Optical Fiber Communications - Present and Future ( 광통신 - 현재와 장래 )

Paul S. Oh 한국통신학회 1985 한국통신학회 학술대회 및 강연회 Vol.1985 No.-

Kingdom View and Mission of WCC

Paul Seung-oh An 장로회신학대학교 세계선교연구원 2003 선교와 신학 Vol.12 No.-

Standardizations of Optical Fiber / Cables in Korea

Paul S. Oh 대한전자공학회 1987 TENCON 87 - Computers and Communications Technolog Vol.- No.-

Animal models for brain arteriovenous malformation

S. Paul Oh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Objective: Brain arteriovenous malformations (BAVMs) occur in about 10% of hereditary hemorrhagic telangiectasia (HHT) patients and can cause life-threating intracranial hemorrhage. Longitudinal studies that allow monitoring the birth and progression of BAVMs would be tremendous not only for understanding the natural history of BAVMs but also for developing preclinical models. Method: We used Tagln (SM22)-Cre:Alk1 <SUP>2f/2f</SUP> mice that were previously shown to develop BAVMs. GEFC (gradient echo with flow compensation) images were periodically acquired from the mutant and control mice starting at 1-2 months of age up to 14 months using Bruker 7T MR spectrometer. Tamoxifen inducible endothelial cell specific CreER (Scl -CreER) was used to determine critical stage of HHT gene deletion to cause BAVMs. Result: Brains of 55 Tagln -Cre (+);Alk1 <SUP>2f/2f</SUP> mutant mice studied with magnetic resonance angiography were categorized into three groups: no detectable vascular lesions (Group 1, 23 of 55, 42%); AV fistulas with no nidus (Group 2, 10 of 55, 18%); and nidal AVMs (Group 3, 22 of 55, 40%). AVMs had the angiographic hallmarks of early nidus opacification, a tangle of arteries and dilated draining veins, and rapid shunting of blood flow. Latex dye perfusion confirmed arteriovenous shunting in all AVMs and AV fistulas. Microhemorrhage was detected adjacent to AV fistulas and AVMs, as visualized by iron deposition, Prussian blue staining, and macrophage infiltration using CD68 immunostaining. Brain AVMs were largely stable over 12 months. Scl -CreER;Eng <SUP>2f/2f </SUP>mice develop BAVMs only when tamoxifen is treated before 2 weeks-old age, indicating a critical developmental timing for ALK1- or ENGdeficiency to cause BAVMs. Conclusion: This longitudinal study platform will be a great resource for studying risk factors for BAVM rupture and for evaluating potential drugs that may induce regression of BAVMs.

Long-term Statistical Analysis of the Simultaneity of Forbush Decrease Events at Middle Latitudes

Seongsuk Lee,Suyeon Oh,Yu Yi,Paul Evenson,Geonhwa Jee,Hwajin Choi 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.1

Forbush Decreases (FD) are transient, sudden reductions of cosmic ray (CR) intensity lasting a few days, to a week. Such events are observed globally using ground neutron monitors (NMs). Most studies of FD events indicate that an FD event is observed simultaneously at NM stations located all over the Earth. However, using statistical analysis, previous researchers verified that while FD events could occur simultaneously, in some cases, FD events could occur non-simultaneously. Previous studies confirmed the statistical reality of non-simultaneous FD events and the mechanism by which they occur, using data from high-latitude and middle-latitude NM stations. In this study, we used long-term data (1971-2006) from middle-latitude NM stations (Irkutsk, Climax, and Jungfraujoch) to enhance statistical reliability. According to the results from this analysis, the variation of cosmic ray intensity during the main phase, is larger (statistically significant) for simultaneous FD events, than for non-simultaneous ones. Moreover, the distribution of main-phase-onset time shows differences that are statistically significant. While the onset times for the simultaneous FDs are distributed evenly over 24- hour intervals (day and night), those of non-simultaneous FDs are mostly distributed over 12-hour intervals, in daytime. Thus, the existence of the two kinds of FD events, according to differences in their statistical properties, were verified based on data from middle-latitude NM stations.

