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Mohamed A. Yassin,Bishnu Kumar Shrestha,Rafiq Ahmad,Sita Shrestha,박찬희,김철상 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.73 No.-
A novel glucose biosensor was designed using cobalt oxide (Co3O4) nanosheets patterned byp-conjugated polyaniline nanofibers (PANINFs). A facile synthesis process was conducted to obtaincost-effective and ecofriendly mesoporous Co3O4@PANINFs hybrid nanomaterial for thefirst time. TheCo3O4@PANINFs on glassy carbon electrode (GCE), working as a biosensor electrode based onelectrochemical technique, showed electrocatalytic activity to glucose with sensitivity of 14.25 mAmM 1cm 2, linear range from (0.1 to 8) mM, minimum detection limit of 0.06 mM, and response time<6 s. Moreover, the biosensor was employed to monitor glucose concentration in human serum sample toprovide effective sensing results.
Mohamed A. Yassin,Bishnu Kumar Shrestha,Joshua Lee,김주연,박찬희,김철상 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-
A novel nanostructure of three-dimensional graphene hydrogel nanotubes (3DGHNTs) is successfullysynthesized for the purpose of sensing non-enzymatic H2O2 in alkaline solution. The 3DGHNTs werefabricated using manganese dioxide nanotubes (MnO2 NTs) as the effective sacrificial template andwithout the use of any acids or a high temperature process. 3DGH with different percentages of MnO2NTs ranging from 5 to 30% are prepared via a hydrothermal method. When the loading percentage ofMnO2 NTs is 10%, the obtained 3DGHNTs-Mn10 nanocomposite exhibits a large specific surface areawith high porosity, which enhance the electrochemical properties for H2O2 detection. The developedbiosensor exhibits excellent sensitivity (220.4 mA mM 1 cm 2) with a wide linear detection range (25 mM–22.57 mM) and a low detection limit (4 mM). The biosensor also shows a fast response time (lessthan 5 s) and good selectivity as well as reproducibility and long-term stability. Hence, the prepared3DGHNTs-Mn10 nanocomposite can be considered a promising electrode material for the detection ofH2O2 in real sample.
Ghareeb Doaa A.,Saleh Samar R.,Seadawy Mohamed G.,Nofal Mohammed S.,Abdulmalek Shaymaa A.,Hassan Salma. F.,Khedr Shaimaa M.,AbdElwahab Miral G.,Sobhy Ahmed A.,Abdel-Hamid Ali saber Ali,Yassin Abdelrah 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.6
Purpose A novel coronavirus (COVID-19) that has not been previously identified in humans and has no specific treatment has recently spread. Treatment trials using antiviral and immune-modulating drugs such as hydroxychloroquine (HCQ) were used to control this viral outbreak however several side effects have emerged. Berberine (BER) is an alkaloid that has been reported to reveal some pharmacological properties including antioxidant and antimicrobial activities. Additionally, Zinc oxide nanoparticles (ZnO-NPs) possess potent antioxidant and anti-inflammatory properties. Therefore, this study was undertaken to estimate the efficiency of both BER and synthetic ZnO/BER complex as an anti-COVID-19 therapy. Methods First, the ZnO/BER complex was prepared by the facile mixing method. Then in vitro studies on the two compounds were conducted including VeroE6 toxicity, anti-COVID-19 activity, determination of inhibitory activity towards papain-like proteinase (PL pro) and spike protein- and receptor- binding domain (RBD) as well as assessment of drug toxicity on RBCs. Results The results showed that ZnO/BER complex acts as an anti-COVID-19 by inhibiting spike protein binding with angiotensin-converting enzyme II (ACE II), PL pro activity, spike protein and E protein levels, and expression of both E-gene and RNA dependent RNA polymerase (RdRp) at a concentration lower than that of BER or ZnO-NPs alone. Furthermore, ZnO/BER complex had antioxidant and antimicrobial properties where it prevents the auto oxidation of 2,2-Diphenyl- 1-picrylhydrazyl (DPPH) and the culture of lower respiratory system bacteria that affected Covid 19 patients. The ZnO/BER complex prevented as well the HCQ cytotoxic effect on both RBC and WBC (in vitro) and hepatotoxicity, nephrotoxicity and anemia that occurred after HCQ long administration in vivo. Conclusion The ZnO/BER complex can be accounted as promising anti-COVID 19 candidate because it inhibited the virus entry, replication, and assembly. Furthermore, it could be used to treat a second bacterial infection that took place in hospitalized COVID 19 patients. Moreover, ZnO/BER complex was found to eliminate the toxicity of long-term administration of HCQ in vivo.
