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Naoki Ohkura,Riyo Morimoto-Kamata,Katsutaka Oishi,Sayaka Higo-Yamamoto,Aya Fujinami,Ken-ichi Inoue,Mitsuhiro Ohta 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
Angelica keiskei Koidzumi (Ashitaba) is a traditional folk medicine and health supplement in Japan. Ashitabayellow stem exudate (AYE) contains abundant chalcones and thus has the potential to treat and prevent many pathologicalstates such as cancer, inflammation, obesity, diabetics, thrombosis, and hypertension. Levels of plasminogen activator inhibitor1 (PAI-1), a key regulator of the fibrinolytic system, increase with age in mouse plasma. Therefore, we aimed todetermine the effects of AYE on plasma thrombotic parameters in aging mice. Long-term (52 weeks) AYE supplementationsignificantly decreased age-induced increases of PAI-1 in mouse plasma. Supplementation with AYE decreased levels of theacute-phase and fibrinolytic protein plasma plasminogen, and significantly decreased those of tumor necrosis factor a. Theseresults suggested that continuous intake of AYE throughout life decreases age-induced systemic inflammation and preventsthrombotic tendencies without affecting body weight gain in aged mice. Our findings showed that supplementing diets withAYE might help to prevent thrombotic diseases in elderly individuals.
Systematic Study for “Kawaii” Products (Fifth Report)
Michiko Ohkura,Sayaka Goto,Tetsuro Aoto 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
In the 21st century, the Kansei values of industrial products are considered crucial. However, since not fewstudies have focused on the kawaii attributes, we focus on a systematic analysis of kawaii interfaces themselves. This paper describes the relation between kawaii colors and biological signals. Based on the experimental results, the mental condition when seeing kawaii colors is relatively similar to excited conditions.
Nohta, Hitoshi,Noma, Shunya,Ohkura, Yosuke,Yoo, Beong-Tae 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-
A highly sensitive method for the assay of catechol-O-methyltransferase in erythrocytes is described, which employs high-performance liquid chromatography with fluorescence detection. A newly synthesized catechol compound, 2-(3,4-dihydroxyphenyl)naptho[1,2-d]-thiazole is used as a highly fluorogenic substrate for catechol-O-methyltransferase; the m-and p-methylated products formed enzymatically from the substrate under the optimum conditions, after extraction with n-hexane-chloroform, are separated by normal-phase chromatography on LiChrosorb Si 100. The limits of detection for m-and p-methylated products are 3 pmol per assay tube (60 fmol per injection volume of 20 ㎕) in each case. The ratio of m-and p-methylated products was 0.54. This method requires as little as 50㎕ of human erythrocytes.
Factors Affecting Blood Loss During Thoracoscopic Esophagectomy for Esophageal Carcinoma
Masayuki Urabe,Yu Ohkura,Shusuke Haruta,Masaki Ueno,Harushi Udagawa 대한흉부외과학회 2021 Journal of Chest Surgery (J Chest Surg) Vol.54 No.6
Background: Major intraoperative hemorrhage reportedly predicts unfavorable survival outcomes following surgical resection for esophageal carcinoma (EC). However, the fac- tors predicting the amount of blood lost during thoracoscopic esophagectomy have yet to be sufficiently studied. We sought to identify risk factors for excessive blood loss during video-assisted thoracoscopic surgery (VATS) for EC. Methods: Using simple and multiple linear regression models, we performed retro- spective analyses of the associations between clinicopathological/surgical factors and estimated hemorrhagic volume in 168 consecutive patients who underwent VATS-type esophagectomy for EC. Results: The median blood loss amount was 225 mL (interquartile range, 126–380 mL). Abdominal laparotomy (p<0.001), thoracic duct resection (p=0.014), and division of the azygos arch (p<0.001) were significantly related to high volumes of blood loss. Body mass index and operative duration, as continuous variables, were also correlated positively with blood loss volume in simple linear regression. The multiple linear regression analysis identified prolonged operative duration (p<0.001), open laparotomy approach (p=0.003), azygos arch division (p=0.005), and high body mass index (p=0.014) as independent pre- dictors of higher hemorrhage amounts during VATS esophagectomy. Conclusion: As well as body mass index, operation-related factors such as operative du- ration, open laparotomy, and division of the azygos arch were independently predictive of estimated blood loss during VATS esophagectomy for EC. Laparoscopic abdominal pro- cedures and azygos arch preservation might be minimally invasive options that would potentially reduce intraoperative hemorrhage, although oncological radicality remains an important consideration.
Emotion Monitoring from Physiological Signals for Service Robots in the Living Space
Kanlaya Rattanyu,Michiko Ohkura,Makoto Mizukawa 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
To increase the amount of happiness in our daily life, we must recover ourselves from displeasing emotional states and try to keep to more pleasing emotions. The way for the user to avoid displeasing emotions depends on the category of the emotion, whether it be fear, anger, disgust or sadness. In this study, we focus on emotion recognition for service robots in the living space. An emotional state is important information that allows a robot system to provide appropriate services in way that are more in tune with users’ needs and preferences. Moreover, the users’ emotional state can be feedbacks to evaluate user’s level of satisfaction in the services. We apply a diagnosis method by using analyzed value of biological signals for the emotion recognition. Our system design is based on wireless and wearable physiological sensors for mobility and convenience of users’ daily lifestyle.
Evolving Adaptive Group Behavior in a Multi-Robot System
Saori Iwanaga,Kazuhiro Ohkura,Tomoya Matsuda 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
The field of multi-robot systems is sometimes called swarn robotics when the systems consist of many simple autonomous robots. However, each robot is usually assumed to have no learning mechanism for adapting to an embedded changing environment. Therefore, collective behavior is expected to emerge in the system only through interactions among the robots. This implies that they cannot be coordinating as a group. In this study, an evolutionary robotics approach is applied empirically to a multi-robot system to realize autonomous task allocation behavior as a kind of intelligent swarm robotics. Although artificial evolution has proven to be a promising approach to coordinate the controller of an autonomous robot, its effectiveness in developing beneficial collective behavior in a multi-robot system has not been verified. Serveral computer simulations are conducted to examine how artificial evolution contributes to autonomous task allocation in a multi-robot system.