Effect of Gas Sensing Properties by Sn-Rh Codoped ZnO Nanosheets

Ziwei Chen,Zhidong Lin,Mengying Xu,Yuyuan Hong,Na Li,Ping Fu,Ze Chen 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.3

The hierarchically porous Sn-Rh codoped ZnO, Sn-doped ZnO and pureZnO nanosheets have been successfully synthesized through a simplehydrothermal reaction process without any surfactant or template at 180°C. The morphology and composition were carefully characterized by X-raydiffraction, energy dispersive X-ray spectrometer, field emission scanningelectronic microscopy and BET. The gas-sensing testing results indicatedthat the Sn-Rh codoped ZnO nanosheets, with the specific surface area was26.9 m2/g, exhibited enhanced gas-sensing performance compared withthat of pure ZnO and Sn-doped ZnO. The high sensitivity of the sensorbased on Sn-Rh codoped ZnO was 149.38 to 100 ppm ethanol and thedetection limit was less than 5 ppm (5.8). The response and recovery timeswere measured to be ~3 s and ~10 s when exposed to 100 ppm ethanol atthe test temperature of 300°C. The good sensing performance of the Sn-Rhcodoped ZnO sensor indicated that hierarchically porous Sn-Rh codopedZnO could be a promising candidate for highly sensitive gas sensors.

TFPI inhibits breast cancer progression by suppressing ERK/p38 MAPK signaling pathway

Xing Mengying,Yang Ying,Huang Jiaxue,Fang Yaqun,Jin Yucui,Li Lingyun,Chen Xiang,Zhu Xiaoxia,Ma Changyan 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: Tissue factor pathway inhibitor-1 (TFPI) is a serine protease inhibitor, which is responsible for inactivating TF-induced coagulation. Recently, increasing studies revealed that TFPI was lowly expressed in tumor cells and exhibited the antitumor activity. Objective: The aim of this study was to explore the role and underlying molecular mechanisms of TFPI in breast cancer. Methods: The expression and prognostic value of TFPI were analyzed using UALCAN and Kaplan-Meier plotter website. The expression level of TFPI in breast cancer tissues and cells was examined by immunohistochemistry (IHC) and western blot analysis, respectively. Cellular proliferation was evaluated by CCK-8 and colony formation assays. Cell migration and invasion were determined by transwell assay. The methylation level of TFPI promoter was determined by methylation-specific PCR. Results: TFPI expression was significantly lower in breast cancer tissues and cells compared to normal breast tissues and normal breast cells. Patients with low TFPI levels showed worse overall survival (OS). Furthermore, overexpression of TFPI significantly inhibited the proliferation, migration and invasion of breast cancer cells. Conversely, knockdown of TFPI promoted the proliferation, migration and invasion of breast cancer cells. Mechanistically, TFPI inhibited the ERK/p38 MAPK signaling pathway in breast cancer. Moreover, DNA hypermethylation of TFPI promoter was responsible for the downregulation of TFPI in breast cancer cells. Conclusion: TFPI inhibited breast cancer cell proliferation, migration and invasion through inhibition of the ERK/p38 MAPK signaling pathway, suggesting that TFPI may serve as a novel prognostic biomarker and therapeutic target for breast cancer.

The Multi-objective VM Resource Scheduling by Using an Improved PSO Algorithm in the Cloud Data Center

Shengjun Xue,Jingyi Chen,Mengying Li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

With the exponential increase of the cloud business volume, Data center occurs load imbalance caused by some physical machine inefficiency due to the diversity of users requirements. Therefore the cloud datacenter need an appropriate algorithm to balance the PMs load and ensure the resource utilization in the cloud datacenter. The paper defines and formulates the problem parameters and proposes a Multi-objective Discrete Particle Swarm Optimization (MDPSO) to schedule the resources to the VMs requests according to the requirements. The simulation shows that the MDPSO algorithm not only guarantees the resource utilization, but also insures the PMs Load balance.

