Mucoadhesive microsphere based suppository containing granisetron hydrochloride for management of emesis in chemotherapy

N. H. Salunkhe,N. R. Jadhav,K. K. Mali,R. J. Dias,V. S. Ghorpade,A. V. Yadav 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4

The purpose of present work was to developsuppositories containing mucoadhesive microspheres ofgranisetron hydrochloride (GH) using combination ofxanthan gum and sodium alginate. Twelve different batchesof microspheres containing GH were prepared bysimple emulsification method and evaluated for surfacemorphology, particle size, equilibrium swelling degree,drug content, in vitro mucoadhesion, and in vitro drugrelease. The suppositories containing optimized batch ofmicrospheres (C2) were formulated by fusion method usinghydrophilic and lipophilic polymer base. The suppositorieswere evaluated for weight variation, hardness, macromeltingrange, drug content, drug release, morphology ofrectal tissues, and in vivo suppository localization. Resultsshow that, all microsphere batches were spherical and hadsize range 23.56–36.76 lm. The % drug encapsulation wasfound in the range 61.67–92.30 %, and showed satisfactorymucoadhesion. Especially, C2 batch had 83.67 % mucoadhesionand 92.30 % drug encapsulation and showedrelease retardation for 4 h. The results of all suppositorieswere within the pharmacopoeial standard limits. Drugcontent of all the suppositories was in the range93.20–98.40 %. The suppository batch (P2M) wasconsidered best on the basis of optimum retardation up to5 h, high drug content, optimum mechanical strength andzero order release (r2 = 0.9860). The suppository of batchP2M showed no morphological changes in rectal tissuesindicating its safety. In vivo localization revealed satisfactorymucoadhesion of microspheres. Hence, it can beconcluded that, delivery of GH in suppository form canavoid its presystemic metabolism, thus, may be an efficientalternative to its oral dosage form and conventionalsuppository.

Sb₂S₃ nanoparticles through solution chemistry on mesoporous TiO₂ for solar cell application

Salunkhe, D.B.,Gargote, S.S.,Dubal, D.P.,Kim, W.B.,Sankapal, B.R. North Holland ; Elsevier Science Ltd 2012 Chemical physics letters Vol.554 No.-

A facile room temperature (27<SUP>o</SUP>C) chemical route, namely successive ionic layer adsorption and reaction (SILAR) method is used to deposit antimony trisulphide (Sb<SUB>2</SUB>S<SUB>3</SUB>) nanoparticles on mesoporous titanium dioxide (TiO<SUB>2</SUB>). The method facilitates linker free approach to deposit the size tuned nanoparticles. The synthesized TiO<SUB>2</SUB>/Sb<SUB>2</SUB>S<SUB>3</SUB> structure on a FTO (fluorine doped tin oxide coated glass substrate) was used as a photoanode with polysulphide as liquid electrolyte and platinum coated FTO as back contact to construct the photovoltaic device. The photovoltaic performances have been tested under light illumination with standard solar simulator condition (AM 1.5G, 10mW/cm<SUP>2</SUP>) and photovoltaic parameters are discussed.

Binary metal hydroxide nanorods and multi-walled carbon nanotube composites for electrochemical energy storage applications

Salunkhe, Rahul R.,Jang, Kihun,Lee, Sung-won,Yu, Seongil,Ahn, Heejoon The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.40

<P>Carbon nanotube and metal oxide/hydroxide hybrids have attracted much interest as electrode materials for electrochemical supercapacitors because of their dual storage mechanism. They can complement or replace batteries in electrical energy storage and harvesting applications, where high power delivery or uptake is needed. Multi-walled carbon nanotube (MWCNT) and nickel–cobalt binary metal hydroxide nanorod hybrids have been developed through the chemical synthesis of binary metal hydroxide on a MWCNT surface. These hybrids show enhanced supercapacitive performance and cycling ability. Growth of a thin film consisting of a coating of binary metal hydroxide, as well as further growth of nanorod structures, is demonstrated using FESEM and TEM, showing that this film is a promising structure for supercapacitor applications. These electrodes yield a significantly high capacitance of 502 F g<SUP>−1</SUP> with a high energy density of 69 W h kg<SUP>−1</SUP> at a scan rate of 5 mV s<SUP>−1</SUP>. The film is stable up to 5000 cycles with greater than 80% capacitance retention.</P> <P>Graphic Abstract</P><P>A novel composite material composed of cost effective pseudocapacitive nanostructures like Ni–Co hydroxide nanorods and CNT was fabricated on a stainless steel substrate and further utilized for supercapacitor applications. The electrodes yield a significantly high specific capacitance of ∼502 F g<SUP>−1</SUP> with an energy density of 69 W h kg<SUP>−1</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm32638h'> </P>

Controlled growth of polythiophene nanofibers in TiO2 nanotube arrays for supercapacitor applications

