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Molecular imaging of atherosclerosis using reporter gene system
Ran Ji Yoo1,Yong Jin Lee 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.1
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using 99mTc-SPECT. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.
이애란,고동완,김유일 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.2 No.2
The city's countryside is adjusting to change by urbanisation. As it, the recent phenomena in this area decline in rural landuse and damage of landscape which has local characteristics. But, no study think together landuse and landscape at present in this area. The aim of this study was to clarify causes and problems of change by investigating intersection of environments and causes, processes and results of landuse and landscape in city's countryside. The sites are 2 Up and 2 Myon belong to Yongin Gun closed by Seoul City. These site are rapidly changed and almost intermediate between city and rural at present. As methods, I exeminated not only various statistical data but also unstatistical data. This case study revealed the diversity of change in city's countryside. 1) The change of landuse is clarified by Local Main commercial district is Yongin Up, Development of Traffic and industry is Kihung Up, Bed-town closed by city is Suji Myon and Recreation development is Pogok Myon. Each landuse divided by landscape types as local diversity in several Ri. Also each case seperatied by its special shape from each Ri and have causes and problems. 2) From these results did I point out problems and make a proposal about national landuse plan and landscape management in city's countryside. It stressed the need of a long-ranged policy of development in countryside considering local characteristics and residential environments. This paper was the start of case study about landuse and landscape in city's countryside.
Yoo, Ran,Lee, Dongmei,Cho, Sungmee,Lee, Wooyoung Elsevier 2018 Sensors and actuators. B Chemical Vol.254 No.-
<P><B>Abstract</B></P> <P>In this work, we report the gas sensing properties of un-doped and M (M=Al, Co, Cu, Mn)-doped ZnO nanoparticles (NPs), synthesized by a hydrothermal method for the detection of 2-chloroethyl ethyl sulfide (2-CEES), as a mustard simulant. X-ray diffraction and X-ray photoelectron spectroscopy characterizations reveal that Al-doped ZnO NPs were successfully fabricated. The sensing response of 1 at% Al-doped ZnO NPs was found to be the maximum (<I>R</I> =954.2) at 500°C, owing to enhanced conductivity and concentration of the oxygen vacancies after Al doping. Al is a more effective dopant for ZnO NPs toward enhancing its sensing properties for the detection of 2-CEES than Cu, Co, or Mn. The Al-doped ZnO NPs are both sensitive and selective to 2-CEES. The sensing performance of these NPs for 2-CEES is approximately 15 times better than the ones reported previously for other types of NPs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We have investigated the effect of doping on the sensing properties of ZnO NPs for the detection of 2-CEES. </LI> <LI> The sensing response of 1 at % Al-doped ZnO NPs was observed to show a maximum value (R=954.2) at 500°C. </LI> <LI> The enhanced conductivity originates from the enhanced conductivity and concentration of oxygen vacancy after Al doping. </LI> <LI> The Al dopant into ZnO NPs is most effective for the detection of 2-CEES as compared to other dopants such as Cu, Co, and Mn. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Somatic mutations of the <i>KEAP1</i> gene in common solid cancers
Yoo, Nam Jin,Kim, Hyung Ran,Kim, Yoo Ri,An, Chang Hyeok,Lee, Sug Hyung Blackwell Publishing Ltd 2012 Histopathology Vol.60 No.6
<P>Yoo N J, Kim H R, Kim Y R, An C H & Lee S H (2012) <I>Histopathology</I>?<B>60,</B> 943–952</P><P><B>Somatic mutations of the <I>KEAP1</I> gene in common solid cancers</B></P><P><B>Aims: </B> KEAP1 inhibits nuclear factor erythroid 2‐related factor 2 (NRF2)‐induced cytoprotection, and is considered to be a candidate tumour suppressor. Somatic mutation of <I>NRF2</I> has been analysed in a wide variety of human cancers, whereas somatic mutation of <I>KEAP1</I> has been reported only in lung and gall bladder cancers. The aim of our study was to investigate whether <I>KEAP1</I> mutations are widespread in human cancers.</P><P><B>Methods and results: </B> We analysed 499 cancer tissues from lung, breast, colon, stomach, liver, larynx and prostate, and leukaemias, by single‐strand conformation polymorphism analysis. We detected somatic mutations of <I>KEAP1</I> in gastric (11.1%), hepatocellular (8.9%), colorectal (7.8%), lung (4.6%), breast (2.0%) and prostate (1.3%) carcinomas. Allelic losses of the <I>KEAP1</I> locus were identified in 42.9% of cancers with <I>KEAP1</I> mutations, but no <I>NRF2</I> mutations were detected in these cancers. The NRF2‐activated cytoprotective proteins (NAD(P)H dehydrogenase quinone 1 and glutamine‐cysteine ligase catalytic subunit) were expressed in all of the cancers with <I>KEAP1</I> mutations.</P><P><B>Conclusions: </B> Our data show that <I>KEAP1</I> mutations occur widely in solid cancers, irrespective of histological type. Biallelic inactivation of <I>KEAP1</I> and increased levels of cytoprotective proteins in the cancers suggest that <I>KEAP1</I> mutations might protect cancer cells from oxidative insults and play a role in the development of solid cancers.</P>
Molecular imaging of atherosclerosis using reporter gene system
Yoo, Ran Ji,Lee, Kyochul,Kang, Joo Hyun,Lee, Yong Jin Korean Society of Radiopharmaceuticals and Molecul 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.1
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using $^{99m}Tc-SPECT$. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.