Recovery of the mitochondrial COI barcode region in diverse Hexapoda through tRNA-based primers

Doo-Sang Park,Soo-Jung Suh,Hyun-Woo Oh,Paul D.N. Hebert 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10

DNA barcoding uses a 650 bp segment of the mitochondrial cytochrome c oxidase I (COI) gene as the basis for an identification system for members of the animal kingdom and some other groups of eukaryotes. PCR amplification of the barcode region is a key step in the analytical chain, but it sometimes fails because of a lack of homology between the standard primer sets and target DNA. Two forward PCR primers were developed following analysis of all known arthropod mitochondrial genome arrangements and sequence alignment of the tRNA-W gene which was usually located within 200 bp upstream of the COI gene. These two primers were combined with a standard reverse primer (LepR1) to produce a cocktail which generated a barcode amplicon from 125 of 141 species that included representatives of 121 different families of Hexapoda. High quality sequences were recovered from 79% of the species including groups, such as scale insects, that invariably fail to amplify with standard primers. The current results show that primers designed to bind to highly conserved gene regions upstream of COI will aid the amplification of this gene region in species where standard primers fail and provide valuable information to design a primer for problem groups.

Characteristics of greenhouse gas concentrations derived from ground-based FTS spectra at Anmyeondo, South Korea

Oh, Young-Suk,Kenea, S. Takele,Goo, Tae-Young,Chung, Kyu-Sun,Rhee, Jae-Sang,Ou, Mi-Lim,Byun, Young-Hwa,Wennberg, Paul O.,Kiel, Matthä,us,DiGangi, Joshua P.,Diskin, Glenn S.,Velazco, Voltaire A.,Gr Copernicus GmbH 2018 Atmospheric measurement techniques Vol.11 No.4

<P><p><strong>Abstract.</strong> Since the late 1990s, the meteorological observatory established in Anmyeondo (36.5382°<span class='thinspace'></span>N, 126.3311°<span class='thinspace'></span>E, and 30<span class='thinspace'></span>m above mean sea level) has been monitoring several greenhouse gases such as CO₂, CH₄, N₂O, CFCs, and SF₆ as a part of the Global Atmosphere Watch (GAW) Program. A high resolution ground-based (g-b) Fourier transform spectrometer (FTS) was installed at this observation site in 2013 and has been operated within the frame work of the Total Carbon Column Observing Network (TCCON) since August 2014. The solar spectra recorded by the g-b FTS cover the spectral range 3800 to 16<span class='thinspace'></span>000<span class='thinspace'></span>cm⁻¹ at a resolution of 0.02<span class='thinspace'></span>cm⁻¹. In this work, the GGG2014 version of the TCCON standard retrieval algorithm was used to retrieve total column average CO₂ and CH₄ dry mole fractions (XCO₂, XCH₄) and from the FTS spectra. Spectral bands of CO₂ (at 6220.0 and 6339.5<span class='thinspace'></span>cm⁻¹ center wavenumbers, CH₄ at 6002<span class='thinspace'></span>cm⁻¹ wavenumber, and O₂ near 7880<span class='thinspace'></span>cm⁻¹ ) were used to derive the XCO₂ and XCH₄. In this paper, we provide comparisons of XCO₂ and XCH₄ between the aircraft observations and g-b FTS over Anmyeondo station. A comparison of 13 coincident observations of XCO₂ between g-b FTS and OCO-2 (Orbiting Carbon Observatory) satellite measurements are also presented for the measurement period between February 2014 and November 2017. OCO-2 observations are highly correlated with the g-b FTS measurements (<i>r</i>² = 0.884) and exhibited a small positive bias (0.189<span class='thinspace'></span>ppm). Both data set capture seasonal variations of the target species with maximum and minimum values in spring and late summer, respectively. In the future, it is planned to further utilize the FTS measurements for the evaluation of satellite observations such as Greenhouse Gases Observing Satellite (GOSAT, GOSAT-2). This is the first report of the g-b FTS observations of XCO₂ species over the Anmyeondo station.</p> </P>

Angiogenesis inhibitor therapies for advanced renal cell carcinoma: Toxicity and treatment patterns in clinical practice from a global medical chart review

