Bilateral Acute Anterior Uveitis and Optic Disc Edema Following a Snake Bite

Praveen K Kumar,Shashi Ahuja,Praveen S Kumar 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2

The authors wish to report a case of bilateral acute anterior uveitis and optic disc edema following ahemotoxic snake bite, in order to highlight the concomitant occurrence of these conditions and the potentialadverse effects of anti-snake venom (ASV). A 35-year-old male was bitten by a viper at seventeen thirtyhours, and was started on ASV. Two days following treatment he experienced sudden onset redness andpainful diminution of vision in both eyes (OU). On examination, the patient’s visual acuity (VA) in OU was 20/ 200. Examination revealed fresh keratic precipitates, cells, and flare in the anterior chamber (AC), posteriorsynechiae, sluggish and ill-sustained pupillary reaction, and hyperemic, edematous disc with blurredmargins in OU. He was started on topical steroids, cycloplegics and intravenous methylprednisolone. Following treatment, the patient showed improvement and was continued on topical medications and oralprednisolone tapered over 3 weeks, after which VA OU improved, the AC showed no cells and flare anddisc edema resolved. Uveitis and optic disc edema in snake bite can either be due to the direct toxic effectsof the venom or the effect of ASV. Steroids have a beneficial role in the management of these symptoms.

Ocular Manifestations of Venomous Snake Bite over a One-year Period in a Tertiary Care Hospital

Praveen Kumar K V,Praveen Kumar S,Nirupama Kasturi,Shashi Ahuja 대한안과학회 2015 Korean Journal of Ophthalmology Vol.29 No.4

Purpose: Ocular manifestations in snake-bite injuries are quite rare. However, the unusual presentations, diagnosis and their management can pose challenges when they present to the ophthalmologist. Early detection of these treatable conditions can prevent visual loss in these patients who are systemically unstable and are unaware of their ocular condition. To address this, a study was conducted with the aim of identifying the various ocular manifestations of snake bite in a tertiary care center. Methods: This is a one-year institute-based prospective study report of 12 snake bite victims admitted to a tertiary hospital with ocular manifestations between June 2013 to June 2014, which provides data about the demographic characteristics, clinical profiles, ocular manifestations, and their outcomes. Results: Twelve cases of snake bite with ocular manifestations were included of which six were viper bites, three were cobra bites and three were unknown bites. Six patients presented with bilateral acute angle closure glaucoma (50%), two patients had anterior uveitis (16.6%) of which one patient had concomitant optic neuritis. One patient had exudative retinal detachment (8.3%), one patient had thrombocytopenia with subconjunctival hemorrhage (8.3%) and two patients had external ophthalmoplegia (16.6%). Conclusions: Bilateral angle closure glaucoma was the most common ocular manifestation followed by anterior uveitis and external ophthalmoplegia. Snake bite can result in significant ocular morbidity in a majority of patients but spontaneous recovery with anti-snake venom, steroids and conservative management results in good visual prognosis.

Pharmacokinetic evaluation of cefdinir-loaded floating alginate beads in rabbits using LC–MS/MS

Praveen R,Sandeep Kumar Singh,Priya Ranjan Prasad Verma 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.3

The present investigation aims to compare the pharmacokinetic parameters of Cefdinir in rabbits, from floating alginate (an anionic polysaccharide obtained from cell walls of brown algae) beads and conventional suspension, using a new LC–MS/MS method. Formulations equivalent to 20 mg/kg were administered orally to test and reference group and blood samples were collected at selected time intervals up to 24 h. Plasma concentrations of Cefdinir were determined using validated LC–MS/MS method and pharmacokinetic parameters were derived by non-compartment model. Statistically significant (p\0.05) increase in Cmax, Tmax, AUC0–? and MRT was observed in case of floating alginate beads, whereas KE and t1/2 remained relatively constant. MRT and tmax increased significantly as a result of controlled drug release. Relative bioavailability was 337.45 % for the floating beads. Thus, alginate based floating formulation improve the bioavailability (3.37 fold) of Cefdinir compared to suspension. The absorption of Cefdinir from floating beads was found mainly from duodenum (73.0 %) and Jejunum 1 and 2 (13.0 %).

