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Phuong Thien Thuong,WenYi Jin,JongPill Lee,RackSeon Seong,Young-Mi Lee,성연희,KyungSik Song,배기환 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.10
Twelve compounds were isolated from the MeOH extract of the leaf and stem of the Korean endemic plant Weigela subsessilis L. H. Bailey. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. These compounds were identified as three sterols, β-sitosterol acetate (2), β- sitosterol (3), daucosterol (11), eight triterpenoids, squalene (1), ursolic acid (4), ilekudinol A (5), corosolic acid (6), ilekudinol B (7), esculentic acid (8), pomolic acid (9), asiatic acid (10), and one iridoid glycoside, alboside I (12). This is the first report pertaining to the isolation of these compounds from Weigela subsessilis L. H. Bailey. In addition, three compounds 7, 9, and 12 were found to display a strong inhibitory effect on the production of IL-8 in the HT29 cells stimulated by TNF-α.
Thuong Phuong Thien,Jin WenYi,Lee JongPill,Seong RackSeon,Lee Young-Mi,Seong YeonHee,Song KyungSik,Bae KiHwan The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.10
Twelve compounds were isolated from the MeOH extract of the leaf and stem of the Korean endemic plant Weigela subsessilis L. H. Bailey. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. These compounds were identified as three sterols, ${\beta}$-sitosterol acetate (2), ${\beta}$-sitosterol (3), daucosterol (11), eight triterpenoids, squalene (1), ursolic acid (4), ilekudinol A (5), corosolic acid (6), ilekudinol B (7), esculentic acid (8), pomolic acid (9), asiatic acid (10), and one iridoid glycoside, alboside I (12). This is the first report pertaining to the isolation of these compounds from Weigela subsessilis L. H. Bailey. In addition, three compounds 7, 9, and 12 were found to display a strong inhibitory effect on the production of IL-8 in the HT29 cells stimulated by TNF-${\alpha}$.
Thuong, Phuong Thien,Hung, Tran Manh,Khoi, Nguyen Minh,Nhung, Hoang Thi My,Chinh, Nguyen Thi,Quy, Nguyen Thi,Jang, Tae Su,Na, MinKyun 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin $A_2$ and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with $IC_{50}$ value of $10.1{\mu}M$. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
Phuong Thien Thuong, Won Keun Oh 朝鮮大學校 2008 藥學硏究誌 Vol.29 No.1
Phytochemical study on a methanol-soluble extract of the leaves of persimmon (Diospyros kaki) resulted in the isolation of ursolic acid as a major constituent of this tea. This compound was examined for cytotoxic activities against three tumor cell lines L1210, K-562 and HL-60 by using MTT method. The result showed that ursolic acid inhibit growth of three tumor cell lines with IC50 values of 8.3, 10.0, and 12.8 µg/mL, respectively.
Thuong, Phuong Thien,Hung, Tran Manh,Ngoc, Tran Minh,Ha, Do Thi,Min, Byung Sun,Kwack, Seung Jun,Kang, Tae Suk,Choi, Jae Sue,Bae, KiHwan John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.1
<P>The aim of this work was to study the structure–activity relationships of the antioxidant activity of natural coumarins isolated from four Korean medicinal plants (1–17) and four purchased coumarins (18–21). The free radical scavenging and lipid peroxidation assays revealed that five phenolic coumarins, scopoletin (1), aesculetin (2), fraxetin (3), umbelliferone (18) and daphnetin (19), possessed considerable antioxidant activities. The coumarins having a catechol group, 2, 3 and 19, showed significant free radical scavenging activity and inhibitory effects on lipid peroxidation, indicating that the catechol group significantly contributed to the antioxidant activities of coumarins. In contrast, the sugar moiety markedly reduced the activities of coumarin glycosides. The results also demonstrate that the α-pyrone ring of coumarins significantly enhanced the capacity of inhibiting oxidative reactions of coumarins. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Phuong Thien Thuong,Tran Manh Hung,Nguyen Minh Khoi,Hoang Thi My Nhung,Nguyen Thi Chinh,Nguyen Thi Quy,장태수,나민균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Four lignans, meso-dihydroguaiaretic acid(DHGA), macelignan, fragransin A2 and nectandrin B,were isolated from the seeds of Myristica fragrans (Vietnamesenutmeg) and investigated for their cytotoxicactivity against eight cancer cell lines. Of these, DHGAexhibited potent cytotoxicity against H358 with IC50 valueof 10.1 lM. In addition, DHGA showed antitumor activityin allogeneic tumor-bearing mice model.
