Predictive Value of Somatosensory Evoked Potential Monitoring during Resection of Intraparenchymal and Intraventricular Tumors Using an Endoscopic Port

Parthasarathy Thirumala,Daniel Lai,Jonathan Engh,Miguel Habeych,Donald Crammond,Jeffrey Balzer 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.4

Background and Purpose Intraoperative neurophysiological monitoring (IONM) using upper and lower somatosensory evoked potentials (SSEPs) is an established technique used to predict and prevent neurologic injury during intracranial tumor resections. Endoscopic port surgery (EPS) is a minimally-invasive approach to deep intraparenchymal and intraventricular brain tumors. The authors intended to evaluate the predictive value of SSEP monitoring during resection of intracranial brain tumors using a parallel endoscopic technique. Methods A retrospective review was conducted of patients operated on from 2007-2010 utilizing IONM in whom endoscopic ports were used to remove either intraparenchymal or intraventricular tumors. Cases were eligible for review if an endoscopic port was used to resect an intracranial tumor and the electronic chart included all intraoperative monitoring data as well as pre- and post-operative neurologic exams. Results 139 EPS cases met criteria for inclusion. Eighty five patients (61%) had intraparenchymal and fifty four (39%) had intraventricular tumors or colloid cysts. SSEP changes were seen in eleven cases (7.9%), being irreversible in three (2.2%) and reversible in eight cases (5.8%). Seven patients (5.0%) with intraparenchymal tumors had SSEP changes which met our criterea for significant changes while there were four (2.9%) with intraventricular (p-value=0.25). Five patients suffered post operative deficits, two reversible and two irreversible SSEP changes. Only one case exhibited post operative hemiparesis with no SSEP changes. The positive predictive value of SSEP was 45.4% and the negative predictive value was 99.2%. Conclusions Based on the high negative and low positive predictive values, the utility of SSEP monitoring for cylindrical port resections may be limited. However, the use of SSEP monitoring can be helpful in reducing the impact of endoscopic port manipulation when the tumor is closer to the somatosensory pathway.

The Cooperative Movement and the Transformation of Rural Society in the Developing Economies

Parthasarathy, G. 한국협동조합학회 1983 韓國協同組合硏究 Vol.1 No.-

Perioperative Stroke, In-Hospital Mortality, and Postoperative Morbidity Following Transcatheter Aortic Valve Implantation: A Nationwide Study

Parthasarathy Thirumala,Felix D. Nguyen,Amol Mehta,John Schindler,Suresh Mulukutla,Vinodh Jeevanantham,Lawrence Wechsler,Thomas Gleason 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4

Background and Purpose Perioperative stroke is a significant complication of transcatheter aortic valve implantation (TAVI). This study aimed to quantify perioperative stroke as an independent risk factor for in-hospital mortality and postoperative morbidity in patients receiving TAVI. Methods A retrospective cohort study was conducted using the National Inpatient Sample. Patients undergoing TAVI during 2012 and 2013 were identified using diagnostic codes of International Classification of Diseases, ninth revision. Univariate and multivariate analyses were performed using patient demographics and comorbidities to identify predictors of mortality and morbidity, defined by a length of stay of >14 days and/or discharge to a place other than home. Results Data were obtained from 7,556 patients undergoing TAVI during 2012 and 2013. The incidence rates of mortality and morbidity were 4.57 and 71.12%, respectively. Perioperative stroke was an independent risk factor for mortality [odds ratio (OR)=3.182, 95% confidence interval (CI)=1.530–6.618, p=0.002], as were infection (OR=17.899, 95% CI=9.876–32.440, p< 0.001) and pericardial tamponade (OR=7.272, 95% CI=2.874–18.402, p<0.001). Stroke also predicted morbidity (OR=5.223, 95% CI=2.005–13.608, p=0.001), which was also associated with age, being female, being Asian, moderate and high Van Walraven scores (VWR), and infection. Conclusions In conclusion, perioperative stroke was found to be independently associated with in-hospital mortality and postoperative morbidity, as are age and high VWR. Our findings support the use of further preoperative, intraoperative, and postoperative management strategies during TAVI.

Slosh reduction due to air-trapping in a roof-top baffled prismatic tank – A numerical study

Parthasarathy Nanjundan,Hyunjong Kim,Yeon Won Lee 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12

Cooperation as an Academic Discipline

Parthasarathy, G. 한국협동조합학회 1984 韓國協同組合硏究 Vol.2 No.-

Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF

Arumugam, Parthasarathy,Song, Joon Myong Oxford University Press 2016 Integrative biology Vol.8 No.6

<P>Elevated expression of drug efflux pumps such as multidrug resistant protein-1 (MDR1/ABCB1) and multidrug resistance associated protein-1 (MRP1/ABCC1) in cancer stem cells (CSCs) among a bulky tumor cell population was attributed to drug resistance. For the first time, we have quantitatively evaluated the cytotoxic profile of camptothecin (CPT) against the CSC. In the present study, a Qdot based total internal reflection fluorescence (TIRF) detection system effectively interpreted that drug resistance to CPT was reduced in the CSC under ABCB1 inhibited conditions. This study revealed that quantitative finding of the EC50 value for apoptosis and necrosis in correlation with the ABC inhibitor and CSC population using TIRF could provide more details of the anti-cancer efficacy of chemotherapeutic agents.</P>

Determination of thermal decomposition kinetics of low grade coal employing thermogravimetric analysis

Prakash Parthasarathy,최항석,황재규,박훈채 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6

