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RISS 인기검색어
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- 저자 : Meihua Yuan (검색결과 2 건)
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Performance of Water-immiscible Silk Fibroin Based Hydrogel as Underwater Biomedical Adhesive
Meihua Yuan,Sheng Yan,Han Liu,S. C. Kundu,Yurong Cai,Juming Yao 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10
The shortcomings of the conventional wound closures like poor wet adhesion strength cause a hydrationpersuadedsoftening, dissolution and viscosity of the adhesives. This happens especially due to the changes in viscosity of theadhesive during underwater surgical operations, which drive the research attention on artificial biomedical adhesives. Theinspiration obtained from the natural protein-based adhesives of marine organisms, we develop a water-immiscible silkprotein fibroin based bioadhesive with the assistance of polyethyleneglycol. The viscosity of the fibroin based bioadhesivecan be modified to meet the application requirement. We adjust the reaction factors like varying the raw materials ratios, pHand gelation time. The fabricated bioadhesive exhibits a high dry adhesive strength of about 120 kPa and an enhanced wetadhesive toughness of about 150 kPa. The adhesive mechanism of the material is also proposed. This simplistic green methodmakes the way for obtaining fibroin based bioadhesive as and when needed. The findings promise the potentiality of the silkfibroin-based biomedical adhesive in future clinical applications.
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C57BL/6 마우스에서 알코올성 간 독성에 대한 DSF의 효과
이윤식,Hai-Dan Yuan,최원형,유재영,Meihua Jiang,Yujing Mi,Han-Hong Xiu,박진희,박유신,강주섭 대한암예방학회 2008 Journal of cancer prevention Vol.13 No.3
The aim of this study was to investigate the effect of disulfiram (tetraethylthiuram disulfide, DSF) on the alcoholic liver diseases in mice. C57BL/6 mice were divided into five groups. Control (normal), ethanol treated, DSF treated, ethanol and DSF treated, DSF treated after ethanol treatment for 3 weeks. We evaluated mice body weight and liver weight. On 1 week, body weight was decreased in ethanol treated mice and the body weight gain was similar in all groups of mice after 2 week. With interests, the body weight was significantly increased after treatment of ethanol and DSF for 3 week. However, in the mice with the treatment of DSF only, there was no change of body weight gain and was similar with that of control group of mice. The liver weight of ethanol treated groups was significantly higher than the other groups. A level of ALT, AST and cholesterol in serum were increased in the ethanol treated mice and the level of cholesterol and LDH were increased in DSF treated mice. By H&E staining, we observed degenerative liver tissue change; periportal lymphocytic infiltration, hepatocytes necrosis, severe imflammatory cell infiltrations in ethanol group, and the liver damage was slightly recovered by the treatment of DSF. These results suggest that drinking ethanol is inducible mouse liver damage and the ethanol-induced liver damage was recovered by the treatment of DSF. (Cancer Prev Res 13, 222-227, 2008)
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