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Methylation Profiles of CpG Island Loci in Major Types of Human Cancers
Eun Joo Yu,이선,강경훈,김백희,Nam Yun Cho,Minhee Choi,Jeong Ho Kim,박석연 대한의학회 2007 Journal of Korean medical science Vol.22 No.2
Several reports have described aberrant methylation in various types of human cancers. However, the interpretation of methylation frequency in various human cancers has some limitations because of the different materials and methods used for methylation analysis. To gain an insight into the role of DNA hypermethylation in human cancers and allow direct comparison of tissue specific methylation, we generated methylation profiles in 328 human cancers, including 24 breast, 48 colon, 61 stomach, 48 liver, 37 larynx, 24 lung, 40 prostate, and 46 uterine cervical cancer samples by analyzing CpG island hypermethylation of 13 genes using methylation- specific PCR. The mean numbers of methylated genes were 6.5, 4.4, 3.6, 3.4, 3.1, 3.1, 3.1, and 2.1 in gastric, liver, prostate, larynx, colon, lung, uterine cervix, and in breast cancer samples, respectively. The number of genes that were methylated at a frequency of more than 40% in each tumor type ranged from nine (stomach) to one (breast). Generally genes frequently methylated in a specific cancer type differed from those methylated in other cancer types. The findings indicate that aberrant CpG island hypermethylation is a frequent finding in human cancers of various tissue types, and each tissue type has its own distinct methylation pattern.
다양한 색 조합이 가능한 시뮬레이션 립 팔레트에 대한 연구
강민희(Minhee Kang),박소라(Sora Park),홍주표(Joo-Pyo Hong) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
This study suggests the color simulation lip palette as a color mixing device. According to the consumer behavior survey, women in their 20`s were most interested in appearance. They tend to buy new cosmetics every time they follow the trend and focus on color makeup that can change their impressions. Also respondents said they thought the color makeup products they use on their lips were the most important. They carry three to five lipsticks on average, wanting a variety of colors, while the number of lipsticks they carry is limited. Lip palettes for color mixing are on the market, but insufficient to them. In this regard, we designed a color simulation and mixing device to eliminate the hassle of choosing multiple colors and to allow users to create desired colors at once. Choosing a color from the circular color panel displayed on the top of the product triggers mixing of pigments inside the device according to the ratio of colors. We believe this multi color simulation lip palette have the potential for the new cosmetics market.
Distinct Protein Expression Profiles of Solid-Pseudopapillary Neoplasms of the Pancreas
Park, Minhee,Lim, Jong-Sun,Lee, Hyoung-Joo,Na, Keun,Lee, Min Jung,Kang, Chang Moo,Paik, Young-Ki,Kim, Hoguen American Chemical Society 2015 Journal of proteome research Vol.14 No.8
<P>Solid-pseudopapillary neoplasm (SPN) is an uncommon pancreatic tumor with mutation in <I>CTNNB1</I> and distinct clinical and pathological features. We compared the proteomic profiles of SPN to mRNA expression. Pooled SPNs and pooled non-neoplastic pancreatic tissues were examined with high-resolution mass spectrometry. We identified 329 (150 up-regulated and 179 down-regulated) differentially expressed proteins in SPN. We identified 191 proteins (58.1% of the 329 dysregulated proteins) with the same expression tendencies in SPN based on mRNA data. Many overexpressed proteins were related to signaling pathways known to be activated in SPNs. We found that several proteins involved in Wnt signaling, including DKK4 and β-catenin, and proteins that bind β-catenin, such as FUS and NONO, were up-regulated in SPNs. Molecules involved in glycolysis, including PKM2, ENO2, and HK1, were overexpressed in accordance to their mRNA levels. In summary, SPN showed (1) distinct protein expression changes that correlated with mRNA expression, (2) overexpression of Wnt signaling proteins and proteins that bind directly to β-catenin, and (3) overexpression of proteins involved in metabolism. These findings may help develop early diagnostic biomarkers and molecular targets.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2015/jprobs.2015.14.issue-8/acs.jproteome.5b00423/production/images/medium/pr-2015-00423a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr5b00423'>ACS Electronic Supporting Info</A></P>