Optimal Software Release Using Time and Cost Benefits via Fuzzy Multi-Criteria and Fault Tolerance

( Praveen Ranjan Srivastava ) 한국정보처리학회 2012 Journal of information processing systems Vol.8 No.1

As we know every software development process is pretty large and consists of different modules, This raises the idea of prioritizing different software modules so that important modules can be tested by preference, In the software testing process, it is not possible to test each and every module regressively, which is due to time and cost constraints. To deal with these constraints, this paper proposes an approach that is based on the fuzzy multi-criteria approach for prioritizing several software modules and calculates optimal time and cost for software testing by using fuzzy logic and the fault tolerance approach.

Potential use of waste rubber shreds in drainage layer of landfills - An experimental study

Praveen, V.,Sunil, B.M. Techno-Press 2016 Advances in environmental research Vol.5 No.3

Laboratory tests were conducted to evaluate the performance of waste rubber shreds in leachate collection layer of engineered landfills. The study found that waste rubber shreds layer in combination with a gravel layer can be of potential use in landfill drainage system. To study the performance, conventional gravel along with waste rubber shreds were used in different combinations (with total layer thickness = 500 mm) as leachate collection media. For the laboratory study poly vinyl chloride (PVC) pipes were used. The size range of waste rubber shreds used were 25 mm to 75 mm in length and width = 10 to 20 mm. The gravel size used in the leachate collection media is 10 mm to 20 mm size. Performance study of 7 Test Cols. with different combinations of waste rubber shreds and gravel bed thickness were studied to find out the best combination. The study found that the Test Col.-3 having waste rubber shreds thickness = 200 mm and gravel layer thickness = 300 mm gave the best results in terms of percentage removal in various physicochemical parameters present in the leachate. Further to find the best size rubber shreds three more Test Cols - 8, 9 and 10 were constructed having the rubber shreds and gravel layer ratio same as that of Test Col.-3 but having rubber shreds width = 10 mm, 15 mm and 20 mm respectively. Based on the results obtained using Test Cols. 8, 9 and 10 the study found that smaller size rubber shreds gave bests results in terms of improvement in various leachate parameters.

Hepatoprotective activity of terpenoids and terpenoid fractions of Scoparia dulcis L

Praveen Thaggikuppe Krishnamurthy,Jitendra Bajaj,Abhishek Sharma,Sellappan Manimaran,Prashantha Kumar Bommenahalli Ravanappa,Vijayan Pottekad 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4

Scoparia dulcis L. is widely used in the traditional system of medicine for treating liver ailments. In the present study the terpenoids and terpenoid fractions isolated from 1:1:1 petroleum ether,diethyl ether and methanol (PDM) extract of Scoparia dulcis L. were tested for their in vitro 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Selected samples from the assay were further tested for their in vitro hepatoprotective activity against CCl4 induced hepatotoxicity in freshly isolated rat hepatocytes. In the in vitro antioxidant study, fractions 7, 11, 13, 14, and 15and PDM extract show the DPPH radical scavenging activity. The phytochemical screening of all these fractions show the presence of terpenoids. In the in vitro hepatoprotective study all these fractions and the PDM extract significantly prevent the CCl4 induced changes in the aspartate aspartate amino transferase, alanine amino transferase and alkaline phosphatase levels (p < 0.05). The above results are comparable with the standard, silymarin. The results of the study indicate that, the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity and this may be attributed to its free radical scavenging potential, which in turn may be attributed to the presence of terpenoids.

