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Changes in Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Liver of C57BL/6 Mice
Beom Jun Lee,Misun Park,Bang Hyun Kim,Ji Yeon Park,Hai Kwan Jung,Hoil Kang,Chang Yong Yoon 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.4
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic environmental pollutants that cause various biological effects on mammals. The purpose of our study was to identify genes involved in hepatotoxicity and hepatocarcinogenesis induced by TCDD. C57BL/6 mice were injected i.p. with TCDD at various doses of 0, 10, 30, and 100 ㎍/㎏ B.W. The mouse liver was analyzed for gene expression profiles at 4, 24, and 72 h after the treatment of TCDD. The relative liver weight was significantly increased at 72 h after treatment of TCDD at the doses of 30 and 100 ㎍/㎏ B.W (p < 0.05). Although the levels of aspatate aminotransferase and alanine aminotransferase were not showed a change in a dose-dependent manner, the enzyme activities were increased at 4 h after treatment of TCDD. A total of 263 genes were changed at least 3-fold by TCDD compared with the vehicle-treated control; 82 genes were changed by 10 ㎍/㎏ of TCDD, 84 genes changed by 30 ㎍/㎏, and 97 genes changed by 100 ㎍/㎏, respectively. Of these, a total of 24 genes was changed more than 3-fold in common with all the three doses; 14 genes were induced and 10 genes were repressed. The genes altered by TCDD were related to cell cycle, cell proliferation, angiogenesis, apoptosis, immune responses, signal transduction, and cell communication. This comprehensive gene expression analysis suggest that many genes are involved in hepatotoxicity by TCDD and that the change in gene profile may help to clarify the mechanism of hepatotoxicity and hepatocarcinogenesis by TCDD.
직장암 환자의 골반 방사선치료에서 벨리보드 하위 경계 위치 변화의 영향
윤홍인(Hong In Yoon),정윤선(Yoonsun Chung),김주호(Joo Ho Kim),박효국(Hyo Kuk Park),이상규(Sang Kyu Lee),김영석(Young Suk Kim),최윤선(Yunseon Choi),김미선(Misun Kim),이하윤(Hayoon Lee),장지석(Jeesuk Chang),차혜정(Hyejung Cha),성진실(Jins 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.4
목 적: 방광압박도구(bladder compression device) 추가에 따른 벨리보드(belly board) 하위 경계의 위치 변화에 따라 조사체적(irradiated volume) 내의 각 장기의 체적 차이 및 선량체적히스토그람을 분석하여 벨리보드의 하위 경계의 위치가 미치는 영향에 대해 알아보고자 하였다. 대상 및 방법: 2010년 5월부터 2010년 9월까지 직장암으로 수술 전이나 후에 방사선치료를 위해 벨리보드만 사용하여 전산화 단층촬영을 시행한 경우와 방광압박도구를 추가하여 전산화 단층촬영을 재 시행한 10명을 대상으로 후향적으로 분석하였다. 환자의 중앙나이는 64세(범위, 45∼75세)로 조직학적으로 선암 진단을 받고, 수술 전 혹은 후에 동시항암화학방사선요법을 시행받았다. 방광압박도구 사용 전후 각 체적과 조사체적비의 평균비교 및 복강과 골반강의 조사체적의 합과 소장의 체적비와 방광의 체적비 간의 상관관계를 분석하였다. 결 과: 방광압박도구 추가 후 벨리보드 하위 경계는 치골결합 부위에서 허리엉치관절 부위 상방으로 올라갔다. 방광압박도구 사용 후 소장의 조사체적은 174.3±89.5 mL로 사용 전 조사체적 373.3±145.0 mL보다 유의하게 감소하였고 (p=0.001), 복부골반강(abdominopelvic cavity)의 조사체적도 사용 전보다 유의하게 감소하였다(1,282.6±218.7 mL vs. 1,571.9±158 mL, p<0.001). 방광압박도구 사용 전과 후의 치료체적 안의 방광 체적은 사용 후가 전보다 유의하게 증가하였다(222.9±117.9 mL vs. 153.7±95.5 mL, p<0.001). 방광압박도구 사용 후 복부골반강 대 방광의 조사체적비는 33.5±14.7%로 사용 전 조사체적비인 27.5±13.1%보다 유의하게 증가하였고(<0.001),복부골반강 대 소장의 조사체적비는 방광압박도구 사용 후 유의하게 감소하였다(13.9±7.6% vs. 24.2±10.2%, p<0.001). 결 론: 방광압박도구를 추가함으로 인해 벨리보드의 하위 경계를 허리엉치관절 부위 상방으로 올리는 것이 복부골반강 내 방광의 체적을 증가시켜 소장의 조사체적을 감소시킬 수 있음을 확인할 수 있었다. Purpose: We investigated the effect of location changes in the inferior border of the belly board (BB) aperture by adding a bladder compression device (BCD). Materials and Methods: We respectively reviewed data from 10 rectal cancer patients with a median age 64 years (range, 45∼75) and who underwent computed tomography (CT) simulation with the use of BB to receive pelvic radiotherapy between May and September 2010. A CT simulation was again performed with the addition of BCD since small bowel (SB) within the irradiated volume limited boost irradiation of 5.4 Gy using the cone down technique after 45 Gy. The addition of BCD made the inferior border of BB move from symphysis pubis to the lumbosacral junction (LSJ). Results: Following the addition of BCD, the irradiated volumes of SB and the abdominopelvic cavity (APC) significantly decreased (174.3±89.5 mL vs. 373.3±145.0 mL, p=0.001, 