Ambade, R.,Ambade, S.,Shrestha, N.,Salunkhe, R.,Lee, W.,Bagde, S.,Kim, J.,Stadler, F.,Yamauchi, Y.,Lee, S. H. Royal Society of Chemistry 2017 Journal of materials chemistry. A, Materials for e Vol.5 No.1

<P>One-dimensional (1D) nanostructured materials have attracted intense interest because they are superior for applications when compared to their bulk counterparts, owing to their unique and fascinating properties. We thus demonstrate the development of conducting 1D polythiophene (PTh) nanofibers in hollow TiO2 nanotube arrays (TNTs) by controlling nucleation and growth during the electropolymerization of the thiophene monomer. The progression of nanofiber (NF) formation in the hollow interiors of the TNTs follows a three-dimensional instantaneous nucleation and growth mode, in which the polymer grows at a rate that does not allow for the build-up of the polymer on new polymerization sites, but only on existing ones. The formation of highly conductive dienes of PTh is confirmed, with increased conjugation in PTh NFs grown in the confined matrix of TNTs. These 1D PTh-TNT NFs show potential as a promising supercapacitor electrode material, exhibiting a high specific capacitance of 1052 F g(-1), which clearly highlights their importance as potential next-generation charge storage entities.</P>

Method development and validation of spectrophotometric and RP-HPLC methods for simultaneous estimation of spironolactone and furosemide in bulk and combined tablet dosage forms

Rohankumar R. Chavan,Somnath D. Bhinge,Mangesh A. Bhutkar,Dheeraj S. Randive,Vijay R. Salunkhe 한국분석과학회 2021 분석과학 Vol.34 No.5

Facile Low-temperature Chemical Synthesis and Characterization of a Manganese Oxide/multi-walled Carbon Nanotube Composite for Supercapacitor Applications

장기훈,이성원,유성일,Rahul R. Salunkhe,정일두,최성민,안희준 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

Mn3O4/multi-walled carbon nanotube (MWCNT) composites are prepared by chemically synthesizing Mn3O4 nanoparticles on a MWCNT film at room temperature. Structural and morphological characterization has been carried out using X-ray diffraction (XRD) and scanning and transmission electron microscopies (SEM and TEM). These reveal that polycrystalline Mn3O4 nanoparticles, with sizes of about 10-20 nm, aggregate to form larger nanoparticles (50-200 nm), and the Mn3O4 nanoparticles are attached inhomogeneously on MWCNTs. The electrochemical behavior of the composites is analyzed by cyclic voltammetry experiment. The Mn3O4/ MWCNT composite exhibits a specific capacitance of 257 Fg−1 at a scan rate of 5 mVs−1, which is about 3.5 times higher than that of the pure Mn3O4. Cycle-life tests show that the specific capacitance of the Mn3O4/ MWCNT composite is stable up to 1000 cycles with about 85% capacitance retention, which is better than the pure Mn3O4 electrode. The improved supercapacitive performance of the Mn3O4/MWCNT composite electrode can be attributed to the synergistic effects of the Mn3O4 nanoparticles and the MWCNTs, which arises not only from the combination of pseudocapacitance from Mn3O4 nanoparticles and electric double layer capacitance from the MWCNTs but also from the increased surface area, pore volume and conducting property of the MWCNT network.

General template-free strategy for fabricating mesoporous two-dimensional mixed oxide nanosheetsviaself-deconstruction/reconstruction of monodispersed metal glycerate nanospheres

Kaneti, Yusuf Valentino,Salunkhe, Rahul R.,Wulan Septiani, Ni Luh,Young, Christine,Jiang, Xuchuan,He, Yan-Bing,Kang, Yong-Mook,Sugahara, Yoshiyuki,Yamauchi, Yusuke The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.14

<P>In this work, we propose a general template-free strategy for fabricating two-dimensional mesoporous mixed oxide nanosheets, such as metal cobaltites (MCo2O4, M = Ni, Zn) through the self-deconstruction/reconstruction of highly uniform Co-based metal glycerate nanospheres into 2D Co-based metal glycerate/hydroxide nanosheets, induced by the so-called “water treatment” process at room temperature followed by their calcination in air at 260 °C. The proposed ‘self-deconstruction/reconstruction’ strategy is highly advantageous as the resulting 2D metal cobaltite nanosheets possess very high surface areas (150-200 m<SUP>2</SUP>g<SUP>−1</SUP>) and mesoporous features with narrow pore size distribution. In addition, our proposed method also enables the crystallization temperature to achieve pure metal cobaltite phase from the precursor phase to be lowered by 50 °C. Using the 2D mesoporous NiCo2O4nanosheets as a representative sample, we found that they exhibit 6-20 times higher specific capacitance and greatly enhanced capacitance retention compared to the NiCo2O4nanospheres achieved through the direct calcination of the Ni-Co glycerate nanospheres. This highlights another advantage of the proposed strategy for enhancing the electrochemical performance of the mixed oxide products for supercapacitor applications. Furthermore, the asymmetric supercapacitor (ASC) assembled using the 2D NiCo2O4nanosheets//graphene oxide (GO) exhibits a maximum energy density of 38.53 W h kg<SUP>−1</SUP>, while also showing a high capacitance retention of 91% after 2000 cycles at 5 A g<SUP>−1</SUP>. It is expected that the proposed general method may be extended to other transition metal elements for creating 2D mixed oxide nanosheets with enhanced surface areas and improved electrochemical performance.</P>

