용언형 전성토 "-이"의 연구에 관한 재검토

신미화 ( Meihua Shen ) 중국한국(조선)어교육연구학회 2015 한국(조선)어교육연구 Vol.10 No.-

This paper aims to review the previous studies of “-이” and reexamine the grammatical status of “-이”. As is known to all, the grammatical status of “-이” is still a controversial issue in Korean academic research. This paper investigates the category of “-이” from a historical point of view and finally concludes the grammatical status of “-이” is considered as a verbal transformation To.

연결어미 하위분류의 사적인 고찰

신미화 ( Shen Meihua ) 중국한국(조선)어교육연구학회 2022 한국(조선)어교육연구 Vol.20 No.0

Due to the division of the Korean Peninsula for more than 70years, the South and the North have been studying languages in different ways of different systems, and have shown differences in many areas, including language policy, language education, and language research. This paper mainly considers the prior study of grammatical formations conjunction endings, which have been conducted on the Korean peninsula and in China for more than 110years from the beginning of the 20th century to the present, in three stages. We would like to find out the differences between the views of the South and the North on grammatical formations conjunction endings, as well as clarify the part of classification of the conjunction endings.

Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy

Li Zhiguo,Shen Hong,Liu Yeqiang,Zhou Xuefeng,Yan Meihua,He Hailan,Zhao Tingting,Zhang Haojun,Li Ping 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Ovarian cancer is a common gynecological malignancy among female patients and poses a serious threat to women's health. Although it has been established that Fos-like antigen 2 (FOSL2) is linked to ovarian cancer (OC), its exact role in the development of OC remains unknown. Objective: This article aims to investigate the role of FOSL2 in ovarian cancer development. Methods: FOSL2 expression in ovarian carcinoma and adjacent tissues was assessed using real-time fluorescent quantitative PCR and western blot. We constructed OE/sh-FOSL2 plasmids and Caspase-1 specific inhibitors (Yvad-CMK) and transfected A 2780 cells with them to identify the relevant cell functions. Furthermore, we used western blot assay to determine the changes in expression of apoptosis-associated speck-like protein containing a CARD (ASC), cysteine aspartate-specific proteasezymogen procaspase 1 (pro-caspase-1), cysteinyl aspartate-specific proteinase-1 (caspase-1), interleukin-1β precursor (pro-IL-1β), interleukin-1β (IL-1β), interleukin-18 precursor (pro-IL-18), and interleukin-18 (IL-18). In addition, we measured the concentration of IL-1β and IL-18 using an enzyme-linked immunosorbent assay (ELISA). Moreover, Tthe level of lactate dehydrogenase (LDH) in the cell supernatant was measured by LDH release assay kit. Results: The expression of FOSL2 was significantly higher compared with the surrounding tissues. The proliferation, migration, and invasion of A2780 cells were enhanced after transfection with OE-FOSL2 plasmids; however, the cell apoptosis was significantly decreased. When FOSL2 was overexpressed, the inflammasome-associated proteins such as ASC, caspase-1, IL-1β, and IL-18 were downregulated. Furthermore, FOSL2 induced apoptosis and activated the production of inflammasomes in A2780 cells. Co-therapy with Yvad-CMK and substantially inhibited apoptosis and activation of inflammasomes. Conclusions: Inhibition of FOSL2 promotes the apoptosis of OC cells by mediating the formation of an inflammasome.

The Association between Dairy Intake and Breast Cancer in Western and Asian Populations: A Systematic Review and Meta-Analysis

Jiajie Zang,Meihua Shen,Sufa Du,Tianwen Chen,Shurong Zou 한국유방암학회 2015 Journal of breast cancer Vol.18 No.4

Purpose: To date, studies investigating the association between dairy consumption and breast cancer in women have produced conflicting results. As diet is an important, modifiable factor affecting cancer development, the aim of this study was to examine the association between dairy consumption and breast cancer risk. Methods: PubMed, Embase, and Cochrane Library databases were searched with a priority for prospective cohort studies. Case-control studies were also considered in case of the absence of a cohort study. Results: We analyzed 22 prospective cohort studies (1,566,940 participants) and five case-control studies (33,372 participants). High and modest dairy consumption (>600 and 400–600 g/day, respectively) significantly reduced the risk of breast cancer compared with low dairy consumption (<400 g/day; risk ratio [RR], 0.90, 95% confidence interval [CI], 0.83–0.98, and RR, 0.94, 95% CI, 0.91–0.98, respectively). A significant linear relationship between dairy consumption and breast cancer risk was found on dose-response analysis. Subgroup analysis found that yogurt (RR, 0.91; 95% CI, 0.83–0.99) and low-fat dairy (RR, 0.85; 95% CI, 0.75–0.96) reduced the risk of breast cancer, while other dairy product types did not. A reduced risk was observed for people in the United States (RR, 0.91; 95% CI, 0.83–0.99) and in those followed for ≥10 years (RR, 0.90; 95% CI, 0.81–0.99). Additionally, the highest level of dairy consumption among Asians was associated with a reduced risk of breast cancer (odds ratio, 0.74; 95% CI, 0.62–0.88). Conclusion: Dairy consumption was inversely associated with the risk of developing breast cancer and this effect was dependent on the dose, dairy-type, and time.

