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Dong-Cheol Kim,Tran Hong Quang,Nguyen Thuy Tien,Kwan-Woo Kim,Youn-Chul Kim,Nguyen Thi Thanh Ngan,Nguyen Xuan Cuong,Nguyen Hoai Nam,Hyuncheol Oh 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.2
Penicillium is a rich source of bioactive compounds. Among all Penicillium species, Penicillium oxalicumhas been reported to produce various types of secondarymetabolites, including alkaloids, phenolics, and tetrahydroxanthonedimeric compounds, exhibiting many pharmacologicaleff ects, such as antiviral, antibacterial, and cytotoxicactivities. Three secondary metabolites were isolated from afermented culture of the sponge-associated fungal strain P. oxalicum CLC-MF05: oxaline ( 1 ), isorhodoptilometrin ( 2 ),and 5-hydroxy-7-(2′-hydroxypropyl)-2-methyl-chromone( 3 ). Their chemical structures were identifi ed by 1D and2D NMR and high-resolution mass spectroscopic analysesand compared with previously reported data. All three compoundsinhibited NO and PGE 2 overproduction and iNOSand COX-2 overexpression in both LPS-stimulated BV2and rat primary microglia. These metabolites also repressed mRNA expression of TNF-α, IL-1β, IL-6, and IL-12. Further,mechanistic studies revealed that the inhibitory actionsof compounds 1–3 were regulated by the inactivation of theNF-κB and MAPK signaling pathways. Furthermore, inactivationof the TLR4/MyD88 pathway contributed to theanti-neuroinfl ammatory activity of these compounds. Theseresults suggest that compounds 1–3 represent potential antiinflammatory candidates for the treatment of neurodegenerativediseases; however, further investigation is needed.
Nguyen Kim Tien,Seong-Young Ko,Jong-Oh Park,Suk-Ho Park 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
This paper describes a terrestrial walking robot using poly-vinylidene fluoride (PVDF) / polyvinyl pyrrolidone (PVP) / polystyrene sulfuric acid (PSSA) blend membrane based ionic polymer metal composite (IPMC). The proposed IPMC actuator based on PVDF/PVP/PSSA polymer mixture of ratio 30/15/55 showed better performance than that of Nafionbased IPMC actuator at low DC voltages. A small scale IPMC was fabricated and employed in this study to sustain and drive the walking robot with sufficient force and displacement. Finally, a terrestrial walking robot (1.3g) with four IPMC legs was designed and fabricated and it showed the walking motion on the ground at speed 0.48 mm/s.
Kim Tien Nguyen,Gwangjun Go,Manh Cuong Hoang,Jincheol Ha,Joong-Oh Park,Chang-Sei Kim 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
This paper presents an optimized design and development of the electromagnetic actuation (EMA) system, which can generate a strong electromagnetic field to control micro/nanomagnetic objects. The EMA system consists of nine electromagnetic sources, so called Ennead Electromagnetic Actuation (EnEMA) system. The system configuration is designed based on our proposed optimization algorithm considering the design constraints given by the user, and the optimal configuration has the most isotropic and the strongest generated field among all available candidates considering the same design constraints. The EnEMA system can control the magnetic object in 5-DoFs without singularity, which is capable of multi-task control of the micro/nanomagnetic objects. The maximum achievable magnetic field and gradient field of the system are 174 mT and 5 T/m. A prototype of the system was constructed, and calibrated, which was then used to perform precise control of magnetic particle in three-dimensional space. The system is ready for in-vivo in small animal such as rats for targeted drug delivery.
Control of Active Suspension System by Using H$\infty$ Theory
Nguyen, Tan-Tien,Nguyen, Van-Giap,Kim, Sang-Bong Institute of Control 2000 Transaction on control, automation and systems eng Vol.2 No.1
This paper presents a control of active suspension for quarter car model with two degree of freedom by using H$\infty$ method. Absolute velocity of car body is measured for feedback. The system parameter variations are treated with multiplicative uncertainty model. Simulation results show that the H$\infty$ control provides good trade-off between ride quality, suspension packaging and road holding constraints. The experiment with a front wheel suspension system was done to verify the simulation results.
Kim Tien Nguyen,Manh Cuong Hoang,Eunpyo Choi,Byungjeon Kang,Jong-Oh Park,김창세 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.1
This paper presents a robotic capsule endoscope integrated a targeted drug delivery module (DDM) for digestive diseases treatments. The capsule with a big permanent magnet inside is wirelessly controlled and actively moves to target region in gastrointestinal tract by an electromagnetic actuation system (EMA). DDM is a separated body composed of a drug container and a non-power drug-releasing mechanism. The force to expel drug is generated by carbon dioxide gas pressure coming from a chemical reaction inside a propellant reservoir. Where the chemical reaction is activated by a mechanical mechanism that allows dry chemical powders contacting with water at the target point. A small permanent magnet is utilized to separate reagents and wet paper before drug injection. It is designed to be stable during locomotion by virtue of the attractive force of a big permanent magnet. To trigger releasing mechanism, gradient magnetic field from EMA system is created to push small magnet slide down, which allows reagents drop and contact with water in wet paper. The designed DDM has length of 11 mm and diameter of 11 mm. The proposed robotic capsule could show high potentials to be utilized for therapeutic treatment of digestive diseases in practical clinical sites through simulation and ex-vivo experiments.
Copper Tolerance of Novel Rhodotorula sp. Yeast Isolated from Gold Mining Ore in Gia Lai, Vietnam
Kim Cuc Thi Nguyen,Phuc Hung Truong,Cuong Tu Ho,Cong Tuan Le,Khoa Dang Tran,Tien Long Nguyen,Manh Tuan Nguyen,Phu Van Nguyen 한국균학회 2023 Mycobiology Vol.51 No.6
In this study, twenty-five yeast strains were isolated from soil samples collected in the goldmining ore in Gia Lai, Vietnam. Among them, one isolate named GL1T could highly tolerateCu2þ up to 10 mM, and the isolates could also grow in a wide range of pH (3–7), and temperature(10–40 �C). Dried biomass of GL1 was able to remove Cu2þ effectively up to 90.49%with a maximal biosorption capacity of 18.1 mg/g at pH 6, temperature 30 �C, and incubationtime 60 min. Sequence analysis of rDNA indicated this strain was closely related toRhodotorula mucilaginosa but with 1.53 and 3.46% nucleotide differences in the D1/D2domain of the 28S rRNA gene and the ITS1-5.8S rRNA gene-ITS2 region sequence, respectively. Based on phylogenetic tree analysis and the biochemical characteristics, the strainappears to be a novel Rhodotorula species, and the name Rhodotorula aurum sp. nov. is proposed. This study provides us with more information about heavy metal-tolerant yeasts andit may produce a new tool for environmental control and metal recovery operations.