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Mun Hui Jeong,Seong Hee Jeong,Su Jeong Park,Na Rae Lee,Mi Hye Bae,박경희,변신연,김충락,Young Mi Han 대한신생아학회 2022 Neonatal medicine Vol.29 No.1
Purpose: We used the Bayley Scales of Infant and Toddler Development (BSID)-III to analyze the incidence and risk factors of developmental delay in very-low-birth-weight infants without severe brain lesions. We further examined the correlation between the cumulative dexamethasone dose and developmental assessment results. Methods: We retrospectively analyzed data of preterm infants (birth weight <1,500 g) admitted to our neonatal intensive care unit between January 2014 to December 2020. The BSID-III scores obtained between the corrected ages of 12 and 24 months and after 24 months were analyzed. Developmental delay was defined as a composite score of <85 for the cognition, language, and motor domains. Univariate and multivariate analyses of developmental delay risk factors and developmental changes from the first to second BSID-III were performed. Correlations between the accumulated dexamethasone dose used for bronchopulmonary dysplasia (BPD) and the first and second test scores were analyzed. Results: Seventy-one and thirty-six infants completed the first and second tests, respectively. In both tests, developmental delay was most commonly observed in the language domain (26.8%, 47.2%). In multivariate analysis, mild BPD was identified as a developmental delay risk factor (P<0.05), whereas prenatal steroid use reduced the developmental delay risk (P<0.05). All domain scores were lower in the second test than in the first test. The cognition and language domain scores in the second test decreased with increasing cumulative dexamethasone doses. Conclusion: Very-low-birth-weight infants typically experience language delay, which can persist as they age.
Risk Factors for Delayed Hyperthyrotropinemia in Late Preterm Infants
Mun Hui Jeong,Na Rae Lee,Mi Hye Bae,Young Mi Han,Kyung Hee Park,변신연 대한신생아학회 2019 Neonatal medicine Vol.26 No.4
Purpose: This study aimed to investigate the prevalence of delayed thyroid dysfunction based on iodine disinfectant use and to analyze associated risk factors. Methods: A retrospective study was conducted on late preterm infants admitted to the neonatal intensive care unit between January 2010 and June 2018, who underwent neonatal thyroid screening (NTS) and ≥2 thyroid function tests (TFTs). NTS was performed 3 days after birth, with at least two TFTs 1 week and 2 to 4 weeks after birth. To distinguish between normal and dysfunctional thyroid levels, we reviewed TFT results at 2 to 4 weeks and examined possible risk factors for the development of thyroid dysfunction. Results: Of 295 late preterm infants, 262 were enrolled with a mean gestational age and birth weight of 34.8±0.7 weeks and 2,170±454 g, respectively. A total of 7.6% developed hyperthyrotropinemia at the age of 24.3±14.6 days (range, 12 to 69). The incidence of hyperthyrotropinemia during iodine use was approximately 12.6%, while that during discontinuation was 2.4% (P=0.002). Multivariate analysis revealed that small for gestational age (SGA), iodine disinfectant use, and abnormal NTS results were significant risk factors for delayed hyperthyrotropinemia (adjusted odds ratio [AOR]: 4.27, P=0.008; AOR: 8.24, P=0.003; and AOR: 7.80, P=0.002, respectively). Conclusion: Delayed hyperthyrotropinemia was prevalent in late preterm infants exposed to topical iodine and those identified as being SGA. Secondary TFTs should be considered 2 to 4 weeks after birth for this population at risk.
A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant
Mun Hui Jeong,Seong Hee Jeong,Chung Su Hwang,조용훈,변신연,Na Rae Lee 대한신생아학회 2022 Neonatal medicine Vol.29 No.3
Sacrococcygeal teratoma is the most common congenital tumor in neonates, and is reported in approximately 1/35,000 to 1/40,000 live births. Oligodendroglioma is a rare central nervous system tumor that is usually found in the cerebral hemisphere of young and middle aged adults. When associated with a teratoma, it is mainly identified in ovarian teratoma in adolescents and adults. We describe a rare case of a preterm infant with oligodendroglioma in a mature sacrococcygeal teratoma. The male neonate was born at a gestational age of 30 weeks with a protruding mass in the sacrococcygeal region. Pelvic magnetic resonance imaging showed a sacrococcygeal teratoma of approximately 11 cm comprising fat components and skeletal structure, that extended from the anterior part of the sacrum to the abdominal cavity. Radical resection was performed at 36 days of age. Macroscopically, the resected intra-abdominal mass had the characteristics of a cystic lesion, and the intrapelvic mass was a predominantly solid mixed cystic-solid lesion. Histologically, this solid lesion in the intrapelvic mass was composed of mature glial tissue, which comprised as a proliferation of monotonous cells with small and round nuclei, surrounded by a perinuclear halo (“fried egg” appearance). Additionally, these cells were immunohistochemically positive for glial fibrillary acidic protein. These findings confirmed the diagnosis of oligodendroglioma in sacrococcygeal mature teratoma. After the treatment, no recurrence was observed during the follow-up period, and no additional intervention was required. However, the patient is undergoing treatment for voiding dysfunction caused by a neurogenic bladder.
