http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Endoscopic Management of Nonvariceal Upper Gastrointestinal Bleeding: State of the Art
Naoki Muguruma,Shinji Kitamura,Tetsuo Kimura,Hiroshi Miyamoto,Tetsuji Takayama 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.2
Nonvariceal upper gastrointestinal (GI) bleeding is one of the most common reasons for hospitalization and a major cause of morbidityand mortality worldwide. Recently developed endoscopic devices and supporting apparatuses can achieve endoscopic hemostasis withgreater safety and efficiency. With these advancements in technology and technique, gastroenterologists should have no concerns regardingthe management of acute upper GI bleeding, provided that they are well prepared and trained. However, when endoscopic hemostasisfails, endoscopy should not be continued. Rather, endoscopists should refer patients to radiologists and surgeons without anydelay for evaluation regarding the appropriateness of emergency interventional radiology or surgery. Nonvariceal upper gastrointestinal (GI) bleeding is one of the most common reasons for hospitalization and a major cause of morbidity and mortality worldwide. Recently developed endoscopic devices and supporting apparatuses can achieve endoscopic hemostasis with greater safety and efficiency. With these advancements in technology and technique, gastroenterologists should have no concerns regarding the management of acute upper GI bleeding, provided that they are well prepared and trained. However, when endoscopic hemostasis fails, endoscopy should not be continued. Rather, endoscopists should refer patients to radiologists and surgeons without any delay for evaluation regarding the appropriateness of emergency interventional radiology or surgery.
Endoscopic Molecular Imaging: Status and Future Perspective
Naoki Muguruma,Hiroshi Miyamoto,Toshiya Okahisa,Tetsuji Takayama 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.6
During the last decade, researchers have made great progress in the development of new image processing technologies for gastrointestinal endoscopy. However, diagnosis using conventional endoscopy with white light optical imaging is essentially limited, and ultimately, we still rely on the histopathological diagnosis from biopsy specimens. Molecular imaging represents the most novel imaging methods in medicine, and the future of endoscopic diagnosis is likely to be impacted by a combination of biomarkers and technology. Endoscopic molecular imaging can be defined as the visualization of molecular characteristics with endoscopy. These innovations will allow us not only to locate a tumor or dysplastic lesion but also to visualize its molecular characteristics and the activity of specific molecules and biological processes that affect tumor behavior and/or its response to therapy. In the near future, these promising technologies will play a central role in endoluminal oncology.
Effect of Heating on Polymerization of Pig Skin Collagen Using Microbial Transglutaminase
Erwanto, Yuny,Muguruma, Michio,Kawahara, Satoshi,Tsutsumi, Takahiko,Katayama, Kazunori,Yamauchi, Kiyoshi,Morishita, Toshiro,Morishita, Toshiro,Watanabe, Shohei Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.8
Polymerization of heated or unheated pig skin collagen using microbial transglutaminase (MTGase) was investigated. Pig skin collagen samples were heated or left unheated, then enzymatically polymerized with MTGase. SDS-PAGE was conducted to confirm the intermolecular polymer and the results showed similar bands between samples without MTGase and unheated samples with MTGase. The polymerized product of pig skin collagen was not formed in unheated samples, even when MTGase was added during incubation. Different results were obtained from samples heated at $80^{\circ}C$ and $100^{\circ}C$ for 2 min, whereas the SDS-PAGE pattern indicated that a polymer band was generated in both cases. The heat treatment successfully modified the native structure of collagen and also made collagen more reactable in the MTGase polymerization system. Scanning Electron Microscope (SEM) investigation of pig skin collagen showed a biopolymer structure through intermolecular collagen crosslinking, while there were no intermolecular crosslinks in samples not treated with MTGase. There were no significant differences in fibril diameter between treated samples and controls. These results suggest that heat treatment of native pig skin collagen enhanced the polymerization capability of MTGase.