论对赌协议的规制路径转变

XUAN ZHIYING,SHEN MEIHUA 원광대학교 법학연구소 2022 圓光法學 Vol.38 No.3

The valuation adjustment mechanism has been widely adopted in judicial practice as an important means of private placement. China's attitude towards the valuation adjustment mechanism contract has turned from the absolute prohibition into conditional acceptance. The promulgation of "the 9th conference minutes" acted as a turning point. From then on, the court begins to adopt the doctrine of separation which takes the validity and the performance of the contract respectively. However,the doctrine just meets with the formal logic and systematism of the judgment of contract validity, and does no help to solve the problem of the valuation adjustment mechanism. Under the restriction and adjustment of the principle of capital maintenance, the trial of prerequisite of the court should return to the indistinction doctrine while hearing the cases regarding valuation adjustment mechanism contracts in order to achieve the unity of form and substance. At the same time, trials should turn to the judgment of the performance possibility of the contract and handle the valuation adjustment mechanism contract properly based on the balance of interests.

所有と経営の分離のない株式会社におけるコーポレートガバナンス

高木康衣(Yasue Takagi),申美花(SHEN MEIHUA) 원광대학교 법학연구소 2019 圓光法學 Vol.35 No.4

本稿は、「所有と経営の分離のない株式会社」すなわち中小閉鎖型の株式会社におけるコーポレートガバナンス上の問題について論ずるものである。取締役会を置かず、最低資本金の拠出もない株式会社における経営判断のリスクを債権者や少数株主に転嫁することは許容されるか。論者はこの問題について立法的な対応を図るべきと考えている。 This paper discusses some of the corporate governance issues of stock companies without separation of ownership and management , i.e., small and medium-sized closed stock companies. Is it acceptable to pass on the risk of business judgment to a creditor or a minority shareholder in a stock company that does not have a board of directors and minimum capital contribution? The writer thinks that legislative action should be taken on this issue.

日本の「会社法」の成立とその後の改正について

丸山秀平(Shuhei MARUYAMA),申美花(SHEN MEIHUA) 원광대학교 법학연구소 2019 圓光法學 Vol.35 No.4

本論文で、まず以て記述されているのは、2005年に成立した「会社法」の概要である。 同法は、株式会社について最低資本金を要求していない。従って、株式会社を設立するには、一名の発起人によって、創立資本として1円のみの出資がなされればよいことになる。株式会社は、機関として、株主総会が必要であることは、当然のことであるが、株主総会以外の機関について見れば、一人または複数の取締役が設置されなければならず(会326条1項)、それが求められている最低限の機関となる。それ以外の機関、すなわち、取締役会、会計参与、監査役、監査役会、会計監査人等は、会社法327条1項(公開会社等)および328条(大会社)で規定されている場合を除き、定款で任意に定めることが出来る(会326条2項)。 「会社法」が制定されてからほぼ10年後の2014年に、会社法の最初の改正法案が可決されている。同法案の内容として掲げられていたのは、「監査等委員会」に関する新たな規制であり(会339条の2~339条の14)、いわゆるキャッシュアウト(会179条)や多重代表訴訟(会874条の3)に関する規制であった。 筆者が最後に取り扱ったのが、2019年12上旬現在、国会で審議中の「会社法」の改正法案である。同法案にはコーポレートガバナンスに関する幾つかの規制が含まれている。同法案によれば、監査役会設置会社(公開会社でありかつ大会社)であって、有価証券報告書の提出が求められている会社は、社外取締役の設置が義務づけられる(会327条の2)。 At first, this Article provides the outline of the Japanese Companies Act (Kaisha-hou), which enacted in 2005. This Act does not require minimum start-up capital for a stock company (Kabushikigaisha). For example a stock company can be incorporated by one founder (Hokkinin) with a minimum start-up capital amount of one Yen. Concerning the establishment of the organs other than shareholders meeting, a stock company must have one or more directors (Torishimariyaku) as the minimum requirement of organs (Art.326(1)). With some exceptions of Article 327(1)(public company (Kokai gaisha), etc.)·328 (large sized company (dai gaisha)), a stock company may have a board of directors(Torishimariyaku kai), an accounting advisor (Kaikeisanyo), a company auditor (Kansayaku) , a board of company auditors (Kansayaku kai) , a financial auditor (Kaikeikansanin), etc. as prescribed by the articles of incorporation (Art.326(2)). About 10 years after the enactment of the Japanese Companies Act, the first Reform Bill was passed in 2014. This Bill had the content of new regulations relating to the system of audit and supervisory committee (Kabsatou iinkai) (Art.339-2~14), cash-out (Art.179), a multiple derivative action(Art.847-3) and etc. Finally, the author treats of the ongoing Reform Bill under discussion in early December 2019, which includes several regulations relating to the corporate governance. According to this Bill, a large sized public company with a board of company auditors, which is required to submit an Annual Report, has obligation to establish an outside director (Shagai torisimariyaku) (Art.327-2).