Mechanistic insight of mitochondrial dysfunctions in cardiovascular diseases with potential biomarkers

Islam Md. Nazmul,Mishra Vineet Kumar,Munalisa Rina,Parveen Farzana,Ali Saieeda Fabia,Akter Khadiza,Ahmed Tanvir,Ho Tsung-Jung,Huang Chih-Yang 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.3

Background Acceleration of atherogenesis is an aftermath of cardiovascular diseases (CVDs), which arise with mitochondrial dysfunction (MD). Endothelium restraint inflammation, repair and fluidic exchange with nearby tissues. Endothelium-mediated mitochondrial damage can trigger the molecular mechanisms of vasodilation, pro-inflammation and process of pro-thrombotic accumulation in microvascular endothelial layer. The oxidation of lipid particles generates modified lipoproteins. Modification of mitochondrial function recently emerged a great concern towards the atherosclerosis initiation and progression, because the powerhouse of energy production mitochondria mutation can release mtDNA into cytoplasm and it can be act as sensor for viral DNA or foreign DNA. Another cause is mitochondrial imbalance can lead to product excess amount of reactive oxygen species (ROS) which can cause cellular metabolism and respiration system. Objectives In previous some studies showed that mitochondrial dysfunction plays a vital role in term of cardiac diseases. However, very few studies provide evidence of endothelium-mediated mitochondrial imbalance. This study investigated the potential involvement of mitochondrial impairment in cardiotoxicity using a series of mechanistic endpoints, including mitochondrial respiration and endothelial suppression of inflammation, mitochondrial DNA. Our study provides some molecular mechanisms regarding mitochondrial role in endothelium function. In each section, we are trying to introduce key concepts and then analysis previous studies revealed the importance of that molecular mechanism regarding mitochondrial dysfunction. Conclusions The ultimate goal of our review is to find out the novel drug discovery or new approaches of therapy. Our review will target different aspects of mitochondrial protein function and their effect of endothelial and cause of atherosclerosis diseases. To evaluate the healthy lifestyle and better condition of mitochondrial balance nowadays it is urgent to utilize the proper function for therapeutical effect for future direction. Background Acceleration of atherogenesis is an aftermath of cardiovascular diseases (CVDs), which arise with mitochondrial dysfunction (MD). Endothelium restraint inflammation, repair and fluidic exchange with nearby tissues. Endothelium-mediated mitochondrial damage can trigger the molecular mechanisms of vasodilation, pro-inflammation and process of pro-thrombotic accumulation in microvascular endothelial layer. The oxidation of lipid particles generates modified lipoproteins. Modification of mitochondrial function recently emerged a great concern towards the atherosclerosis initiation and progression, because the powerhouse of energy production mitochondria mutation can release mtDNA into cytoplasm and it can be act as sensor for viral DNA or foreign DNA. Another cause is mitochondrial imbalance can lead to product excess amount of reactive oxygen species (ROS) which can cause cellular metabolism and respiration system. Objectives In previous some studies showed that mitochondrial dysfunction plays a vital role in term of cardiac diseases. However, very few studies provide evidence of endothelium-mediated mitochondrial imbalance. This study investigated the potential involvement of mitochondrial impairment in cardiotoxicity using a series of mechanistic endpoints, including mitochondrial respiration and endothelial suppression of inflammation, mitochondrial DNA. Our study provides some molecular mechanisms regarding mitochondrial role in endothelium function. In each section, we are trying to introduce key concepts and then analysis previous studies revealed the importance of that molecular mechanism regarding mitochondrial dysfunction. Conclusions The ultimate goal of our review is to find out the novel drug discovery or new approaches of therapy. Our review will target different aspects of mitochondrial protein function and their effect of endothelial and cause of atherosclerosis diseases. To evaluate the healthy lifestyle and better condition of mitochondrial balance nowadays it is urgent to utilize the proper function for therapeutical effect for future direction.