m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis

Yang Jiashu,Zhang Ming,Yang Dawei,Ma Yunfei,Tang Yuting,Xing Mengying,Li Lingyun,Chen Li,Jin Yucui,Ma Changyan 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Long noncoding RNAs (lncRNAs) have emerged as important regulators of osteoarthritis (OA), but the biological roles and clinical significance of most lncRNAs in OA are not fully understood. Microarray analysis was performed to identify differentially expressed lncRNAs, mRNAs, and miRNAs between normal and osteoarthritic cartilage. We found that AC008440.5 (abbreviated AC008), as well as AQP1 and ANKH, were highly expressed in osteoarthritic cartilage, whereas miR-328-3p was expressed at a low level in osteoarthritic cartilage. Functional assays showed that ectopic expression of AC008, AQP1, and ANKH significantly decreased chondrocyte viability and promoted chondrocyte apoptosis and extracellular matrix (ECM) degradation, whereas knockdown of AC008, AQP1, and ANKH resulted in the opposite effects. Moreover, miR-328-3p overexpression increased chondrocyte viability and attenuated chondrocyte apoptosis and ECM degradation, whereas inhibition of miR-328-3p resulted in the opposite effects. Bioinformatics analysis, RNA immunoprecipitation (RIP), and luciferase assays revealed that AC008 functioned as a competing endogenous RNA (ceRNA) to regulate miR-328-3p, which specifically targeted the AQP1 and ANKH genes. In addition, miR-328-3p significantly ameliorated MIA-induced OA, whereas AC008 accelerated OA progression in vivo. Furthermore, fat mass and obesity-associated (FTO)-mediated N6-methyladenosine demethylation downregulated AC008 transcription, while lower FTO expression led to upregulation of AC008 transcription in OA. In conclusion, our data reveal that AC008 plays a critical role in OA pathogenesis via the miR-328-3p‒AQP1/ANKH pathway, suggesting that AC008 may be a potential therapeutic target for OA.

Insights into carbon formation over molten salt-promoted NiO/Al2O3 during methane pyrolysis

He Yangdong,Jing Xingsheng,Qin Li,Wang Dan,Wu Chen,Liu Mengying,Yang Mingkai,Huang Zeai 한국탄소학회 2024 Carbon Letters Vol.34 No.5

Pyrolysis of methane is a carbon-economic method to obtain valuable carbon materials and COx-free H2, under the carbon peaking and carbon neutrality goals. In this work, we propose a methane pyrolysis process to produce graphite and H2 using bubble column reactor containing NiO/Al2O3 and NaCl–KCl (molten salt). The process was optimized by the different amounts of NaCl–KCl, the CH4/Ar ratio and temperature, indicating that the CH4 conversation rate could reach 92% at 900 °C. Meanwhile, we found that the addition of molten salt could obtain pure carbon materials, even if the conversation rate of CH4 decreases. The analysis of the carbon products revealed that graphite could be obtained.

Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion

Shuyin Ma,Meijuan Zhang,Huiyang Qu,Yuxuan Cheng,Shuang Du,Jiaxin Fan,Qingling Yao,Xiao Dong Zhang,Mengying Chen,Nan Zhang,Kaili Shi,Yizhou Huang,Shuqin Zhan 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.1

Background and Purpose Collateral circulation is considered an important factor affecting the risk of stroke, but the factors that affect collateral circulation remain unclear. This study was performed to identify the factors associated with collateral circulation, especially blood lipids. Methods The study involved patients who had undergone digital subtraction angiography and were confirmed as having severe unilateral stenosis or occlusion of the internal carotid artery (ICA). We classified the collateral circulation status of each patient as good (Grade 3 or 4) or poor (Grade 0, 1, or 2) according to the grading system of the American Society of Interventional and Therapeutic Neuroradiology/American Society of Interventional Radiology. We collected data on patients’ characteristics and identified the factors that affect collateral circulation. Results This study included 212 patients. The multivariate logistic regression analysis showed that the high-density lipoprotein cholesterol (HDL-C) concentration and a complete anterior half of the circle of Willis were independent protective factors for good collateral circulation, whereas elevated lipoprotein(a) [Lp(a)] and serum creatinine concentrations were independent risk factors for good collateral circulation. The area under the receiver operating characteristics curve (AUC) was 0.68 (95% confidence interval [CI], 0.61–0.76) for HDL-C and 0.69 (95% CI, 0.62–0.76) for Lp(a). A binary logistic regression model analysis of the joint factor of HDL-C and Lp(a) yielded an AUC of 0.77 (95% CI, 0.71–0.84). Conclusions In patients with severe unilateral ICA stenosis or occlusion, the combination of HDL-C and Lp(a) is a useful predictor of collateral circulation.