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- 저자 : Padilla, Eleazar Lara (검색결과 70 건)
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Cristina Rodriguez-Padilla,Moises A. Franco-Molina,Edgar Mendoza-Gamboa,Leonardo Castillo-Le?,Reyes S. Tamez-Guerra,Cristina Rodriguez-Padilla 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.1
Lipopolysaccharides (LPS) released from Gram-negative bacteria after infection initiate an exagerated responsethat leads to a cascade of pathophysiological events termed sepsis. Monocytes or macrophages produce many of the media-tors found in septic patients. Targeting of these mediators, especially tumor necrosis factor (TNF)-. and nitric oxide (NO),has been pursued as a mean of reducing mortality in sepsis. Bovine dialyzable leukocyte extract (bDLE) is a dialysate of aheterogeneous mixture of low-molecular-weight substances released from disintegrated leukocytes of the blood or tissue lym-phoid. In this study, to determine whether bDLE modulates NO and pro-inflammatory cytokine production, murine peritonealmacrophages were treated with bDLE (0.05 or 0.5 U/mL) before LPS (20 mg/mL) stimulation, and also LPS-stimulated murineperitoneal macrophages were treated with bDLE (0.05 or 0.5 U/mL) at 0, 4, 8, 12, and 24 hours. The bDLE significantly de-creased NO production, and also decreased TNF-. and interleukin (IL)-6 but increased IL-10 production in LPS-stimulatedmurine peritoneal macrophages. Our results demonstrate that bDLE plays an important role in modulating TNF-., IL-6, andNO production through IL-10, and this may offer therapeutic potential in clinical endotoxic shock.
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EXERGY ANALYSIS OF THE PERFORMANCE OF A VARIABLE REFRIGERANT FLOW (VRF) AIR CONDITIONING SYSTEM
MIGUEL PADILLA 대한설비공학회 2011 International Journal Of Air-Conditioning and Refr Vol.19 No.1
Commercial multiple evaporators variable refrigerant flow (VRF) HVAC systems present many advantages such as being energy saving and the capability of adjusting refrigerant mass flow rate according to the change of high rises occurrence. This paper deals with an experimental control volume exergy analysis in a VRF air conditioning system. The experimental results show that the brunt of the total exergy destroyed in the whole system occurs in the outdoor unit, where the exergy destroyed in the condenser is more important. The values of coefficient of performance (COP) obtained for the tests increase as the system reaches operational conditions imposed in every indoor unit zone. The VRF system analyzed is highly sensitive to the action of the constant speed compressor. The use of an inverter compressor improves the system performance by adjusting the power consumption according to the cooling load in the evaporators.
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Neural Transdifferentiation: MAPTau Gene Expression in Breast Cancer Cells
Lara-Padilla, E,Miliar-Garcia, A,Gomez-Lopez, M,Romero-Morelos, P,Bazan-Mendez, CI,Alfaro-Rodriguez, A,Anaya-Ruiz, M,Callender, K,Carlos, A,Bandala, C Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: In tumor cells, aberrant differentiation programs have been described. Several neuronal proteins have been found associated with morphological neuronal-glial changes in breast cancer (BCa). These neuronal proteins have been related to mechanisms that are involved in carcinogenesis; however, this regulation is not well understood. Microtubule-associated protein-tau (MAP-Tau) has been describing in BCa but not its variants. This finding could partly explain the neuronal-glial morphology of BCa cells. Our aim was to determine mRNA expression of MAP-tau variants 2, 4 and 6 in breast cancer cell lines. Materials and Methods: Cultured cell lines MCF-10A, MDA-MB-231, SKBR3 and T47D were observed under phase-contrast microscopy for neural morphology and analyzed for gene expression of MAP-Tau transcript variants 2, 4 and 6 by real-time PCR. Results: Regarding morphology like neural/glial cells, T47D line shown more cells with these features than MDA-MB-231 and SKBR. In another hand, we found much greater mRNA expression of MAP-Tau transcript variants 2, and to a lesser extent 4 and 6, in T47D cells than the other lines. In conclusion, regulation of MAP-Tau could bring about changes in cytoskeleton, cell morphology and motility; these findings cast further light on neuronal transdifferentiation in BCa.
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Agrobacterium-Mediated Co-transformation of Multiple Genes in Metarhizium robertsii
( Israel Enrique Padilla-guerrero ),( Michael J. Bidochka ) 한국균학회 2017 Mycobiology Vol.45 No.2
Fungi of the Metarhizium genus are a very versatile model for understanding pathogenicity in insects and their symbiotic relationship with plants. To establish a co-transformation system for the transformation of multiple M. robertsii genes using Agrobacterium tumefaciens, we evaluated whether the antibiotic nourseothricin has the same marker selection efficiency as phosphinothricin using separate vectors. Subsequently, in the two vectors containing the nourseothricin and phosphinothricin resistance cassettes were inserted eGFP and mCherry expression cassettes, respectively. These new vectors were then introduced independently into A. tumefaciens and used to transform M. robertsii either in independent events or in one single cotransformation event using an equimolar mixture of A. tumefaciens cultures. The number of transformants obtained by cotransformation was similar to that obtained by the individual transformation events. This method provides an additional strategy for the simultaneous insertion of multiple genes into M. robertsii.
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EL ESTADO DEMOCRÁTICO DE CALIDAD EN AMÉRICA LATINA. UNA REVISIÓN CRÍTICA DEL ESTADO DEL ARTE.
Roy González Padilla. Institute of Iberoamerican Studies Pusan Universit 2012 International Journal of Latin American Studies Vol.2 No.-
Abstract. In spite of the outstanding way in which democracy has been studied under an approach that focus its attention to the analysis about the steps that lead to power, it doesn’t care about solving the disputes of the ownership of power, but gives a different meaning to politics not just by the celebration of elections but also involves its understanding and study under qualitative parameters, which have motivated the study of the confirmation of democracy under a new academic agenda recently known as «quality of democracy», that in spite of its pertinence, requires a theoretical revision that allow us be aware of the implications, challenges and perspectives which face the construction of a democratic and valuable state. Resumen. A pesar de que se ha privilegiado el estudio de la democracia bajo un enfoque que centra su atención en el análisis sobre las pautas de acceso al poder, esta no se ocupa solo de dirimir las disputas de titularidad del poder, sino que connota un orden que refiere al hacer de la política más allá de la celebración de elecciones e involucra su entendimiento y estudio bajo parámetros cualitativos, que han motivado el estudio del afianzamiento de la democracia bajo una nueva agenda académica conocida actualmente como «calidad de la democracia», que no obstante su pertinencia, requiere de una revisión teórica que permita advertir las implicaciones, retos y perspectivas que enfrenta la construcción de un Estado democrático de calidad.
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