Antinociceptive Effect of Glyasperin F Isolated from Glycyrrhiza inflata in Mice

Kim, Jin Kyu,Oh, Joa Sub,Lee, Jin-Koo The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6

Antinociceptive effect of glyasperin F isolated from Glycyrrhiza inflata extract (GIE) in ICR mice was studied. Oral administration of GIE (1-100 mg/kg) caused a dose-dependent reduction in acetic acid-induced writhing responses. To identify the active antinociceptive compound from the GIE, sub-fractions were obtained from the EtOAc layer of GIE by using a medium pressure liquid chromatography. From the sub-fractions obtained, the sub-fraction, which, when administered orally (10 mg/kg) showed an antinociceptive effect in both the writhing test and second phase of the formalin test was identified as glyasperin F using NMR and MS analyses. Finally, the antinociceptive effect of glyasperin F in mouse models of pain was confirmed. Orally administered glyasperin F (0.1-10mg/kg) showed a dose-dependent antinociceptive effect in both the writhing test and second phase of the formalin test. Taken together, glyasperin F isolated from the GIE may be used as a leading compound for further studies on pain and as a new drug derived from natural products for pain therapy.

신경망을 이용한 동적 제조공정의 탐지 및 인식

허정준,김광섭,구자항 대한설비관리학회 1997 대한설비관리학회지 Vol.2 No.2

This research is focused on developing a methodology for detecting the time of model change in the pocess and on designing a procedure for identifying the change based on neuro-modeling. The proposed detection procedure uses a fixed series of one-step prediction errors, which are obtained from a pre-determined neural network model. The model identification procedure is based on neuro-modeling. Kohonen's Self-Organizing Map (SOM) neural network and Radial Basis Function (RBF) neural network are used for modeling of a dynamic manufacturing process which is considered as a quasi-stationary time series. The proposed SOM and RBF neural networks attempt to decompose a picewise stationary series into a set of stationary segments and predict each sub-series thereby. Three different approaches are compared for model identification: the first approach is based on the feedforward network with the back-propagation error rule; the second one is based on the Bayesian discriminant function for minimizing the average probability of error; and the third one is based on the minimum distance measure for mininuzing the Euclidean distance between the input feature vector and feature vectors of the each sub-models. The proposed approaches are verified throught simulations. The performance of the proposed approaches are efficient and the suggested methods can readily employed for real manufacturing applications.

交感神經節遮斷劑에 의한 Norepinephrine, Angiotensin에 대한 家兎血壓反應의 變動

安龜燮 全南大醫大 1970 전남의대학술지 Vol.7 No.4

Ultrathin supercapacitor electrodes with high volumetric capacitance and stability using direct covalent-bonding between pseudocapacitive nanoparticles and conducting materials

Ko, Yongmin,Shin, Dongyeeb,Koo, Bonkee,Woo Lee, Seung,Yoon, Won-Sub,Cho, Jinhan Elsevier 2015 Nano energy Vol.12 No.-

<P><B>Abstract</B></P> <P>We introduce high-performance ultrathin supercapacitor electrodes obtained through the direct covalent-bonding layer-by-layer (LbL) assembly (or ligand-exchange LbL assembly) of amine-functionalized multiwalled carbon nanotubes (CNTs) and transition metal oxide nanoparticles (TMO NPs). The main characteristic of our approach is that the internal interfacial resistance of the electrodes can be minimized through the direct covalent-bonding adsorption of densely packed, high-quality TMO NPs onto CNTs without the aid of nonactive binders or insulating NP ligands, and the resulting volumetric capacitance and cycling stability of the electrodes can be significantly enhanced. For this study, well-defined oleic acid-stabilized pseudocapacitive metal oxide nanoparticles (i.e., OA–Fe<SUB>3</SUB>O<SUB>4</SUB> and OA–MnO NPs) prepared in toluene were densely adsorbed onto the CNT layer due to the high affinity between the surface of the TMO NPs and the NH<SUB>2</SUB> moieties of the CNTs. The (CNT/OA–Fe<SUB>3</SUB>O<SUB>4</SUB> NP)<SUB>20</SUB> multilayer electrode exhibited a high volumetric capacitance of 248±15Fcm<SUP>−3</SUP> (128±7Fg<SUP>−1</SUP>) at 5mVs<SUP>−1</SUP> despite the intrinsically low specific capacitance of the Fe<SUB>3</SUB>O<SUB>4</SUB> NPs. Additionally, these film electrodes exhibited high performance stability, maintaining 99.2% of their initial capacitance after 1000 cycles. Furthermore, upon the insertion of OA–MnO NPs with high crystallinity and a high theoretical pseudocapacitance value within multilayers instead of OA–Fe<SUB>3</SUB>O<SUB>4</SUB> NPs, the formed electrodes (i.e., (CNT/OA–MnO NP)<SUB>20</SUB> multilayers) exhibited a higher volumetric capacitance of 305±10Fcm<SUP>−3</SUP> (183±5Fg<SUP>−1</SUP>) (at a scan rate of 5mVs<SUP>−1</SUP>) than other conventional ultrathin supercapacitor electrodes, including manganese oxide or iron oxide NPs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Various well-defined NPs could be incorporated into carbon materials in organic media. </LI> <LI> Internal interfacial resistance of electrode was minimized by direct covalent bonding. </LI> <LI> Remarkable volumetric capacitance was achieved by high packing density of NPs. </LI> <LI> High operation stability of electrode was caused by covalent bonding. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Hybrid supercapacitor electrodes for electrochemical energy storage devices were prepared from covalent-bonding LbL-assembled (CNT/OA–Fe<SUB>3</SUB>O<SUB>4</SUB> or OA–MnO NP)<SUB>n</SUB> multilayers. The resulting (CNT/OA–Fe<SUB>3</SUB>O<SUB>4</SUB> NP)<SUB>n</SUB> and (CNT/OA–MnO NP)<SUB>n</SUB> electrodes exhibited the high volumetric capacitances of 248±15Fcm<SUP>−3</SUP> (128±7Fg<SUP>−1</SUP>) and 305±10Fcm<SUP>−3</SUP> (183±5Fg<SUP>−1</SUP>) at 5mVs<SUP>−1</SUP>, respectively and the excellent operation stability due to a facile electrolyte access, a dense adsorption of pseudocapacitive TMO NPs, and high surface area for fast electrochemical reactions.</P> <P>[DISPLAY OMISSION]</P>

