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박상욱,Sarah M. Smith,Anthony I. Cognato,Roger A. Beaver 국립중앙과학관 2020 Journal of Asia-Pacific Biodiversity Vol.13 No.2
A catalogue of the fauna of Korean Xyleborine species is provided with information on the Korean records,local and world distribution and taxonomy. The following seven new species and 11 newlyrecorded species are added to the Korean fauna: Cyclorhipidion laciniosum Park & Smith sp. nov.,Cyclorhipidion triste Park & Smith sp. nov., Microperus molestus Park & Smith sp. nov., Xyleborinuskwangreungensis Park & Smith sp. nov., Xyleborus singhi Park & Smith sp. nov., Xylosandrus dentipennisPark & Smith sp. nov., Xylosandrus trunculus Park & Smith sp. nov., Cyclorhipidion fukiense (Eggers),Cyclorhipidion japonicum (Nobuchi), Cyclorhipidion laetum (Niisima), Diuncus haberkorni (Eggers), Dryoxylononoharaense (Murayama), Euwallacea interjectus (Blandford), Microperus quercicola (Eggers),Xyleborus glabratus Eichhoff, Xyleborus muticus Blandford, Xyleborus ohtoensis Nobuchi, and Xylosandruscompactus (Eichhoff). Two new combinations, Euwallacea praevius (Blandford) comb. nov. and Dryocoeteslongipilus (Eggers) comb. nov. (both from Xyleborus), are given. The record of Euwallacea minutusis removed from the Korean fauna.
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Proceedings from the Ice Hockey Summit III: Action on Concussion
Aynsley M Smith(Aynsley M Smith ),Patrick A Alford(Patrick A Alford ),Mark Aubry(Mark Aubry ),Brian Benson(Brian Benson ),Amanda Black(Amanda Black ),Alison Brooks(Alison Brooks ),Charles Burke(Charle 사피엔시아 2019 Exercise Medicine Vol.3 No.-
Objectives: The Ice Hockey Summit III provided updated scientific evidence on concussions in hockey to inform these five objectives: (1) describe sport related concussion (SRC) epidemiology, (2) classify prevention strategies, (3) define objective, diagnostic tests, (4) identify treatment and (5) integrate science and clinical care into prioritized action plans and policy. Methods: Our action plan evolved from 40 scientific presentations. The 155 attendees (physicians, athletic trainers, physical therapists, nurses, neuropsychologists, scientists, engineers, coaches and officials) voted to prioritize these action items in the final Summit session. Results: (1) establish a national and international hockey data base for SRCs at all levels; (2) eliminate body checking in Bantam youth hockey games; (3) expand a behavior modification program (Fair Play) to all youth hockey levels; (4) enforce game ejection penalties for fighting in Junior A and professional hockey leagues; (5) establish objective tests to diagnose concussion at point of care (POC); and (6) mandate baseline testing to improve concussion diagnosis for all age groups. Conclusions: Expedient implementation of the Summit III prioritized action items is necessary to reduce the risk, severity and consequences of concussion in the sport of ice hockey.
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Colin M. Smith(Colin M. Smith ),Morgan Santalucia(Morgan Santalucia ),Hannah Bunn(Hannah Bunn ),Andrew Muzyk(Andrew Muzyk ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Acute agitation is common amongst individuals with bipolar disorder and schizophrenia and represents a medical emergency. Commonly used medications for agitation, such as benzodiazepines and antipsychotics, are often delivered intramuscularly and may cause adverse effects. Non-invasive, effective, and safe alternative treatment options are needed. The purpose of this review article is to describe the efficacy and safety of sublingual formulation of dexmedetomidine (Igalmi), a selective α2-adrenergic receptor agonist, U.S. Food and Drug Administration approved for the treatment of acute agitation in adults with schizophrenia or bipolar I and II disorder. In two phase 3 trials, two dose strengths of sublingual dexmedetomidine 180 μg and 120 μg were safe and effective in managing acute agitation in patients with bipolar disorder or schizophrenia. Both doses significantly reduced Positive and Negative Syndrome Scale-Exited Component scores two hours after receiving a single dose as compared to placebo, indicating a substantial improvement in agitation. The beneficial effects of sublingual dexmedetomidine were achieved without serious adverse events with the most common side effect being mild somnolence. The clinical trial data suggest that sublingual dexmedetomidine represents a safe and effective treatment option in the armamentarium for acute agitation for people with schizophrenia or bipolar disorder.
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ASSESSMENT OF CFD CODES USED IN NUCLEAR REACTOR SAFETY SIMULATIONS
Smith, Brian L. Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.4
Following a joint OECD/NEA-IAEA-sponsored meeting to define the current role and future perspectives of the application of Computational Fluid Dynamics (CFD) to nuclear reactor safety problems, three Writing Groups were created, under the auspices of the NEA working group WGAMA, to produce state-of-the-art reports on different aspects of the subject. The work of the second group, WG2, was to document the existing assessment databases for CFD simulation in the context of Nuclear Reactor Safety (NRS) analysis, to gain a measure of the degree of quality and trust in CFD as a numerical analysis tool, and to take initiatives to extend the existing databases. The group worked over the period of 2003-2007 and produced a final state-of-the-art report. The present paper summarises the material gathered during the study, illustrating the points with a few highlights. A total of 22 safety issues were identified for which the application of CFD was considered to potentially bring real benefits in terms of better understanding and increased safety. A list of the existing databases was drawn up and synthesised, both from the nuclear area and from other parallel, non-nuclear, industrial activities. The gaps in the technology base were also identified and discussed. In order to initiate new ways of bringing experimentalists and numerical analysts together, an international workshop -- CFD4NRS (the first in a series) -- was organised, a new blind benchmark activity was set up based on turbulent mixing in T-junctions, and a Wiki-type web portal was created to offer online access to the material put together by the group giving the reader the opportunity to update and extend the contents to keep the information source topical and dynamic.
