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Park, Gyeong-Su,Kwon, Hyuksang,Kwak, Dong Wook,Park, Seong Yong,Kim, Minseok,Lee, Jun-Ho,Han, Hyouksoo,Heo, Sung,Li, Xiang Shu,Lee, Jae Hak,Kim, Young Hwan,Lee, Jeong-Gun,Yang, Woochul,Cho, Hoon Young American ChemicalSociety 2012 Nano letters Vol.12 No.3
<P>We report on rapid thermal chemical vapor depositiongrowth of silicon nanowires (Si NWs) that contain a high density ofgold nanoclusters (Au NCs) with a uniform coverage over the entirelength of the nanowire sidewalls. The Au NC-coated Si NWs with anantibody-coated surface obtain the unique capability to capture breastcancer cells at twice the highest efficiency currently achievable(∼88% at 40 min cell incubation time) from a nanostructuredsubstrate. We also found that irradiation of breast cancer cells capturedon Au NC-coated Si NWs with a near-infrared light resulted in a highmortality rate of these cancer cells, raising a fine prospect forsimultaneous capture and plasmonic photothermal therapy for circulatingtumor cells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-3/nl2045759/production/images/medium/nl-2011-045759_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2045759'>ACS Electronic Supporting Info</A></P>
Minseok Son,Dongwook Hwang,Jaemoon Jung,Jungmin Park,Woojin Park 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.11
Objective: This study evaluated and compared two methods for gesture design, that is, the method of utilizing sign language gestures and that of using user created gestures. Three evaluation criteria were employed: intuitiveness, preference and physical stress. The objective was to evaluate the possible utility of sign language gestures in gesture design. Background: A number of methods have been developed for designing gestures. They include: design by experts or system designers, computer generation of gestures and using user created gestures. Adopting existing sign language gestures may be considered as an alternative as it has a couple of distinct advantages: first, the existing sign languages are complete human languages rich in vocabulary and expressions; thus, utilizing them may provide an easy means for developing large gesture vocabularies and continually extending them. Second, utilizing existing sign languages will allow disabled individuals to quickly adopt newly developed gesture-based interaction systems. Method: Eight university students designed gestures for a set of 22 commands; the design was conducted without using any references. Also, the Korean and American sign language gestures for the 22 commands were found from sign language dictionaries. Ten individuals who were blind to both the user created gestures and sign language gestures, evaluated the designed gestures in intuitiveness, preference and physical stress. The Borg CR-10 scale was used to evaluate intuitiveness and preference. A modified version of RULA was utilized to assess physical stress. Results: Significant differences were found between the two gesture design methods in intuitiveness and physical stress. Conclusion: It is necessary to explore new gesture design methods that overcome the limitations of sign language gestures while retaining their distinct advantages. Application: The study results suggest possible directions for developing new methodologies for gesture design.
Park, MinSeok,Kim, Gi-sub,Ji, Young Hoon,Jung, Min-sun,Kim, Kum Bae,Jung, Haijo Nuclear Technology Publishing 2014 Radiation Protection Dosimeetry Vol.158 No.2
<P>This work proposes the basic reference data of occupational dose management and statistical dose distribution with the classification of radiation work groups though analysis of occupational dose distribution. Data on occupational radiation exposure from medical and scientific usage of radiation in Korea Institute of Radiological and Medical Sciences for the years 2002–11 are presented and evaluated with the characteristic tendency of radiation working groups. The results of occupational radiation exposure were measured by personal dosemeters. The monitored occupational exposure dose data were evaluated according to the average effective dose and collective dose. The most annual average effective dose for all occupational radiation workers was under 1 mSv. Considering the dose distribution of each department, most overexposure workers worked in radiopharmaceutical product facilities, nuclear medicine department and radiation oncology department. In addition, no monitored workers were found to have received an occupational exposure over 50 mSv in single year or 100 mSv in this period. Although the trend of occupational exposure was controlled <1 mSv after 2007 and the radiation protection status was sufficient, it was consistently necessary to optimise and reduce the occupational radiation exposure.</P>
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
Park, Min Hee,Lee, Ju Youn,Park, Kang Ho,Jung, In Kyung,Kim, Kyoung-Tae,Lee, Yong-Seok,Ryu, Hyun-Hee,Jeong, Yong,Kang, Minseok,Schwaninger, Markus,Gulbins, Erich,Reichel, Martin,Kornhuber, Johannes,Ya Elsevier 2018 Neuron Vol.100 No.1