Application example: Field Velocity Resistivity Probe (FVRP) for predicting pore pressure parameter B

Lee, Jong-Sub,Yoon, Hyung-Koo Elsevier 2018 Soil dynamics and earthquake engineering Vol.107 No.-

<P><B>Abstract</B></P> <P>Even though the pore pressure parameter B is essential to understand the soil condition, directly obtaining this value in a field test is difficult. The objective of this study is to propose a method for deducing B based on the elastic wave velocity measured in the field. In this study, the Field Velocity Resistivity Probe (FVRP), which has already been introduced in “Journal of Soil Dynamic and Earthquake Engineering”, is selected to demonstrate the extension of the application. The wave propagation theory is applied, and B is rewritten in terms of the bulk moduli of the skeleton (K<SUB>sk</SUB>), grain (K<SUB>g</SUB>), and mixture (K<SUB>mix</SUB>). This high-sensitivity parameter is ordered as K<SUB>mix</SUB>, K<SUB>g</SUB>, and K<SUB>sk</SUB>. The bulk moduli of the skeleton and grain are determined by referring to a previously performed study, and the bulk modulus of the mixture is calculated using the compressional and shear wave velocity. B is close to unity with the average B value being calculated to be 0.9867. Even though the site is completely saturated, the reason for the small B value is the characteristic of the soil, which is highly compacted and in a consolidated condition. This result demonstrates that it is possible to determine B in the field through the elastic wave velocity, and the applicability of FVRP is excellent.</P> <P><B>Highlights</B></P> <P> <UL> <LI> FVRP can measure the elastic wave velocity in the field. </LI> <LI> Reliability was verified in Soil Dynamic and Earthquake Engineering. </LI> <LI> The objective of this study is to extend application. </LI> <LI> The FVRP is excellent to deduce B value. </LI> </UL> </P>

소산 실험을 이용한 관입 장비의 교란 효과 추정

윤형구(Yoon Hyung-Koo),홍성진(Hong Sung-Jin),이우진(Lee Woojin),이종섭(Lee Jong-Sub) 대한토목학회 2008 대한토목학회논문집 C Vol.28 No.6