Research Trends in Library and Information Science in Bangladesh: An Analytical Study

Islam, Md. Shariful,Islam, Md. Nazmul,Mondal, Madhob Korea Institute of Science and Technology Informat 2018 Journal of Information Science Theory and Practice Vol.6 No.2

The utmost intention of this work is to identify various field areas which are most prevalent in library and information science education. The study also denotes the rate of tendency on the rapid growth and development of research production among information specialists in Bangladesh. In order to carry out the study, an extensive literature review was carefully done to collect the basic elements of research patterns. It is noted that in the period of 1980-2016, 200 articles were published in library and information science by Bangladeshi researchers in 62 journals. In this article a total of 200 articles were reviewed. The result of the present study shows that the ratio of female authors had fewer contributions than male authors did. The majority of articles were published from the United Kingdom. The study also shows that the largest numbers of articles (19 papers, 9.50%) were published in the Social Science Journal of the University of Rajshahi from Bangladesh. The paper also shows that about 71.50% of papers have been cited while 28.50% of papers did not receive any citation. The present research might be helpful for revealing the country's research trends in library and information science. However, this study may also inspire development of a subject-based indigenous database and can act as an important device for research scholars.

Ultrasonic Effects on the Kinetics and Thermodynamics of Dyeing Wool Fiber with Reactive Dye

G. M. Nazmul Islam,Guizhen Ke 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5

Decreasing the temperature for dyeing wool fiber with reactive dye using a laboratory based ultrasonic machinewas investigated as a way to obtain good quality dyed samples. Ultrasonic irradiation was used to reduce dyeing time andtemperature whilst increasing dye migration and fastness. The ultrasonic machine was set at a 40 kHz frequency level, witheffective power of 130 W and heating power of 350 W to carry out the dyeing process of the wool fiber within thetemperature range 60-80 °C. The dyeing processes used both ultrasonic dyeing and without ultrasonic dyeing to obtain thelaboratory results. At every dyeing stage from 60 °C to 80 °C, the exhaustion rate of dyeing was measured. Ultrasonic dyeingyielded better results compared to without ultrasonic dyeing. The diffusion coefficient, partition ratio, and standard affinityincreased with the increased dyeing temperature and the use of an ultrasonic bath. The efficiency of ultrasonic dyeing wasmeasured and the absorption rate constant was at least 55 % greater than without ultrasonic dyeing at every dyeingtemperature i.e. 60 °C, 70 °C, and 80 °C. The color fastness to washing and rubbing was better for samples dyed withultrasonic dyeing. Scanning electron microscopy (SEM) was used to measure the surface changes of the fiber. SEM analysisshowed no evidence of scale damage on the wool fiber surface.

Polydopamine Treated and PEDOT:PSS Coated Wash Durable Conductive Textiles for Wearable Applications

G. M. Nazmul Islam,M. Azam Ali,Stewart Collie 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4

Fabrication of wash durable conductive textiles are one of the most critical issues for the production of wearableconductive textiles. Here, this manuscript has reported on a low-cost, and simple sensor fabrication method for producingelectronically conductive textiles. Polydopamine (PODA) treated and untreated 100 % cotton plain woven fabrics were madeelectrically conductive with a mixture of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) andethylene glycol (EG) (70:30) solution through a dip-coating process. Strongly adhering the PEDOT:PSS and ethylene glycolcoating yielded a low resistance of 278 Ω/sq for the coated fabrics without significant mechanical degradation. Fouriertransform infrared spectroscopy (FTIR) studies revealed interactions between the cotton fibers and PEDOT:PSS. The coatedfabrics were characterized by Scanning Electron Microscope (SEM). SEM imaging of the PEDOT:PSS:EG coated fabricsrevealed slight texturing to the fibres due to the coating on PODA treated fabrics compared to the untreated coated fabrics. The PODA treated conductive cotton fabrics exhibited great durability against repeated multiple washing cycles. The tensilestrength and mechanical properties of the conductive fabrics were also evaluated. Ageing effects of the conductive fabricswas also analyzed. Electrical resistance of the untreated fabrics increased by 51 % in 5 weeks compared to PODA treatedfabrics due to controlled ageing under storage conditions. It is expected that the PEDOT:PSS:EG coated conductive fabricsfabricated by this process can be applied for healthcare applications.