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Smith, S. B.,Go, G. W.,Johnson, B. J.,Chung, K. Y.,Choi, S. H.,Sawyer, J. E.,Silvey, D.T.,Gilmore, L. A.,Ghahramany, G.,Kim, K. H. Oxford University Press 2012 Journal of animal science Vol.90 No.8
<P>We have demonstrated that among carcass adipose tissue depots, brisket subcutaneous adipose tissue contains the greatest concentration of MUFA and lowest concentration of SFA. Therefore, we hypothesized that brisket subcutaneous adipose tissue depots would exhibit greater adipogenic gene expression over time than other major subcutaneous adipose tissue depots. Four Angus steers, each at 9, 12, 14, and 16 mo of age, were harvested and fresh subcutaneous adipose tissue samples were collected from over the brisket, chuck, rib, loin, sirloin, round, flank, and plate. Relative gene expression for C/EBPβ, PPARγ, carnitine palmitoyltransferase-1 beta (CPT-1β), stearoyl-coenzyme A desaturase (SCD), AMP-activated protein kinase alpha (AMPKα), and G-coupled protein receptor 43 (GPR43) was analyzed by quantitative real-time PCR. Expression of C/EBPβ, PPARγ, and CPT-1β was greatest at 12 to 14 mo of age (all P < 0.0001) and declined to very low abundance by 16 mo of age in all depots. Expression of PPARγ and CPT-1β was greater (P < 0.03) in flank, rib, and sirloin subcutaneous adipose tissues than in brisket and round adipose tissues. The expression of the SCD gene did not differ among the 4 age groups (P = 0.95). The palmitoleic:stearic acid ratio (an estimate of SCD activity) was greater (P < 0.001) in the subcutaneous adipose tissues from brisket, plate, and round than in the loin, rib, and sirloin. Conversely, subcutaneous adipose tissue from the loin, rib, and sirloin had greater (P < 0.001) SCD gene expression than the brisket, plate, and round. In general, subcutaneous adipose tissues with the highest concentration of MUFA and least SFA consistently exhibited the least SCD gene expression and adipogenic gene expression. We conclude that MUFA in the brisket and other depots with large SCD indices were deposited before 9 mo of age, during a time when the subcutaneous adipocytes were highly differentiated.</P>
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Smith Alison A.,Bellows Charles F. 대한창상학회 2022 Journal of Wound Management and Research Vol.18 No.3
Background: Chronic wounds are a serious medical condition affecting over 6 million people in the United States. Biofilms, which alter the host immune response and establish a microenvironment that prevents wound healing, are intimately associated with the development of chronic wounds. Current treatment options do not specifically target the underlying molecular mechanisms of biofilm pathology. Paracrine factors secreted by mesenchymal stem cells (MSCs) have been demonstrated to play an important role in wound healing. The objective of this study was to examine the effects of the paracrine factors secreted from MSCs on reducing infection and accelerating wound closure in biofilm-infected wounds.Methods: MSCs were cultured by seeding on an extracellular matrix (ECM). The supernatant from MSCs containing paracrine factors were applied to mature <i>Pseudomonas aeruginosa</i> biofilms <i>in vitro</i> and the number of viable bacteria were quantitated. BALB/cJ mice were wounded and infected with <i>P. aeruginosa</i> biofilms and the paracrine factors from reprogrammed MSCs were applied topically. The wound surface area and colony forming units counts of the treatment group were compared to control (culture media) and biofilm (untreated) groups. Results: The paracrine factors from MSCs grown on ECM were found to reduce <i>P. aeruginosa</i> biofilm growth significantly (P<0.01). Wounds in the treatment group had lower bacterial counts and an increased rate of wound closure compared to non-treated mice wounds. Conclusion: The results indicate that paracrine factors from reprogrammed MSCs accelerated wound healing and reduced the bacterial burden in biofilm-infected wounds. Future studies are needed to further characterize this phenomenon.
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Catalyzing social media scholarship with open tools and data
Smith, Marc A. World Association for Triple Helix and Future Stra 2015 Journal of Contemporary Eastern Asia Vol.14 No.2
Social media comprises a vast and consequential landscape that has been poorly mapped and understood. Hundreds of millions of people have eagerly moved many of the conversations and discussions that compose civil society into these services and platforms. There is a need to document and analyze these social spaces for many academic and commercial purposes. The Social Media Research Foundation has engaged a strategy to cultivate better research into the structure and dynamics of social media. The foundation is dedicated to the creation of open tools, open data, and open scholarship related to social media. It has implemented a free and open network collection, analysis, and visualization tool called NodeXL to facilitate social media network research. Using NodeXL a group of researchers has collectively authored a publicly available archive, called the NodeXL Graph Gallery, composed of network data sets and visualizations from users around the world. This site has enabled the aggregation of tens of thousands of network datasets and images. Use of the archive has led to scholarly research results that are based on the wide range and scope of social media data sets available.
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