Hydrophilic polyaniline nanofibrous architecture using electrosynthesis method for supercapacitor application

D.S. Dhawale,R.R. Salunkhe,V.S. Jamadade,D.P. Dubal,S.M. Pawar,C.D. Lokhande 한국물리학회 2010 Current Applied Physics Vol.10 No.3

An electrosynthesis process of hydrophilic polyaniline nanofiber electrode for electrochemical supercapacitor is described. The TGA–DTA study showed polyaniline thermally stable up to 323 K. Polyaniline nanofibers exhibit amorphous nature as confirmed from XRD study. Smooth interconnected fibers having diameter between 120–125 nm and length typically ranges between 400–500 nm observed from SEM and TEM analysis. Contact angle measurement indicated hydrophilic nature of polyaniline fibers. Optical study revealed the presence of direct band gap with energy 2.52 eV. The Hall effect measurement showed room temperature resistivity ~3 × 10-4 Ω cm and Hall mobility 549.35 cm-2V-1 s-1. The supercapacitive performance of nanofibrous polyaniline film tested in 1 M H2SO4 electrolyte and showed highest specific capacitance of 861 F g-1 at the voltage scan rate of 10 mV/s.

Plant Extract: A Promising Biomatrix for Ecofriendly, Controlled Synthesis of Silver Nanoparticles

Borase, H. P.,Salunke, B. K.,Salunkhe, R. B.,Patil, C. D.,Hallsworth, J. E.,Kim, B. S.,Patil, S. V. HUMANA PRESS INC 2014 Applied biochemistry and biotechnology Vol.173 No.1

Uses of plants extracts are found to be more advantageous over chemical, physical and microbial (bacterial, fungal, algal) methods for silver nanoparticles (AgNPs) synthesis. In phytonanosynthesis, biochemical diversity of plant extract, non-pathogenicity, low cost and flexibility in reaction parameters are accounted for high rate of AgNPs production with different shape, size and applications. At the same time, care has to be taken to select suitable phytofactory for AgNPs synthesis based on certain parameters such as easy availability, large-scale nanosynthesis potential and non-toxic nature of plant extract. This review focuses on synthesis of AgNPs with particular emphasis on biological synthesis using plant extracts. Some points have been given on selection of plant extract for AgNPs synthesis and case studies on AgNPs synthesis using different plant extracts. Reaction parameters contributing to higher yield of nanoparticles are presented here. Synthesis mechanisms and overview of present and future applications of plant-extract-synthesized AgNPs are also discussed here. Limitations associated with use of AgNPs are summarised in the present review.

Facile Low-temperature Chemical Synthesis and Characterization of a Manganese Oxide/multi-walled Carbon Nanotube Composite for Supercapacitor Applications

Jang, Kihun,Lee, Sung-Won,Yu, Seongil,Salunkhe, Rahul R.,Chung, Ildoo,Choi, Sungmin,Ahn, Heejoon Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

$Mn_3O_4$/multi-walled carbon nanotube (MWCNT) composites are prepared by chemically synthesizing $Mn_3O_4$ nanoparticles on a MWCNT film at room temperature. Structural and morphological characterization has been carried out using X-ray diffraction (XRD) and scanning and transmission electron microscopies (SEM and TEM). These reveal that polycrystalline $Mn_3O_4$ nanoparticles, with sizes of about 10-20 nm, aggregate to form larger nanoparticles (50-200 nm), and the $Mn_3O_4$ nanoparticles are attached inhomogeneously on MWCNTs. The electrochemical behavior of the composites is analyzed by cyclic voltammetry experiment. The $Mn_3O_4$/MWCNT composite exhibits a specific capacitance of $257Fg^{-1}$ at a scan rate of $5mVs^{-1}$, which is about 3.5 times higher than that of the pure $Mn_3O_4$. Cycle-life tests show that the specific capacitance of the $Mn_3O_4$/MWCNT composite is stable up to 1000 cycles with about 85% capacitance retention, which is better than the pure $Mn_3O_4$ electrode. The improved supercapacitive performance of the $Mn_3O_4$/MWCNT composite electrode can be attributed to the synergistic effects of the $Mn_3O_4$ nanoparticles and the MWCNTs, which arises not only from the combination of pseudocapacitance from $Mn_3O_4$ nanoparticles and electric double layer capacitance from the MWCNTs but also from the increased surface area, pore volume and conducting property of the MWCNT network.