The Effect of Electron-withdrawing Group Functionalization on Antibacterial and Catalytic Activity of Palladium(II) Complexes

Feng, Zhi-Qiang,Yang, Xiao-Li,Ye, Yuan-Feng,Hao, Lin-Yun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.4

The design, synthesis, and structural characterization of two new palladium complexes based on Schiff base ligands is reported; $[Pd(L1)_2]$ (1) and $[Pd(L2)_2]$ (2), [HL1 = 2-((E)-(2,6-diethylphenylimino)methyl)-4,6-dibromophenol, L2 = (E)-N-benzylidene-2,6-diethylbenzenamine], which are obtained by functionalizing Schiff base ligands with or without electron-withdrawing groups. Both compounds are mononuclear structures. Comparisons are made to the compounds 1 and 2 to analyze and understand the effect of electron-withdrawing groups. Antibacterial activity studies indicate the electron-withdrawing groups on Schiff base ligands enhance antibacterial activity. Catalytic activity, however, is reduced due to the enhanced steric-hindrance of the electron-withdrawing groups. Electronic absorption and emission properties of HL1, L2, 1 and 2 are also reported.

Numerical Study of Coherent Structures and Sound Radiation in a High Subsonic Jet

Feng Feng,Qiang Wang 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10

The noise radiated by subsonic turbulent jet with a Mach number of 0.9 is investigated by the high-order accuracy parallel compressible LES (Large Eddy Simulation) method, and the far field sound is solved and analyzed by the permeable FW-H (Ffowcs Williams-Hawkings) wave extrapolation method. The jet mean flow and turbulence statistics is verified carefully to ensure the fidelity and accuracy of the simulation. Applying the frequency domain permeable FW-H method educe the predominant sound mode of the jet flow, and it is found that the coherent structures or the instability waves at the potential core end region form the low wave number wave packets lead to the predominant sound modes radiation.

Topology Optimization Method of Lattice Structures Based on a Genetic Algorithm

Feng Ruo-qiang,Liu Feng-cheng,Xu Wei-jia,Liu Yang 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.3

A two-stage topology optimization method of lattice structures based on a genetic algorithm is proposed. The first stage is the form-finding analysis of lattice structures, and the optimal initial shape was achieved with the numerical inverse hanging method. The second stage is the topology optimization of single-layer lattice structures, which can be realized by changing the mesh size and the tube configurations to minimize the total weight of steel tubes subject to the design requirements. The mesh configuration optimization is realized through the adjustment of the nodal horizontal co-ordinates and the removal of tubes with lower stress. The maximum displacement of the structure, the maximum stress of the circular steel tubes, and the nonlinear buckling load are the state variables, and a genetic algorithm (GA) is the optimization algorithm. Different stress-limiting values used to delete the tubes were discussed. The numerical examples show that the two-stage topology optimization method for lattice structures proposed in this paper is correct and efficient. Furthermore, the forms of the optimized structure are rich, and the structure is lightweight and efficient.

Analytical Elasto-plastic Solution for Frost Force of Cold-Region Tunnels considering Anisotropic Frost Heave in the Surrounding Rock

Qiang Feng,Shenggang Fu,Chengxiang Wang,Weiwei Liu,Ying Wang,Weiguo Qiao 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.9

There is an increasing trend of tunnel infrastructure construction in cold regions due to the advance of a western development strategy. To reduce the frost damage sustained by a tunnel, it is important to consider the mechanical properties of frost heave in the surrounding rock by analyzing the anisotropic frost heave of a cold-region tunnel. This paper elaborates on the behavior of anisotropic frost heave in the rock surrounding a cold-region tunnel, and the coefficient of displacement relief is adopted to indirectly quantify the influence of the tunnel construction process. The analytical elasto-plastic solutions of the stress and deformation in the surrounding rock are derived with Drucker-Prager criteria (hereinafter referred to as the D-P criteria) by modifying the constitutive equation for the frozen surrounding rock. Finally, an example is given to obtain the influence law of the distribution of stress and deformation in the surrounding rock. The results indicate that the plastic radius and frost force calculated by considering isotropic frost heave are greater than those obtained by considering anisotropic frost heave. The influence of the related parameters also analyzed. Some useful insights are provided for future numerical simulations and the design and construction of cold-region tunnels.

