Epithelial-mesenchymal Transition and Its Role in the Pathogenesis of Colorectal Cancer

Zhu, Qing-Chao,Gao, Ren-Yuan,Wu, Wen,Qin, Huan-Long Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Epithelial-to-mesenchymal transition (EMT) is a collection of events that allows the conversion of adherent epithelial cells, tightly bound to each other within an organized tissue, into independent fibroblastic cells possessing migratory properties and the ability to invade the extracellular matrix. EMT contributes to the complex architecture of the embryo by permitting the progression of embryogenesis from a simple single-cell layer epithelium to a complex three-dimensional organism composed of both epithelial and mesenchymal cells. However, in most tissues EMT is a developmentally restricted process and fully differentiated epithelia typically maintain their epithelial phenotype. Recently, elements of EMT, specially the loss of epithelial markers and the gain of mesenchymal markers, have been observed in pathological states, including epithelial cancers. Increasing evidence has confirmed its presence in human colon during colorectal carcinogenesis. In general, chronic inflammation is considered to be one of the causes of many human cancers including colorectal cancer(CRC). Accordingly, epidemiologic and clinical studies indicate that patients affected by ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel disease, have an increased risk of developing CRC. A large body of evidence supports roles for the SMAD/STAT3 signaling pathway, the NF-kB pathway, the Ras-mitogenactivated protein kinase/Snail/Slug and microRNAs in the development of colorectal cancers via epithelial-tomesenchymal transition. Thus, EMT appears to be closely involved in the pathogenesis of colorectal cancer, and analysis refered to it can yield novel targets for therapy.

Comparative Phylogenetic Relationships and Genetic Structure of the Caterpillar Fungus Ophiocordyceps sinensis and Its Host Insects Inferred from Multiple Gene Sequences

Qing-Mei Quan,Qing-Xia Wang,Xue-Li Zhou,Shan Li,Xiao-Ling Yang,Yun-Guo Zhu,Zhou Cheng 한국미생물학회 2014 The journal of microbiology Vol.52 No.2

Ophiocordyceps sinensis (Ascomycota: Ophiocordycipitaceae)is a native fungal parasite of Hepialidae caterpillars and oneof the most economically important medicinal caterpillarfungi in China. However, little is known about the phylogeneticand evolutionary relationships between O. sinensis andits host insects. In this study, nuclear ITS and β-tubulin sequencesfrom O. sinensis and mitochondrial COI, COII, andCytb sequences from its hosts were analyzed across 33 populationssampled from five regions in China. Phylogenetically,both O. sinensis and its hosts were divided into three geographicallycorrelated clades, and their phylogenies were congruent. Analysis of molecular variance and calculated coefficientsof genetic differentiation revealed significant geneticdivergence among the clades within both O. sinensis (FST=0.878, NST=0.842) and its hosts (FST=0.861, NST=0.816). Estimatedgene flow was very low for O. sinensis (Nm=0.04) andthe host insects (Nm=0.04) among these three clades. Manteltests demonstrated a significant correlation (P<0.01) betweenthe genetic distances for O. sinensis and its hosts, as well as asignificant association (P<0.05) between geographic and geneticdistances in both. The similar phylogenetic relationships,geographic distributions, and genetic structure and differentiationbetween O. sinensis and its hosts imply that they have coevolved.

Optimal Soil Moisture Monitoring Design Based on Hierarchical Cluster and Temporal Stability Analyses

Qing Zhu,Kaihua Liao,Fei Xu 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Dynamic eigenvalue analysis of structures with interval parameters based on affine arithmetic

Zhu Zeng-qing,Chen Jian-jun 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.33 No.4

The Factors on Relation between Sharing Economy Characteristics and Consumer Traits