Twin Rectal Tonsils Mimicking Carcinoid or Mucosa-Associated Lymphoid Tissue Lymphoma
Masanori Takehara,Naoki Muguruma,Shinji Kitamura,Tetsuo Kimura,Koichi Okamoto,Hiroshi Miyamoto,Yoshimi Bando,Tetsuji Takayama 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.5
The rectal tonsil is a rare polypoid lesion exclusively found in the rectum and is considered a reactive proliferation of the lymphoid tissue. Although this lesion is benign, we recommend that it should be differentiated from carcinoid or polypoid type of mucosa-associated lymphoid tissue lymphomas, based on gross findings. In this case report, we describe a case of rectal lesions with a unique appearance in a 41-year-old man. Colonoscopy revealed two 5-mm-sized nodules located opposite from each other on the left and right sides of the lower rectum. Endoscopic mucosal resection was conducted. Histopathologically, both lesions were mainly located in the submucosa and consisted of prominent lymphoid follicles with germinal centers of various sizes. No immunoreactivity of Bcl-2 was seen in the germinal centers. Immunohistochemical staining for kappa and lambda light chains revealed a polyclonal pattern. Therefore, these lesions were diagnosed as rectal tonsils.
Sulphur dioxide plasma modification on poly(methyl methacrylate) for fluidic devices
Atsunori Hiratsuka,Hiroyuki Fukui,Yoshio Suzuki,Hitoshi Muguruma,Koji Sakairi,Toshiyuki Matsushima,Yuji Maruo,Kenji Yokoyama 한국물리학회 2008 Current Applied Physics Vol.8 No.2
We developed a sulphur dioxide plasma modication on a poly(methyl methacrylate) (PMMA) material for uidic electrophoresisdevices. The inner surface of the PMMA channel of a chip was modied by using sulphur dioxide plasma treatment. Contact angle mea-surements indicated that the buer solutions were able to ll the capillary because of the hydrophilic property of the internal surface ofthe chip. XPS analysis indicated that the sulphur dioxide plasma treatment introduced a negative charge originating from the dissoci-ation of the hydrogen atoms of sulphonic groups. Since this introduced a negative charge originating from strong acid sulphonic groupsonto the surface of the channel, the electroosmotic ow (EOF) was observed to be large (~7×10-⁴m²V-¹ s-¹) and stable over a widerange of pH (410). The chip was fabricated by using plastic injection moulding methods for enabling the mass fabrication and dispos-able use of chips. The separation method is based on the net electric charge of the material, which enables the separation of identicalsamples on the basis of both isoelectric points and molecular weight. Two synthetic peptides with similar isoelectric points and molecularweights but dierent net charges were selected as model protein samples for the separation. The sample peptides were detected underuorescence microscopy. The resulting electropherograms obtained by using the sulphur dioxide plasma-treated PMMA chip demon-strated that the two peptides were separated and that the migration time of the peptides was correlated with the net charge.
Makoto Taguchi,Takaaki Inoue,Kouei Muguruma,Takashi Murota,Hidefumi Kinoshita,Tadashi Matsuda 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.6
Purpose: To evaluate urination-related quality of life (QoL) in patients with an indwelling ureteral stent immediately after ureteroscopic lithotripsy (URSL) for upper urinary calculi. We compared the effects of loop-tail and pigtail ureteral stents on urination-related QoL. Materials and Methods: Of 135 patients who underwent URSL between May 2014 and March 2015 at our hospital, we retrospectively analyzed the records of 70 patients (42 men, 28 women; median age, 63 years) in whom the stent tail was positioned inside the bladder without crossing the midline and who completed the core lower urinary tract symptoms score (CLSS) questionnaire pre- and postoperatively. Results: There were significant differences in incomplete emptying (p=0.048) and bladder pain (p=0.041) between patients with loop-tail versus pigtail ureteral stents after URSL. In the multivariate analysis, stent type had a stronger association with incomplete emptying (p=0.022) and bladder pain (p=0.018) than age, sex, body mass index, stent side, operation time, diameter of ureteral access sheath, and stent type. Conclusions: Patients with loop-tail ureteral stents had better urination-related QoL in the immediate post-URSL stage than patients with pigtail stents.