Palm oil industry’s bi-products as coarse aggregate in structural lightweight concrete

Md. Nazmul Huda,Mohd Zamin Jumaat,A. B. M. Saiful Islam,Kh Mahfuz ud Darain,M. Obaydullah,Md. Akter Hosen 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.5

Recent trend is to use the lightweight concrete in the construction industry because it has several advantages over normal weight concrete. The Lightweight concrete can be produced from the industrial waste materials. In South East Asian region, researchers are very keen to use the waste materials such as oil palm shell (OPS) and palm oil clinker (POC) from the palm oil producing industries. Extensive research has been done on lightweight concrete using OPS or POC over the last three decades. In this paper the aggregate properties of OPS and POC are plotted in conjunction with mechanical and structural behavior of OPS concrete (OPSC) and POC concrete (POCC). Recent investigation on the use of crushed OPS shows that OPSC can be produced to medium and high strength concrete. The density of OPSC and POCC is around 20-25% lower than normal weight concrete. Generally, mechanical properties of OPSC and POCC are comparable with other types of lightweight aggregate concrete. It can be concluded from the previous study that OPSC and POCC have the noteworthy potential as a structural lightweight concrete.

Bioactivities of leaf and root extract of Ceriscoids turgida (Roxb.)

Md. Nazmul Hasan Zilani,Nazneen Ahmeda Sultana,Monjurul Kader Bakshi,Israt Jahan Shampa,Samia Jaman Sumi,Ohidul Islam 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2

In traditional medicine leaf and root of Ceriscoides turgida (Roxb.) are commonly used to treat indigestion in child, leucorrhoea, dog bite, snake bite, scorpion string, epilepsy, stomachache and a number of ailments. The present study was carried out to investigate antioxidant, analgesic, antibacterial and cytotoxic activities of methanol extract of leaves and roots of C. turgida. Total flavonoids content was spectrophotometrically determined using aluminum chloride colorimetric assay while total phenolic and tannin content by Folin Chiocalteu’s reagent. Antioxidant activity was determined by DPPH free radical scavenging and reducing power assay. Analgesic activity was assessed by acetic acid induced writhing method. Antibacterial activity was evaluated by disc diffusion assay while brine shrimp lethality bioassay was carried out to verify the cytotoxic potential. Root extract contains greater amount of total phenolic (79.99 mg GAE/g dry extract) and flavonids content (35.27 mg QE/g dry extract) in comparison to leaf extract (30.75 mg GAE/g and 25.93 mg QE/g dry extract respectively). Root extracts showed DPPH scavenging (157.45 μg/mL) that was comparable to standard ascorbic acid (14.15 μg/mL). Reducing power of root extract was prominent than leaf extract in comparison to ascorbic acid. Both extract showed significant (P < 0.01) analgesic activity. In disc diffusion assay leaf extract showed greater antibacterial activity than root extract. Furthermore, extracts showed moderate cytotoxic effect. The present study demonstrates that methanol extract of C. turgida leaf and root has significant antioxidant and analgesic effect. The extracts also showed moderate antibacterial and cytotoxic activities.

Static deflection of nonlocal Euler Bernoulli and Timoshenko beams by Castigliano's theorem

Devnath, Indronil,Islam, Mohammad Nazmul,Siddique, Minhaj Uddin Mahmood,Tounsi, Abdelouahed Techno-Press 2022 Advances in nano research Vol.12 No.2

This paper presents sets of explicit analytical equations that compute the static displacements of nanobeams by adopting the nonlocal elasticity theory of Eringen within the framework of Euler Bernoulli and Timoshenko beam theories. Castigliano's theorem is applied to an equivalent Virtual Local Beam (VLB) made up of linear elastic material to compute the displacements. The first derivative of the complementary energy of the VLB with respect to a virtual point load provides displacements. The displacements of the VLB are assumed equal to those of the nonlocal beam if nonlocal effects are superposed as additional stress resultants on the VLB. The illustrative equations of displacements are relevant to a few types of loadings combined with a few common boundary conditions. Several equations of displacements, thus derived, matched precisely in similar cases with the equations obtained by other analytical methods found in the literature. Furthermore, magnitudes of maximum displacements are also in excellent agreement with those computed by other numerical methods. These validated the superposition of nonlocal effects on the VLB and the accuracy of the derived equations.

