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Zinc-containing tricalcium phosphate and related materialsfor promoting bone formation
Atsuo Ito,Makoto Otsuka,Haruo Kawamura,Masako Ikeuchi,Hajime Ohgushi,Yu Sogo,Noboru Ichinose 한국물리학회 2005 Current Applied Physics Vol.5 No.5
Calcium phosphate is a suitable carrier of zinc, an essential element that has stimulatory effects on bone formation in vitro and in vivo as well as an inhibitory effect on osteoclastic bone resorption in vitro. The highest zinc content is attained in b-tricalcium phosphate, where the zinc content reaches 6 wt%. Both rat and human bone marrow cells (BMCs) cultured on zinc-containing b-tricalcium phosphate and hydroxyapatite composite ceramics differentiated more than BMCs cultured on zinc-free composite ceramics in the presence of b-glycerophosphate and dexamethasone. The acceptable dose of zinc was higher for human BMCs than for rat BMCs. The solubility of ZnTCP, which contains a nontoxic level of zinc, decreased to 52–92% that of pure TCP in the pH range of 5.0–7.4. However, the resorbed volume of ZnTCP was much lower than that expected from the in vitro solubility of ZnTCP, becoming as low as 26–20% that of TCP, which indicates that the reduction in the resorbability of ZnTCP would be attributable principally to its lowered cellular activation property relative to that associated with pure TCP. Probably due to the lowered cellular activation property associated with ZnTCP, bone loss at the bone-implant interface was significantly arrested in the longterm implantation of ZnTCP/HAP. The intramuscular injection of ZnTCP powder is effective in increasing bone mineral density in the vicinity of the injected site in osteopenic animals. All these findings suggest that zinc-containing calcium phosphate is a biomaterial that promotes bone formation.
L<SUB>p</SUB>-Norm-Based All-Pass System Design with Improved Convergence and Robustness
Wei Qin,Noboru Ito 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
When the least-pth algorithm is used for designing all-pass digital systems in the minimax error sense, an appropriate large p must be used. However, a large p may lead to divergent solution, i.e., the least-pth algorithm may diverge. This paper describes how to select a large p for the minimax design and thus guarantee the convergence of the iterative least-pth design procedures. A design example is given to show the convergence improvement as well as the effectiveness of the proposed search scheme for selecting a large p.
Coprecipitation of cytochrome C with calcium phosphateon hydroxyapatite ceramic
Yu Sogo,Atsuo Ito,Koshiro Fukasawa,Nao Kondo,Yusuke Ishikawa,Noboru Ichinose,Atsushi Yamazaki 한국물리학회 2005 Current Applied Physics Vol.5 No.5
Cytochrome C (cyt C), which has a molecular weight and an isoelectric point similar to those of broblast growth factor(FGF-2), was coprecipitated with calcium phosphates in the presence or absence of a hydroxyapatite ceramic (HAP) using super-saturated calcium phosphate solutions that can be prepared by mixing infusion uids. The precipitates formed in the solutionconsisted of amorphous calcium phosphate in the absence of a HAP. In the presence of a HAP, precipitates morphologically iden-tical to bone-like apatite formed a calcium phosphate layer on the surface of HAP. The optimum conditions for coprecipitation ofcyt C with calcium phosphate on HAP were a Ca/P molar ratio of 1.5 and a NaHCO3 concentration of 7.90 mM. The release of cytis also expected to be coprecipitated with calcium phosphates onto HAPs using infusion fluids..
Arai Hikaru,Asami Koki,Ito Hajime,Katayama Noboru 한국물리학회 2022 Current Applied Physics Vol.39 No.-
Catalyst layers of proton exchange membrane fuel cells (PEMFC) are formed by electrospray deposition (ESD) method. The cathode catalyst layers are formed and characterized by varying the settings of the system, such as flow rate, applied voltage and the distance between the capillary and the substrate. The dryness of the aggregates during deposition is evaluated using the Damkh¨oler number (Da), and the structure of the catalyst layer is observed using SEM, which shows that the catalyst layer is porous when dry and non-porous when insufficiently dry. In the case of insufficient drying, the structure changed significantly depending on the position. Single cell tests show that the maximum power density varies from 105 to 253 mWcm-2 depending on the settings, even with the same catalyst ink and the same amount of platinum. Electrochemical impedance spectroscopy shows that the charge transfer and mass transport resistances tend to decrease with increase in Da.
