Do platelet concentrates accelerate orthodontic tooth movement?: a systematic review

Sergio Herrero-Llorente,Angel-Orión Salgado-Peralvo,Jan G.J.H. Schols 대한치주과학회 2023 Journal of Periodontal & Implant Science Vol.53 No.1

Purpose: Surgical techniques in orthodontics have received widespread attention in recent years. Meanwhile, biomaterials with high molecular content have been introduced, such as platelet concentrates (PCs), which may accelerate orthodontic tooth movement (OTM) and reduce periodontal damage. The present systematic review aimed to answer the following PICO question: “In patients in whom orthodontic surgical techniques are performed (P), what is the effectiveness of using PCs over the surgical site (I) when compared to not placing PCs (C) to achieve faster tooth movement (O)?” Methods: A search was performed in 6 databases. The criteria employed were those described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses declaration. The present review included studies with a control group that provided information about the influence of PCs on the rate of OTM. Results: The electronic search identified 10 studies that met the established criteria. Conclusions: The included studies were very diverse, making it difficult to draw convincing conclusions. However, a tendency was observed for OTM to be accelerated when PCs were used as an adjuvant for canine distalization after premolar extraction when distalization was started in the same session. Likewise, studies seem to indicate an association between PC injection and the amount of canine retraction. However, it is not possible to affirm that the use of PCs in corticotomy shortens the overall treatment time, as this question has not been studied adequately.

Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice

Silva Janayne L.,Leocádio Paola C. L.,Reis Jonas M.,Campos Gianne P.,Capettini Luciano S. A.,Foureaux Giselle,Ferreira Anderson J.,Windmöller Cláudia C.,Santos Flávia A.,Oriá Reinaldo B.,Crespo-López 한국독성학회 2021 Toxicological Research Vol.37 No.3

Methylmercury (MeHg) intoxication is associated with hypertension, hypercholesterolemia, and atherosclerosis by mechanisms that are not yet fully understood. We investigated the effects of MeHg intoxication in atherosclerosis-prone (ApoE-KO) and resistant C57BL/6 mice. Mice were submitted to carotid stenosis surgery (to induce atherosclerosis faster) and received water or MeHg solution (20 mg/L) for 15 days. Tail plethysmography was performed before and after MeHg exposure. Food and MeHg solution intakes were monitored weekly. On the 15th day, mice were submitted to intravital fluorescence microscopy of mesenteric vasculature to observe in vivo leukocyte rolling and adhesion. Results showed that despite the high hair and liver Hg concentrations in the MeHg group, food and water (or MeHg solution) consumption and liver function marker levels were similar to those in controls. MeHg exposure increased total cholesterol, the atherogenic (non-HDL) fraction and systolic and diastolic blood pressure. MeHg exposure also induced inflammation, as seen by the increased rolling and adhered leukocytes in the mesenteric vasculature. Atherosclerosis lesions were more extensive in the aorta and carotid sites of MeHg-ApoE knockout mice. Surprisingly, MeHg exposure also induced atherosclerosis lesions in C57BL/6 mice, which are resistant to atherosclerosis formation. We concluded that MeHg intoxication might represent a risk for cardiovascular diseases since it accelerates atherogenesis by exacerbating several independent risk factors.

한국인 성인남성 사체에서 시행한 인중 구륜근 섬유들의 효소-조직화학적 분석

Orbicularis oris muscle,Enzyme histochemistry,Fresh cadaver,Muscle fiber type,Lip reconstruction 대한구순구개열학회 2009 대한구순구개열학회지 Vol.12 No.2

The orbicularis oris muscle (OOM) is a very important muscle that originate from the second branchial arch and is innervated by the facial nerve. The aim of this study was to elucidate distribution types of two muscle fibers that composing OOM by using enzyme‐ histochemical examinations and tried to make a basis for a clinical application. The fresh frozen tissues from the superior and inferior portions of the OOM were taken from post mortem 65‐year‐old Korean male adult. Total five different sagittal sections were used on the midline of the philtrum, the middle portion of lower lip, the mouth corner, and each midlateral side of upper and lower mouth. We used enzyme‐histochemical staining such as Periodic Acid‐Schiff (PAS), Succinic Dehydrogenase (SDHase), reduced Nicotinamide Adenine Dinucleotide‐Tetrazolium Reductase (NADH‐TR), Adenosine Triphosphatase (ATPase) in pH 9.4, 4.6 and 4.3, and Modified Gomori Trichrome. There were about 30.24 % type 1 muscle fiber and 65.40 % type 2 muscle fiber in the midline of the philtrum (p < 0.05). Enzyme‐histochemical staining is very useful and innovative method to elucidate characteristics of muscle fibers. We expect that chiloplasty and reconstruction of the lip portions for cleft lip patients, based on these results, are better to recovery function and aesthetic. However, we have some problems as an intramuscular variability and the inter‐individual variation etc. Therefore we have to make progress these studies continuously to overcome these problems.

