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박정훈,김휘준,이무형,허충림 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.1
Metastasis to the skin from the urinary bladder carcinoma are very rare and their incidence is 1 % to 2% of the cutaneous metastasis. A 78-year-old man developed cutaneous metastasis 2 years later after the diagnosis of carcinoma of the bladder had been made. He visited our department with skin colored, soft, tender, subcutaneous nodule on the lower abdomen which had been detected 5 days ago. Histologic examination of the skin lesion showed atypical cells having hyperchromatic and pleomorphic nuclei. Herein we report a case of cutaneous metastasis from carcinoma of the urinary bladder in a 78-year-old man. (Korean J Dermatol 2003:41(1) : 133∼134)
Le Fort I 골절단술을 이용한 진구성 상악골 골절의 치험 2예
이재휘,박형식,권준호 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1
This is a report of 2 cases on old maxilla fractures accompanied with sagittal palatal fracture and severe malocclusion. We treated them by using of classic Le Fort 1 osteotomy and modified Le Fort I osteotomy along the old fracture lines satisfactorily. The results obtained from treatment are as follows : 1. Careful examination and correct care on sagittal palatal fracture should be need during initial diagnosis and emergency care of maxilla fracture showed malocclusion. 2. Although early definite treatment of maxilla injuries is difficult due to major organ injuries associated with accident, the positive effort to induce normal occlusion is always necessary as soon as possible. 3. In the cases of malocclusion due to transverse discrepancy of maxillary dentition associated with injury as like as our cases, classic and modified Le Fort I osteotomy and rigid internal fixation were useful to correct occlusion, to ease operation and return normal functions early.
최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.
<i>In-Situ</i> Synchrotron X-Ray Scattering Study of Thin Film Growth by Atomic Layer Deposition
Park, Yong Jun,Lee, Dong Ryeol,Lee, Hyun Hwi,Lee, Han-Bo-Ram,Kim, Hyungjun,Park, Gye-Choon,Rhee, Shi-Woo,Baik, Sunggi American Scientific Publishers 2011 Journal of Nanoscience and Nanotechnology Vol.11 No.2
<P>We report an atomic layer deposition chamber for in-situ synchrotron X-ray scattering study of thin film growth. The chamber was designed for combined synchrotron X-ray reflectivity and two-dimensional grazing-incidence X-ray diffraction measurement to do a in-situ monitoring of ALD growth. We demonstrate ruthenium thermal ALD growth for the performance of the chamber. 10, 20, 30, 50, 70, 100, 150 and 250-cycled states are measured by X-ray scattering methods during ALD growth process. Growth rate is calculated from thickness values and the surface roughness of each state is estimated by X-ray reflectivity analysis. The crystal structure of initial growth state is observed by Grazing-incidence X-ray diffraction. These results indicate that in-situ X-ray scattering method is a promising analysis technique to investigate the initial physical morphology of ALD films.</P>
( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
Hydroquinone (HQ) occurs naturally in various plants and food, and is also manufactured for commercial use. Recently, it has been reported that HQ has potent antioxidant properties with radical scavenging activities. In this study, the neuroprotective effect of HQ against ischemic damage following transient focal and global ischemia was examined using 2,3,5-triphenyltetrazoliumchloride (TTC) staining, NeuN immunohistochemistry and F-J B histofluorescence. Fig. It was proven that pre- and post-treatment with 100 mg/kg of HQ protects neurons from ischemic damage. In addition, we also investigated effects of HQ on gliosis and endogenous antioxidants in the hippocampal CA1 region after transient cerebral ischemia using immunohistochemistry. Pre- and post-treatment with 100 mg/kg of HQ notably inhibited the glial activation and maintained the expression of endogenous antioxidants in the gerbil ischemic CA1 region. Briefly, these results indicate that pre- and post-treatment with HQ can protect against ischemic damage induced by transient focal and global ischemia, and the neuroprotective effects of HQ may be closely associated with the attenuation of glial activation and the maintenance of the expression of endogenous antioxidants.
( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
5-hydroxytryptamine (5-HT, serotonin) plays protective or detrimental roles in the development of ischemic damage. In the present study, we investigated the time-course changes in 5-HT1A receptor protein expression in the gerbil hippocampal CA1 region after transient global cerebral ischemia via immunohistochemistry and western blot analysis. 5-HT1A receptor immunoreactivity in the stratum pyramidale (SP) of the hippocampal CA1 region was decreased from 6 h, and hardly observed at 1 day and 2 days after ischemic damage. At 5 days and 10 days after ischemia-reperfusion, 5-HT1A receptor immunoreactivity was increased and detected newly in astrocyte of the ischemic CA1 region. The pattern of changes in 5-HT1A receptor protein levels in the hippocampal CA1 region after ischemia-reperfusion was similar to that observed in the immunohistochemical data. These results indicate that 5-HT1A receptor protein expressions may be related with the ischemia-induced neuronal death and the function of astrocyte in the ischemic hippocampal CA1 region.
( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
Redd1 (known as RTP801/Dig2/DDIT4) is a stress-induced protein, and it is known to be regulated in response to some stresses including hypoxia and oxidative stress. In the present study, we investigated the time-course changes in Redd1 immunoreactivity and its protein levels in the gerbil hippocampus proper (CA1-3 regions) after 5 min of transient global cerebral ischemia using immunohistochemistry and western blot analysis. Redd1 immunoreactivity was apparently changed in the pyramidal neurons of the ischemic CA1 region, not the ischemic CA2/3 region. Redd1 immunoreactivity in the CA1 pyramidal neurons was significantly increased at 6 h post-ischemia, decreased until 1 day postischemia, increased again at 2 days post-ischemia and weakly observed at 5 days post-ischemia. Especially, at 5 days after ischemic damage, Redd1 immunoreactivity was newly expressed in astrocytes and GABAergic interneurons in the CA1 region. Redd1 protein levels in the ischemic CA1 region were changed like the pattern of the Redd1 immunoreactivity. These results indicate that Redd1 immunoreactivity and protein levels are increased in the ischemic CA1 region at early time after ischemic damage and that the increased Redd1 expression may be closely related to the delayed neuronal death of the CA1 pyramidal neurons following 5 min of transient global cerebral ischemia.
( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of tanshinone I (TsI) against ischemic damage and its neuroprotective mechanism in the gerbil hippocampal CA1 region (CA1) induced by 5 min of transient global cerebral ischemia. Pre-treatment with TsI protected pyramidale neurons from ischemic damage in the stratum pyramidale of the CA1 after ischemiareperfusion. The pre-treatment with TsI increased the immunoreactivities and protein levels of anti-inflammatory cytokines (interleukin (IL)-4 and IL- 13) in the TsI-treated-sham-operated-groups compared with those in the vehicle-treated-sham-operated-groups; however, the treatment did not increase the immunoreactivities and protein levels of pro-inflammatory cytokines (IL-2 and tumor necrosis factor (TNF)-α). On the other hand, in the TsI-treated-ischemia-operated-groups, the immunoreactivities and protein levels of all the cytokines were maintained in the stratum pyramidal of the CA1 after transient ischemia. In conclusion, these findings indicate that the pre-treatment with TsI can protect against ischemia-induced neuronal death in the CA1 via the increase or maintenance of inflammatory cytokines.
( Jun Hwi Cho ),( Chan Woo Park ),( Myoung Chul Shin ),( Taek Geun Ohk ),( Joon Ho Bae ),( Dae Jin Jeong ),( Jun Yeol Lee ),( Ka Eul Kim ),( Ki Joong Kim ),( Doo Hyun Lee ),( Jung Hoon Lee ),( Moo Ho 대한응급의학회 2014 대한응급의학회 학술대회초록집 Vol.2014 No.2
Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little study regarding the effects of HFD induced obesity in the septum of animal models of cerebral ischemia. Therefore, in the present study, we investigated effects of HFD on neuronal damage and gliosis in the septum induced by transient cerebral ischemia. Body weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. And, we also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry. The levels of blood glucose, serum triglyceride and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septo-hippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much severer compared with the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils. These results indicate that HFD can lead to much exacerbated effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion and that it may be associated with accelerated change in glial activation.
Park, Jun Yeon,Park, Do Hwi,Jeon, Youngsic,Kim, Young-Joo,Lee, Jaemin,Shin, Myoung-Sook,Kang, Ki Sung,Hwang, Gwi Seo,Kim, Hyun Young,Yamabe, Noriko Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.19
<P><B>Abstract</B></P> <P>Metastasis is responsible for the great majority of deaths in cancer patients. Matrix metalloproteinases (MMPs) have critical functions in cancer metastasis. Especially, MMP-2 and MMP-9 play a major role in tumor-cell migration and invasion. Therefore, to first find out the inhibitory effect of eupatilin on expression of MMPs in SNU182 cells, we used quantitative real-rime PCR to measure MMP-2 and MMP-9 mRNA levels. Eupatilin suppressed transcription of MMP-2 in SNU182 cells more than did the corresponding controls. Also, eupatilin significantly blocked tube formation when treated with a concentration of 3.125 or 6.25 μg/mL on human umbilical vein vascular endothelial cells (HUVECs). Eupatilin induced significant anti-angiogenic potential associated with down-regulation of hypoxia-inducible factor 1-alpha (HIF-1α), vascular endothelial growth factor (VEGF), and phosphorylated Akt expression. Thus, tube-formation inhibition and MMP-2-mediated migration are likely to be important therapeutic targets of eupatilin in hepatocellular carcinoma metastasis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Eupatilin inhibits human hepatocellular metastasis. </LI> <LI> HIF-1α is important therapeutic targets of eupatilin. </LI> <LI> Eupatilin inhibits angiogenesis in HUVECs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>