Satomi Seki,Naoko Kato,Naomi Ito,Koichiro Kinugawa,Minoru Ono,Noboru Motomura,Atsushi Yao,Masafumi Watanabe,Yasushi Imai,Norihiko Takeda,Masashi Inoue,Masaru Hatano,Keiko Kazuma 한국간호과학회 2010 Asian Nursing Research Vol.4 No.2
Purpose The aim of this study was to evaluate the validity and reliability of the Seattle Angina Questionnaire, Japanese version (SAQ-J) as a disease-specific health outcome scale in patients with coronary artery disease. Methods Patients with coronary artery disease were recruited from a university hospital in Tokyo. The patients completed self-administered questionnaires, and medical information was obtained from the subjects’medical records. Face validity, concurrent validity evaluated using Short Form 36 (SF-36), known group differences, internal consistency, and test-retest reliability were statistically analyzed. Results A total of 354 patients gave informed consent, and 331 of them responded (93.5%). The concurrent validity was mostly supported by the pattern of association between SAQ-J and SF-36. The patients without chest symptoms showed significantly higher SAQ-J scores than did the patients with chest symptoms in 4 domains. Cronbach’s alpha ranged from .51 to .96, meaning that internal consistency was confirmed to a certain extent. The intraclass correlation coefficient of most domains was higher than the recommended value of 0.70. The weighted kappa ranged from .24 to .57, and it was greater than .4 for 14 of the 19 items. Conclusions The SAQ-J could be a valid and reliable disease-specific scale in some part for measuring health outcomes in patients with coronary artery disease, and requires cautious use. [Asian Nursing Research 2010;4(2):57–63]
Present Status of Endoscopic Submucosal Dissection for Non-Ampullary Duodenal Epithelial Tumors
Naomi Kakushima,Masao Yoshida,Yohei Yabuuchi,Noboru Kawata,Kohei Takizawa,Yoshihiro Kishida,Sayo Ito,Kenichiro Imai,Kinichi Hotta,Hirotoshi Ishiwatari,Hiroyuki Matsubayashi,Hiroyuki Ono 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.6
Prediction of histology by endoscopic examination is important in the clinical management of non-ampullary duodenal epithelial tumors (NADETs), including adenoma and adenocarcinoma. The use of a simple scoring system based on the findings of white-light endoscopy or magnified endoscopy with narrow-band imaging is useful to differentiate between Vienna category 3 (C3) and C4/5 lesions. Less invasive endoscopic resection procedures, such as cold snare polypectomy, are quick to perform and convenient for small (<10 mm) C3 lesions. Neoplasms with higher grade histology, such as C4/5 lesions, should be treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or surgery. Although EMR often requires piecemeal resection, the complication rate is acceptable. Excellent complete resection rates could be achieved by ESD; however, it remains a challenging method considering the high risk of complications. Shielding or closure of the ulcer after ESD is effective at decreasing the risk of delayed bleeding and perforation. Laparoscopic endoscopic cooperative surgery is an ideal treatment with a high rate of en bloc resection and a low rate of complications, although it is limited to high-volume centers. Patients with NADETs could benefit from a multidisciplinary approach to stratify the optimal treatment based on endoscopic diagnoses.
Natural History of Early Gastric Cancer: a Case Report and Literature Review
Tomohiro Iwai,Masao Yoshida,Hiroyuki Ono,Naomi Kakushima,Kohei Takizawa,Masaki Tanaka,Noboru Kawata,Sayo Ito,Kenichiro Imai,Kinichi Hotta,Hirotoshi Ishiwatari,Hiroyuki Matsubayashi 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1
Early detection and treatment decrease the mortality rate associated with gastric cancer (GC). However, the natural history of GC remains unclear. An 85-year-old woman was referred to our hospital for evaluation of a gastric tumor. Esophagogastroduodenoscopy identified a 6 mm, flat-elevated lesion at the lesser curvature of the antrum. A biopsy specimen showed a well-differentiated tubular adenocarcinoma.
Brylev, Konstantin A.,Mironov, Yuri V.,Fedorov, Vladimir E.,Kim, Sung-Jin,Pietzsch, Hans-Jü,rgen,Stephan, Holger,Ito, Akitaka,Kitamura, Noboru Elsevier 2010 Inorganica chimica acta Vol.363 No.11
<P><B>Graphical abstract</B></P><P>A new hexanuclear anionic rhenium cluster complex [Re<SUB>6</SUB>S<SUB>8</SUB>(CH<SUB>3</SUB>COO)<SUB>6</SUB>]<SUP>4–</SUP> have been synthesized and characterized by X-ray single-crystal diffraction analysis, IR, <SUP>1</SUP>H NMR, UV/vis, and luminescence spectroscopies. The complex is the first demonstration of any chalcogenide hexanuclear clusters coordinated with acetic acid anions.</P><ce:figure></ce:figure> <P><B>Abstract</B></P><P>A room-temperature reaction between [Re<SUB>6</SUB>S<SUB>8</SUB>(OH)<SUB>6</SUB>]<SUP>4−</SUP> and acetic acid in an aqueous solution resulted in the substitution of all terminal hydroxo groups by acetate ligands, affording a new hexanuclear anionic rhenium cluster complex [Re<SUB>6</SUB>S<SUB>8</SUB>(CH<SUB>3</SUB>COO)<SUB>6</SUB>]<SUP>4−</SUP>. The complex was isolated as a potassium salt with the composition of K<SUB>4</SUB>[Re<SUB>6</SUB>S<SUB>8</SUB>(CH<SUB>3</SUB>COO)<SUB>6</SUB>]·8H<SUB>2</SUB>O (<B>1</B>) and characterized by X-ray single-crystal diffraction and elemental analyses, IR, <SUP>1</SUP>H NMR, UV–Vis, and luminescence spectroscopies.</P>
Natural History of Early Gastric Cancer: a Case Report and Literature Review
Iwai, Tomohiro,Yoshida, Masao,Ono, Hiroyuki,Kakushima, Naomi,Takizawa, Kohei,Tanaka, Masaki,Kawata, Noboru,Ito, Sayo,Imai, Kenichiro,Hotta, Kinichi,Ishiwatari, Hirotoshi,Matsubayashi, Hiroyuki The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1
Early detection and treatment decrease the mortality rate associated with gastric cancer (GC). However, the natural history of GC remains unclear. An 85-year-old woman was referred to our hospital for evaluation of a gastric tumor. Esophagogastroduodenoscopy identified a 6 mm, flat-elevated lesion at the lesser curvature of the antrum. A biopsy specimen showed a well-differentiated tubular adenocarcinoma. The depth of the lesion was estimated to be intramucosal. Although the lesion met the indications for endoscopic resection, periodic endoscopic follow-up was performed due to the patient's advanced age and comorbidities. The mucosal GC invaded into the submucosa 3 years later, and finally progressed to advanced cancer 5 years after the initial examination. The patient died of tumor hemorrhage 6.4 years after the initial examination. In this case, mucosal GC progressed to advanced GC, eventually leading to the patient's death from GC. Early and appropriate treatment is required to prevent GC-related death.