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Antitumor activity of spinasterol isolated from Pueraria roots
Gook-Che Jeon,Myoung-Soon Park,윤도영,C hul-Ho Shin,Hong-Sig Sin,엄수종 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.2
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenat-ing folk medicine in Thailand and China. Dried, powdered plant material was extracted with 100% ethanol and further separated by concentration, filtration, and thin layer silica gel chromatogra-phy. Using the fractions obtained during separa-tion, we first investigated their cytotoxicity in se-veral cancer cel lines from various tissues. The ethanol-extracted components (PE1, PE4) had sig-nificant antiproliferative efects on breast cancer cel lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. Second, we compared flavonoids, sterols, and coumarins from Pueraria root. The known compounds were not as efec-tive, and occured in a diferent polarity region on HPLC. Third, further separation resulted in the isolation of eight diferent components (Sub PE-A to -H). One of these, PE-D, affected the growth of some breast cancer cel lines (MCF-7, MDA- MB-231) in a dose- and time-dependent maner, as wel as the growth of ovarian (2774) and cervical cancer cels (HeLa). Finaly, a transfec-tion assay showed that this component had an estrogenic effect similar to 17βactivates both estrogen receptor α (ERα) and ERβ. The NMR analysis determined that spin-asterol (stigmasta-7, 22-dien-3beta-ol) is an active cytotoxic component of Pueraria root.
박승창,김달식,임채웅,조남표,강명재,이혜수,최호열,김상호 의과학연구소 1994 全北醫大論文集 Vol.18 No.2
Author evaluated specimens of the uterine cervix submitted in Chonbuk National University Hospital laboratory from Sept. 1983 to Aug. 1986. The specimens were diagnosed hitologically under the light microscope previously. The results were as follows ; 1. The analyzed cervical tissues were 982 cases, e.g. 681 cases by punch biopsy, 166 cases by polypectomy, 32 cases by conization, 51 cases by total hysterectomy, 51 cases by radical hysterectomy, and one cases by endocervical curettage. 2. On the hitological classification of the tissue, chronic cervicities and chronic cervicitis with wquamous metaplasia were 483 cases, cervical polyps 164 cases, dyplasia 123 cases, carcinoma in situ 22 cases, microinvasivee carcinoma 6 cases, invasive squamous cell carcinoma 157 cases, adenocarcinoma 13 cases, condyloma accuninaturn 3 cases and verrucous carcinoma was one case. 3. The peak incidence of cervical lesions occurs 5th decade (365cases), and the average was 44.2 year of age. The youngest and oldest cases were 16 and 79 year of age. 4. The average age of chronic cervicitis was 40.6 years, chronic cervicitis with squamous metaplasia was 40.7 years, cervical polyp was 42.9 years, dysplasia was 42.2 years, carcinoma in sity was 42.8 years, microinvasive carcinoma was 49.8 years, invasive squamous cell carcinoma was 48.4 years, and adenocarcinoma was 50.8 years. 5. Clinical manifestation of the patients with performed biopsy of the uterine cervix were leukorrhea(289 cases), vaginal spotting(279 cases), contact bleeding(229 cases), and irregular vaginal bleeding(221 cases). And other many symptoms were complained. 6. Clinical manifestations of the chronic cervicitis and chronic cervicitis with squamous metaplasia were leukorhea, vaginal spotting and contact bleeding, dysplasia was contact bleeding and leukorrhea, and invasive carcinoma was irregular vaginal bleeding, vaginal spotting, and contact bleeding. 7. The main histological diagnosis of the cervical tissues obtained by punch biopsy(681 cases) were chronic cervicitis and squamous metaplasia(442 cases), invasive carcinoma(128 cases), and dysplasia(85 cases). The tissues by polypectomy(166 cases) were diagnosed with polyp(160 cases) mostly, and conebiopsy tissues(32 cases) were disclosed with dysplasia(16 cases) and chronic cervicitis & squamous metaplasia(10 cases). The specimens by total hysterectomy specimens(51 cases) were confirmed with invasive carcinoma(38 cases) mainly.