Anti-complementary Activity of Ursane-Type Triterpenoids from <i>Weigela subsessilis</i>
Thuong, Phuong Thien,Min, Byung-Sun,Jin, WenYi,Na, MinKyun,Lee, JongPill,Seong, RackSeon,Lee, Young-Mi,Song, KyungSik,Seong, YeonHee,Lee, Hyeong-Kyu,Bae, KiHwan,Kang, Sam Sik Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.4
<P>A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of <I>Weigela subsessilis</I>. The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1—2 and 4—8 exhibited anti-complement activity with IC<SUB>50</SUB> values of 152, 90, 130, 51, 56, 4, and 163 μ<SMALL>M</SMALL>, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.</P>
Dual Anti-oxidative Effects of Fraxetin Isolated from <i>Fraxinus rhinchophylla</i>
Thuong, Phuong Thien,Pokharel, Yuba Raj,Lee, Moo Yeol,Kim, Sang Kyum,Bae, KiHwan,Su, Nguyen Duy,Oh, Won Keun,Kang, Keon Wook Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.9
<P>Atherosclerosis is main cause of arteriosclerosis. The pivotal role of low-density lipoprotein (LDL) oxidation in atherogenesis suggests antioxidants may help prevent cardiovascular disease. <I>Fraxinus rhynchophylla</I> D<SMALL>ENCE</SMALL> (Oleaceae) is a traditional medicinal plant from East Asia. During the course of characterizing potential drug candidates from natural products, we isolated two major coumarins, esculetin and fraxetin and found that fraxetin has dual-antioxidative functions. Low concentrations (1—5 μ<SMALL>M</SMALL>) of fraxetin potently inhibited LDL oxidation induced by metal and free radicals. Moreover, treatment of vascular smooth muscle cells (VSMCs) with higher concentrations (above 30 μ<SMALL>M</SMALL>) of fraxetin significantly increased the protein level of heme oxygenase-1 (HO-1), a key enzyme that inhibits vascular proliferation and atherosclerosis. Subcellular fractionation and reporter gene analysis using an antioxidant response element (ARE) construct revealed that fraxetin increased the level of nuclear factor (NF)-E2-related factor 2 (Nrf2) and reporter activity, and these were associated with the induction of antioxidant enzymes, such as HO-1 and glutathione <I>S</I>-transferase-α. In conclusion, fraxetin has direct protective properties against LDL oxidation at lower concentrations, and higher concentrations of fraxetin induce antioxidant enzymes <I>via</I> Nrf2/ARE activation. These effects suggest potential anti-atherosclerosis effects of <I>Fraxinus rhynchophylla</I> D.</P>
Antioxidant Activities of Vietnamese Medicinal Plants
Phuong Thien Thuong,나민균,Nguyen Hai Dang,Tran Manh Hung,Pham Thanh Ky,Tran Van Thanh,Nguyen Hai Nam,Nguyen Duy Thuan,석대은,배기환 한국생약학회 2006 Natural Product Sciences Vol.12 No.1
hundred and twenty six Vietnamese traditional herbals belonging to 59 families were screened forof seven plants, including Euphorbia thymifolia (leaf), Gnetum montanum (stem), Heterosmilax erythrantha(root), Morus alba (leaf), Syzygium formosum (leaf), Jussiaea repens (aerial parts), and Camellia sinensis (leaf),exhibited significant antioxidant activities. All of these herbs showed remarkable free radical scavenging activitieswith IC50 values of 11.0, 14.5, 17.0, 13.6, 10.8, 7.7, and 8.5g/ml, respectively, and significant inhibitory effectsconcentration of 50g/ml.KeywordsVietnamese medicinal plants, antioxidant activity, free radical scavenging, lipid peroxidation