Resequencing 295 accessions of heuristic and Korean breeding rice deciphers the milestones for breeding and domestication history of Korean rice

Qiang He,Byung-Kook Yun,Min-Young Yoon,Xiao-Qiang Wang,Feng-Peng Li,Aye-Aye Khaing,Won-Hee Ra,Win Htet Oo,Cheol-Soon Park,Sun-Kyung Min,Wei Tong,Jie Yu,Bu-Woong Choi,Eun-Beom Heo,Khandakar Md.Rayhanul 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

As one of the most important crop, rice is not only a staple food of half world’s population but a wonderful model plant, which has been leading the evolution and functional genomics study. The next-generation sequencing technology are expediting rice genomic study, by providing a simple but powerful way. In this study, we re-sequenced a core collection of 137 rice accessions from all over the world along with 158 Korean breeding varieties. Finally, 6.3G uniquely mapped reads were obtained, and about 10 million SNPs and ~1.2 million InDels were identified with average sequencing depth of 7.5X. These will help us to maximize our germplasm utilization and assists all the deep research in population dynamics and functional studies. Here, we’d like to show the approaches applied to resequencing data mining and on-going activities.

Research Articles : The Influence of Challenge on Cathepsin B and D Expression Patterns in the Silkworm Bombyx mori L

( Feng Yao Wu ),( Feng Ming Zou ),( Jun Qiang Jia ),( Sheng Peng Wang ),( Guo Zheng Zhang ),( Xi Jie Guo ),( Zhong Zheng Gui ) 한국잠사학회 2011 International Journal of Industrial Entomology Vol.23 No.1

Cathepsins are well-characterized proteases that are ubiquitously expressed in lysosomes. Previous work revealed that Bombyx mori cathepsins B and D are expressed in the fat body and undergo decomposition during larval-pupal metamorphosis. Quantitative RTPCR was performed to detect cathepsin gene expression at the transcription level when challenged by B. mori nuclear polyhedrosis virus (BmNPV), temperature and hormones (20-hydroxyecdysone (20E) and juvenile hormone analogue (JHA)). mRNAs encoding cathepsins B and D were significantly enhanced after the larvae were infected with BmNPV, and the peak of the induction appeared at 1 day before spinning. This attenuated the inducing effect on cathepsin expression caused by infection. Temperature shock induced cathepsin expression at the later stage of the 5th instar, and transcription levels varied with development stage and temperature. Cathepsin B and D mRNA expression in the fat body were significantly induced by JHA at the day before spinning, and with 20E, the expression reached a peak at the last day of the 5th instar. Cathepsin B and D mRNA expression exhibited detectable changes post-treatment, without significant differences between or among the hormone concentrations.

Hierarchical Colored Petri Nets Based Components for Workflow Systems

Feng Zhou,Rui-Feng Bo,Hong-Zhong Huang,Dan Ling,Qiang Miao 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.10

Workflow systems have benefited the enterprise and customer in many aspects. But with the increasing complexity of the system, workflow design becomes a complicated and time-consuming process. In this paper, we model the system based on the Hierarchical Colored Petri Nets (HCPN) to avoid the complexity of the system, and the super nets of the model are abstracted as independent components to increase the flexibility, acceptability and maintainability of the system. Another important characteristic of this model is its convenience for reuse and workflow mining. The development process of the overhead traveling crane was given to demonstrate the proposed method.

Prognostic Value of Subcarinal Lymph Node Metastasis in Patients with Esophageal Squamous Cell Carcinoma

Feng, Ji-Feng,Zhao, Qiang,Chen, Qi-Xun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Purpose: The 7th edition of the American Joint Committee on Cancer Staging Manual for esophageal cancer (EC) categorizes N stage according to the number of metastatic lymph nodes (LNs), irrespective of the site. The aim of this study was to determine the prognostic value of subcarinal LN metastasis in patients undergoing esophagectomy for esophageal squamous cell carcinoma (ESCC). Methods: A retrospective analysis of 507 consecutive patients with ESCC was conducted. Potential clinicopathological factors that could influence subcarinal LN metastasis were statistically analyzed. Univariate and multivariate analyses were also performed to evaluate the prognostic parameters for survival. Results: The frequency of subcarinal LN metastasis was 22.9% (116/507). Logistic regression analysis showed that tumor length (>3cm vs ${\leq}3cm$; P=0.027), tumor location (lower vs upper/middle; P=0.009), vessel involvement (Yes vs No; P=0.001) and depth of invasion (T3-4a vs T1-2; P=0.012) were associated with 2.085-, 1.810-, 2.535- and 2.201- fold increases, respectively, for risk of subcarinal LN metastasis. Multivariate analyses showed that differentiation (poor vs well/moderate; P=0.001), subcarinal LN metastasis (yes vs no; P=0.033), depth of invasion (T3-4a vs T1-2; P=0.014) and N staging (N1-3 vs N0; P=0.001) were independent prognostic factors. In addition, patients with subcarinal LN metastasis had a significantly lower 5-year cumulative survival rate than those without (26.7% vs 60.9%; P<0.001). Conclusions: Subcarinal LN metastasis is a predictive factor for long-term survival in patients with ESCC.