Artificial Intelligence Based Machine Learning Models Predict Sperm Parameter Upgrading after Varicocele Repair: A Multi-Institutional Analysis

Ory Jesse,Tradewell Michael B.,Blankstein Udi,Lima Thiago F.,Nackeeran Sirpi,Gonzalez Daniel C.,Nwefo Elie,Moryousef Joseph,Madhusoodanan Vinayak,Lau Susan,Jarvi Keith,Ramasamy Ranjith 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.4

Purpose: Varicocele repair is recommended in the presence of a clinical varicocele together with at least one abnormal semen parameter, and male infertility. Unfortunately, up to 50% of men who meet criteria for repair will not see meaningful benefit in outcomes despite successful treatment. We developed an artificial intelligence (AI) model to predict which men with varicocele will benefit from treatment. Materials and Methods: We identified men with infertility, clinical varicocele, and at least one abnormal semen parameter from two large urology centers in North America (Miami and Toronto) between 2006 and 2020. We collected pre and postoperative clinical and hormonal data following treatment. Clinical upgrading was defined as an increase in sperm concentration that would allow a couple to access previously unavailable reproductive options. The tiers used for upgrading were: 1–5 million/mL (ICSI/IVF), 5–15 million/mL (IUI) and >15 million/mL (natural conception). Thus moving from ICSI/IVF to IUI, or from IUI to natural conception, would be considered an upgrade. AI models were trained and tested using R to predict which patients were likely to upgrade after surgery. The model sorted men into categories that defined how likely they were to upgrade after surgery (likely, equivocal, and unlikely). Results: Data from 240 men were included from both centers. A total of 45.6% of men experienced an upgrade in sperm concentration following surgery, 48.1% did not change, and 6.3% downgraded. The data from Miami were used to create a random forest model for predicting upgrade in sperm concentration. On external validation using Toronto data, the model accurately predicted upgrade in 87% of men deemed likely to improve, and in 49% and 36% of men who were equivocal and unlikely to improve, respectively. Overall, the personalized prediction for patients in the validation cohort was accurate (AUC 0.72). Conclusions: A machine learning model performed well in predicting clinically meaningful post-varicocelectomy sperm parameters using pre-operative hormonal, clinical, and semen analysis data. To our knowledge, this is the first prediction model to show the utility of hormonal data, as well as the first to use machine learning models to predict clinically meaningful upgrading. This model will be published online as a clinical calculator that can be used in the preoperative counseling of patients.

Trigonelline Ameliorates Oxidative Stress in Type 2 Diabetic Goto-Kakizaki Rats

Orie Yoshinari,Asako Takenake,Kiharu Igarashi 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.1

Previously, we showed that trigonelline (TRG) exerts antidiabetic effects in type 2 diabetic Goto-Kakizaki (GK) rats and also lowers blood and liver thiobarbituric acid reactive substances and urinary 8-hydroxydeoxyguanosine when compared with those levels in GK control rats without TRG. These results suggested that TRG also mitigates oxidative stress, which accelerates diabetes. In this study, the mechanisms of TRG prevention of oxidative stress were determined by measuring erythrocyte and liver antioxidant enzyme activities, and expressions of genes associated with reactive oxygen species production, and carbohydrate and lipid metabolisms by DNA microarray. Erythrocyte and liver glutathione peroxidase, and liver catalase activities in the GK rats fed with TRG were significantly lower than those of the GK control rats. TRG downregulated the gene expressions involved with NADPH oxidase and mitochondrial electron transfer system when compared with those of the GK control group. These results suggested that mitigation of diabetes by TRG is mediated by its ameliorating effects on oxidative stress.