Incorporation preference for rubber-steel bearing isolation in retrofitting existing multi storied building

A.B.M. Saiful Islam,University of MalayaMohd Zamin Jumaat,Raja Rizwan Hussain,Md. Akter Hosen,Md. Nazmul Huda 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.4

Traditionally, multi-story buildings are designed to provide stiffer structural support to withstand lateral earthquake loading. Introducing flexible elements at the base of a structure and providing sufficient damping is an alternative way to mitigate seismic hazards. These features can be achieved with a device known as an isolator. This paper covers the design of base isolators for multi-story buildings in medium-risk seismicity regions and evaluates the structural responses of such isolators. The well-known tower building for police personnel built in Dhaka, Bangladesh by the Public Works Department (PWD) has been used as a case study to justify the viability of incorporating base isolators. The objective of this research was to establish a simplified model of the building that can be effectively used for dynamic analysis, to evaluate the structural status, and to suggest an alternative option to handle the lateral seismic load. A finite element model was incorporated to understand the structural responses. Rubber-steel bearing (RSB) isolators such as Lead rubber bearing (LRB) and high damping rubber bearing (HDRB) were used in the model to insert an isolator link element in the structural base. The nonlinearities of rubber-steel bearings were considered in detail. Linear static, linear dynamic, and nonlinear dynamic analyses were performed for both fixed-based (FB) and base isolated (BI) buildings considering the earthquake accelerograms, histories, and response spectra of the geological sites. Both the time-domain and frequency-domain approaches were used for dynamic solutions. The results indicated that for existing multi-story buildings, RSB diminishes the muscular amount of structural response compared to conventional non-isolated structures. The device also allows for higher horizontal displacement and greater structural flexibility. The suggested isolation technique is able to mitigate the structural hazard under even strong earthquake vulnerability.

Performance Analysis of Cloud based Deep Learning Models in OFDM based Image Communication system

Ijaz Ahmad(아흐마드 이자즈),Nazmul Islam(이슬람 나즈물),Eunkyung Kim(김은경),Seokjoo Shin(신석주) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.6

Reproductive management of dairy cows: an existing scenario from urban farming system in Bangladesh

Nayeema Khan Sima,Munni Akter,M. Nazmul Hoque,Md. Taimur Islam,Ziban Chandra Das,Anup Kumar Talukder 한국동물생명공학회(구 한국수정란이식학회) 2023 한국동물생명공학회지 Vol.38 No.4

Background: Reproductive management practices play crucial roles to maximize the reproductive performance of cows, and thus contribute to farm profitability. We aimed to assess the reproductive management of cows currently practiced in the dairy farms in an urban farming system. Methods: A total of 62 dairy farms were randomly selected considering all size of farms such as small (1-5 cattle), medium (6-20 cattle) and large farms (> 20 cattle) from selected areas of Dhaka city in Bangladesh. The reproductive managementrelated parameters viz. estrus detection, breeding method, pregnancy diagnosis, dry cow and parturition management, vaccination and treatment of reproductive problems etc. were obtained in a pre-defined questionnaire during the farm visit. Results: The visual observation method was only used (100.0%; 62/62) for estrus detection irrespective of size of the farms; while farmers observed cows for estrus 4-5 times a day, but only for 20-60 seconds each time. Regardless of farm size, 89.0% (55/62) farms used artificial insemination (AI) for breeding the cows. Intriguingly, all farms (100.0%) routinely checked the cows for pregnancy at 35-40 days post-breeding using rectal palpation technique by registered veterinarian. However, only 6.5% (4/62) farms practiced dry cow management. Notably, all farms (100.0%) provided nutritional supplements (Vit D, Ca and P) during late gestation. However, proper hygiene and cleanliness during parturition was not practiced in 77.4% (48/62) farms; even though 96.7% (60/62) farms treated cows by registered veterinarian for parturition-related problems. Conclusions: While farmers used AI service for breeding and timely check their cows for pregnancy; however, they need to increase observation time (30 minutes/ observation, twice in a day: early morning and early night) for estrus detection, consider dry cow management and ensure hygienic parturition for maximizing production.