현장 관입 실험은 프로브 관입에 따라 주변 지반을 의도적으로 파괴시켜 지반특성을 파악할 수 있다. 본 논문의 목적은 현장 점토지반에 서로 다른 크기의 프로브 관입으로 인한 간극 수압 소산 특성을 이용하여 파괴에 따른 교란 효과를 분석 하는 것이다. 현장 실험을 수행하기 위해 콘관입 시험(CPT), 딜라토미터 시험(DMT) 그리고 현장 속도 프로브 장비(FVP: Field Velocity Probe)가 사용되었다. 샌드 매트(sand mat), PBD 그리고 사석을 이용한 지반 개량 중인 부산 북컨테이너 현장에서 실험이 진행 되었으며, 샌드 매트(sand mat)공법 이후 실내 실험을 수행하기 위해 시료가 채취 되었다, 실내에서는 물성치 실험 및 압밀 실험을 수행하여 지반 특성과 수평압밀계수 값을 도출하였다. 현장 실험은 지반 개량 후 압밀도 90% 시점에서 사석 제거 후 케이싱을 통해 CPT, DMT 그리고 FVP 순서대로 실험이 수행 되었다. 관업에 따른 영향 범위를 최소화시키기 위해 각각의 실험은 3m 간격을 유지 하였으며, 매 심도 24m에서 관업을 멈추고 시간에 따른 간극 수압 변화 양상을 측정하였다. 실내 압밀 실험을 통해 수평 압밀 계수(C<SUB>h</SUB>)를 산정하였으며, 현장 실험을 통해 각 프로브에 따른 t?? 값을 계산 하였다. t??값을 이용하여 산정된 등가 유효 반경은 FVP가 가장 작게 그리고 DMT가 가장 크게 산정되었다. The penetration of the probe produces the excess pore pressure due to the disturbance. The objective of this study is to evaluate the disturbance zone by using the dissipation of the excess pore water pressure, which was generated due to the penetration of the penetrometer with different size. The CPT, DMT and FVP (Field Velocity Probe) are adopted for in-situ tests. The tests are carried out in the construction site of north container pier of Busan new port, Korea where is accelerating the consolidation settlement using plastic board drains (PBD) and surcharges by crushed gravels. The coefficient of consolidation (C<SUB>h</SUB>) and soil properties are deduced by the laboratory test. The in-site tests are performed after the predrilling the surcharge zone at the point of 90% degree of consolidation. To minimize the penetration effect, the horizontal distance between penetration tests is 3m, the change of the pore pressure is monitored at the fixed depth of 24m. The coefficient of consolidation (C<SUB>h</SUB>) and the t??s are calculated based on the laboratory test and the in-situ data, respectively. The equvalent radi based on the t?? shows that the FVP and the DMT produce the smallest and the greatest equivalent radi, respectively.

Substance of North Korea's military threats and the security environment in Northeast Asia

Koo Sub Kim 한국국방연구원 2009 The Korean Journal of Defense Analysis Vol.21 No.3

Despite continued strains on its economy, North Korea has yet to relinquish its nuclear weapons program. Coupled with such unwavering determination and tangible actions in the form of nuclear and missile tests, the perception that North Korea is only a threat within the region of the Korean peninsula and its immediate vicinity is antiquated. In fact, given the possibilities of North Korea exporting its missile or nuclear weapons technology to states such as Syria and Iran, ignoring the implications of the security threat posed by Pyongyang as global in scope would be committing a dangerous fallacy. Without exaggerating the threat through ulterior motives far removed from pursuing peace and stability in the region, one needs to set concrete principles on which to base a coherent policy toward North Korea. This would mean correctly identifying the threat from North Korea's arsenals, as well as departing from a highly paternalistic view of the North that only seeks to make Seoul more vulnerable to the security threat. In particular, coordinated bilateral cooperation between the respective administrations of Presidents Lee Myung-bak and Barack Obama may act as an auspicious harbinger to the possible resolution of the North Korean security threat.

전단파 속도를 이용한 선행압밀하중 평가

이창호(Lee Changho),윤형구(Yoon Hyung-Koo),유정동(Yoo Jung-Dong),이충호(Lee Choong-Ho),이종섭(Lee Jong-Sub) 대한토목학회 2007 대한토목학회 학술대회 Vol.2007 No.10

Comparison of IOL powers by corrected method in eyes after PRK and LASIK

O Sub Koo,June Gone Kim,Byung Joo Song 대한안과학회 2002 Korean Journal of Ophthalmology Vol.16 No.1

The purpose of this study is to compare, by statistical analysis, intraocular lens (IOL) powers by SRK/T formula using autorefractokeratometer-measured keratometric (K) values (SRK/T-ARK-mK), by SRK/T formula using refraction-derived K values (SRK/T-R-dK), and by refraction corrected method (RCM), in eyes treated with photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) for myopia. Thirty-eight consecutive eyes of 23 patients with PRK for mild to moderate myopia and 35 consecutive eyes of 25 patients with LASIK for high myopia were followed up for more than 1 year. In the two groups, IOL powers by SRK/T-ARK-mK, by SRK/T-R-dK, and by RCM were compared by statistical analysis. In PRK group, the mean value of IOL powers by RCM was statistically higher than that obtained by the other two methods (p <; 0.05), while there was no significant statistical difference between the mean values of IOL powers by SRK/T-ARK-mK and by SRK/T-R-dK (p > 0.05). However, in LASIK group, the mean values of IOL powers by RCM and by SRK/T-R-dK, which did not differ statistically (p > 0.05), were both statistically higher than that by SRK/T-ARK-mK (p < 0.05). In conclusion, there is a statistical difference in IOL powers by the methods used for IOL calculation, as there is according to the level of myopia in patients with PRK and LASIK treatment. We suggest that, in IOL power calculation in eyes with previous corneal refractive surgery, correction methods such as RCM and SRK/T-R-dK are more effective at higher levels of myopia.

PRK 후 백내장 수술시 교정법에 사용된 인공수정체 도수 계산 공식에 따른 인공수정체 도수의 비교

구오섭 ( O Sub Koo ),조희준 ( Hee Jun Cho ),김중곤 ( June Gone Kim ),송병주 ( Byung Joo Song ) 대한안과학회 2002 대한안과학회지 Vol.43 No.10