OH, WILLIAM K.,McDERMOTT, DAVID,PORTA, CAMILLO,LEVY, ANTONIN,ELAIDI, REZA,SCOTTE, FLORIAN,HAWKINS, ROBERT,CASTELLANO, DANIEL,BELLMUNT, JOAQUIM,RHA, SUN YOUNG,SUN, JONG-MU,NATHAN, PAUL,FEINBERG, BRUCE D.A. Spandidos 2014 International journal of oncology Vol.44 No.1

<P>The aim of this study was to assess the treatment patterns and safety of sunitinib, sorafenib and bevacizumab in real-world clinical settings in US, Europe and Asia. Medical records were abstracted at 18 community oncology clinics in the US and at 21 tertiary oncology centers in US, Europe and Asia for 883 patients ≥18 years who had histologically/cytologically confirmed diagnosis of advanced RCC and received sunitinib (n=631), sorafenib (n=207) or bevacizumab (n=45) as first-line treatment. No prior treatment was permitted. Data were collected on all adverse events (AEs) and treatment modifications, including discontinuation, interruption and dose reduction. Treatment duration was estimated using Kaplan-Meier analysis. Demographics were similar across treatment groups and regions. Median treatment duration ranged from 6.1 to 10.7 months, 5.1 to 8.5 months and 7.5 to 9.8 months for sunitinib, sorafenib and bevacizumab patients, respectively. Grade 3/4 AEs were experienced by 26.0, 28.0 and 15.6% of sunitinib, sorafenib and bevacizumab patients, respectively. Treatment discontinuations occurred in 62.4 (Asia) to 63.1% (US) sunitinib, 68.8 (Asia) to 90.0% (Europe) sorafenib, and 66.7 (Asia) to 81.8% (US) bevacizumab patients. Globally, treatment modifications due to AEs occurred in 55.1, 54.2 and 50.0% sunitinib, sorafenib and bevacizumab patients, respectively. This study in a large, global cohort of advanced RCC patients found that angiogenesis inhibitors are associated with high rates of AEs and treatment modifications. Findings suggest an unmet need for more tolerable agents for RCC treatment.</P>

Ozone sensitivity of tropical upper-troposphere and stratosphere temperature in the MetOffice Unified Model

Oh, Jiyoung,Son, Seok-Woo,Williams, Keith,Walters, David,Kim, Junsu,Willett, Martin,Earnshaw, Paul,Bushell, Andrew,Kim, Yoonjae,Kim, Joowan Wiley (John WileySons) 2018 Quarterly journal of the Royal Meteorological Soci Vol.144 No.715

Alteration in miRNA Expression Profiling with Response to Nonylphenol in Human Cell Lines

Paul, Saswati,Kim, Seung-Jun,Park, Hye-Won,Lee, Seung-Yong,An, Yu-Ri,Oh, Moon-Ju,Jung, Jin-Wook,Hwang, Seung-Yong The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.1

Exposures to environmental chemicals that mimic endogenous hormones are proposed for a number of adverse health effects, including infertility, abnormal prenatal and childhood development and above all cancers. In addition, recently miRNA (micro RNA) has been recognized to play an important role in various diseases and in cellular and molecular responses to toxicants. In this study, endocrine disrupting environmental toxicant, nonylphenol (NP) was treated to MCF-7 (Human breast cancer cell) and HepG2 (Human hepatocellular liver carcinoma) cell line at 3 hrs and 48 hrs time point and miRNA analysis using $mirVana^{TM}$ miRNA bioarray was performed and compared with total mRNA microarray data for the same cell line and treatment. Robust data quality was achieved through the use of dye-swap. Analysis of microarray data identifies a total of 20 and 11 miRNA expressions at 3 hrs and 48 hrs exposure to NP in MCF-7 cell line and a total of 14 and 47 miRNA expression at 3 hrs and 48 hrs exposure respectively to NP in HepG2 cell line. Expression profiling of the selected miRNA (let-7c, miR-16, miR-195, miR-200b, miR200c, miR-205, and miR-589) reveals changes in the expression of target genes related to metabolism, immune response, apoptosis, and cell differentiation. The present study can be informative and helpful to understand the role of miRNA in molecular mechanism of chemical toxicity and their influence on hormone dependent disease. Also this study may prove to be a valuable tool for screening potential estrogen mimicking pollutants in the environment.