Effect of Microwave Irradiation Time on Microwave-Assisted Weak Acid Protein Hydrolysis
Kim, Dahee,Joo, Minhee,Lee, Dabin,Nguyen, Huu-Quang,Kim, Jeongkwon Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.3
Horse heart myoglobin (MYG) and bovine serum albumin (BSA) were hydrolyzed by microwave-assisted weak-acid hydrolysis for 10, 20, 30, 40, 50, and 60 min using 2% formic acid (FA) at $100^{\circ}C$. Generally, the number of identified peptides increased with increasing irradiation time, indicating that the duration of microwave irradiation is linked to the efficiency of hydrolysis. For MYG, irradiation for 60 min provided the highest number of identified peptides, the greatest sequence coverage values and the highest MASCOT score values among the investigated irradiation times. Irradiation of BSA for 50 min, however, yielded a greater number of peptides than irradiation for 60 min due to the generation of miscleaved peptides after microwave irradiation for 50 min.
Benzo(a)pyrene represses melanogenesis in B16F10 mouse melanoma cells
Da Hye Joo,Hwa Jun Cha,Karam Kim,Minhee Jung,Jung Min Ko,In Sook An,Sung Nae Lee,Hyun Hee Jang,Seunghee Bae,Nam Kyung Roh,Kyu Joong Ahn,Sungkwan An 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.3
Benzo(a)pyrene (BaP) is a chemically based polycyclic aromatic hydrocarbon (PAH) that is readily absorbed by the skin. BaP is metabolized to BaP-diolepoxide by cytochromes P-450 1A1/2 (CYP1A1/2) and cytochromes P-450 1B1 (CYP1B1) in the cytosol. BaP and its metabolites induce genotoxicity and cancer. Although BaP easily accumulates in melanin-containing tissues as well as other tissue types, the effects of BaP on melanocytes are not fully understood. Here, we show that 40-100 μM BaP represses melanin synthesis in B16F10 cells. The decrease of melanin contents is induced by tyrosinase activity in BaP-exposed B16F10. However, this repression of melanin synthesis is not induced by direct inhibition of tyrosinase in in vitro assay. Therefore, we show whether BaP regulated melanin synthesis-related enzyme. BaP regulates melanin synthesis by Tyr and Tyrp1 expression. In addition, these genes expression is down-regulated by Mitf repressed by BaP. Importantly, the repression was provoked in the absence and presence of α-melanocyte stimulating hormone (α-MSH). Therefore, we hypothesize BaP interrupts the UV protection mechanism by repressing melanin synthesis in the skin. Taken together our results have revealed new side effects that exposure of BaP abolished melanin synthesis in melanocytes.
Effect of Microwave Irradiation Time on Microwave-Assisted Weak Acid Protein Hydrolysis
Dahee Kim,Minhee Joo,Dabin Lee,NGUYEN HUU QUANG,김정권 사단법인 한국질량분석학회 2019 Mass spectrometry letters Vol.10 No.3
Horse heart myoglobin (MYG) and bovine serum albumin (BSA) were hydrolyzed by microwave-assisted weak-acid hydrolysis for 10, 20, 30, 40, 50, and 60 min using 2% formic acid (FA) at 100°C. Generally, the number of identified peptides increased with increasing irradiation time, indicating that the duration of microwave irradiation is linked to the efficiency of hydrolysis. For MYG, irradiation for 60 min provided the highest number of identified peptides, the greatest sequence coverage values and the highest MASCOT score values among the investigated irradiation times. Irradiation of BSA for 50min, however, yielded a greater number of peptides than irradiation for 60 min due to the generation of miscleaved peptides after microwave irradiation for 50min.