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Colorectal Cancer Concealment Predicts a Poor Survival: A Retrospective Study
Li, Xiao-Pan,Xie, Zhen-Yu,Fu, Yi-Fei,Yang, Chen,Hao, Li-Peng,Yang, Li-Ming,Zhang, Mei-Yu,Li, Xiao-Li,Feng, Li-Li,Yan, Bei,Sun, Qiao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Objectives: Understanding the situation of cancer awareness which doctors give to patients might lead to prognostic prediction in cases of of colorectal cancer (CRC). Methods: Subsets of 10,779 CRC patients were used to screen the risk factors from the Cancer Registry in Pudong New Area in cancer awareness, age, TNM stage, and gender. Survival of the patients was calculated by the Kaplan-Meier method and assessed by Cox regression analysis. The views of cancer awareness in doctors and patients were surveyed by telephone or household. Results: After a median observation time of 1,616 days (ranging from 0 to 4,083 days) of 10,779 available patients, 2,596 of the 4,561 patients with cancer awareness survived, whereas 2,258 of the 5,469 patients without cancer awareness and 406 of the 749 patients without information on cancer awareness died of the disease. All-cause and cancer-specific survival were poorer for the patients without cancer awareness than those with (P < 0.001 for each, log-rank test). Cox multivariate regression analysis showed that cancer concealment cases had significantly lower cancer-specific survival (hazard ratio (HR) = 1.299; 95 % confidence interval (CI): 1.200-1.407)and all-cause survival (HR = 1.324; 95 % CI: 1.227-1.428). Furthermore, attitudes of cancer awareness between doctors and patients were significantly different (P < 0.001). Conclusion: Cancer concealment, not only late-stage tumor and age, is associated with a poor survival of CRC patients.
Dysregulated Fatty Acid Metabolism in Hepatocellular Carcinoma
( Ming-da Wang ),( Jun Han ),( Hao Xing ),( Han Zhang ),( Zheng Wang ),( Zhen-li Li ),( Liang Lei ),( Chao Li ),( Feng Shen ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Studies are urgently needed on it molecular pathogenesis and biological characteristics of hepatocellular carcinoma (HCC). Dysregulation of fatty acid (FA) metabolism, in which aberrant activation of oncogenic signaling pathways alters the expression and activity of lipid-metabolizing enzymes, is an emerging hallmark of cancer cells, and it may be involved in HCC development and progression. Methods: We summarize the characteristics of FA metabolism in HCC, focusing on the pathways of FA synthesis, oxidation, uptake and transport. We also provide a brief review of the relationship between NAFLD and HCC development. Results: The current review summarizes the dysregulated FA metabolism in HCC and pathways through which this dysregulation may regulate HCC survival and growth. Aberrant activation of oncogenic signaling pathways regulates the expression and activity of lipid-metabolizing enzymes, thus reprogramming FA metabolism to promote HCC development and progression. Intracellular FAs are required for biosynthesis of most biological membrane lipids and signaling molecules, and are also used to provide energy to support HCCs survival and proliferation, when necessary, through β-oxidation process. HCC cells can employ appropriate metabolic pathways as different situation demands. Intrahepatic cholangiocarcinoma (ICC) and HCC exhibits differential requirement for de novo lipogenesis and distinct response to therapeutic approaches focusing on inhibition of exogenous FA uptake. Non-alcoholic fatty liver disease related obesity and diabetes have increasingly emerged as two major factors responsible for the rise in prevalent of HCC. Conclusions: Our understanding of dysregulated FA metabolism and associated signaling pathways may contribute to the development of novel and efficient anti-tumor approaches for patients with HCC.
