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- 검색키워드
- 저자 : Suresh Mulukutla (검색결과 2 건)
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Terbinafine hydrochloride loaded nanoemulsion based gel for topical application
V. V. S. Narayana Reddy Karri,Suresh Kumar Raman,Gowthamarajan Kuppusamy,Shashank Mulukutla,Shanmugam Ramaswamy,Rajkumar Malayandi 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.1
The objective of the present study was todesign and develop topical nanoemulsion based TerbinafineHCl (TBH) gel to increase its permeability and efficacyusing rat as an animal model. Nanoemulsions wereprepared by two different techniques viz. high pressurehomogenization and high speed homogenization, the preparednanoemulsions were incorporated into carbomer gelto obtain nanoemulsion based gel, which designated asGel-P and Gel-S respectively. The developed gels wereevaluated for drug content, stability, spreadability, andin vitro permeation using pork skin. The in vivo antifungalefficacy of the developed gels was assessed in albino Wistarrats. The globule size obtained by high pressurehomogenization was less than 2 nm in radius (r.nm) andthat by high speed homogenization was less than 10 r.nm. In vitro permeation studies revealed that Gel-P(51.19 ± 0.81 %) had higher permeation when comparedto Gel-S (31.72 ± 1.12 %) and marketed cream(19.78 ± 1.01 %) which is essential to treat topical fungaldiseases. In vivo antifungal studies in Wistar rats infectedwith Trichophyton mentagrophytes revealed that topicalapplication of Gel-P and Gel-S cured the infection within3 days compared to 14 days for Marketed Cream (M.C). This study confirms that the nanoemulsion gels providedgreater permeation followed by cure rates of poorly solubleTBH in animal model and hence these systems could be thepreferred drug carriers for drugs intended for topical use toovercome the permeability and efficacy problems.
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Parthasarathy Thirumala,Felix D. Nguyen,Amol Mehta,John Schindler,Suresh Mulukutla,Vinodh Jeevanantham,Lawrence Wechsler,Thomas Gleason 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4
Background and Purpose Perioperative stroke is a significant complication of transcatheter aortic valve implantation (TAVI). This study aimed to quantify perioperative stroke as an independent risk factor for in-hospital mortality and postoperative morbidity in patients receiving TAVI. Methods A retrospective cohort study was conducted using the National Inpatient Sample. Patients undergoing TAVI during 2012 and 2013 were identified using diagnostic codes of International Classification of Diseases, ninth revision. Univariate and multivariate analyses were performed using patient demographics and comorbidities to identify predictors of mortality and morbidity, defined by a length of stay of >14 days and/or discharge to a place other than home. Results Data were obtained from 7,556 patients undergoing TAVI during 2012 and 2013. The incidence rates of mortality and morbidity were 4.57 and 71.12%, respectively. Perioperative stroke was an independent risk factor for mortality [odds ratio (OR)=3.182, 95% confidence interval (CI)=1.530–6.618, p=0.002], as were infection (OR=17.899, 95% CI=9.876–32.440, p< 0.001) and pericardial tamponade (OR=7.272, 95% CI=2.874–18.402, p<0.001). Stroke also predicted morbidity (OR=5.223, 95% CI=2.005–13.608, p=0.001), which was also associated with age, being female, being Asian, moderate and high Van Walraven scores (VWR), and infection. Conclusions In conclusion, perioperative stroke was found to be independently associated with in-hospital mortality and postoperative morbidity, as are age and high VWR. Our findings support the use of further preoperative, intraoperative, and postoperative management strategies during TAVI.
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