A Diesel Generator Model with Fluctuating Engine Torque Including Magnetic Saturation for Transient Analysis using XTAP

Orie Sakamoto 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3

Diesel engine generators are widely used in the world, especially in remote site power systems as distributed generators. A weak distribution feeder with a small diesel engine may suffer from voltage and power fluctuations due to misfiring of the engine cylinder. In this study, new generator model with example engine torque was developed for the electromagnetic transient analysis program for power systems named XTAP. The configuration and verification results of the developed model are presented in the paper. The model is considered to be useful for analyses of small power systems with those diesel engines.

Нека питања творбе речи у славеносрпском језику

Ćorić, B. 한국슬라브어학회 2014 슬라브어연구 Vol.19 No.1

Den Postulaten der Artikel zur Beispielanalyse von Lehnübersetzungen folgend könnte man schlussfolgern, dass diese hauptsächlich durch Zusammensetzung (Komposition) entstanden sind. Analysiert man jedoch dieselben Beispiele anders, und zwar indem man die Präfigierung gesondert und unabhängig von der Komposition betrachtet und Motivaitonsbeziehungen zwischen den Grundkomponenten und Derivaten herzustellen versucht, zeigt sich die Dominanz der Affigierung.

Water-Soluble Undenatured Type II Collagen Ameliorates Collagen-Induced Arthritis in Mice

Orie Yoshinari,Yoshiaki Shiojima,Hiroyoshi Moriyama,Junichi Shinozaki,Takahisa Nakane,Kazuo Masuda,Manashi Bagchi 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.11

Earlier studies have reported the efficacy of type II collagen (C II) in treating rheumatoid arthritis (RA). However, a few studies have investigated the ability of the antigenic collagen to induce oral tolerance, which is defined as active nonresponse to an orally administered antigen. We hypothesized that water-soluble undenatured C II had a similar effect as C II in RA. The present study was designed to examine the oral administration of a novel, water-soluble, undenatured C II (commercially known as NEXT-II) on collagen-induced arthritis (CIA) in mice. In addition, the underlying mechanism of NEXT-II was also identified. After a booster dose (collagen-Freund’s complete adjuvant), mice were assigned to control CIA group, or NEXT-II treatment group, to which saline and NEXT-II were administered, respectively. The arthritis index in the NEXT-II group was significantly lower compared with the CIA group. Serum IL-6 levels in the NEXT-II group were significantly lower compared with the CIA group, while serum IL-2 level was higher. Furthermore, oral administration of NEXT-II enhanced the proportion of CD4 + CD25 + T (Treg) cells, and gene expressions of stimulated dendritic cells induced markers for regulatory T cells such as forkhead box p3 (Foxp3), transforming growth factor (TGF)-b1, and CD25. These results demonstrated that orally administered water-soluble undenatured C II (NEXT-II) is highly efficacious in the suppression of CIA by inducing CD4 + CD25 + Treg cells.

자궁외임신의 진단 및 치료시 새로운 선택 : Summary of Special Communication

Ory, Steven J.,金石鉉 대한의학협회 1992 대한의학협회지 Vol.35 No.8

Прасловенско *godě ињегови српски континуанти

Božo Ćorić 한국슬라브어학회 2009 슬라브어연구 Vol.14 No.2

Прасловенско *godě изгубило је у српском језику током средњег вијека своје првобитно прилошко значење, али је на бази тог значења развило нова значења и функције. Функција раставног везника потврђена је у нашој најстаријој повељи и то редуплицирано и у комбинацији са речцом си (gody si...gody si...). То је једина потврда ове везничке формације. Једини траг ове старе ријечи у савременом српском језику сачуван је у рјечци год, која долази у поспозицији неких замјеница, прилога и везника. Ова рјечца има тада своју ненаглашену и наглашену верзију, а тако сложене формације различиту семантику. У правопису се ова прозодијска дистинкција огледа у састављеном и растављеном писању (нпр. когод и ко год). На дијалекатском плану има ова рјечца разноврсне форме. Не треба је доводити у вез са прилогом гдје (где): у питању се, генетски и семантички, двије различите ријечи. Protoslavic *godě, in Serbian language, has lost its primary adverbial meaning, but it developed new meanings and functions based on that (adverbial) meaning. The function of the adversative conjunction (reduplicated and in combination with the particle si – gody si… gody si…) is affirmed only in the Charter of Ban Kulin. The only trace of this old word in the contemporary Serbian is preserved in particle god, which is used in postposition of some pronouns, adverbs and conjunctions. At the dialectal level, this particle has different forms.