http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mizoguchi Yasushi,Guan Le Luo 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2
Advanced and innovative breeding and management of meat-producing animals are needed to address the global food security and sustainability challenges. Beef production is an important industry for securing animal protein resources in the world and meat quality significantly contributes to the economic values and human needs. Improvement of cattle feed efficiency has become an urgent task as it can lower the environmental burden of methane gas emissions and the reduce the consumption of human edible cereal grains. Cattle depend on their symbiotic microbiome and its activity in the rumen and gut to maintain growth and health. Recent developments in high-throughput omics analysis (metagenome, metatranscriptome, metabolome, metaproteome and so on) have made it possible to comprehensively analyze microbiome, hosts and their interactions and to define their roles in affecting cattle biology. In this review, we focus on the relationships among gut microbiome and beef meat quality, feed efficiency, methane emission as well as host genetics in beef cattle, aiming to determine the current knowledge gaps for the development of the strategies to improve the sustainability of beef production. Advanced and innovative breeding and management of meat-producing animals are needed to address the global food security and sustainability challenges. Beef production is an important industry for securing animal protein resources in the world and meat quality significantly contributes to the economic values and human needs. Improvement of cattle feed efficiency has become an urgent task as it can lower the environmental burden of methane gas emissions and the reduce the consumption of human edible cereal grains. Cattle depend on their symbiotic microbiome and its activity in the rumen and gut to maintain growth and health. Recent developments in high-throughput omics analysis (metagenome, metatranscriptome, metabolome, metaproteome and so on) have made it possible to comprehensively analyze microbiome, hosts and their interactions and to define their roles in affecting cattle biology. In this review, we focus on the relationships among gut microbiome and beef meat quality, feed efficiency, methane emission as well as host genetics in beef cattle, aiming to determine the current knowledge gaps for the development of the strategies to improve the sustainability of beef production.
Mizoguchi, Tadashi,Saga, Yoshitaka,Tamiaki, Hitoshi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Eight intact bacteriochlorophyll (BChl)-d homologs and isomers were isolated from a strain of green sulfur bacterium Chlorobium vibrioforme. All the molecular structures of the BChl-d components were fully determined by a combination of mass spectrometry and $^1$H-NMR spectroscopy. The aggregation behavior of the isomerically pure BChls-d in hydrophobic organic solvents was examined with respect to the stereoisomeric configuration at the C3$^1$ position as well as the bulkiness of the C8 and C12 side-chains by using electronic- absorption spectroscopy.
Generic model for the hyperkagome iridateNa4Ir3O8in the local-moment regime
Mizoguchi, Tomonari,Hwang, Kyusung,Lee, Eric Kin-Ho,Kim, Yong Baek American Physical Society 2016 Physical Review B Vol.94 No.6
<P>The hyperkagome iridate, Na4Ir3O8, has been regarded as a promising candidate material for a three-dimensional quantum spin liquid. Here the three-dimensional network of corner-sharing triangles forms the hyperkagome lattice of Ir4+ ions. Due to strong spin-orbit coupling, the local moments of Ir4+ ions are described by the pseudospin j(eff) = 1/2 Kramers doublet. The Heisenberg model on this lattice is highly frustrated, and quantum/classical versions have been studied in earlier literature. In this work, we derive a generic local-moment model beyond the Heisenberg limit for the hyperkagome iridate by considering multiorbital interactions for all the t(2g) orbitals and spin-orbit coupling. The lifting of massive classical degeneracy in the Heisenberg model by various spin-anisotropy terms is investigated at the classical level, and the resulting phase diagram is presented. We find that different anisotropy terms prefer distinct classes of magnetically ordered phases, often with various discrete degeneracy. The implications of our results for recent mu SR and NMR experiments on this material and possible quantum spin liquid phases are discussed.</P>
( Emiko Mizoguchi ),( Daren Low ),( Yui Ezaki ),( Toshiyuki Okada ) 대한장연구학회 2020 Intestinal Research Vol.18 No.2
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and both disorders affect individuals throughout life. Despite every extensive effort, the interplay among genetic factors, immunological factors, environmental factors and intestinal microbes is still completely unrevealed. Animal models are indispensable to find out mechanistic details that will facilitate better preclinical setting to target specific components involved in the pathogenesis of IBD. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, not only IBD but also colon cancer, obesity, psoriasis as well as allergic disorders, in both human and animal models. Advanced technologies including cell-specific and inducible knockout systems, which are recently employed to mouse IBD models, have further enhanced the ability of developing new therapeutic strategies for IBD. Furthermore, data from these mouse models highlight the critical involvement of dysregulated immune responses and impaired colonic epithelial defense system in the pathogenesis of IBD. In this review, we will explain from the history of animal models of IBD to the recent reports of the latest compounds, therapeutic strategies, and approaches tested on IBD animal models. (Intest Res 2020;18:151-167)
Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
( Emiko Mizoguchi ),( Takayuki Sadanaga ),( Toshiyuki Okada ),( Takanori Minagawa ),( Jun Akiba ) 대한장연구학회 2023 Intestinal Research Vol.21 No.3
Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates, and so on. Our group previously reported that oral administration of CAF efficiently suppressed the development of intestinal inflammation in a dextran sulfate sodium (DSS)-induced murine acute colitis model by suppressing the expression of chitinase 3-like 1, one of the mammalian chitinases without enzymatic activity. Chitinases are hydrolytic enzymes that break down chitin, a polymer of N-acetylglucosamine, and chitinase-like proteins have no enzymatic activity with preserving chitin-binding ability. CAF binds a cleft of the chitinase active site and plays a role as a pan-chitinase inhibitor. Although CAF showed an anti-inflammatory effect in the above model, oral administration of low-dose CAF with 10% sucrose showed potentially neoplastic effects in colonic epithelial cells in a DSS-induced murine chronic colitis model. In this review, we would like to discuss the pros and cons of coffee/CAF in colonic inflammation and neoplasia with an example of pathological finding. (Intest Res 2023;21:306-317)