A Comparative Study on High School Students" Mathematical Modeling Cognitive Features
( Ming Zhen Li ),( Yu Ting Hu ) 한국수학교육학회 2012 수학교육연구 Vol.16 No.2
Comparative studies on mathematical modeling cognition feature were carried out between 15 excellent high school third-grade science students (excellent students for short) and 15 normal ones (normal students for short) in China by utilizing protocol analysis and expert-novice comparison methods and our conclusions have been drawn as below. 1. In the style, span and method of mathematical modeling problem representation, both excellent and normal students adopted symbolic and methodological representation style. However, excellent students use mechanical representation style more often. Excellent students tend to utilize multiple-representation while normal students tend to utilize simplicity representation. Excellent students incline to make use of circular representation while normal students incline to make use of one-way representation. 2. In mathematical modeling strategy use, excellent students tend to tend to use equilibrium assumption strategy while normal students tend to use accurate assumption strategy. Excellent students tend to use sample analog construction strategy while normal students tend to use real-time generation construction strategy. Excellent students tend to use immediate self-monitoring strategy while normal students tend to use review-monitoring strategy. Excellent students tend to use theoretical deduction and intuitive judgment testing strategy while normal students tend to use data testing strategy. Excellent students tend to use assumption adjustment and modeling adjustment strategy while normal students tend to use model solving adjustment strategy. 3. In the thinking, result and efficiency of mathematical modeling, excellent students give brief oral presentations of mathematical modeling, express themselves more logically, analyze problems deeply and thoroughly, have multiple, quick and flexible thinking and the utilization of mathematical modeling method is shown by inspiring inquiry, more correct results and high thinking efficiency while normal students give complicated protocol material, express themselves illogically, analyze problems superficially and obscurely, have simple, slow and rigid thinking and the utilization of mathematical modeling method is shown by blind inquiry, more fixed and inaccurate thinking and low thinking efficiency.
볼록형 와이어 직조 카고메 트러스 PCM의 압축특성평가
이명진(Ming-Zhen Li),강기주(Ki-Ju Kang) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
Recently, a new periodic cellular metal(PCM) named as Wire wove Bulk Kagome(WBK) was introduced. Based on the shape of tetrahedra composing a WBK, WBKs are classified into two types, namely, concave and convex type. They are easily differentiated by changing the assembling sequence. The effect of geometrical parameters such as the wire diameter, strut length and number of layers on the compressive behavior of concave type WBK has already been investigated. In this work, the similar works were performed with the convex type WBKs. It was shown that the compressive strength of the convex type WBK was quite similar to that of the concave type. The compressive strengths of convex type specimens also depend on the slenderness ratio, but a little different from those of concave type specimens in the detailed behavior. And densification occurs earlier than the concave type WBK.
Xiao-li Chen,,Tian-wu Chen,Zhi-jia Fang,Xiao-ming Zhang,Zhen-lin Li,Hang Li,Hong-jie Tang,Li Zhou,Dan Wang,Zishu Zhang 대한의학회 2014 Journal of Korean medical science Vol.29 No.2
The aim of this study was to investigate how patterns of lymph nodes recurrence after radical surgery impact on survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma. One hundred eighty consecutive patients with thoracic esophageal squamous cell carcinoma underwent radical surgery, and the tumors were staged as pT1-3N0M0 by postoperative pathology. Lymph nodes recurrence was detected with computed tomography 3-120 months after the treatment. The patterns of lymph nodes recurrence including stations, fields and locations of recurrent lymph nodes, and impacts on patterns of survival were statistically analyzed. There was a decreasing trend of overall survival with increasing stations or fields of postoperative lymph nodes involved (all P<0.05). Univariate analysis showed that stations or fields of lymph nodes recurrence, and abdominal or cervical lymph nodes involved were prognostic factors for survival(all P<0.05). Cox analyses revealed that the field was an independent factor (P<0.05, odds ratio=2.73). Lymph nodes involved occurred predominantly in cervix and upper mediastinum (P<0.05). In conclusion, patterns of lymph node recurrence especially the fields of lymph nodes involved are significant prognostic factors for survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma.
새로운 다공질 구조체 제안, WBK-MHS 복합체의 압축 특성평가
이명진(Ming-Zhen Li),Gunter Stephani,강기주(Ki-Ju Kang) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
Ultra-light materials with open, periodic cell structures are studied by many scientists, because of their potential multi-functionality. Our research group invented the new cellular metal named WBK, fabricated with helical forming wires, and has investigated the performance of the WBK. It has been found that WBK fails by buckling of struts composing WBK. Therefore, for enhancing the resistance against buckling, this work suggests a new idea, that is WBK comprising metal hollow spheres (MHSs) in the inner space, which is named WBK-MHS hybrids. The reason of selecting MHS is that, it also had ultra light weight and high energy absorption. The compressive properties of WBK-MHS hybrid have been investigated and compared to other competitive structures. From the result, the maximum stress and energy absorption are much enhanced in comparison with simple addition of those of the corresponding stand-alone WBK and MHS. The result is attributed to suppression of buckling of struts composing WBK and uniforms deformation over the entire components. The WBK-MHS hybrids out performs competitors in the mechanical performance. Its means Hybrid WBK can widely apply to industry just like car impact bar, bumper and so on.