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Andre´ Luiz A. Pizzolatti,Florian Gaudig,Daniel Seitz,Carlos R. M. Roesler,Gean Vitor Salmoria 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.6
BACKGROUND: Glucosamine hydrochloride (GlcNHCl) has been shown to inhibit cell growth and matrix synthesis, but not with N-acetyl-glucosamine (GlcNAc) supplementation. This effect might be related to an inhibition of critical growth factors (GF), or to a different metabolization of the two glucosamine derivatives. The aim of the present study was to evaluate the synergy between GlcNHCl, GlcNAc, and GF on proliferation and cartilage matrix synthesis. METHOD: Bovine chondrocytes were cultivated in monolayers for 48 h and in three-dimensional (3D) chitosan scaffolds for 30 days in perfusion bioreactors. Serum-free (SF) medium was supplemented with either growth factors (GF) TGF-b (5 ng mL-1) and IGF-I (10 ng mL-1), GlcNHCl or GlcNAc at 1mM each or both. Six groups were compared according to medium supplementation: (a) SF control; (b) SF ? GlcNHCl; (c) SF ? GlcNAc; (d) SF ? GF; (e) SF ? GF ? GlcNHCl; and (f) SF ? GF ? GlcNAc. Cell proliferation, proteoglycan, collagen I (COL1), and collagen II (COL2) synthesis were evaluated. RESULTS: The two glucosamines showed opposite effects in monolayer culture: GlcNHCl significantly reduced proliferation and GlcNAc significantly augmented cellular metabolism. In the 30 days 3D culture, the GlcNHCl added to GF stimulated cell proliferation more than when compared to GF only, but the proteoglycan synthesis was smaller than GF. However, GlcNAc added to GF improved the cell proliferation and proteoglycan synthesis more than when compared to GF and GF/GlcNHCl. The synthesis of COL1 and COL2 was observed in all groups containing GF. CONCLUSION: GlcNHCl and GlcNAc increased cell growth and stimulated COL2 synthesis in long-time 3D culture. However, only GlcNAc added to GF improved proteoglycan synthesis.
Ríos-Osorio Néstor,Muñoz-Alvear Hernan Darío,Jiménez-Castellanos Fabio Andrés,Quijano-Guauque Sara,Jiménez-Peña Oscar,García-Perdomo Herney Andrés,Caviedes-Bucheli Javier 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.3
Objectives This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans. Materials and Methods We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3). Results 6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%). Conclusions Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure. Objectives This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans. Materials and Methods We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3). Results 6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%). Conclusions Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure.
Emanoel R. Q. Chaves Jr.,André F. O. de A. Dantas,André L. Maitelli 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.7
This paper presents an Unknown Input robust Observer (UIO) capable of simultaneously estimate both sensor fault and system states. The system is assumed to be discrete-time Takagi-Sugeno (T-S) Fuzzy with uncertainties. An augmented system is obtained from the dynamic fault model and original system. Afterward, a UIO is designed for the augmented system aiming at decoupling process disturbances. Its design is obtained by using an H∞ optimization technique and developed to maintain the observer stable, reducing the non-decoupled process disturbances effect. The proposed method is validated by two numerical examples as it is compared to a regular UIO technique and the extended Kalman filter. Results show the proposed technique presents better performance when the dynamic system is not purely nonlinear even if the same tuning parameters are chosen. Although other techniques are not able to ensure the error limitation, the proposed one is capable of it even in nonlinear systems.
Anick R. Fournier,John T.A. Proctor,Shahrokh Khanizadeh,André Gosselin,Martine Dorais 고려인삼학회 2008 Journal of Ginseng Research Vol.32 No.4
Forest-grown American ginseng (Panax quinquefolius L.) is exposed to daily and seasonal light variations. Our goal was to determine the effect of understory light changes on the maximum quantum yield of photosystem II, expressed as Fv/Fm, and photosynthetic pigment composition of two-year-old plants. Understory light photon flux density and sunfleck durations were characterized using hemispherical canopy photography. Our results showed that understory light significantly affected the Fv/Fm of American ginseng, especially during the initial development of the plants when light levels were the highest, averaging 28 mol m-2 d -1. Associated with low Fv / Fm during its initial development, American ginseng had the lowest levels of epoxidation state of the xanthophyll cycle of the season, suggesting an active dissipation of excess light energy absorbed by the chlorophyll pigments. As photon flux density decreased after the deployment of the forest canopy to less than 10 mol m-2 d -1, chlorophyll a/b decreased suggesting a greater investment in light harvesting pigments to reaction centers in order to absorb the fleeting light energy.