<P><B>Summary</B></P> <P>Although many reports have revealed dysfunction of endothelial cells in aging, resulting in blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to be explored. Here, we find that acid sphingomyelinase (ASM) is a critical factor for regulating brain endothelial barrier integrity. ASM is increased in brain endothelium and/or plasma of aged humans and aged mice, leading to BBB disruption by increasing caveolae-mediated transcytosis. Genetic inhibition and endothelial-specific knockdown of ASM in mice ameliorated BBB breakdown and neurocognitive impairment during aging. Using primary mouse brain endothelial cells, we found that ASM regulated the caveolae-cytoskeleton interaction through protein phosphatase 1-mediated ezrin/radixin/moesin (ERM) dephosphorylation and apoptosis. Moreover, mice with conditional ASM overexpression in brain endothelium accelerated significant BBB impairment and neurodegenerative change. Overall, these results reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ASM activity is upregulated in brain and/or plasma of aged humans and mice </LI> <LI> Brain endothelial cell is a main contributor of increased ASM in aging </LI> <LI> Increased ASM in aging causes BBB impairment and neuronal dysfunction </LI> <LI> It is regulated by caveolae-mediated transcytosis and ERM dephosphorylation </LI> </UL> </P>
Park, Jong-Myeon,Kim, Minseok S.,Moon, Hui-Sung,Yoo, Chang Eun,Park, Donghyun,Kim, Yeon Jeong,Han, Kyung-Yeon,Lee, June-Young,Oh, Jin Ho,Kim, Sun Soo,Park, Woong-Yang,Lee, Won-Yong,Huh, Nam American Chemical Society 2014 ANALYTICAL CHEMISTRY - Vol.86 No.8
<P>Full automation with high purity for circulating tumor cell (CTC) isolation has been regarded as a key goal to make CTC analysis a “bench-to-bedside” technology. Here, we have developed a novel centrifugal microfluidic platform that can isolate the rare cells from a large volume of whole blood. To isolate CTCs from whole blood, we introduce a disc device having the biggest sample capacity as well as manipulating blood cells for the first time. The fully automated disc platform could handle 5 mL of blood by designing the blood chamber having a triangular obstacle structure (TOS) with lateral direction. To guarantee high purity that enables molecular analysis with the rare cells, CTCs were bound to the microbeads covered with anti-EpCAM to discriminate density between CTCs and blood cells and the CTCs being heavier than blood cells were only settled under a density gradient medium (DGM) layer. To understand the movement of CTCs under centrifugal force, we performed computational fluid dynamics simulation and found that their major trajectories were the boundary walls of the DGM chamber, thereby optimizing the chamber design. After whole blood was inserted into the blood chamber of the disc platform, size- and density-amplified cancer cells were isolated within 78 min, with minimal contamination as much as approximately 12 leukocytes per milliliter. As a model of molecular analysis toward personalized cancer treatment, we performed epidermal growth factor receptor (EGFR) mutation analysis with HCC827 lung cancer cells and the isolated cells were then successfully detected for the mutation by PCR clamping and direct sequencing.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2014/ancham.2014.86.issue-8/ac403456t/production/images/medium/ac-2013-03456t_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac403456t'>ACS Electronic Supporting Info</A></P>
Park, MinSeok,Yoo, Jaeryong,Ha, Wi-Ho,Park, Sunhoo,Jin, Young Woo Pergamon Press 2018 Health physics Vol.114 No.3
<P>The examination of internal contamination is important for providing an adequate medical response during a radiological emergency. A whole-body counting system can assess gamma-emitting radionuclides in a human body when monitoring internal contamination. It is necessary to calibrate whole-body counting systems by using a calibration phantom, such as a Bottle Manikin Absorption phantom, to properly assess internal contamination. However, the total weight of the Bottle Manikin Absorber phantom is high, and there can be leakage of radioactive sources, which are disadvantages of using such a phantom. This study proposes a calibration phantom that is designed to overcome these disadvantages. The proposed phantom consists of rod sources that are inserted in each part of the phantom. The counting efficiency of the rod-source-inserted calibration phantom was acquired using a Monte Carlo simulation method, but the results were evaluated by comparing the experimental efficiencies with those of a conventional Bottle Manikin Absorption phantom by using two commercial whole-body counting systems (stand-up type and bed type). The efficiency curve of the rod-source-inserted phantom matched well that of the conventional calibration phantom. The relative deviation between the efficiencies of the conventional Bottle Manikin Absorption phantom and the proposed calibration phantom in both whole-body counting systems was less than 11%, and the total weight of the phantom was also reduced. These results suggest that the proposed phantom can be manipulated more easily and replace the conventional Bottle Manikin Absorption calibration phantom for these two types of whole-body counting systems.</P>