Mohamed, Ibrahim M.A.,Dao, Van-Duong,Yasin, Ahmed S.,Mousa, Hamouda M.,Yassin, Mohamed A.,Khan, Muhammad Yasir,Choi, Ho-Suk,Barakat, Nasser A.M. Elsevier 2017 Materials characterization Vol.127 No.-
<P><B>Abstract</B></P> <P>This work introduces the synthesis of N-doped nanocomposite of ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> nanofibers (NFs) by use of both electrospinning and hydrothermal methods. The physicochemical properties of the introduced TiO<SUB>2</SUB> NFs are investigated to describe the morphology, crystallinity and chemistry through FESEM, SEM-EDX, XRD, TEM and XPS. As the results, the investigated material can be described as N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs. The crystal structure of the prepared TiO<SUB>2</SUB> is only anatase structure. Then, the novel NFs are utilized to design novel photoanode and photo-electrochemical characterization such as current-potential response under light, incident photon-to-current efficiency (IPCE) and electrochemical impedance spectroscopy (EIS) of the dye-sensitized solar cell (DSC) are also investigated. The photovoltaic response showed that the efficiency of the DSCs employed N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> photoanode gave 4.95%, which was higher than those of DSCs designed with ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs (4.51%) and N@TiO<SUB>2</SUB> NFs (4.41%) photoanodes. The high photo-response of DSC by use of N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs can be attributed to enhanced electrical conductivity, which is studied via EIS, and presence of active sites of N. These active sites can easily absorb dye-molecules in the step of dye-loading in the fabrication of DSC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-doped ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> nanofibers (NFs) are synthesized via facile two steps; electrospinning followed by hydrothermal. </LI> <LI> The produced NFs have only anatase crystal structure. </LI> <LI> 4.95% PV efficiency was achieved by the synthesized NFs. </LI> <LI> DSC based on N-doped ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs shows high electrical conductivity and low charge transfer resistance; 9.375Ω. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Iqbal M. Ismail,Ahmad S. Summan,Jalal M. Basahi,Essam Hammam,Mohamed F. Yassin,Ibrahim A. Hassan 한국대기환경학회 2021 Asian Journal of Atmospheric Environment (AJAE) Vol.15 No.2
Concentrations of black carbon (BC), organic carbon (OC), and total suspended particulate matter (TSP) were simultaneously assessed in urban, rural and residential areas in Jeddah city for one year from January to December 2017. It was aimed in the present study to provide information about the spatial and seasonal variability of these aerosol species in Jeddah, and insight into sources, processes and effects of meteorological conditions. To the best of our knowledge, this is the first study investigating the variability of carbonaceous aerosols (OC and BC) in Saudi Arabia. The average concentrations of OC, BC, and TSP varied spatially and temporally. The annual average concentrations of OC, BC, and TSP were 134.05, 7.16, and 569.41 μg m-3 and 34.32, 5.14, and 240.64 μg m-3 and 10.67, 4.39 and 101.31 μg m-3 in the urban, residential and rural areas, respectively. Moreover, there was a clear seasonal variation in the concentration of carbonaceous aerosols; the highest concentrations were recorded in February and September, while the lowest concentrations of OC were recorded during April, May and August in the urban, residential and rural sites, respectively. Nevertheless, the lowest concentrations of BC were recorded during March in the urban and residential sites and during November in the rural site. The relative concentrations of OC and BC to the TSP were relatively high, and they have a significant correlation with prevalent wind speed (-0.636, and -0.581 in the urban area), (-0.539 and -0.511 in the residential area), and (-0.508 and -0.501 in the rural area), respectively. The marked differences in the concentrations of BC and OC were reflected on OC/BC ratio, which is a good representative of different source types. This preliminary study showed that the potential local sources were emissions from traffic (fossil fuel), biomass burning, anthropogenic activities (e.g. car drifting and outdoor cooking), and industrial activities. The present study suggest the presence of highly inefficient combustion sources and highlight the need for the regulation of such emissions.