A Rare Case of Oligodendroglioma in Sacrococcygeal Mature Teratoma Diagnosed in Preterm Infant
Mun Hui Jeong,Seong Hee Jeong,Chung Su Hwang,Yong Hoon Cho,Shin-Yun Byun,Na Rae Lee 대한신생아학회 2022 Neonatal medicine Vol.29 No.3
Sacrococcygeal teratoma is the most common congenital tumor in neonates, and is reported in approximately 1/35,000 to 1/40,000 live births. Oligodendroglioma is a rare central nervous system tumor that is usually found in the cerebral hemisphere of young and middle aged adults. When associated with a teratoma, it is mainly identified in ovarian teratoma in adolescents and adults. We describe a rare case of a preterm infant with oligodendroglioma in a mature sacrococcygeal teratoma. The male neonate was born at a gestational age of 30 weeks with a protruding mass in the sacrococcygeal region. Pelvic magnetic resonance imaging showed a sacrococcygeal teratoma of approximately 11 cm comprising fat components and skeletal structure, that extended from the anterior part of the sacrum to the abdominal cavity. Radical resection was performed at 36 days of age. Macroscopically, the resected intra-abdominal mass had the characteristics of a cystic lesion, and the intrapelvic mass was a predominantly solid mixed cystic-solid lesion. Histologically, this solid lesion in the intrapelvic mass was composed of mature glial tissue, which comprised as a proliferation of monotonous cells with small and round nuclei, surrounded by a perinuclear halo (“fried egg” appearance). Additionally, these cells were immunohistochemically positive for glial fibrillary acidic protein. These findings confirmed the diagnosis of oligodendroglioma in sacrococcygeal mature teratoma. After the treatment, no recurrence was observed during the follow-up period, and no additional intervention was required. However, the patient is undergoing treatment for voiding dysfunction caused by a neurogenic bladder.
Jeong, Huisu,Kim, Ki Seok,Kim, Yong Hwan,Jeong, Hyun,Song, Hui,Lee, Kwang Ho,Jeong, Mun Seok,Wang, Deli,Jung, Gun Young IOP Pub 2011 Nanotechnology Vol.22 No.27
<P>Single crystalline vertical ZnO nanorods were grown in a one hole–one rod configuration using a hydrothermal method with a patterned polymer template generated by nanoimprint lithography, allowing precise control over the position and density of the ZnO nanorods. An 8 × 8 ZnO nanorod-based ultraviolet photodetector array is demonstrated, in which a well-confined number of ZnO nanorods are sandwiched between crossbar-type platinum and indium tin oxide electrodes (e.g. 16 nanorods in a 2 × 2 µm<SUP>2</SUP> area). A high photocurrent/dark current ratio of 3 × 10<SUP>3</SUP> at a reverse bias of 1.5 V under UV illumination at room temperature, a responsivity of 4381.4 A W<SUP> − 1</SUP> at 365 nm, and an ultraviolet-to-visible rejection ratio of 83 are obtained and maintained, irrespective of pixel size. A uniform photoresponse is achieved in each of the pixels, indicating the scalability with this technique for fabricating an integrated UV photodetector array circuit. </P>
하우스 베드재배 시 상토조성이 복령의 생육에 미치는 영향
Yong Mun Lee,Jeong Seop Mun,Song Hui An,Jong Yeop Kim,Hui Jun Kim 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.05
Background : The hyphal growth of Poria cocos are known to grow well under medium temperature(25 - 28 ℃) and acidic(pH 4.0 - 5.0) conditions. Also, it is known that a large difference in the yield of Poria cocos depending on the cultivation method and environment. Therefore, this research was carried out to secure stable yield of Poria cocos using plastic house and bed soil. Methods and Results : The inoculation time was in mid-April 2016 and the inoculation amount was 3/4 lb each in pine trees of 60 (L) × 10 (D) ㎝. The inoculated wood was buried directly in the bed by soil composition and growth characteristics investigated after cultivating in plastic house from April to September, 2016. The composition of the bed soil was 6 treatments using peatmoss, cocopeat and perlite. The combination ratio ranges of peatmoss, cocopeat and perlite were 0 to 80 %, 0 to 60 % and 20 to 60 %, respectively. We assumed that the combination ratio of peatmoss (organic material) 60 % : perlite(inorganic material) 40% is good for the growth of the Poria cocos. In this ratio, instead of peatmoss, the amount of cocopeat was replaced by 20, 40, and 60 %, respectively. The pH and EC range of bed soil was 4.8 - 5.6, 0.7 - 2.2 dS/m, respectively. pH and EC tended to be lower in treatments with only peat moss and perlite. On the other hand pH and EC tended to raise with increasing cocopeat content. Volumetric soil water content and soil temperature were in the range of 13 - 28 % and 20 - 29℃, respectively, during the period of July to September. Soil water content tended to be higher with increasing cocopeat and peatmoss content and soil temperature tended to be lower. The degree of initial hyphal development and sclerotia formation were good in all treatments compared to the control. However, the number of sclerotia was 6 times higher in the ② treatment than in the control. The size of sclerotia was also the best at 12 (L) × 8 (W) ㎝ in the ② treatment. Conclusion : As a result of cultivating Poria cocos in plastic house, growth characteristics were different according to composition of bed soil. The first reason for this result is that the difference of soil moisture content depending on organic matter content affected the soil temperature. Actually, the average soil water content and soil temperature of ① treatment (organic material 80% ) showed 24% and 22℃ respectively during July to September, and no sclerotia was formed. However, in the ② treatment(organic material 60%), the average soil moisture and soil temperature were 14% and 26℃ during July to September, respectively and sclerotia formation was good. Another reason is that the pH of the bed soil affects the formation of sclerotia. Overall, the degree of hyphal development was good in low pH treatments, but no significant difference was found between the pH and the formation of sclerotia.