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Burley와 황색종 잎담배들의 Toast과정 중 Pyrazine의 생성
명평근,김천석 충남대학교 약학대학 의약품개발연구소 1989 藥學論文集 Vol.5 No.-
The change of volatile flavoring components and the formation of pyrazine during toasting condition of Burley and Flue-cured tobacco leaves in the manufacturing process were analyzed by Gas Chromatograph. The results are as following: 1. After the toasting treatment of Burley 21 and Flue-cured tobacco leaves, the amounts of pyrazine and its derivatives, furfural and its derivatives, benzaldehyde, maltol, beta-Ionone and beta-Ionone epoxide were reduced, while the increasing components were hexanol, terpineol and neophytadiene. 2. The optimum condition of Burley 21 tobacco leaves on the toasting treatment was that the addition of sucrose was 4~7% and that of the formation of pyrazine was 125℃ for the treatment temperature and 5 minutes for the treatment time.
Basma 잎담배의 Vacuum Tobacco Conditioning (VTC)와 Compressed Tobacco Conditioning(CTC)처리에 따른 향기성분분석
명평근,김천석 충남대학교 약학대학 의약품개발연구소 1989 藥學論文集 Vol.5 No.-
Volatile flavors of Basma tobacco by Vacuum Tobacco Conditioning (VTC) and Compressed Tobacco Conditioning (CTC) treatments were analyzed by Gas Chromatogaphy. The Results obtained from this experiment are as following: 1. As Basma tobacco leaves were processed by VTC treatment, the amounts of volatile components of benzyl alcohol, phenyl acetaldehyde and dibutyl phthalate were reduced, while that of damascone was increased. 2. After CTC treatment the reduced volatile flavors of Basma tobacco leaves were benzyl alcohol, 7-undecane+Linalool, 2-phenylethyl alcohol, thymol, dibutyl phthalate, n-pentacosane and n-hexacosane, while the increasing components were furfural, phenyl acetate and n-eicosane. 3. In order to minimize the change of flavoring components of Basma tobacco leaves during the preconditioning, we should plan to improve the working method to minimize the heating and steam flow and to treat at the lower temperature and within short time.
배기환,김봉희,명평근,변재화 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-
The isolation and identification of an antibacterial component, from the leaves of Liriodendron tulipifera. K. Kotch against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for developing of anticariogenic agents. The bioactive component was elucidated as β-liriodenolide, which was isolated newly from the leaves of L.tulipifera. The minimal inhibitory concentration (MIC) of β-liriodenolide was 100 ㎍/㎖ and the antibacterial activity was stronger than that of berberine. β-Liriodenolide inhibited β-lactamase activity, 50. 100 and 200 μM β-liriodenolide did β-lactamase activity as 0.7, 3.5 and 19.7%, respectively. The toxicity of β-liriodenolide was not found with the method of photohemolysis.
Regulation of IL-18 expression by CRH in mouse microglial cells
Yang, Yoolhee,Hahm, Eunsil,Kim, Youngin,Kang, Jaeseung,Lee, Wangjae,Han, Innoc,Myung, Pyungkeun,Kang, Hyungsik,Park, Hyunjeong,Cho, Daeho 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
Corticotropin Releasing Hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.