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Jutty Parthiban1,Oscar L. Alves,Komal Prasad Chandrachari,Premanand Ramani,Mehmet Zileli 대한척추신경외과학회 2019 Neurospine Vol.16 No.3
Cervical spondylotic myelopathy (CSM) is a common cause of adult spinal cord dysfunction. Although the therapeutic options for moderate to severe CSM patients have been established well, the existing guidelines for therapeutic decisions in mild cases of CSM are unclear. We present a review of literature on conservative treatment and surgery for CSM and suggest general recommendations applicable in various clinical presentations and in different geographic locations across the globe, with due considerations to available resources and locally prevalent practices.
Novel hybrids of drug with bioactive heterocycles for enhancing biological activity
Parthiban Valentina,Kaliappan Ilango,Muthu K. Kathiravan 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.10
A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and synthesised 6a–j. The structural integrity was confirmed by analytical methods. The hybrid molecules were subjected to in vitro cytotoxic studies against four human cancer cell lines PA1, OAW-42, T47-D and MCF-7 by MTT assay method. The results indicate that the hybrid molecules bearing halogen on phenyl ring in 6th position of triazolo-thiadiazole exhibited significant cytotoxic activity. The test compounds were also screened for antifungal activity against two strains.
Parthiban, S.,Kim, S.,Tamilavan, V.,Lee, J.,Shin, I.,Yuvaraj, D.,Jung, Y.K.,Hyun, M.H.,Jeong, J.H.,Park, S.H. ELSEVIER 2017 Current Applied Physics Vol.17 No.10
<P>Solution-processed nickel oxide (s-NiOx) was synthesized for use as hole-transport layers (HTLs) in the fabrication of polymer solar cell (PSC) devices. The s-NiOx thin-films were deposited using spin-coating and post-annealed at 300 degrees C, 400 degrees C, or 500 degrees C. With increased annealing temperature, the nickel acetate precursor decomposes more fully and forms s-NiOx films that show larger crystalline grain sizes with lower root mean square surface roughness. Bulk heterojunction solar cells fabricated with the new random polymer RP(BDT-PDBT) and [6,6]-phenyl-C-70-butyric acid methyl ester (PC70BM) using s-NiOx as HTLs exhibit a 4.46% enhancement in power conversion efficiency and better stability compared to conventional PSCs using poly (3,4-ethylenedioxythiophene):poly(styrene sulfonate) as HTLs. We believe that the solution-processable and highly stable s-NiOx could be a potential alternative for functional interface materials in optoelectronic devices. (C) 2017 Elsevier B.V. All rights reserved.</P>
Role of dwell on compact deformation during tableting: an overview
Parthiban Anbalagan,Celine Valeria Liew,Paul Wan Sia Heng 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.3
Tablet compaction is an important unit operation in the pharmaceutical industry. Among the compaction parameters, dwell time is a key parameter that has been consistently been shown to impact the mechanical quality of tablets. Compacts experience a state of relatively constant strain during the dwell phase and this allows time dependent reactions such as viscoelastic flow to take place within the tablet microstructure. The importance of time dependent compact deformation during the dwell phase has been extensively researched over the years. The amount of plastic flow during the dwell phase has been quantified by researchers by calculating the amount of compaction force decay from stress relaxation curves and by determining certain deformation parameters from compaction force–time profiles during high speed tableting. Dwell time prolongation often led to significant enhancements in the mechanical strength of the tablets, due to a favorable timedependent shift in the elastic–plastic equilibrium in the compact. The influence of dwell phase on tablet properties is governed by the predominant deformation properties of constituents being compressed along with other coexisting compaction parameters such as strain rate during the consolidation phase of the compaction cycle. Research work on the impact of dwell time on tablet compaction in conjunction with formulation and process variables are useful as the findings that are representative of manufacturing conditions would be useful for understanding of the compaction process especially in high speed tableting. Press or tool designs may also be accentuated at increasing dwell time without compromising tablet production rate.
Parthiban Subramanian,Manoharan Melvin Joe,임우종,홍보희,Sherlyn C. Tipayno,Venkatakrishnan Sivaraj Saravanan,유재홍,정종배,Tahera Sultana,사동민 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.4
Cold-adapted bacteria survive in extremely cold temperature conditions and exhibit various mechanisms of adaptation to sustain their regular metabolic functions. These adaptations include several physiological and metabolic changes that assist growth in a myriad of ways. Successfully sensing of the drop in temperature in these bacteria is followed by responses which include changes in the outer cell membrane to changes in the central nucleoid of the cell. Their survival is facilitated through many ways such as synthesis of cryoprotectants,cold acclimation proteins, cold shock proteins, RNA degradosomes, Antifreeze proteins and ice nucleators. Agricultural productivity in cereals and legumes under low temperature is influenced by several cold adopted bacteria including Pseudomonas, Acinetobacter, Burkholderia, Exiguobacterium, Pantoea, Rahnella,Rhodococcus and Serratia. They use plant growth promotion mechanisms including production of IAA,HCN, and ACC deaminase, phosphate solublization and biocontrol against plant pathogens such as Alternaria, Fusarium, Sclerotium, Rhizoctonia and Pythium.
Parthiban Pazhamalai(파자말라이 파르티반),Karthikeyan Krishnamoorthy(케이 카티케 이얀),Sindhuja Manoharan(마노하란 신드후자),Sang-Jae Kim(김상재) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
Self-charging supercapacitor power cell (SCSPC) is one of the nascent areas of research for the surrogating to renewable energy resources. The prime obstacle in development SCSPC is the utilization of liquid electrolyte hinders the energy conversion efficiency which in turn creates a demand to explore and replace with new solid electrolytes for the SCSPCs. Herein, a new all solid state self-charging supercapacitor power cell (SCSPC) has been fabricated using Nafion as solid polyelectrolyte cum energy harvester and spray coated MoS2 quantum sheets (MoS2-QSs) as energy storage electrodes. The Nafion polyelectrolyte exhibits energy harvesting characteristics under mechanical deformation due to the change in ion concentration gradients between electrodes that leads to the generation of output voltage. The fabricated MoS2-Nafion-MoS2 SCSPC shows the self-charging characteristics upon various levels of compressive forces with a self-charging voltage of 243 mV. The self-charging mechanism of the fabricated MoS2-Nafion-MoS2 SCSPC is explained via piezo-ionic effect. These experimental findings have profound significance in the context of developing a potential all-in-one self-charging system.