Qing Zhu LI,Jong Ho Lee 한국유통과학회 2017 한국유통과학회 학술대회 논문집 Vol.2017 No.-

The purpose of this study is to grasp the concept, characteristics and application status of sharing economy based on the existing research and to summarize the study on the characteristics of the sharing economic service and consumer characteristics. Second, this study attempts to derive a research model based on research on sharing economic service, consumer characteristics, satisfaction, reliability and reuse intention. Third, it analyzes the factors and influences of consumers intention to reuse of sharing economy. Fourth, Based on the results of this study, we suggest strategy of service activation for the sharing economy enterprises. The questionnarie was created to examine every relevant variables to practical and theoretical implications were discussed. Through the process, IBM SPSS Statistics 23.0 and IBM SPSS AMOS 23.0. were used. It is meaningful to identify the revenue mechanism of the business model of the sharing economic platform. In this study, we systematized the theoretical structure by examining existing studies on the characteristics of the sharing economic service and consumer characteristics, and by examining empirically. After then, satisfaction and reliability are related to the characteristics of Sharing Economic Service(Security, Conveniency, Discount, Sharing, Social Interaction), and Consumer Characteristics(Personal Innovation, Word-of-Mouth). The sharing economy business is significant in that it is a new consumption trend that changes the meaning of consumption to consumers.

Lessons from the Successful Case Studies on Sharing Economy

Qing Zhu Li,Jong Ho Lee 한국유통과학회 2016 KODISA ICBE (International Conference on Business Vol.2016 No.-

The concept of sharing economy(shared economy) is being interested in Korea especially. Of course all over the world, many related persons are interested in its concept, situation, successful cases and methods for its adjustment to real world. But they are depending on the situation according to each country's condition. So, at that point, it is necessary to look for or investigate them in detail. Similarly, in Korea, too. Therefore, the purposes of this study are as follows. First, to review and define the concept of sharing economy from both previously literature study and leaders. Second, to look for and classify its characteristics and types suitable for our status. After looking for them, to derive common points from them. Third, to analyze market status in detail and find out what is the problem to make better or what is good point fit for situation. Fourth, to investigate its successful contents from real cases in market. After making analyses about them, to arrange helpful lessons from them.

소비 리스크와 불완전자산시장하의 선물환 프리미엄

Qing-Lin Zhu,김시원 경성대학교 산업개발연구소 2012 산업혁신연구 Vol.28 No.4

본 연구에서는 우리나라 제조업에 속한 중소기업들을 대상으로 표준화 활동이 기술혁신활동에 미치는 영향을 실증적으로 분석하였다. 표준화 활동을 기업의 전사적 표준경영, 국내표준활동, 국제표준활동, 인증획득 등으로 구분하였으며, R&D집약도와 특허출원을 각각 기술혁신활동의 대용변수로 삼았다. 분석대상은 636개 중소제조기업으로, 정성적 분석방법인 로지스틱 회귀모형을 사용하였다. 분석결과 인증획득활동은 기술혁신활동변수를 R&D집약도로 놓았을 경우와 특허출원으로 놓았을 경우 공히 기술혁신에 정(+)의 영향을 미치는 것으로 나타났다. 전사적 표준경영과 국제표준활동은 기술혁신활동변수를 특허출원으로 놓았을 경우에만 각각 기술혁신에 정(+)의 영향을 미치는 것으로 나타났다. 그러나 KS(Korean Standards) 등 국내표준활동 요인은 R&D집약도와 특허출원에 대해서 모두 아무런 영향을 미치지 않는 것으로 분석되었다. 전반적으로 우리나라 제조업에 속한 중소기업들에 있어서 표준화 활동은 제품기획, R&D 등 기술혁신활동의 초기 단계에서는 어떠한 영향을 가지지 못하지만 특허출원 등 성과와 관련된 중기 이후 단계에서는 긍정적인 역할을 하는 것으로 볼 수 있다. 따라서 표준화 활동을 기술혁신의 전주기에 걸쳐서 연계시키는 정부와 기업의 노력이 요청된다고 하겠다.

