) or a voluntary SPA group. The rats were induced to perform voluntary SPA (lifting a load equal to their body weight), while the food height (18.0 cm) in cages was increased progressively by 3.5 every 4 weeks until it reached 28.5 cm for 12 weeks. The SPA group showed a lower body weight compared to the CON group, but voluntary SPA did not affect the skeletal muscle and heart weights, food intake, and echocardiography results. Although the SPA group showed higher grip strength, running time, and distance compared to the CON group, the level of irisin, corticosterone, genetic expression of mitochondrial biogenesis, and nuclei numbers were not affected. These findings show that voluntary SPA without any forced stimuli in rats can effectively reduce body weight and enhance endurance exercise capacity, suggesting that it may be an important alternative strategy to enhance endurance exercise capacity.
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Oh, Hea-Young,Shin, Su-Kyung,Heo, Hyoung-Sam,Ahn, Ji-Sook,Kwon, Eun-Young,Park, Jung Han Yoon,Cho, Yun-Young,Park, Hae-Jin,Lee, Mi-Kyung,Kim, Eun Jung,Jung, Un-Ju,McGregor, Robin A,Hur, Cheol-Goo,Choi New Century Health Publishers 2013 GENES AND NUTRITION Vol.8 No.3
<P>Prolonged high-fat diet leads to the development of obesity and multiple comorbidities including non-alcoholic steatohepatitis (NASH), but the underlying molecular basis is not fully understood. We combine molecular networks and time course gene expression profiles to reveal the dynamic changes in molecular networks underlying diet-induced obesity and NASH. We also identify hub genes associated with the development of NASH. Core diet-induced obesity networks were constructed using Ingenuity pathway analysis (IPA) based on 332 high-fat diet responsive genes identified in liver by time course microarray analysis (8 time points over 24?weeks) of high-fat diet-fed mice compared to normal diet-fed mice. IPA identified five core diet-induced obesity networks with time-dependent gene expression changes in liver. These networks were associated with cell-to-cell signaling and interaction (Network 1), lipid metabolism (Network 2), hepatic system disease (Network 3 and 5), and inflammatory response (Network 4). When we merged these core diet-induced obesity networks, Tlr2, Cd14, and Ccnd1 emerged as hub genes associated with both liver steatosis and inflammation and were altered in a time-dependent manner. Further, protein-protein interaction network analysis revealed Tlr2, Cd14, and Ccnd1 were interrelated through the ErbB/insulin signaling pathway. Dynamic changes occur in molecular networks underlying diet-induced obesity. Tlr2, Cd14, and Ccnd1 appear to be hub genes integrating molecular interactions associated with the development of NASH. Therapeutics targeting hub genes and core diet-induced obesity networks may help ameliorate diet-induced obesity and NASH.</P>
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