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Kim, Jong-Hoon,Chung, Hwan-Suck,Kang, Moonkyu,Kim, Yong,Kim, Byung-Su,Kim, Youn-Sub,Bae, Hyunsu Elsevier 2011 Diabetes research and clinical practice Vol.93 No.2
<P><B>Abstract</B></P> <P>PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long–Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age male OLETF rats were treated daily with PM021 or vehicle for five months. Specifically, changes in body weight, blood glucose, urine volume, food intake and oral glucose tolerance were measured in rats for five months. The rats in this study were divided into four groups: a Long–Evans Tokushima Otsuka (LETO) rat group, which is a genetic control group for OLETF, that received no treatment; a PM021 treatment group of LETO rats; OLETF rats that received no treatment; and OLETF rats that received PM021 treatment. The results showed that PM021 significantly prevented increases in body weight, blood glucose, and urine and food intake that resulted from the induction of obesity and diabetes. PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities.</P>
Kim, Jiyoon,Hong, Jongin,Park, Moonkyu,Zhe, Wu,Kim, Dongjin,Jang, Yu Jin,Kim, Dong Ha,No, Kwangsoo WILEY‐VCH Verlag 2011 Advanced Functional Materials Vol.21 No.22
<P><B>Abstract</B></P><P>A facile route is presented for the fabrication of spherical PbTiO<SUB>3</SUB> (PTO) nanodot arrays on platinized silicon substrates using PbO vapor phase reaction sputtering on micellar monolayer films of polystyrene‐<I>block</I>‐poly(ethylene oxide) (PS‐<I>b</I>‐PEO) loaded with TiO<SUB>2</SUB> sol–gel precursor. Short exposure to PbO transforms the amorphous TiO<SUB>2</SUB> into polycrystalline PTO, while keeping the inherent size and periodicity of TiO<SUB>2</SUB> nanodots. HRTEM images show that the spherical PTO nanodots, with an average size and height of 63 nm and 40 nm, respectively, are fixed on the Pt supported by residual carbon. XPS narrow scan spectra of Ti 2p and O 1s strongly verify the evolution of chemical identity and the reduction of the Ti‐O binding energy from TiO<SUB>2</SUB> to PTO. The amplitude and phase images of piezoelectric force microscopy (PFM) confirm a multidomain structure attributed by the crystalline orientation of the PTO nanodots. Furthermore, the discrete PTO nanodots show remarkable switching properties due to the low strain field induced by the small lateral size, and the absence of domain pinning effects by grain boundary.</P>
Kang, Moonkyu,Kim, Jong-Hoon,Cho, Chongwoon,Chung, Hwan-Suck,Kang, Chang-Woon,Kim, Yangseok,Shin, Minkyu,Hong, Moochang,Bae, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Aurantii Fructus (AF) is one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Korea. The anti-ischemic effects of AF on ischemia-induced isolated rat heart were investigated through analyses of changes in perfusion pressure, aortic flow, coronary How, and cardiac output. The subjects in this study were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group with AF treatment. There were no significant differences in perfusion pressure, aortic How, coronary flow. and cardiac output between them before ischcmia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and AF was administered during ischemia induction. AF treatment significantly prevented decreases in perfusion pressure, aortic How, coronary flow, and cardiac output under ischemic conditions (P<0.01).These results suggest that AF has distinct anti-ischemic effects through recovery of contractile dysfunction in ischemic heart.
Rakesh Kumar Jha,Kanghae Kim,Mansik Jeon,JeeHyun Kim,Min Young Kang,Insook Han,Moonkyu Kim 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.5
Swept-source optical coherence tomography (SS-OCT), a bio-photonic imaging modality, was used to demonstrate an initial feasibility experiment for detecting morphological variations of invivo mouse hair follicles for the anagen and the telogen growth stages. Two C57BL/6 adult male mice, one undergoing the anagen stage and the other undergoing the telogen stage of the hair follicle growth cycle, were selected for the experiment. The OCT cross-sectional images of mice skin were acquired in-vivo within an interval of 15 days, and the observed morphological changes were analyzed. The micro-structural features of mice skin on the 15th experimental day were further compared with corresponding histological observations. The preliminary result of this study provides clear insights into the structural details of mouse skin, confirming the resemblance of the OCT images with the corresponding histological measurements, and ensures the suitability of SSOCT for non-invasive analysis of hair follicle conditions.