MicroRNA-130a Increases and Predicts Cardiotoxicity during Adjuvant Chemotherapy in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer

Qiang Feng,Yanbin Ren,Aijun Hou,Jing Guo,Zhezhe Mao,Shaojun Liu,Boya Wang,Zhichao Bai,Xiaoying Hou 한국유방암학회 2021 Journal of breast cancer Vol.24 No.2

Purpose: This study aimed to investigate the changes in microRNA-130a (miR-130a) and its correlation with cardiotoxicity during epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab (EC-D+T) adjuvant chemotherapy in human epidermal growth factor receptor-2-positive (HER2+ ) breast cancer patients. Methods: A total of 72 HER2+ breast cancer patients who underwent resection and were scheduled to receive EC-D+T adjuvant therapy were consecutively enrolled. The expression of miR-130a and cardiotoxicity (defined as any of the following situations: 1) absolute decline of left ventricular ejection fraction (LVEF) ≥ 10% and LVEF < 53%; 2) heart failure; 3) acute coronary artery syndromes; and 4) fatal arrhythmia) were assessed every 3 months throughout the 15-month EC-D+T treatment. Results: The accumulating cardiotoxicity rate was 12 (16.7%), of which the incidence of heart failure, acute coronary syndrome, life-threatening arrhythmias, ΔLVEF ≥ 10%, and LVEF < 53% was 0 (0.0%), 1 (1.4%), 0 (0.0%), and 12 (16.7%), respectively. Baseline miR-130a expression was negatively correlated with LVEF (%) and positively correlated with cardiac troponin I. The expression of miR-130a gradually increased in both cardiotoxicity and noncardiotoxicity patients during EC-D+T treatment, while the increment of miR-130a was more obvious in cardiotoxicity patients compared with non-cardiotoxicity patients. Further logistic regression and receiver operating characteristic curve analysis indicated that miR-130a was an independent predictive factor for increased cardiotoxicity risk. Conclusion: MiR-130a increases constantly and predicts high cardiotoxicity risk during ECD+T adjuvant chemotherapy in HER2+ breast cancer patients.

Analysis of Wind-Induced Vibration Response of High-Rise Structure of Heat Sink Tower Based on Large Eddy Simulation

Ruo-qiang Feng,Chang-jun Zhong,Jing He 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1

Taking the heat absorption tower of Dubai photothermal project as the research object, a three-dimensional fi nite element model of the high-rise structure of the heat absorption tower is established by using large eddy simulation technology and a new generation method of turbulent fl uctuating fl ow fi eld—Random Number Recycling Method. Then the rationality of random number cyclic pre simulation method is analyzed. On this basis, the turbulent boundary conditions of the fl ow fi eld around the heat absorption tower structure are simulated, the wind fl ow fi eld and wind load time history data around the structure are obtained, and the modal analysis and wind vibration response analysis are carried out. In addition, the eff ects of tower top wind speed, wind direction angle and damping ratio on wind-induced vibration response are explored, and the eff ects of cross wind vortex induced vibration and wind break ring on vortex induced vibration are analyzed. The results show that it is reasonable to use the random number cyclic pre simulation method as the inlet boundary condition of large eddy simulation. Secondly, the actual critical wind speed at the top of the tower for vortex induced resonance of the highrise structure of the heat absorption tower is 63 m/s, and the most unfavorable wind angle is 75°. In addition, for this kind of high-rise structure of heat absorption tower, the recommended value range of damping ratio is 0.15–1%. In addition, the setting of wind break ring makes the average decrease of structural displacement and internal force up to 39.3%, which eff ectively reduces the infl uence of cross wind vortex induced resonance.