The decomposition kinetics of low grade coals was studied and compared with the kinetics of higher grade coals using thermogravimetric analysis. The effect of atmospheres (air, O2 and N2) on coal decomposition kinetics was also investigated. Experiments were carried out under non-isothermal conditions from room temperature to 950 oC at a heating rate of 10 oC/min. Three kinetic models--multiple linear regression equation, unreacted shrinking core and continuous reaction--were used to determine the kinetic parameters of coal decomposition. From the kinetic parameters determined through the multiple linear regression equation, coal type and the atmosphere had an effect on coal decomposition kinetics. Also, there was some variation in the kinetic parameters of coal decomposition determined by the chosen kinetic models. However, the model employing multiple linear regressions yielded consistent results with respect to theoretical background. Under air, the order of the secondary decomposition of coal samples was found to be 0.88, 1.33, 1.69 and 1.52 for samples A, B, C and D, respectively. The order of the secondary decomposition of coal samples when operated under O2 was 1.09, 1.45, 2.36 and 1.81 for samples A, B, C and D, respectively. Under N2, the order of the secondary decomposition of coal samples was 0.72, 0.79, 1.15 and 1.02 for samples A, B, C and D, respectively.

Effect of combined slow pyrolysis and steam gasification of sugarcane bagasse on hydrogen generation

Prakash Parthasarathy,Sheeba Narayanan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.11

The present work aims at improving the generation of H2 from sugarcane bagasse in steam gasification process by incorporating slow pyrolysis technique. As a bench scale study, slow pyrolysis of sugarcane bagasse is performed at various pyrolysis temperature (350, 400, 450, 500 and 550 oC) and feed particle size (90<DP<212, 212< Dp<355, 355<Dp<500, 500<Dp<850 μm) to determine effective conditions of char generation. In the combined process (slow pyrolysis of biomass followed by steam gasification of char), first slow pyrolysis is carried out at the effective conditions (pyrolysis temperature and particle size) of char generation (determined from bench scale study) and steam gasification is at varying gasification temperature (600, 650, 700, 750 and 800 oC) and steam to biomass (S/B) ratio (1, 2, 3, 4, 5 and 6) to determine the effective conditions of H2 generation. The effect of temperature and S/B on gas product composition and overall product gas volume was also investigated. At effective conditions (gasification temperature and S/B) of H2 generation, individual slow pyrolysis and steam gasification were also experimented to evaluate the performance of combined process. The effective condition of H2 generation in combined process was found to be 800 oC (gasification temperature) and 5 (S/B), respectively. The combined process produced 35.90% and 23.60% more gas volume (overall) than slow pyrolysis and steam gasification process, respectively. With respect to H2 composition, the combined process generated 72.37% more than slow pyrolysis and 17.91% more than steam gasification process.

Perceptions of team-based learning using the Team-Based Learning Student Assessment Instrument: an exploratory analysis amongst pharmacy and biomedical students in the United Kingdom

Prabha Parthasarathy,Bugewa Apampa,Andrea Manfrin 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-

PurposeThis study aimed to evaluate students’ perception of team-based learning (TBL) amongst a cohort exposed to this methodology for the first time at a university in the United Kingdom. MethodsBetween November and December 2018, 26 first-year Master of Pharmacy and 90 second-year Biomedical Science students of the School of Life Sciences, University of Sussex, United Kingdom were invited to participate and requested to complete a questionnaire that contained quantitative and qualitative questions. The quantitative component was based on the Team-Based Learning Student Assessment Instrument (TBL-SAI). It additionally contained questions about key student characteristics. ResultsThe response rate was 60% (70 of 116); of the participants, 74% (n=52) were females and 26% (n=18) males. The percentage of agreement in the TBL-SAI suggested a favourable response to TBL. The overall mean score for the TBL-SAI was 115.6 (standard deviation, 5.6; maximum score, 140), which was above the threshold of 102, thus suggesting a preference for TBL. Statistically significant differences were not found according to demographic characteristics. Students who predicted a final grade of ≥70% strongly agreed that TBL helped improve their grades. Some students highlighted issues with working in teams, and only 56% of students agreed that they could learn better in a team setting. ConclusionThis study shows that students exposed to TBL for the first time favoured several aspects of TBL. However, more focused strategies including team-building activities and expert facilitation skills could potentially tackle resistance to working in teams.

Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil

Sampath Parthasarathy,Shylesh Bhaskaran,Nalini Santanam,Meera Penumetcha 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4

Diet has profound effects on the development of atherosclerosis. Fatty acid composition, antioxidants, andother components such as lignans have major effects on the atherosclerotic process. Sesame oil has both mono- and polyun-saturated fatty acid constituents in equal proportions. In addition, it also has high levels of numerous antioxidants and induc-ers of peroxisome proliferator-activated receptor. The objective of this study was to determine the anti-atherosclerotic effectsof sesame oil. In this study, male low-density lipoprotein (LDL) receptor (LDLR) . /. mice were fed atherogenic diet oratherogenic diet reformulated with the same level of sesame oil (sesame oil diet). Plasma lipids and atherosclerotic lesionswere quantified after 3 months of feeding. Sesame oil-containing diet significantly reduced the atherosclerotic lesion forma-tion and plasma cholesterol, triglyceride, and LDL cholesterol levels in LDLR . /. mice. These findings suggest that sesameoil could inhibit atherosclerosis lesion formation effectively, perhaps because of the synergistic actions of fatty acid and non-saponifiable components.