Revisiting Medical Entity Recognition through the Guidelines of the Aurora Initiative

Praveen Kumar,Sabah Mohammed,Arnold Kim,Jinan Fiaidhi 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.4

Clinical Document Processing is growing importance because of unstructured nature of clinical notes as well as limitation of crucial time of clinical professionals to analyses the unstructured clinical notes. Named entity recognition (NER) is a subtask of Clinical documentation processing which is important not only for text analysis but knowledge extraction. Although there are a number of clinical named entity recognition systems, they lack user flexibility and NER scalability. Clinical NER is a challenging work which required consistent research to improve clinical documentation. Accordingly, in this paper, keeping an eye on user’s flexibility, we combined the NER technique with DSL (Domain Specific Language) based user queries. This research focused to produce a prototype system which allows the user to input their queries about a clinical text in a syntax free language which will be reformulate into DSL format in background. The reformulated query then matches against the rules defined by using the DSL to get the matched rule-type. The DSL is created using Xtext framework specifically to create NER rules easily. Then NER is done as per the found NER rule-types. We used the lingpipe API to do the NER using unsupervised technique (dictionary based approach). Again considering user flexibility, research also focused on graphical visualization of the annotated recognized entities, flexibility to store the annotated document into database for later use as well as can conversion the recognized entities into CDA (Clinical Document Architecture) format for interoperability. This research is initiated and inspired by the Aurora research initiative which is an ongoing attempt lead by Dr. Arnold Kim to integrate the design of clinical documentation workflows from the physician perspective that starts with variety DSLs and ends with series of interpretations and analytics in the background

Ultra-high tensile strength nanocrystalline CoCrNi equi-atomic medium entropy alloy processed by high-pressure torsion

Praveen, S.,Bae, Jae Wung,Asghari-Rad, Peyman,Park, Jeong Min,Kim, Hyoung Seop Elsevier 2018 Materials science & engineering. properties, micro Vol.735 No.-

<P><B>Abstract</B></P> <P>A nanocrystalline CoCrNi alloy of ~50 nm grain size with the ultra-high ultimate tensile strength of ~2.2 GPa and fracture strain of ~9% was fabricated using high-pressure torsion. The presence of high density of nano-twins, stacking faults, dislocations, and nano-grains is attributed to the superior mechanical properties.</P>

Novel blend microspheres of cellulose triacetate and bee wax for the controlled release of nateglinide

Praveen B. Kajjari,Lata S. Manjeshwar,Tejraj M. Aminabhavi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.2

Blend microspheres of cellulose triacetate (CTA) and bee wax (BW) were prepared by oil-in-water (o/w)emulsion/solvent evaporation method for investigating the controlled release (CR) of nateglinide (NTG),an antidiabetic drug with a plasma half-life of 1.5 h. The novel carrier was analyzed for surfacemorphology, particle size, drug–polymer interactions, physical state of the encapsulated drug andmicromeritic properties. In vitro release experiments were performed in simulated gastric (pH 1.2) andintestinal pH (7.4) media that was affected by blend composition and initial drug loading. In vitro releasedata were analyzed by empirical equations to understand the release profile of NTG

Microcellular SiC foams containing in situ grown nanowires for electromagnetic interference shielding

Praveen Wilson,Sujith Vijayan,K. Prabhakaran 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

Microcellular SiC foams (MSiCFs) are produced by thermal setting of dispersions of silicon and NaClpowders in molten sucrose-glycerol solutions in a mould followed by carbonization, NaCl removal andreaction bonding at 1500 C. The acidic silica layer on silicon particle surface catalyses the setting of thepastes byOH condensation. The SiC nanowires grown in situ by a catalyst-free vapour–solid (VS)mechanism creates web-like architecture within the microcells (cell size2 to 22 mm) of the foams. TheMSiCFs with porosity in the range of 86.8–91.1 vol.% exhibit thermal conductivity and compressivestrength in the ranges of 0.334–0.758 W m 1 K 1 and 0.97–2.38 MPa, respectively. The MSiCFs showexcellent electromagnetic interference (EMI) shielding property in the X-band frequency regionenhanced by the in situ grown SiC nanowires within microcells. The EMI shielding effectiveness (45.6 dB)and specific shielding effectiveness (137 dB g-1 cm3) are the highest reported for SiC foams.