CHUNG, Hwan-Suck,KANG, Moonkyu,CHO, Chongwoon,PARVEZ, Shoukat,PARK, Chong-heong,KIM, Dongwoo,OH, Joonghwan,KIM, Hongyeoul,SHIN, Minkyu,HONG, Moochang,KIM, Yangseok,BAE, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the efTect of MC on lipopolysaccharide (LPS) and rccombinant interferon-gamma(rIF)-indiiced productioii ofnitric oxide (NO) and tumor necrosis factor (TNFγ)-aIpha were examined using mouse perituneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rlFN-γ-induced production of NO and TNF-atpha by MC is due to the inhibition of NF-kappaB activation.
Vertical ZnO nanowires/graphene hybrids for transparent and flexible field emission
Hwang, Jin Ok,Lee, Duck Hyun,Kim, Ju Young,Han, Tae Hee,Kim, Bong Hoon,Park, Moonkyu,No, Kwangsoo,Kim, Sang Ouk Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.10
<P>We present a transparent and flexible optoelectronic material composed of vertically aligned ZnO NWs grown on reduced graphene/PDMS substrates. Large-area reduced graphene films were prepared on PDMS substrates by chemical exfoliation from natural graphite <I>via</I> oxidative aqueous dispersion and subsequent thermal reduction. ZnO NWs were hydrothermally grown on the reduced graphene film substrate and maintained their structural uniformity even in highly deformed states. The electrical contact between semiconducting ZnO NWs and the metallic graphene film was straightforwardly measured by electric force microscopy (EFM). It shows a typical metal–semiconductor ohmic contact without a contact barrier. Owing to the mechanical flexibility, transparency, and low contact barrier, the ZnO NWs/graphene hybrids show excellent field emission properties. Low turn-on field values of 2.0 V μm<SUP>−1</SUP>, 2.4 V μm<SUP>−1</SUP>, and 2.8 V μm<SUP>−1</SUP> were measured for convex, flat, and concave deformations, respectively. Such variation of field emission properties were attributed to the modification of ZnO NWs emitter density upon mechanical deformation.</P> <P>Graphic Abstract</P><P>A hybrid structure consisting of ZnO nanowires on a metallic graphene film would be the cornerstone of transparent and flexible electronics due to excellent field emission properties based on structural and electrical stability. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm01495h'> </P>
Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma
Sung, Young Kwan,Hwang, Sun Young,Park, Mi Kyung,Bae, Han Ik,Kim, Woo Ho,Kim, Jung-Chul,Kim, Moonkyu Wiley (Blackwell Publishing) 2003 Cancer Science Vol.94 No.5
<P>Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic acid (AA) level in cells. It has been shown that FACL4 blocks apoptosis and promotes colon carcinogenesis by lowering the cellular level of unesterified AA. Consistent with this, FACL4 is upregulated in colon adenocarcinoma. The status of FACL4 in other tumors including hepatocellular carcinoma (HCC) is not known. Here, we report that FACL4 is overexpressed in human HCC compared with adjacent normal liver tissues. FACL4 mRNA and protein were overexpressed in 5 out of 12 (41.7%) and 3 out of 8 (37.5%) cases of HCC, respectively. Immunohistochemical staining showed strong fine granular intracytoplasmic staining in tumor cells, whereas we observed occasional weak staining in normal liver tissues surrounding the tumors. We found that 14 out of 37 (37.8%) HCC expressed moderate to strong FACL4 immunostaining. Both normal adult and fetal liver tissues showed very weak to no detectable staining, whereas 3 out of 10 (30%) cirrhotic livers expressed weak staining. In addition, we found that 4 out of 8 (50%) human hepatoma cell lines expressed high levels of FACL4 by northern blot analysis. Our results show that FACL4 is a new molecular marker for HCC and suggest that the FACL4 pathway may be involved in liver carcinogenesis.</P>