The Influential Relations on Sharing Economy and Consumer Traits

Qing-Zhu LI,Jong-Ho Lee 한국유통과학회 2017 The Journal of Industrial Distribution & Business( Vol.8 No.6

Purpose - The purpose of this study is to grasp the concept, characteristics and application status of sharing economy, and to derive a research model based on sharing economic service, and to analyze factors and influences of consumers' intention to reuse of sharing economy. Research design, data, and methodology - The questionnaires were created to examine variables for practical and theoretical implications. After pilot survey, conducted for 24 days from March 10th to April 2st in 2017, total numbers were 377. But 330 copies were used for the analysis with IBM SPSS Statistics 23.0 and IBM SPSS AMOS 23.0. The structural equation model was applied for this. Results - First, sharing economic services remain at an early stage, but it is meaningful to identify the revenue mechanism of the business model of the sharing economic platform. Second, in this study, it is meaningful that we systematized the theoretical structure by examining existing studies on the characteristics of the sharing economic service and consumer characteristics, and by examining empirically. Third, Satisfaction and Reliability are related to the characteristics of Sharing Economic Service (Security, Convenience, Discount, Sharing, Social Interaction), Consumer Characteristics (Personal Innovation, Word-of-Mouth) It is meaningful to broaden the understanding of the factors by verifying the mediating effect. Fourth, the sharing economy business is meaningful in that it is a new consumption trend that changes the meaning of consumption to consumers. Gradually, more and more people are recalling that purchasing something is not consumption, but sharing and borrowing is also consumption. In other words, through the sharing economy, consumers can experience more products and services, have more choices, and are expected to have a positive impact on economic growth by increasing the utilization of idle resources. Conclusions - Currently, the sharing economy is growing rapidly all over the world. Therefore, in the subsequent study, it is necessary to compare Korea and China's sharing economy and study the cultural and social characteristics of Korea and China. In particular, I think that steady research is necessary for more precise and specific direction on the influence of the shared economy.

ON NIL-EXTENSIONS OF LEFT STRONGLY SIMPLE po-SEMIGROUPS

Zhu, Qing Shun Korean Mathematical Society 2011 대한수학회논문집 Vol.26 No.3

In this paper, we first introduce the concept of left strongly simple po-semigroups, then we discuss properties and characterizations nil-extensions of left strongly simple po-semigroups and semilattices of leftstrongly simple po-semigroups. Finally, we give some characterizations of the chain of left strongly simple po-semigroups.

Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa

Qing-Zhu Yang,Che Wang,Lei Lang,Yang Zhou,He Wang,De-Jing Shang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11

Recent advances in the search for novel anticanceragents have indicated that the positively chargedantimicrobial peptides have emerged as promising agentsoffering several advantages over the conventional anticancerdrugs. As a naturally occurring, cationic, a-helicalantimicrobial peptide, temproin-1CEa has been proved toexhibit a potent anticancer effect and a moderate hemolyticactivity. In order to reduce the hemolytic activity of temporin-1CEa and improve its anticancer potency towards arange of human breast cancer cells, in the present study, sixanalogs of temporin-1CEa were rationally designed andsynthesized. The amphipathicity levels and a-helicalstructural patterns of peptides were reserved, while theircationic property and hydrophobicity were changed. Theresults of MTT and hemolysis assay indicated that theanalog peptides displayed an improved anticancer activityand showed an overall optimized therapeutic index. Thehydrophobicity of peptides was positively correlated withtheir hemolytic and antitumor activities. Moreover, the datasuggest a strategy of increasing the cationicity whilemaintaining the moderate hydrophobicity of naturallyoccurring amphipathic a-helical peptides to generate analogswith improved cytotoxicity against tumor cells butdecreased activity against non-neoplastic cells such ashuman erythrocytes. This work highlights the potential forrational design and synthesis of improved antimicrobialpeptides that have the capability to be used therapeuticallyfor treatment of cancers.