1282.6±218.7 mL vs. 1571.9±158 mL, p<0.001, respectively). Bladder volume within the treated volume increased with BCD (222.9±117.9 mL vs. 153.7±95.5 mL, p<0.001). The ratio of irradiated bladder volume to APC volume with BCD (33.5±14.7%) increased considerably compared to patients without a BCD (27.5±13.1%) (p<0.001), and the ratio of irradiated SB to APC volume decreased significantly with BCD (13.9±7.6% vs. 24.2±10.2%, p<0.001). The ratios of the irradiated SB volumeand irradiated bladder volume to APC volume negatively correlated (p=0.001). Conclusion: This study demonstrated that the addition of BCD, which made the inferior border of BB move up to the LSJ, increased the ratio of the bladder to APC volume and as a result, decreased the irradiated volume of SB.
Indirect Effects of Work Stress on Liver Function through Alcohol Use and Body Mass Index
Misun Lee,Ki-Do Eum,Sung-Il Cho,Chang-Bum Byun,Domyung Paek 한국보건교육건강증진학회 2007 한국보건교육·건강증진학회 학술대회 발표논문집 Vol.- No.-
This study designed to examine whether stress at work aggregate the liver function. The indirect effects of effort on liver function were significant through elevated alcohol consumption and increased BMI. Stressful psychosocial work environment may play an adverse role in liver function through alcohol-mediated increase in BMI.
MiSun Lee,SooYoung Bhang,CheolSoon Lee,HyoungYoon Chang,JiYoun Kim,JuHyun Lee,Eunji Kim,SeungMin Bae,JangHo Park,HyeJin Kim,JunWon Hwang 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-The goal of this study was to describe the psychiatric symptoms in the teachers from Danwon High School who were exposed to the sinking of the Motor Vessel Sewol. Methods-Data were collected from 32 teachers who underwent psychiatric interventions by 16 volunteer psychiatrists for 3 months after the sinking of the Motor Vessel Sewol. Results-The most commonly diagnosed clinical diagnosis in the teachers were normal reaction, acute stress disorder and adjustment disorder. Psychiatric symptoms including anxiety, depressed mood and sleep disturbances were also observed. Conclusion-In the acute aftermath of the Sewol Ferry sinking on April 16, 2014, psychiatrists volunteered to provide professional psychiatric interventions to Danwon High School teachers. These results suggest the importance of crisis intervention focused on the teachers who are exposed to disasters. The implications for future research and interventions are discussed.
( Misun Yang ),( Jin Wha Choi ),( Ji Sook Kim ),( So Yoon Ahn ),( Se In Sung ),( Yun Sil Chang ),( Won Soon Park ) 대한주산의학회 2018 Perinatology Vol.29 No.3
Objective: The purpose of this study is to compare the clinical characteristics of newborn hearing test results between infants in well-baby nursery (WBN) versus neonatal intensive care unit (NICU) and to determine the optimal strategies of hearing screening for each group. Methods: A total of 2,161 newborns admitted to WBN and NICU were enrolled in this retrospective cohort study. Automated audio brainstem response was used for hearing screening test. The screening rates, referral rates, prevalence rates, false positive rates and predictive positive value (PPV) were analyzed for infants in WBN and NICU. Results: The referral rates of the screening test were 2.2% and 5.0% in WBN and NICU groups (P<0.01); the prevalence rate of congenital hearing loss (HL) were 0.5% and 4.6% in the WBN and NICU groups (P<0.01). The false positive rates and PPV of screening test were 0.9% and 36.8% in WBN; 0.8% and 80% in NICU. Infants with bilateral refer results in both WBN and NICU were at the higher risk of congenital HL, compared with infants with unilateral refer results in WBN who were mostly confirmed to have false positive. Conclusion: The infants in WBN showed high unilateral referral rate with low prevalence rate of HL. However, the infants with bilateral refer results in WBN and uni- or bi-lateral refer results in NICU had higher prevalence rate of HL, compared with those with unilateral refer results in WBN. Different strategies for hearing screening might be considered in infants in WBN and NICU.