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I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
Rajendran, Senthilnathan,Muthupalani, Rajendran Shanmugam,Ramanathan, Arvind Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: In normal cells, activated epidermal growth factor receptor (EGFR) molecules are subjected to ubiquitination-mediated proteasome degradation pathway by c-Cbl, an ubiquitin ligase that checks uncontrolled proliferation. Hence expression of wild type c-Cbl molecule is essential to keep this degradation machinery in a functional state. Loss of expression or function of c-Cbl may consequently lead to sustained activation of EGFR and promote carcinogenesis, loss of function mutations in the c-Cbl gene already being reported in lung and hematopoietic cancers. However, the genetic status of c-Cbl in oral squamous cell carcinoma (OSCC) is not known. Hence in the present study we investigated the genomic DNA isolated from OSCC tissue biopsy samples for mutations in the RING finger domain coding region of c-Cbl gene, which has also been reported to be most frequently mutated in other cancers. Materials and Methods: Total genomic DNA isolated from thirty two post surgical OSCC tissue samples were amplified using primers flanking the exon 8 of c-Cbl gene that codes for the RING finger domain. The PCR amplicons were then resolved in a 1.2% agarose gel, purified and subjected to direct sequencing to screen for mutations. Results: The sequencing data of the thirty two OSCC samples did not identify mutations in the RING finger domain coding region of c-Cbl gene. Conclusions: To the best of our knowledge, this is the first time that the genetic status of c-Cbl gene in OSCC samples has been investigated. The present data indicates that genetic alteration of RING finger domain coding region of c-Cbl gene is relatively infrequent in OSCC samples.
Rajendran Selvamani,Hepzibah Christinal,Farzad Ebrahimi Techno-Press 2023 Advances in materials research Vol.12 No.4
The humid thermal vibration characteristics of a nonhomogeneous thermopiezoelectric nonlocal plate of polygonal shape are addressed in the purview of generalized nonlocal thermoelasticity. The plate is initially stressed, and the three-dimensional linear elasticity equations are taken to form motion equations. The problem is solved using the Fourier expansion collocation method along the irregular boundary conditions. The numerical results of physical variables have been discussed for the triangle, square, pentagon, and hexagon shapes of the plates and are given as dispersion curves. The amplitude of non-dimensional frequencies is tabulated for the longitudinal and flexural symmetric modes of the thermopiezoelectric plate via moisture and thermal constants. Also, a comparison of numerical results is made with existing literature, and good agreement is reached.
Rajendran Rajaram,Pandiyaraj Kanagavalli,Shanmugam Senthilkumar,Jayaraman Mathiyarasu 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.5
Glutathione (GSH) is an important bio-thiol which is playing vital role in the human system, such as treating glaucoma, preventing asthma, cancer, etc. Therefore, electrochemical sensing of GSH is becoming very vital to know the level of the biomolecule in living systems. Hence, the present work aims to develop a sensor matrix for electrochemical biosensing of GSH at Au nanoparticle decorated Nanoporous poly(3,4)ethylene dioxythiophene (PEDOT) modified glassy carbon electrode (AuNPPEDOT/ GCE). The electrode is modified with a nanoporous fibrillar network of PEDOT containing Au nanoparticles and characterized using UV-Visible spectroscopy and Field Emission Scanning Electron Microscopy (FESEM). The platform is capable of producing enhanced signal against the bio-analyte at the applied overpotential of 0.6 V. Whereas bare glassy carbon electrode is unable to produce the signal. Conversely, Nanoporous PEDOT modified glassy carbon electrode can sense GSH of very low sensitivity at an applied overpotential of 0.7 V. From single step chronoamperometric measurements, kinetic parameters such as diffusion coefficient and apparent rate constant of the reaction were found as 5.01 × 10-5 cm2·s-1 and 1.106 × 103 M-1·s-1 respectively. From the amperometric response, the sensitivity and limit of detection (LOD) of the electrode were to be 10.7 μA cm-2/μM and 0.173 μM respectively with the linear range of 0.5 to 10 μM. The matrix can detect GSH in the presence of other possible interfering molecules present in blood samples.
Rajendran, S.,Subramanian, S. Techno-Press 2004 Structural Engineering and Mechanics, An Int'l Jou Vol.17 No.6
The classical 8-node isoparametric serendipity element uses parametric shape functions for both test and trial functions. Although this element performs well in general, it yields poor results under severe mesh distortions. The distortion sensitivity is caused by the lack of continuity and/or completeness of shape functions used for test and trial functions. A recent element using parametric and metric shape functions for constructing the test and trial functions exhibits distortion immunity. This paper discusses the choice of parametric or metric shape functions as the basis for test and/or trial functions, satisfaction of continuity and completeness requirements, and their connection to distortion sensitivity. Also, the performances of four types of elements, viz., parametric, metric, parametric-metric, and metric-parametric, are compared for distorted meshes, and their merits and demerits are discussed.
Eight-node field-consistent hexahedron element in dynamic problems
Rajendran, S.,Prathap, G. Techno-Press 1999 Structural Engineering and Mechanics, An Int'l Jou Vol.8 No.1
Superior performance of field consistent eight-node hexahedron element in static bending problems has already been demonstrated in literature. In this paper, its performance in free vibration is investigated. Free vibration frequencies of typical test problems have been computed using this element. The results establish its superior performance in free vibration, particularly in thin plate application and near incompressibility regimes, demonstrating that shear locking, Poisson's stiffening and volumetric locking have been eliminated.
Design of a Smart Safety Vest Incorporated With Metal Detector Kits for Enhanced Personal Protection
Rajendran, Salini D.,Wahab, Siti N.,Yeap, Swee P. Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.4
Background: Personal protective equipment (PPE) has been designed in such a way to reduce accident rates. Unfortunately, existing PPE is rather ineffective as it is not able to provide warning signals when hazard is around. The integration of intelligent systems is envisaged to increase the efficiency of existing PPE. Methods: This project designed a safety vest incorporated with metal detectors which can provide immediate warning to the field workers when there is metal hazard around. This product has greater freedom of design via smart manufacturing as it involves the assembly of few commercially available parts into a single entity. Briefly, the metal detector is a do it yourself (DIY) kit, and the safety vest is purchasable from any local market. The DIY kit was connected to a copper coil and being sewed into the safety vest. Results: The metal detector induces beeping sound when there is metal hazard around. A total of 121 engineering students were introduced to the prototype before being requested to answer a survey associated with the design. Respondents have rated >3.00/5.00 for the design simplicity, ease of usage, and light weight. Meanwhile, respondents suggested that the design should be further improved by increasing the metal detection range. Conclusion: It is envisaged that the introduction of this smart safety vest will allow the workers to carry out their duties securely by reducing the accident rates. Particularly, such design is expected to reduce workplace accident especially during night time at construction sites where the visibility is low.