Johannes Rübenthaler,Dirk-André Clevert,Maximilian Reiser 대한초음파의학회 2016 ULTRASONOGRAPHY Vol.35 No.4
The use of ultrasonography and especially of contrast-enhanced ultrasonography (CEUS) in the diagnosis of vascular pathologies before and after interventions has significantly increased over the past years due to the broader availability of modern ultrasound systems with CEUS capabilities and more trained user experience in this imaging modality. For the preinterventional and postinterventional work-up of carotid diseases, duplex ultrasound as well as CEUS have been established as the standard-of-care examination procedures for diagnosis, evaluation, and follow-up. In addition to its use for carotid arterial diseases, ultrasonography has also become the primary modality for the screening of vascular pathologies. This review describes the most common pathologies found in ultrasonography of the carotid arteries, the abdominal aorta, and the femoral arteries.
Johannes Rübenthaler,Stephanie Wilson,Dirk-André Clevert 대한초음파의학회 2019 ULTRASONOGRAPHY Vol.38 No.2
Ultrasonography is a generally accepted imaging technique for diagnosing and monitoring cystic renal lesions. The widely used Bosniak classification (I-IV) categorizes renal cystic lesions into five distinctive groups according to ultrasonography and computed tomography (CT) image criteria. For solid renal lesions, determination of vascularity is discriminatory for malignancy in most instances. In indeterminate cases, contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging/CT-ultrasound image fusion are able to detect and characterize difficult pathologies, with superior performance to either technique alone. In contrast to multislice CT (MS-CT), ultrasound image fusion is a real-time imaging technique that can be used in combination with other cross-sectional imaging modalities. This technical note describes stateof-the-art image fusion of CEUS and MS-CT to detect and characterize unclear renal pathologies.
Random magnetic anisotropy in a new compound Sm2AgSi3
Sahu Baidyanath,Fobasso R. Djoumessi,Strydom André M. 한국물리학회 2023 Current Applied Physics Vol.45 No.-
We report the experimental study on the structural and magnetic properties of a new ternary intermetallic compound Sm2AgSi3. The properties of the sample were investigated in detail by X-ray diffraction, dc–magnetization, and heat capacity measurements. The polycrystalline compound of Sm2AgSi3 crystallizes in the ThSi2- type tetragonal structure (space group I41 /amd). The temperature dependent dc–magnetization and heat capacity results demonstrate that the compound undergoes ferromagnetic behaviour with a Curie temperature (TC) of 14 K. The large coercive field in hysteresis loops and the thermomagnetic irreversibility in the ferromagnetic region revealed that the compound exhibits a large magnetic anisotropy. The magnitude of the applied field and the coercivity obtained from the M-H loops corroborate with the thermomagnetic irreversibility in the magnetization data. The magnetic contribution of the heat capacity reveals a broad Schottky–type anomaly above TC, due to the presence of the crystal electric field effect of Sm3+ in Sm2AgSi3.
Benefits of contrast-enhanced ultrasonography for interventional procedures
Constantin Arndt Marschner,Johannes Rübenthaler,Matthias Frank Froelich,Vincent Schwarze,Dirk-André Clevert 대한초음파의학회 2021 ULTRASONOGRAPHY Vol.40 No.2
For evaluating unclear tumorous lesions, contrast-enhanced ultrasonography (CEUS) is an important imaging modality in addition to contrast-enhanced computed tomography and magnetic resonance imaging, and may provide valuable insights into the microvascularization of tumors in dynamic examinations. In interventional procedures, CEUS can make a valuable contribution in pre-, peri-, and post-interventional settings, reduce radiation exposure and, under certain circumstances, decrease the number of interventions needed for patients.
Hélène Sénéchal,Sanaz Keykhosravi,Rémy Couderc,Marie-Ange Selva,Youcef Shahali,Tomoyasu Aizawa,Jean-Marc Busnel,Rihane Arif,Inna Mercier,Nhan Pham-Thi,Denis-André Charpin,Pascal Poncet 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.1
A pollen/food-associated syndrome (PFAS) has been described between peach and cypress pollen. Cross-reactive allergens were characterized which belong to the Gibberellin-regulated protein (GRP) family, BP14 in cypress pollen and Pru p 7 in peach. GRP are small cationic protein with anti-microbial properties. A patient suffering from a peach/cypress syndrome was explored clinically and biologically using 2 types of immunoglobulin E (IgE) multiarray microchip, immunoblots and a basophil activation test to assess the clinical relevance of various extracts and purified allergens from fruits or cypress pollen. In addition to PR10 sensitization, the patient showed specific IgE to Pru p 7, BP14 and allergen from pomegranate. These last 3 allergens and allergenic sources are able to induce ex vivo basophil activation characterized by the monitoring of the expression of CD63 and CD203c, both cell surface markers correlated with a basophil mediator release. Up to 100% of cells expressed CD203c at 50 ng/mL of BP14 protein. In contrast, snakin-1, a GRP from potato sharing 82% sequence identity with Pru p 7 did not activate patient's basophils. These results strongly suggest that, like Pru p 7, BP14 is a clinically relevant allergenic GRP from pollen. Allergen members of this newly described protein family are good candidates for PFAS where no cross-reactive allergens have been characterized.