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Two-way open innovation and firm growth: the moderating effect of external environment
Ling Zhang,Mian-Bin Zheng 기술경영경제학회 2016 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.24 No.1
A few researchers have studied the relationship of open innovation and firm performance, butthe results are controversial. One of the reasons for this inconsistence may be the ignorance ofthe impact on the external environment. Under the context of open innovation, innovationactivities are divided into inbound open innovation and outbound open innovation. Basedon a sample of 224 Chinese entrepreneurs from the Pearl River Delta and Yangtze RiverDelta, the relationship between the two kinds of open innovation and firm growth isdiscussed, and how this relationship is being affected by environment competitiveness (EC)and environment munificence (EM) is explored. Results show that both the inbound openand outbound open innovations have a positive effect on firm growth. Both EC and EMweaken the relationship between inbound open and firm growth. The study also finds anegative effect of both EC and EM on the relationship between outbound open innovationand firm growth significantly. Limitations and suggestions are proposed for future researchon the implementation of open innovation under different circumstances.
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Liang Li,Mian Zheng 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.2
To gain the insights into the influence of the morphology of solid particles on rheological behavior of semisolid metal slurries, the time evolution of Hausdorff dimensionality describing the particle morphology is deduced in order to quantitatively analyze the time evolution of the particle morphology. In consideration of the role of the liquid entrapped by non-spherical solid particles, the non-spherical solid particles with the entrapped liquid are treated as spherical solid particles, and the equivalent solid volume fraction is defined as the sum of solid volume fraction and the volume fraction of the entrapped liquid. This model could be used to analyze the rheological behavior of the semisolid metal slurries containing the non-spherical particles with Hausdorff dimensionality less than 3. Moreover, the rheological behavior of semisolid magnesium alloy AZ91D is theoretically analyzed by this model during isothermal shearing and continuous cooling. The calculated results are found coinciding with the experimental results and the calculated results also reveal that the shear rate and cooling rate could influence the rheological behavior of semisolid metal slurries by changing the morphology of solid particles except by affecting agglomeration degree.
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Zhou, Zhengkui,Jiang, Yu,Wang, Zheng,Gou, Zhiheng,Lyu, Jun,Li, Weiyu,Yu, Yanjun,Shu, Liping,Zhao, Yingjun,Ma, Yanming,Fang, Chao,Shen, Yanting,Liu, Tengfei,Li, Congcong,Li, Qing,Wu, Mian,Wang, Min,Wu, Nature Publishing Group, a division of Macmillan P 2015 Nature biotechnology Vol.33 No.4
Understanding soybean (Glycine max) domestication and improvement at a genetic level is important to inform future efforts to further improve a crop that provides the world's main source of oilseed. We detect 230 selective sweeps and 162 selected copy number variants by analysis of 302 resequenced wild, landrace and improved soybean accessions at >11× depth. A genome-wide association study using these new sequences reveals associations between 10 selected regions and 9 domestication or improvement traits, and identifies 13 previously uncharacterized loci for agronomic traits including oil content, plant height and pubescence form. Combined with previous quantitative trait loci (QTL) information, we find that, of the 230 selected regions, 96 correlate with reported oil QTLs and 21 contain fatty acid biosynthesis genes. Moreover, we observe that some traits and loci are associated with geographical regions, which shows that soybean populations are structured geographically. This study provides resources for genomics-enabled improvements in soybean breeding.
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Wang Qi,Dai Huajie,Hou Tianzhichao,Hou Yanan,Wang Tiange,Lin Hong,Zhao Zhiyun,Li Mian,Zheng Ruizhi,Wang Shuangyuan,Lu Jieli,Xu Yu,Liu Ruixin,Ning Guang,Wang Weiqing,Bi Yufang,Zheng Jie,Xu Min 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3
Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites. Results Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In the two-step MR, <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family, <i>Desulfovibrio</i> genus, apolipoprotein A1 (ApoA1), phospholipids in high-density lipoprotein (HDL_PL), and the ratio of apolipoprotein B to ApoA1 (ApoB/ApoA1) were causally associated with stroke (all <i>P</i><0.044). The causal associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were validated using the weighted median method in an independent cohort. The three GM taxa were all positively associated with ApoA1 and HDL_PL, whereas <i>Desulfovibrio</i> genus was negatively associated with ApoB/ApoA1 (all <i>P</i><0.010). Additionally, the causal associations between the three GM taxa and ApoA1 remained significant after correcting for the false discovery rate (all q-values <0.027). Multivariable MR showed that the associations between <i>Bifidobacteriales</i> order, <i>Bifidobacteriaceae</i> family and stroke were mediated by ApoA1 and HDL_PL, each accounting for 6.5% (<i>P</i>=0.028) and 4.6% (<i>P</i>=0.033); the association between <i>Desulfovibrio</i> genus and stroke was mediated by ApoA1, HDL_PL, and ApoB/ApoA1, with mediated proportions of 7.6% (<i>P</i>=0.019), 4.2% (<i>P</i>=0.035), and 9.1% (<i>P</i>=0.013), respectively. Conclusion The current MR study provides evidence supporting the causal relationships between several specific GM taxa and stroke and potential mediating metabolites.
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